Journal of cannabis research最新文献

{"title":"Harnessing machine learning and multivariate analysis to explore global trends in Cannabis sativa research.","authors":"Javier De La Hoz-M, Karime Montes-Escobar, Carlos Alfredo Salas-Macias","doi":"10.1186/s42238-026-00397-w","DOIUrl":"10.1186/s42238-026-00397-w","url":null,"abstract":"<p><p>This study employs advanced data science techniques to explore global research trends in Cannabis sativa from 1974 to 2024. This research integrated bibliographic datasets from PubMed, Scopus, and Web of Science. By combining latent Dirichlet allocation (LDA) and HJ-Biplot methods, we extracted actionable insights from large-scale data to address the current gap in long-term global research monitoring. The analysis identified key research topics, geographic disparities, and temporal trends, providing a comprehensive overview of the evolution of Cannabis sativa studies. The results highlight an increasing focus on the medical applications of Cannabis sativa, particularly in North America and Europe, while highlighting research gaps in emerging regions such as Africa and South America. Furthermore, the integration of multivariate methods with machine learning offers a replicable framework for managing large bibliographic datasets and enhancing data-driven decision-making in research management. Additionally, combining topic modeling with multivariate visualization provides a novel framework to understand how research themes evolve and interact. This approach serves as a strategic tool for stakeholders navigating the rapidly changing cannabis field.</p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micropropagation of Cannabis sativa: genetic and epigenetic stability assessment over multiple generations.","authors":"Vincent Lefebvre, Davoud Torkamaneh, Sylvie Deslauriers, Théo Devèze, Maxime de Ronne, Mélodie B Plourde, Mebarek Lamara, Hugo Germain","doi":"10.1186/s42238-026-00406-y","DOIUrl":"10.1186/s42238-026-00406-y","url":null,"abstract":"<p><strong>Background: </strong>Micropropagation is an increasingly sought-after propagation method in the cannabis industry as growers seek to maximize production efficiency, improve multiplication rates and cultivate plants that are free from biotic stress. However, knowledge about the impact of micropropagation on cannabis is still limited in the scientific literature, as most studies have primarily focused on optimizing environmental parameters and growth conditions.</p><p><strong>Methods: </strong>In vitro cultures of three cannabis cultivars (Critical Purple Kush, Green Crack, and Gelato) were initiated and maintained for 60 weeks with subcultures every three weeks. Leaf samples were collected at the start and after every five subcultures for DNA extraction, and the genomes were sequenced using 3D-GBS and EM-seq to identify genetic (SNPs) and epigenetic (DMPs) variations, followed by GO and KEGG pathway analyses.</p><p><strong>Results: </strong>The results revealed that genomic variants from our CPK (16,169), GC (15,472) and GEL (16,605) samples were mostly located within the intergenic regions. Mutations seem to mostly occur during culture initiation and the first five subcultures, plateauing afterwards up to the 20th subculture. Methylation sequencing revealed that DMPs were less frequent than SNPs, with differential methylation levels showing cultivar-specific patterns varying between CPK, GC and GEL with respectively 22%, 9% and 13% for promoter regions, 13%, 5% and 6% for exon regions, 4%, 4% and 3% for intron regions and 61%, 82% and 78% for intergenic regions. These results indicate a strong cultivar dependency of epimutation and suggest their potential phenotypic impact. GO and KEGG pathway enrichment analyses of genes harboring SNPs and DMPs revealed functional associations relevant to cannabis micropropagation.</p><p><strong>Conclusion: </strong>Our results highlight the importance of monitoring both genetic and epigenetic stability for long-term cannabis cultivation.