JOURNAL OF CELLULAR AND MOLECULAR MEDICINE最新文献

{"title":"Berberine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice and Regulates the PI3K-AKT Pathway: A Network Pharmacology Study","authors":"Xuan Li,&nbsp;Shiyu Meng,&nbsp;Jiayi Liu,&nbsp;Meixian Sun,&nbsp;Mao Zhou,&nbsp;Fengtao Ji,&nbsp;Yu Hong","doi":"10.1111/jcmm.70744","DOIUrl":"https://doi.org/10.1111/jcmm.70744","url":null,"abstract":"<p>In this study, we investigated the therapeutic potential of Berberine (BBR), an anti-inflammatory agent capable of penetrating the blood–brain barrier, for mitigating postoperative cognitive dysfunction (POCD) in aged mice. BBR was administered at a dose of 10 mg/kg daily for 2 weeks and significantly improved cognitive impairments induced by surgical and anaesthesia-related factors. Specifically, BBR markedly suppressed glial cell activation and reduced levels of pro-inflammatory cytokines such as tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β). Additionally, it alleviated oxidative stress markers and lipid accumulation. Using network pharmacology analysis, we demonstrated that BBR modulates neuroinflammation, oxidative processes and lipid metabolism by inhibiting the phosphorylation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. Furthermore, extended research revealed that BBR upregulated the expression of PPAR-<i>γ</i> mRNA, suggesting a neuroprotective mechanism via regulation of the PI3K-Akt pathway. These findings support the potential application of BBR as a therapeutic agent for managing POCD in elderly populations.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 15","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Advances in Classification, Prediction and Management of Microvascular Invasion in Hepatocellular Carcinoma","authors":"Zhenli Li,&nbsp;Lindi Xu,&nbsp;Shuaishuai Zhu,&nbsp;Xingshun Qi,&nbsp;Wei Zhang,&nbsp;Yufu Tang","doi":"10.1111/jcmm.70746","DOIUrl":"https://doi.org/10.1111/jcmm.70746","url":null,"abstract":"<p>Liver resection remains the mainstay curative treatment for hepatocellular carcinoma (HCC); however, the recurrence rate is reported to exceed 70% within 5 years after surgery. Microvascular invasion (MVI) has attracted great research interest in the last decade and has been confirmed to be an independent risk factor for postoperative recurrence and survival. Presently, the diagnosis of MVI depends on pathological specimens, which are not helpful in guiding preoperative planning and intraoperative decision-making. However, preoperative MVI prediction has developed rapidly with the widespread application of predictive models. Besides the well-defined clinical predictive factors, radiomics and artificial intelligence (AI)-based models can provide accurate predictions of MVI. In terms of the specific management of MVI, multiple pre- and intraoperative therapeutic choices have shown favourable effects in patients at high risk of MVI indicated by predictive models. Several postoperative adjuvant therapies were also demonstrated to be associated with improved surgical outcomes in patients diagnosed with MVI. Considering that the present perspectives concerning MVI-related management are still controversial, based on the latest research, the present paper provides updated insights into the <b>1</b>) diagnosis and classification of MVI, <b>2</b>) the predictive factors and models of MVI and <b>3</b>) effective therapeutic choices of MVI in pre-, intra- and postoperative processes. The remaining challenges in the management of MVI are highlighted to stimulate further explorations of the precise and individualised management of MVI.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 15","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Diagnostic and Therapeutic Targets for Spinal Cord Injury: GRN Gene","authors":"Han Ding,&nbsp;Lei Feng,&nbsp;Jianping Zhang,&nbsp;Tuo Fang,&nbsp;Jun Shang,&nbsp;Ke Fang,&nbsp;Shiqing Feng","doi":"10.1111/jcmm.70749","DOIUrl":"https://doi.org/10.1111/jcmm.70749","url":null,"abstract":"<p>Spinal cord injury (SCI) is a severe disabling disease due to the poor self-healing of the central nervous system. Studies showed that many N6-methyladenosine (m6A) RNA methylation profiles are hypomethylated after SCI, which are related to neural regeneration and different m6A marker