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Best practice & research. Clinical gastroenterology最新文献

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Microbiota in gastrointestinal malignancies. 胃肠道恶性肿瘤中的微生物群。
Best practice & research. Clinical gastroenterology Pub Date : 2024-09-01 Epub Date: 2024-10-11 DOI: 10.1016/j.bpg.2024.101953
Ludovica Bricca, Serena Porcari, Edoardo Savarino, Massimo Rugge
{"title":"Microbiota in gastrointestinal malignancies.","authors":"Ludovica Bricca, Serena Porcari, Edoardo Savarino, Massimo Rugge","doi":"10.1016/j.bpg.2024.101953","DOIUrl":"10.1016/j.bpg.2024.101953","url":null,"abstract":"<p><p>This manuscript provides an overview of the microbiota profile associated with precancerous lesions in the esophagus, stomach, and large bowel. The critical review of the available data reveals significant variability in the methods used for microbiota profiling. This variability may affect the reliable identification of specific biological links between histologically profiled neoplastic diseases and the microbiota population. Overall, this critical review reveals significant links between microbiota communities and the different lesions within the spectrum of the oncogenetic cascade in various epidemiological contexts and anatomical districts.</p>","PeriodicalId":101302,"journal":{"name":"Best practice & research. Clinical gastroenterology","volume":"72 ","pages":"101953"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiome in children undergoing hematopoietic stem cell transplantation. 接受造血干细胞移植的儿童肠道微生物组。
Best practice & research. Clinical gastroenterology Pub Date : 2024-09-01 Epub Date: 2024-10-24 DOI: 10.1016/j.bpg.2024.101955
Paweł Józefczuk, Jarosław Biliński, Aleksandra Minkowska, Paweł Łaguna
{"title":"Gut microbiome in children undergoing hematopoietic stem cell transplantation.","authors":"Paweł Józefczuk, Jarosław Biliński, Aleksandra Minkowska, Paweł Łaguna","doi":"10.1016/j.bpg.2024.101955","DOIUrl":"10.1016/j.bpg.2024.101955","url":null,"abstract":"<p><p>Hematopoietic stem cell transplantation (HSCT) is used in children as a treatment for various cancers, e.g. acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), or other diseases, e.g. severe congenital immunodeficiency, metabolic disorders, hence the patient population is quite diverse. There is an increasing interest on the role of the microbiome in peri-transplant period. In this review, concepts of HSCT with the focus on the importance of microbiome composition, its changes during treatment and possible microbiota oriented interventions will be discussed. This paper analyzes data in pediatric population, but in view of interesting results and absence of analogous data for pediatric patients, it also looks at studies performed on adult population and pre-clinical trials on animals discussing possible translation to children.</p>","PeriodicalId":101302,"journal":{"name":"Best practice & research. Clinical gastroenterology","volume":"72 ","pages":"101955"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of microbiome in the development of gluten-related disorders. 微生物组在麸质相关疾病发展中的作用。
Best practice & research. Clinical gastroenterology Pub Date : 2024-09-01 Epub Date: 2024-09-05 DOI: 10.1016/j.bpg.2024.101951
Giulia Catassi, Elena Lener, Maria Maddalena Grattagliano, Sofya Motuz, Maria Antonietta Zavarella, Stefano Bibbò, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro, Carlo Catassi