</p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between marijuana use and erectile dysfunction in a sample of sexual minority men: a cross-sectional analysis.","authors":"Marion Otieno, Yunan Zhao, Alvin Tran","doi":"10.1186/s42238-026-00411-1","DOIUrl":"10.1186/s42238-026-00411-1","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a condition characterized by difficulty in achieving or maintaining an erection, consequently affecting sexual performance. ED is often a symptom of underlying health conditions such as cardiovascular heart disease and can lead to psychological distress. Previous studies show an association between marijuana use and ED through its potential impact on the endocannabinoid pathways. However, few studies have explored this relationship among sexual minority men (SMM). Considering this knowledge gap, this study aims to assess the association between marijuana use and erectile dysfunction in a sample of SMM in the United States.</p><p><strong>Methods: </strong>A secondary analysis of the Men's Body Project (MBP)-a cross-sectional study involving an online survey assessing SMM health outcomes-data was conducted. Multivariable logistic regression and bivariate analyses were used to examine the association between marijuana use and ED. Participants provided demographic information, self-reported ED, erection confidence, erection difficulty, and history of substance use.</p><p><strong>Results: </strong>A total of 549 participants completed the survey (52.1% gay and 47.9% bisexual). The prevalence of ED was higher in bisexual men compared to gay men. Results from the adjusted logistic regression analysis suggested that people who use marijuana had 1.83 times the odds (95% CI: 1.23, 2.74) of reporting erectile dysfunction compared to non-users.</p><p><strong>Conclusion: </strong>Our results suggest a significant association between marijuana use and elevated odds of experiencing erectile dysfunction. These findings highlight the importance of integrating sexual health screening into primary care and considering substance use during sexual health assessments to support early identification and management of ED. Additional research is needed to explore temporal and causal relationships between marijuana use frequency and erectile function.</p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacogenetic association study of cannabis use in chronic pain.","authors":"William Beauchesne, Jordan Turcotte, Philippe Mercier, Flore Lavoie, Laurence Tessier, Ann-Lorie Gagnon, Catherine Allard, Elliot Fortin, Guillaume Léonard, Louis Gendron, Karine Tremblay","doi":"10.1186/s42238-026-00408-w","DOIUrl":"10.1186/s42238-026-00408-w","url":null,"abstract":"<p><p>BACKGROUND: Pain is one of the leading causes of disability worldwide. Despite the various pharmacological treatments available, patients with chronic pain often remain with significant disabilities and unsatisfactory pain control. Cannabis and cannabinoids are sometimes used in the treatment of chronic pain as they have been shown to be useful in a subset of patients. Some of the adverse effects associated with cannabis use, such as cannabis use disorder (CUD) and cannabis-induced psychosis, have been associated with several genetic variants. Despite this, the paucity of the data or the contradictory results for reported variants limits our ability to use them as genetic markers to personalize cannabis treatment tailored to patients’ genetic background. The aim of this genetic association study was to investigate the link between previously reported genes and cannabinoid response in terms of pain response, CUD and risk of psychotic adverse events in patients with chronic pain. METHODS: Phone or in person interviews were conducted to document participants’ characteristics, cannabis use and effects, concurrent pharmacotherapy and comorbid conditions. Screening for CUD was performed using the Cannabis Use Disorders Identification Test – Revised. Blood or saliva samples were collected for the genotyping of 18 variants in 11 genes (BDNF, CNR1, CNR2, COMT, CYP2C9, FAAH, GABRA2, HES7, KAT2B, NRG1 and OPMR1). RESULTS: One hundred participants were recruited, with blood or saliva samples collected from 77 of them. Two single-nucleotide polymorphisms (SNP) in cannabinoid receptor 1 (CNR1) were associated, before multiple testing correction, with psychotic adverse events. Namely, T allele carriage of the CNR1 rs1049353 C > T variant increased the odds of having psychotic adverse events (OR = 6.1, 95% CI 1.7 – 27.9, p-value = 0,009) and C allele carriage of the CNR1 rs2023239 T > C intronic variant also increased these odds (OR = 3.5, 95% CI 1.5 – 9.4, p-value = 0,033). These findings were not significant after adjustment for multiple SNPs testing and none of the variants were associated with CUD or pain response. CONCLUSIONS: These results suggest alternative allele carriers of rs1049353 and rs2023239 could be at