NMC case report journal最新文献

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A Case of Recurrence of Benign Convexity Primary Intraosseous Meningioma. 一例良性凸面原发性骨内脑膜瘤复发病例
NMC case report journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.2176/jns-nmc.2023-0171
Masahiro Ueno, Shinji Shimato
{"title":"A Case of Recurrence of Benign Convexity Primary Intraosseous Meningioma.","authors":"Masahiro Ueno, Shinji Shimato","doi":"10.2176/jns-nmc.2023-0171","DOIUrl":"10.2176/jns-nmc.2023-0171","url":null,"abstract":"<p><p>Meningiomas originating within the bones of the skull are rare and have been reported as primary intraosseous meningiomas (PIOM). Moreover, PIOMs with a skull base location or malignant pathology are predisposed to recurrence; however, recurrence is quite rare among PIOMs characterized by a convexity location and benign pathology. Here, we present a case of extensive recurrence of a convex intraosseous meningioma with benign pathology. A 72-year-old woman presented with a headache to our hospital. Gd contrast-enhanced magnetic resonance imaging revealed an enhanced tumor in the left frontal to the parietal region extending through the calvarial bone and invading the subdural space and subcutaneous tissue. Skull radiograph and computed tomography identified a remarkable osteolytic change in the lesion. Macroscopic complete resection (MCR) of the tumor and the surrounding tissues was performed. The tumor was histopathologically diagnosed as a transitional meningioma (World Health Organization grade 1). Seven years after the surgery, the patient presented with dysarthria, and the recurrence of the tumor was identified as massive lesions extending through the calvarial bone to the orbital bone, partially protruding into the brain and scalp. MCR was performed again, with the reconstruction of the skull for an extensive calvarial area using a titanium plate. This case is unique due to the extensiveness of the recurrent tumor and its rarity. Here, we report the details of the clinical course and discuss the characteristics of this case.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"11 ","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simple Procedure of Epidural Electrode Lead Replacement through a Tissue Sheath in Spinal Cord Stimulation. 脊髓刺激术中通过组织鞘更换硬膜外电极导线的简易程序
NMC case report journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.2176/jns-nmc.2023-0183
Kotaro Kohara, Ryo Hashimoto, Tatsuya Maegawa, Motoo Kubota
{"title":"A Simple Procedure of Epidural Electrode Lead Replacement through a Tissue Sheath in Spinal Cord Stimulation.","authors":"Kotaro Kohara, Ryo Hashimoto, Tatsuya Maegawa, Motoo Kubota","doi":"10.2176/jns-nmc.2023-0183","DOIUrl":"10.2176/jns-nmc.2023-0183","url":null,"abstract":"<p><p>Spinal cord stimulation (SCS) is widely performed to treat several types of intractable chronic pain. To maintain lasting SCS, epidural electrode leads must be replaced sometimes due to problems like lead breakage. However, in lead replacement, guiding the new lead to the original position may be difficult because granulation tissue sheath forms around the lead. We encountered a surgical case where we inserted new leads through tissue sheaths forming around the old leads from the epidural space to the thoracolumbar fascia; the lead was smoothly introduced to the original place. This procedure is simpler than previously reported techniques. Here, we report the detailed surgical procedure and review the relevant literature.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"11 ","pages":"33-36"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moyamoya Syndrome Associated with Late-onset Idiopathic Aqueduct Stenosis Successfully Treated with Endoscopic Third Ventriculostomy. 内镜下第三脑室造口术成功治疗伴有晚发型特发性导水管狭窄的莫亚莫亚综合征
NMC case report journal Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.2176/jns-nmc.2023-0195
Taishi Honda, Masaki Ito, Haruto Uchino, Taku Sugiyama, Miki Fujimura