genes. In addition, immune cell infiltration may significantly affect the development and progression of SCI. Therefore, we attempted to identify the correlation between SCI-related biomarkers and m6A methylation regulators in order to classify them. To this end, we collected two gene expression profile datasets (GSE464 and GSE45006) from the GEO database, performed differential expression analysis between pairs before and after SCI, and identified 19 constant differentially expressed genes (DEGs). We found that the constant differential genes were strongly correlated with m6A methylation regulators, which could modulate the immune microenvironment of SCI. Next, this paper used a consensus clustering algorithm to classify SCI patients into three subtypes. There are significant differences between 19 constant DEGs and 28 immune cells among different subtypes. Finally, the correlation analysis of the intersection genes between constant DEGs and immune genes was performed, and GRN was identified as a potential immune biomarker for SCI.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 15","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC01614: A Potential Therapeutic Target in Astrocytoma Progression","authors":"Fatemeh Karimpour,&nbsp;Mohammad Hosseini Hooshiar,&nbsp;Shima Abbasnejad,&nbsp;Kimia Abdi,&nbsp;Arsalan Jalili,&nbsp;Amir Khanmirzaei,&nbsp;Sara Tutunchi,&nbsp;Amir-Reza Javanmard,&nbsp;Mohammadreza Hajiesmaeili,&nbsp;Sayyed Mohammad Hossein Ghaderian","doi":"10.1111/jcmm.70623","DOIUrl":"https://doi.org/10.1111/jcmm.70623","url":null,"abstract":"<p>Astrocytomas are aggressive brain tumours with limited treatment options, making the identification of novel therapeutic targets crucial. Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene expression and have been implicated in various cancers, including astrocytoma. LINC01614 is a lncRNA that has been found to be upregulated in astrocytoma, suggesting its potential role in tumour progression. In this study, we investigated the functional role of LINC01614 in astrocytoma and its interaction with miR-128, a known regulator of the RAS/Map kinase signalling pathway. Through in vitro experimental assays, we demonstrated that LINC01614 upregulation promotes astrocytoma cell proliferation and invasion, potentially through the sponging of miR-128. Furthermore, <i>in silico</i> analysis revealed potential binding sites of miR-128 within the RAS/Map kinase signalling pathway, suggesting a regulatory role for miR-128 in this pathway. Our findings provide novel insights into the molecular mechanisms underlying astrocytoma progression and highlight the potential of LINC01614 as a therapeutic target. Targeting LINC01614 or modulating miR-128 expression may offer new therapeutic strategies for astrocytoma treatment. Additionally, our <i>in silico</i> analysis provides a foundation for further exploration of the regulatory network involving LINC01614, miR-128 and the RAS/Map kinase signalling pathway. Overall, this study sheds light on the intricate regulatory network in astrocytoma and presents promising avenues for the development of targeted therapies for this devastating disease.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 15","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Comprehensively Analysis of Splicing Factors to Construct Prognosis Prediction Classifier in Prostate Cancer”","authors":"","doi":"10.1111/jcmm.70743","DOIUrl":"https://doi.org/10.1111/jcmm.70743","url":null,"abstract":"<p>H. Zhang, J. Tian, S. Ren, B. Han, R. Tian, X. Zuo, H. Liu, Z. Wang, Y. Cui, L. Liu, H. Guo, F. Zhang, and R. Niu, “Comprehensively Analysis of Splicing Factors to Construct Prognosis Prediction Classifier in Prostate Cancer,” <i>Journal of Cellular and Molecular Medicine</i> 27, no. 18 (2023): 2684–2700, https://doi.org/10.1111/jcmm.17849.</p><p>Concerns were raised by a third party regarding the shape of the ROC curves (Figures 4–6) and the apoptosis measurements in Figure 8 of this article.