an increased risk of psychotic adverse events related to cannabis use, although additional investigation is required to replicate and confirm these findings. </p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146198369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expected population prevalence following decriminalization of recreational use of cannabis in Sweden.","authors":"Filip Andersson, Mats Ramstedt, Robert Thiesmeier, Cecilia Magnusson, Nicola Orsini, Maria Rosaria Galanti","doi":"10.1186/s42238-026-00405-z","DOIUrl":"10.1186/s42238-026-00405-z","url":null,"abstract":"<p><p>BACKGROUND: Many countries and jurisdictions have recently adopted more lenient cannabis laws. While use remains prohibited in Sweden, this stance is debated due to high drug-related mortality. To inform this debate, we predicted changes in cannabis use following a hypothetical decriminalization in Sweden. METHODS: Jurisdiction-level data on self-reported cannabis use from 12 countries (across Europe and Australia) and four U.S. states were used in a multilevel meta-regression model to predict the most likely changes in past 12-month and past 30-day cannabis use following decriminalization in Sweden. RESULTS: We predicted an immediate increase in the prevalence of both past 12-month and past 30-day cannabis use following decriminalization. However, the longer-term trends differed between these measures. For past 12-month use, the gap in prevalence between scenarios with and without decriminalization gradually narrowed over time. In contrast, for past 30-day use, the gap widened. CONCLUSIONS: Decriminalizing cannabis use in Sweden would lead to an initial increase of self-reported cannabis use. The extent to which this reflects a genuine increase in use or an increased propensity to disclose the behavior remains to be understood. After this initial increase experimental use tends to stabilize, while recurrent use may continue to increase, probably indicating an increasing pool of individuals transitioning towards dependence. The method we propose for predicting population trends in cannabis use following decriminalization can be easily replicated in other context and used to support evidence-based policy decisions. </p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and analgesic potential of minor cannabinoids in vivo.","authors":"S O Vanegas, T F Gamage, J Maturano, D Sarlah, S G Kinsey","doi":"10.1186/s42238-025-00384-7","DOIUrl":"10.1186/s42238-025-00384-7","url":null,"abstract":"<p><p>BACKGROUND: The cannabis plant produces many bioactive compounds, including the major cannabinoids THC and CBD, and many lesser studied “minor” phytocannabinoids including cannabinol (CBN), cannabichromene (CBC), cannabicyclol (CBL), and cannabigerol (CBG). These compounds are touted for various ailments, including pain, inflammation, and anxiety, but experimental data on their effects are lacking, especially that of CBL, which has yet to be assessed in vivo. METHODS: To assess in vivo activity, adult male and female C57BL/6J mice were administered each compound and tested repeatedly in the tetrad battery. The potential analgesic effects in chronic pain states were assessed using the lipopolysaccharide (LPS)-induced hindpaw inflammatory pain and chronic constriction injury (CCI) neuropathic pain paradigms. Lastly, to address common psychological comorbidities of pain, CBN, CBL, and CBG were assessed in the tail suspension and marble burying tests. RESULTS: Cannabinol (≥ 25 mg/kg) induced classic cannabinoid effects, including acute antinociception. These effects were differentially and partially blocked by selective antagonism of CB1, adenosine A2A, or TRPV1 receptors. CBL (≥ 50 mg/kg) induced hypothermia that was fully blocked by A2A antagonism but had no apparent CB1-mediated activity. LPS-induced edema and paw proinflammatory cytokine levels were reduced by either CBN or CBL (100 mg/kg). CCI-induced cold allodynia was attenuated by either CBN (≥ 50 mg/kg) or CBL (100 mg/kg), but only at high doses that also induce catalepsy and hypothermia. None of these minor cannabinoids displayed anxiolytic- or antidepressant-like activity without concomitant locomotor effects. CONCLUSIONS: Together, these findings suggest that CBN produces anti-inflammatory effects via cannabinoid receptor-dependent and -independent pathways, whereas CBL acts primarily through CB receptor-independent mechanisms. </p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review