{"title":"Moyamoya Syndrome Associated with Late-onset Idiopathic Aqueduct Stenosis Successfully Treated with Endoscopic Third Ventriculostomy.","authors":"Taishi Honda, Masaki Ito, Haruto Uchino, Taku Sugiyama, Miki Fujimura","doi":"10.2176/jns-nmc.2023-0195","DOIUrl":"10.2176/jns-nmc.2023-0195","url":null,"abstract":"<p><p>Moyamoya disease (MMD) is a rare idiopathic cerebrovascular disorder that causes transient ischemic attack (TIA) and ischemic stroke in the pediatric population. Herein, we report an extremely rare case of Moyamoya syndrome (MMS) and late-onset idiopathic aqueduct stenosis, a unique form of non-communicating hydrocephalus. A 17-year-old female presented with an intractable headache and occasional faintness. Pertinent medical history included a fourth ventricle epidermoid cyst without any evidence of aqueduct stenosis, which was surgically removed when she was two years of age. The patient subsequently experienced a TIA and was diagnosed with MMD at 14 years of age. Under the definitive diagnosis of MMS associated with a brain tumor, the patient underwent surgical revascularization of the symptomatic right hemisphere without complications. Although the ischemic symptoms resolved postoperatively, a medically intractable headache with occasional faintness persisted. Serial magnetic resonance imaging ultimately revealed newly developed non-communicating hydrocephalus due to acquired aqueduct stenosis at the age of 17. After careful exclusion of the development of either or both a periventricular anastomosis and vault moyamoya vessels along the surgical route using cerebral angiography, we performed an endoscopic third ventriculostomy (ETV) via the right anterior horn without complications. A complete resolution of her chronic headache with the shrinkage of the third ventriculomegaly was observed postoperatively. In cases of MMS associated with symptomatic aqueduct stenosis, transdural collaterals on the cranial vault and periventricular collaterals should be meticulously evaluated preoperatively using cerebral angiography to safely perform an ETV.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"11 ","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transvenous Embolization for Isolated Superior Petrosal Sinus Dural Arteriovenous Fistula. 经静脉栓塞治疗孤立的上皮下窦硬脑膜动静脉瘘。
NMC case report journal Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.2176/jns-nmc.2023-0224
Koji Hirata, Kyoji Tsuda, Keishi Fujita, Eiichi Ishikawa, Yuji Matsumaru
{"title":"Transvenous Embolization for Isolated Superior Petrosal Sinus Dural Arteriovenous Fistula.","authors":"Koji Hirata, Kyoji Tsuda, Keishi Fujita, Eiichi Ishikawa, Yuji Matsumaru","doi":"10.2176/jns-nmc.2023-0224","DOIUrl":"10.2176/jns-nmc.2023-0224","url":null,"abstract":"<p><p>Isolated superior petrosal sinus dural arteriovenous fistula (SPSdAVF) is a rare condition for which transvenous embolization is a safe treatment, even if accessing the isolated sinus can be challenging. A 39-year-old female patient with dizziness and right facial palsy underwent magnetic resonance imaging, revealing a venous infarction at the posterior fossa and a dural arteriovenous fistula. Digital subtraction angiography showed an isolated SPSdAVF. The shunt point was posterior to the isolated superior petrosal sinus, and the shunt flowed only through the petrosal vein. Contrast-enhanced magnetic resonance imaging showed thrombosis at the anterior segment of the superior petrosal sinus. Transvenous embolization was successfully performed via the thrombosed anterior segment of the superior petrosal sinus without associated complications. This case shows that transvenous embolization through a thrombosed superior petrosal sinus is an alternative treatment option for isolated SPSdAVF.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"11 ","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Symptomatic Multiple Tarlov Cysts Treated with Microsurgical Wrapping Technique -Efficacy and Limitation of Surgical Procedure. 一例采用显微外科包裹技术治疗的症状性多发性塔洛夫囊肿--手术的有效性和局限性。
NMC case report journal Pub Date : 2024-01-16 eCollection Date: 2024-01-01 DOI: 10.2176/jns-nmc.2023-0213
Naokado Ikeda, Yutaka Ito, Kunio Yokoyama, Hidekazu Tanaka, Makoto Yamada, Akira Sugie, Toshihiro Takami, Masahiko Wanibuchi, Masahiro Kawanishi