</p><p>As stated by the authors, the observed irregularity in the curve shape results from methodological distinctions between the Kaplan–Meier (KM) and nearest neighbour estimation (NNE) approaches in the ‘survivalROC’ analysis package (R software, version 4.2.1). The selection of KM methodology was based on three considerations: (1) The results of NNE are highly dependent on the choice of span parameter; (2) KM provides reproducible results without parameter tuning requirements; and (3) KM maintains data fidelity despite producing less visually smooth curves. This methodological decision prioritises analytical precision over aesthetic considerations.</p><p>Regarding the apoptosis measurements, the main concern was that based on the data presented and the apoptosis detection kit used, it is not possible to clearly distinguish between late apoptotic and necrotic cells. The fraction of cells labelled as ‘necrotic’ in Figure 8G could be an artifact due to mechanical damage of the cell membrane and false positive cytoplasmic RNA staining by PI. Additional technical issues were identified regarding the lack of manual compensation of the FACS samples in Figure 8F, leading to incorrect live, early apoptotic, and late apoptotic cell population percentages; therefore, incorrect FACS analysis results in Figure 8F,G. Hence, the authors were asked to repeat the experiments in question to provide further clarification.</p><p>The new results confirmed the conclusions presented in section 3.8 of the published manuscript: ‘down-regulation of both LSM3, DHX16 and NOVA2 induced cell apoptosis in DU145 cells (Figure 8F,G)’ ‘NOVA2 did not affect the apoptosis of PC3 cells, and LSM3 did not associate with the apoptosis in PC3 cells (Figure 8F,G)’, the experimental results and conclusions of the paper remain unaffected.</p><p>The corrected Figure 8F,G are as follows:</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 15","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Critical Role of APOE+ Macrophages in the Immune Microenvironment and Prognosis of Lung Adenocarcinoma","authors":"Xiaofei Wang,&nbsp;Pengpeng Zhang,&nbsp;Wei Ye,&nbsp;Mingjun Du,&nbsp;Chenjun Huang,&nbsp;Jianan Zheng","doi":"10.1111/jcmm.70731","DOIUrl":"https://doi.org/10.1111/jcmm.70731","url":null,"abstract":"<p>The immunoregulatory functions and clinical implications of APOE+ macrophages within the tumour microenvironment of lung adenocarcinoma remain incompletely defined. In this study, single-cell transcriptome analysis revealed distinct subsets of APOE+ macrophages, and subsequent CellChat analyses highlighted that these cells predominantly interact with other components of the tumour microenvironment via MIF-(CD74+CXCR4) and MIF-(CD74+CD44) signalling pathways, thereby contributing to the establishment of an immunosuppressive milieu. Integrating mutation profiles with multiple machine learning techniques, we developed an APOE+ Macrophage-related Risk Model (ARM) through a combination of RSF and Ridge approaches, achieving the highest prognostic accuracy (C-index) among all tested algorithms. The robustness and predictive value of the ARM model were validated across seven public cohorts and three prospective immunotherapy cohorts. Patients classified in the low-ARM group consistently exhibited better prognoses, as demonstrated by survival analyses, ROC curves and PCA discrimination. Additionally, multiplex immunofluorescence analysis in the in-house cohort confirmed significantly decreased infiltration of CD4+, CD8+ and CD20+ immune cells in the high-ARM group, further supporting a more pronounced immunosuppressive microenvironment in these patients. Collectively, our findings not only clarify the critical role of APOE+ macrophages in shaping the immune landscape and prognosis of lung adenocarcinoma, but also provide a validated, practical risk model for individualised patient prognostication and clinical management.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 15","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia–Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis","authors":"Weisong Wang,&nbsp;Zengyu Zhang,&nbsp;Rongzhen Liu,&nbsp;Yu Zheng,&nbsp;Yaqi Hu,&nbsp;Xia Li,&nbsp;Zihao Shen,&nbsp;Hengyou Yuan,&nbsp;Jianhe Liu","doi":"10.1111/jcmm.70666","DOIUrl":"https://doi.org/10.1111/jcmm.70666","url":null,"abstract":"<p>Previous studies have shown the potential of Chaihu Sanshen capsule (CHSSC) to ameliorate myocardial ischemia-reperfusion injury (MIRI), but there is yet no corresponding research on its chemical ingredients and multi-target action network. The