on cannabis seed phenolic compounds from extraction to functional applications.","authors":"Chaymae Benkirane, Rafika El Ati, Malika Abid, Jacques Nkengurutse, Hana Serghini-Caid, Ahmed Elamrani, Farid Mansouri","doi":"10.1186/s42238-026-00401-3","DOIUrl":"10.1186/s42238-026-00401-3","url":null,"abstract":"<p><p>BACKGROUND: Cannabis sativa L. seeds have long been regarded as a by-product of cannabis cultivation. Beyond their nutritional value, cannabis seeds are increasingly recognized as a source of specialized phenolic compounds with potential biological relevance. However, research on seed phenolics remains fragmented, often receiving only marginal attention, and a dedicated synthesis focused specifically on these compounds is still lacking. MAIN BODY: This review provides a focused and up-to-date synthesis of phenolic compounds reported in cannabis seeds, critically examining their chemical diversity, extraction and analytical strategies, and key factors influencing phenolic recovery and composition. Cannabis seeds exhibit a diverse phenolic profile dominated by hydroxycinnamic acid amides (mainly N-trans-caffeoyltyramine) and lignanamides (particularly Cannabisins A and B). Their extraction remains largely reliant on conventional solvent-based approaches, with limited adoption of innovative and green technologies, except for ultrasound assisted extraction. Advances in high-resolution analytical tools for phenolic separation and identification enabled comprehensive profiling and a deeper understanding of phenolic diversity. The extractability and final content of phenolic compounds result from a complex interplay between extraction-related parameters, biological variability, and seed processing conditions. Biological activities associated with cannabis seed phenolics include antioxidant, anticancer, neuroprotective, anti-inflammatory, dermo-protective, antibacterial, and metabolic regulatory effects. These activities are discussed with reference to reported mechanisms, such as free radical scavenging, modulation of inflammatory mediators, and inhibition of cancer cell proliferation. CONCLUSION: Current evidence highlights cannabis seeds as a promising yet underexploited source of phenolic compounds with potential applications in nutraceutical, pharmaceutical, and dermato-cosmetic fields. Nevertheless, important challenges remain, such as methodological heterogeneity, limited in-vivo and clinical validation, and insufficient data on bioavailability and formulation. Addressing these limitations and gaps through standardized protocols, mechanistic studies, and translational research will be essential to support the effective valorization of cannabis seed phenolics in industrial and health-related applications. </p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the research landscape of minor cannabinoids: a bibliometric analysis of research trends and hotspots.","authors":"Hanane Abbou, Lahcen Belyamani, Rachid Eljaoudi","doi":"10.1186/s42238-026-00402-2","DOIUrl":"10.1186/s42238-026-00402-2","url":null,"abstract":"<p><p>BACKGROUND: Minor cannabinoids, including cannabigerol (CBG), cannabinol (CBN), and cannabichromene (CBC), are gaining scientific attention for their distinct therapeutic potential beyond THC and CBD. Despite this growing interest, research on these compounds remains fragmented and underrepresented in the literature. This study aims to map the global research landscape of minor cannabinoids through bibliometric mapping analyses, identifying key trends, collaboration patterns, and emerging thematic areas. METHODS: A structured database search of the Scopus, PubMed, and WOS databases identified 1516 eligible articles published between 1969 and 2024. An inclusive search strategy was employed to capture minor cannabinoid research as it is embedded within the broader cannabinoid literature, ensuring that studies co-analyzing major and minor cannabinoids were not overlooked. Bibliometric analysis was conducted using the Biblioshiny tool to assess publication trends, journal impact, geographic distribution, and author collaboration networks. RESULTS: Publication activity showed exponential growth starting in 2017, reaching a peak in 2024. The United States, Italy, and Canada led global contributions, with widespread international collaboration. Core publishing venues included Molecules, The Journal of Analytical Toxicology, the British Journal of Pharmacology, and Cannabis and Cannabinoid