{"title":"A Case of Symptomatic Multiple Tarlov Cysts Treated with Microsurgical Wrapping Technique -Efficacy and Limitation of Surgical Procedure.","authors":"Naokado Ikeda, Yutaka Ito, Kunio Yokoyama, Hidekazu Tanaka, Makoto Yamada, Akira Sugie, Toshihiro Takami, Masahiko Wanibuchi, Masahiro Kawanishi","doi":"10.2176/jns-nmc.2023-0213","DOIUrl":"10.2176/jns-nmc.2023-0213","url":null,"abstract":"<p><p>Tarlov cysts (TCs) rarely cause clinical symptoms, such as leg pain, buttock pain, and bladder/bowel dysfunction. Surgery is considered when these symptoms persist despite medical treatments. Among several surgical procedures, microsurgical wrapping (MSW) is a relatively novel, simple technique with few complications, including cerebrospinal fluid leakage. Herein, we report a case of multiple TCs treated with MSW and present the mechanism of symptoms generated by TC and the procedure's limitations. A 58-year-old man complained of severe right leg and buttock pain for 3 months and was admitted to our hospital. His symptoms aggravated with sitting and standing and improved with the prone position. Spinal magnetic resonance imaging (MRI) demonstrated multiple sacral cysts containing intense cerebrospinal fluid. The cysts connect to the right S3 and S4 nerve roots. He was treated conservatively with medications; however, his symptoms were not improved. Therefore, MSW was performed for TCs connected to the S3 and S4 roots. The postoperative course was uneventful, and cerebrospinal fluid leakage did not occur. MRI performed 1 year after the operation demonstrated no recurrence of the TCs, and his leg pain was completely relieved; however, the buttock pain remained. MSW for TCs is effective for symptoms of adjacent nerve root compression; however, repairing the damaged nerve root in TCs is sometimes difficult. This may be a limitation of present surgical interventions because these symptoms may be difficult to treat even with other interventions.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"11 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Thoracic Disk Herniation without Spinal Stenosis Presenting with Acute Myelopathy: Three Case Reports. 无椎管狭窄的胸椎小椎间盘突出症伴有急性脊髓病:三个病例报告。
NMC case report journal Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI: 10.2176/jns-nmc.2023-0110
Rika Nakamura, Keisuke Takai
{"title":"Small Thoracic Disk Herniation without Spinal Stenosis Presenting with Acute Myelopathy: Three Case Reports.","authors":"Rika Nakamura, Keisuke Takai","doi":"10.2176/jns-nmc.2023-0110","DOIUrl":"https://doi.org/10.2176/jns-nmc.2023-0110","url":null,"abstract":"<p><p>We herein describe three patients with thoracic disk herniation (TDH) that presented with acute myelopathy at the Tokyo Metropolitan Neurological Hospital between 2014 and 2021 (age range, 45-76 years; male/female ratio = 1:2), with a focus on the mechanisms underlying their development. All patients had sudden-onset gait disturbance due to acute nontraumatic paraparesis. The specialties of the doctors at the first hospital were neurology and orthopedic surgery. TDH was overlooked at the first hospital, and the patients were referred to our hospital. The TDH in all cases was of the central type; however, since they were small, no spinal stenosis was observed. The key feature of all three cases is the small anterior deformation of the spinal cord, making a vascular etiology for the symptoms more plausible than a compressive etiology. After a follow-up of several months or years, two out of three patients underwent surgery with the use of the transfacet pedicle-sparing approach due to residual symptoms. Intraoperative ultrasonography showed that the spinal cord was anchored to TDH by the dural attachment of dentate ligaments. The physical relationship between the dentate ligaments and TDH may be associated with the vascular cause of the symptoms of small TDH.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"10 ","pages":"331-335"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10731420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversible Bilateral Transverse Sinus Occlusion Treated by Lumboperitoneal Shunt in Idiopathic Intracranial Hypertension: A Case Report. 通过腰腹腔分流术治疗特发性颅内高压的可逆性双侧横窦闭塞:病例报告。