study aims to identify the chemical composition and potential bioactive compounds of CHSSC and elucidate its underlying mechanisms in MIRI treatment. Ultra-high-performance liquid chromatography-Q exactive focus-mass spectrometry was used to analyse the chemical composition and potential bioactive compounds of CHSSC. The active compounds were analysed via network pharmacology to identify the core targets and pathways. The oxygen–glucose deprivation/reoxygenation (OGD/R) H9C2 cell model and MIRI rat model were established, followed by intervention with CHSSC. TUNEL, flow cytometry and western blotting assays were used to observe the effects of CHSSC on apoptosis, pyroptosis and the PI3K/AKT/p53 signalling pathway, respectively, of cardiomyocytes. In all, 1587 compounds were detected in CHSSC, of which 106 were absorbed into the bloodstream, mainly comprising flavonoids, terpenoids, alkaloids, organic acids, coumarins and phenols. CHSSC primarily targeted TP53, AKT, STAT3, HSP90AA1 and MAPK and involved the regulation of p53, PI3K/AKT, JAK2/STAT3 and MAPK signalling pathways; however, these predicted targets have not yet been validated by confirmatory binding assays. In vitro experiments showed that CHSSC reduced the apoptosis and pyroptosis rates of OGD/R H9C2 cells. In vivo, CHSSC ameliorated myocardial injury in MIRI rats, decreased the cardiomyocyte apoptosis rate, increased PI3K and AKT phosphorylation and inhibited p53 phosphorylation. In conclusion, this study elucidated the potential bioactive compounds and multi-targets action network of CHSSC in mitigating MIRI, and verified that the effects of CHSSC on MIRI are link to the PI3K/AKT/p53 signalling pathway.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 14","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: Gonadal Steroids Regulate the Expression of Aggrecanases in Human Endometrial Stromal Cells In Vitro","authors":"","doi":"10.1111/jcmm.70755","DOIUrl":"https://doi.org/10.1111/jcmm.70755","url":null,"abstract":"<p>Expression of Concern: J. Wen, H. Zhu, and P. C. K. Leung, “Gonadal Steroids Regulate the Expression of Aggrecanases in Human Endometrial Stromal Cells In Vitro,” <i>Journal of Cellular and Molecular Medicine</i> 17, no. 10 (2013): 1325–1334, https://doi.org/10.1111/jcmm.12110.</p><p>This Expression of Concern is for the above article, published online on 15 August 2013 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Stefan N. Constantinescu; the Foundation for Cellular and Molecular Medicine; and John Wiley and Sons Ltd. A third party reported that three of the four lanes in the beta-actin control bands in Figure 4D had been duplicated in Figure 4E. The third party also noted that seven of the ADAMTS8 experimental bands in Figure 5C had been duplicated in Figure 6D even though both images are intended to show different treatments. Additional investigation by the publisher confirmed these duplications and found that the ADAMTS8 band in Figure 6D was altered with high contrast compared to the same band in Figure 5C.</p><p>The authors responded to an inquiry by the publisher and stated that the ADAMTS8 image in Figure 5C was correct and that the ADAMTS8 image in Figure 6D was mistakenly replaced with the image of the other treatment during the assembly of the ADAMTS8 Western blot panels, and that adjustments to image brightness and contrast were made during figure preparation. The authors also stated that the beta-actin images were not duplicated and were generated from separate experiments. The authors provided what they stated was the correct image for Figure 6D. However, the authors confirmed that not all of the original data for the article were available. Because the original data could not be evaluated, the journal is not able to verify the provided replacement image for the ADAMTS8 band in Figure 6D. As such, the editors are not able to validate the data included in Figures 5 and 6. The journal has decided to issue an Expression of Concern to inform and alert readers. The authors were informed of the Expression of Concern.