Research. Keyword co-occurrence analysis revealed three major thematic clusters. A sharp thematic shift has been observed since 2015, highlighting the rise of “CBG”, “CBGA” and “molecular docking”. This evolution marks a convergence of traditional pharmacology with molecular targeting and bioinformatics, signaling a transition toward computational and receptor-targeted research. CONCLUSIONS: Minor cannabinoid research is expanding rapidly, with strong interdisciplinary foundations and growing global collaboration. This study provides a comprehensive overview of the field’s evolution and highlights underexplored areas ripe for future investigation. </p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating cannabis and gaming: re-evaluating their business intersection.","authors":"Riana Durrett, Juliana Ness, Marla Royne Stafford, Margaret McLetchie, Jordyn Sanders","doi":"10.1186/s42238-025-00382-9","DOIUrl":"10.1186/s42238-025-00382-9","url":null,"abstract":"<p><p>This paper examines the intersection of cannabis and gaming laws in the United States. A particular emphasis is placed on Nevada for its recognition as a leader in the gaming and cannabis industry. To better understand the issue, we explored various factors contributing to the separation, ranging from federal to local concerns at both the operational and state levels. Given the unpredictability of federal enforcement, gaming regulators and state regulators must address the risks associated with cannabis innovation. Despite the exclusion, there is growing support for incorporating cannabis into the gaming sector, similar to other markets, particularly in high-profile areas like the Las Vegas Strip. The paper questions whether the separations are appropriate within legal, policy, and business structures, apart from the activities. While acknowledging that public initiatives focused on practical activities are essential, this paper focuses on the framework that led to the original findings. Moreover, this paper examines the regulatory differences between jurisdictions that permit gambling and gaming, and identifies potential risks associated with the separation of these industries.</p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marijuana use and its association with unhealthy weight control and muscle-enhancing behaviors among sexual minority men in the United States: a cross-sectional analysis.","authors":"Chiamaka Ibeh, Yunan Zhao, Alvin Tran","doi":"10.1186/s42238-026-00398-9","DOIUrl":"10.1186/s42238-026-00398-9","url":null,"abstract":"<p><strong>Introduction: </strong>Following marijuana legalization in several U.S. states, motivations for its use have expanded, especially among marginalized populations. While prior research links marijuana use with disordered eating, little is known about this relationship within sexual minority groups, who are already at elevated risk for body dissatisfaction and unhealthy weight control behaviors. This study examines associations between marijuana use and unhealthy weight control and muscle-enhancing behaviors among sexual minority men in the U.S.</p><p><strong>Methods: </strong>We conducted a secondary analysis using data from the Men's Body Project, a cross-sectional study on body image and health behaviors. The sample included sexual minority men across diverse backgrounds. Logistic regression was used to assess associations between marijuana use and seven behaviors considered risk factors linked to body image concerns: fasting, vomiting, laxative use, diet pill use, muscle-building supplement use, protein powder use, and anabolic steroid use.</p><p><strong>Results: </strong>Marijuana users had significantly greater odds of engaging in all measured behaviors. Adjusted odds ratios (AORs) ranged from 1.88 (fasting) to 3.12 (diet pill use), all with p-values < 0.001. Other notable associations included vomiting (AOR = 2.61), laxative use (AOR = 2.23), protein powder use (AOR = 2.60), and anabolic steroid use (AOR = 2.62).</p><p><strong>Conclusion: </strong>Our results suggest a significant association between marijuana use and elevated odds of engaging in unhealthy weight control and muscle-enhancing behaviors among sexual minority men. Findings highlight the need for tailored public health interventions addressing both substance use and body image within LGBTQ + communities.</p>","PeriodicalId":101310,"journal":{"name":"Journal of cannabis research","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}