NMC case report journal Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI: 10.2176/jns-nmc.2023-0140
Atsuhito Taishaku, Takayuki Ohno, Takashi Iwata, Hiromi Shibata, Motoki Ishida, Noritaka Aihara
{"title":"Reversible Bilateral Transverse Sinus Occlusion Treated by Lumboperitoneal Shunt in Idiopathic Intracranial Hypertension: A Case Report.","authors":"Atsuhito Taishaku, Takayuki Ohno, Takashi Iwata, Hiromi Shibata, Motoki Ishida, Noritaka Aihara","doi":"10.2176/jns-nmc.2023-0140","DOIUrl":"https://doi.org/10.2176/jns-nmc.2023-0140","url":null,"abstract":"<p><p>We report a patient with idiopathic intracranial hypertension (IIH) with bilateral transverse sinus occlusion treated by a lumboperitoneal shunt. A 45-year-old woman presented with visual disturbance and chronic headache. Magnetic resonance (MR) venography and three-dimensional computed tomography angiography (3D-CTA) showed occlusion of both transverse sinuses. After the surgery, MR venography and 3D-CTA showed no blockages in both transverse sinuses. This phenomenon reveals that obstruction of the bilateral transverse sinus is a consequence of intracranial hypertension, not just a single cause. Since many patients have an obstruction or stenosis of the venous sinus, there are some reports of endovascular treatment. Sinus reconstruction is usually effective, but it is not effective in some cases. Reversal of sinus occlusion suggests that endovascular therapy for IIH is inadequate in some cases.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"10 ","pages":"327-330"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Response to Radiation Therapy without Surgical Intervention in a Giant Cavernous Sinus Hemangioma with Hydrocephalus: A Case Report. 巨大海绵窦血管瘤伴脑积水患者对放射治疗的早期反应而无需手术干预:病例报告。
NMC case report journal Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI: 10.2176/jns-nmc.2023-0094
Noriyuki Watanabe, Masashi Mizumoto, Taishi Amano, Hisayuki Hosoo, Akinari Yamano, Alexander Zaboronok, Masahide Matsuda, Shingo Takano, Yuji Matsumaru, Eiichi Ishikawa
{"title":"Early Response to Radiation Therapy without Surgical Intervention in a Giant Cavernous Sinus Hemangioma with Hydrocephalus: A Case Report.","authors":"Noriyuki Watanabe, Masashi Mizumoto, Taishi Amano, Hisayuki Hosoo, Akinari Yamano, Alexander Zaboronok, Masahide Matsuda, Shingo Takano, Yuji Matsumaru, Eiichi Ishikawa","doi":"10.2176/jns-nmc.2023-0094","DOIUrl":"https://doi.org/10.2176/jns-nmc.2023-0094","url":null,"abstract":"<p><p>Cavernous sinus hemangioma (CSH) is a rare vascular malformation, arising from the cavernous sinus. Because of its anatomically complex location, a large lesion can cause a variety of symptoms due to cranial nerve compression. A 69-year-old woman with an unsteady gait was admitted to our hospital, and magnetic resonance imaging revealed an extra-axial giant tumor in the cavernous sinus and enlarged ventricles. A radiographic diagnosis of CSH was made. As the risk of surgical removal was considered high, the patient underwent intensity-modulated radiation therapy of 50.4 Gy in 28 fractions. The size of the tumor decreased markedly over time, and the symptoms improved soon after treatment. A 61.8% reduction in tumor size was confirmed immediately after irradiation, and a 75.9% reduction was revealed at a follow-up visit one year later. We reported a case of a giant CSH with hydrocephalus, where tumor shrinkage was confirmed immediately after radiation therapy, and the symptoms of hydrocephalus improved without surgical intervention.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"10 ","pages":"337-342"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient with Diffuse Midline Glioma, H3 K27-altered, Carrying an FGFR1 Mutation Who Experienced Thalamic Hemorrhage: A Case Report and Literature Review. 弥漫中线胶质瘤患者,H3 K27 变异,携带 FGFR1 基因突变,丘脑出血:病例报告与文献综述
NMC case report journal Pub Date : 2023-11-11 eCollection Date: 2023-01-01 DOI: 10.2176/jns-nmc.2023-0035
Kyosuke Matsunaga, Shinjiro Fukami, Nobuyuki Nakajima, Norio Ichimasu, Michihiro Kohno