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 14","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70755","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farnesoid X Receptor Alleviates Cisplatin-Induced Kidney Inflammatory Injury by Inhibiting Tlr4/NF-κB Pathway","authors":"Fangyuan Peng,&nbsp;Jinghan Feng,&nbsp;Xinni Zhang,&nbsp;Ting Ren,&nbsp;Qi Zeng,&nbsp;Qian Sun,&nbsp;Zhouping Zou,&nbsp;Xiaoqiang Ding,&nbsp;Ping Jia","doi":"10.1111/jcmm.70730","DOIUrl":"https://doi.org/10.1111/jcmm.70730","url":null,"abstract":"<p>Inflammatory responses play a critical role in cisplatin-induced acute kidney injury (AKI). Farnesoid X receptor (FXR) has been shown to mitigate kidney dysfunction, but its mechanism remains unclear. This study aims to explore whether FXR reduces cisplatin-induced AKI by modulating inflammation. Using a mouse model of AKI, we demonstrated that cisplatin-induced obvious inflammation in the kidney, evidenced by increased macrophage and neutrophil infiltration, elevated expression of pro-inflammatory cytokines, including interleukin-1 beta (IL-1β), IL-6, C-X-C motif chemokine ligand (CXCL) 1, 2, 5, 20, and C-C motif chemokine ligand (CCL) 2, and activation of the toll-like receptor 4 (Tlr4)/nuclear factor-kappa B (NF-κB) pathway. RNA sequencing further corroborated these findings, revealing upregulation of inflammation-related genes and activation of several inflammatory pathways in the kidney after cisplatin administration. Pretreatment with GW4064 (a FXR agonist) reduced inflammatory cytokine expression, immune cell infiltration, and Tlr4/NF-κB activation, alleviating kidney injury. However, proximal tubule-specific FXR knockout worsened renal inflammation and increased NF-κB activity. In vitro, GW4064 decreased pro-inflammatory cytokine production, suppressed Tlr4/NF-κB signalling, and reduced apoptosis in cisplatin-treated renal tubular epithelial cells. Together, these findings demonstrate that FXR significantly alleviates cisplatin-induced renal inflammation via suppressing Tlr4/NF-κB signalling. FXR activation may represent a promising therapeutic strategy to mitigate cisplatin-induced AKI.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 14","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70730","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miR-542-3p as a Prognostic Marker for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis","authors":"Ranjith Balakrishnan,&nbsp;Rajasekaran Subbarayan,&nbsp;Maheshkumar Kuppusamy,&nbsp;Rupendra Shrestha,&nbsp;Arunkumar Radhakrishnan,&nbsp;Ankush Chauhan","doi":"10.1111/jcmm.70748","DOIUrl":"https://doi.org/10.1111/jcmm.70748","url":null,"abstract":"<p>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, particularly in Asia. Despite therapeutic advancements, the prognosis of HCC remains poor. MicroRNAs have emerged as potential biomarkers for HCC prognosis and therapeutic response. This systematic review and meta-analysis examined the association between circulating <i>miR-542-3p</i> levels and HCC progression. Seven studies on HCC and <i>miR-542-3p</i> were selected for the meta-analysis. <i>miR-542-3p</i> showed significant diagnostic potential for HCC prognosis and therapeutic evaluation. Two independent researchers performed data extraction and used the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) method to assess the quality and risk of bias of the included studies. After the meta-analysis, human miRNA pattern analysis was conducted using the miRBase database, and the expression of <i>miR-542-3p</i> was confirmed based on the results obtained from the human miRNA profile in the tissue atlas database. <i>miR-542-3p</i> has been shown to have significant diagnostic potential for HCC prognosis and therapeutic evaluation. The pooled sensitivity was 0.79 (95% CI, 0.75–0.83), while the pooled specificity was 0.34 (95% CI, 0.29–0.40). The diagnostic odds ratio was 7.2, with an AUC of 0.806, indicating moderate diagnostic accuracy. Network analysis in miRBase links <i>miR-542-3p</i> to liver function, and its location on the X chromosome allows its expression in both sexes, making it widely applicable for the diagnosis of HCC. Thus, <i>miR-542-3p</i> has potential as a prognostic biomarker for HCC, with prospects for integration into therapeutic strategies. Future studies should explore the combination of this with targeted therapies to improve patient outcomes.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 14","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}