{"title":"Patient with Diffuse Midline Glioma, H3 K27-altered, Carrying an <i>FGFR1</i> Mutation Who Experienced Thalamic Hemorrhage: A Case Report and Literature Review.","authors":"Kyosuke Matsunaga, Shinjiro Fukami, Nobuyuki Nakajima, Norio Ichimasu, Michihiro Kohno","doi":"10.2176/jns-nmc.2023-0035","DOIUrl":"https://doi.org/10.2176/jns-nmc.2023-0035","url":null,"abstract":"<p><p>Diffuse midline glioma (DMG), H3 K27M-altered, is a tumor with a poor prognosis mainly found in children. An adolescent patient presented with thalamic hemorrhage, which initially could not be diagnosed as DMG by pathological analysis. A neoplasm in the lateral ventricle close to the previous thalamic hemorrhagic lesion was detected 12 months after the hemorrhage. Thus, endoscopic resection was performed, and a diagnosis was made. Gene expression profiling demonstrated mutation in genes, such as <i>H3F3A</i> and <i>FGFR1</i>. <i>FGFR1</i> mutation was associated with intratumoral hemorrhage in low-grade gliomas and contributed to longer survival than wild-type <i>FGFR1</i> in DMG H3K27M. Our findings suggest that patients with DMG, H3 K27-altered, with <i>FGFR1</i> mutation may be predisposed to intratumoral hemorrhaging and/or have a longer survival time than patients without <i>FGFR1</i> mutation.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"10 ","pages":"309-314"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138816132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant Transformation and Leptomeningeal Melanomatosis in a Primary Meningeal Melanocytoma: A Case Report and Review of Literature. 原发性脑膜黑色素细胞瘤的恶性转化和脑膜黑色素瘤病:病例报告和文献综述。
NMC case report journal Pub Date : 2023-11-11 eCollection Date: 2023-01-01 DOI: 10.2176/jns-nmc.2023-0109
Kenta Nakase, Ryosuke Matsuda, Tomoya Okamoto, Ichiro Nakagawa, Maiko Takeda, Katsumi Sakata, Hiroyuki Nakase
{"title":"Malignant Transformation and Leptomeningeal Melanomatosis in a Primary Meningeal Melanocytoma: A Case Report and Review of Literature.","authors":"Kenta Nakase, Ryosuke Matsuda, Tomoya Okamoto, Ichiro Nakagawa, Maiko Takeda, Katsumi Sakata, Hiroyuki Nakase","doi":"10.2176/jns-nmc.2023-0109","DOIUrl":"10.2176/jns-nmc.2023-0109","url":null,"abstract":"<p><p>Meningeal melanocytomas of the central nervous system, although typically benign, rarely undergo malignant transformations. A 46-year-old man presented with headache and nausea 4 years after gross total resection of a craniovertebral junction meningeal melanocytoma at another hospital. The initial clinical course was previously reported.<sup>1</sup><sup>)</sup> Computed tomography revealed the presence of multiple intracranial mass lesions. Furthermore, magnetic resonance imaging showed multiple intracranial lesions and meningeal dissemination. A biopsy was performed for a circumflex lesion located in the right frontal lobe. Pathological examination showed anaplastic changes and a Ki-67 index of 33%. Based on the pleomorphic changes and high mitotic activity, the patient was diagnosed with primary cerebral malignant melanoma. The patient received four cycles of nivolumab (80 mg) and ipilimumab (165 mg), followed by whole-brain radiotherapy (37.5 Gy). However, the disease progressed after the third cycle. Genome analysis revealed <i>GNAQ</i> Q209P and <i>SF3B1</i> R625C mutations, but no treatments related to these gene mutations were available. Despite the seven cycles of nivolumab therapy, the patient eventually passed away 9 months after surgery. This case was a rare example of malignant transformation and leptomeningeal melanomatosis in a meningeal melanocytoma. It highlights the importance of careful follow up after gross total resection. Identification of molecular alterations can lead to better detection of melanocytic melanomas with poor prognosis and high risk of recurrence and metastasis. It can also facilitate the development of novel therapeutic options for these patients.</p>","PeriodicalId":101331,"journal":{"name":"NMC case report journal","volume":"10 ","pages":"315-320"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138816131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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