{"title":"The role of microbiome in the development of gluten-related disorders.","authors":"Giulia Catassi, Elena Lener, Maria Maddalena Grattagliano, Sofya Motuz, Maria Antonietta Zavarella, Stefano Bibbò, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro, Carlo Catassi","doi":"10.1016/j.bpg.2024.101951","DOIUrl":"10.1016/j.bpg.2024.101951","url":null,"abstract":"<p><p>Gluten-related disorders (GRD) include celiac disease (CD), non celiac gluten sensitivity (NCGS) and wheat allergy (WA), conditions that are associated with the ingestion of gluten-containing food. Gut microbiota composition and function may be involved in the pathogenesis of GRD. In untreated CD the microbiota is characterized by a reduction in beneficial microbes like Lactobacillus and Bifidobacterium and an increase in pathogenic ones such as Bacteroides and E. coli. Dysbiosis is a hallmark of CD, persists across various disease stages and is only partially corrected by a gluten-free diet. NCGS patients show a different microbial profile, with a notable decrease in microbial richness, and an increase of Ruminococcaceae and decrease of Bacteroidetes and Fusobacteria. The increase of certain bacterial groups such as Clostridium and Anaerobacter, in contrast with the decline of Bacteroides and Clostridium XVIII, marks a distinctive microbial signature associated with allergic responses to food. Mechanisms linking the gut microbiota to the development of GRD include effects on the gut barrier function, microbiota-mediated immune response to gluten, and an impact of microbial metabolites on gluten digestion and tolerance. Although the gluten-free diet is the primary therapy of GRDs, treatment with probiotics may contribute to improve the natural history of these disorders, for instance by minimizing the damaging effects of gluten contamination and accelerating the catch-up growth at the beginning of the dietary treatment of CD. Additional high-quality trials are still needed to identify and standardize the use of probiotics/prebiotics in GRDs.</p>","PeriodicalId":101302,"journal":{"name":"Best practice & research. Clinical gastroenterology","volume":"72 ","pages":"101951"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial dysbiosis in gastric cancer: Association or causation? 胃癌微生物生态失调：关联还是原因？
Best practice & research. Clinical gastroenterology Pub Date : 2024-09-01 Epub Date: 2024-11-23 DOI: 10.1016/j.bpg.2024.101961
Pallavi Huma Arya, Bhamini Vadhwana, Munir Tarazi
{"title":"Microbial dysbiosis in gastric cancer: Association or causation?","authors":"Pallavi Huma Arya, Bhamini Vadhwana, Munir Tarazi","doi":"10.1016/j.bpg.2024.101961","DOIUrl":"https://doi.org/10.1016/j.bpg.2024.101961","url":null,"abstract":"","PeriodicalId":101302,"journal":{"name":"Best practice & research. Clinical gastroenterology","volume":"72 ","pages":"101961"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the immune microenvironment on prognosis in oesophageal adenocarcinoma. 免疫微环境对食管癌预后的影响。
Best practice & research. Clinical gastroenterology Pub Date : 2024-09-01 Epub Date: 2024-10-25 DOI: 10.1016/j.bpg.2024.101954
Dimitra V Peristeri, Munir Tarazi, Patrick Casey, Arfon Powell, Javed Sultan
{"title":"Effect of the immune microenvironment on prognosis in oesophageal adenocarcinoma.","authors":"Dimitra V Peristeri, Munir Tarazi, Patrick Casey, Arfon Powell, Javed Sultan","doi":"10.1016/j.bpg.2024.101954","DOIUrl":"10.1016/j.bpg.2024.101954","url":null,"abstract":"<p><p>Oesophageal adenocarcinoma (OAC) is amongst the most lethal cancers worldwide, with poor treatment response leading to low survival rates. Recent improvements have been achieved by including the tumour microenvironment (TME) and patients' immune profiles in treatment decisions. We already know that patients with immune-enriched/inflamed TME have better survival outcomes. However, OAC TME is largely immunosuppressed and appears to be treatment-resistant. Immunotherapeutic strategies are already part of the therapeutic plans in OAC; a greater understanding of the immune microenvironment underlying oesophageal adenocarcinoma is needed if we are to exploit the inherent cancer-fighting capabilities of each patient's immune system. Therefore, implementing the crosstalks between the tumour and its microenvironment (TME) might be the key to improving overall survival. In this review, we discuss accumulated evidence regarding TME and immune checkpoint inhibitors in OAC, as well as recent and ongoing therapeutic attempts to improve patient treatment and outcomes at an individual level.</p>","PeriodicalId":101302,"journal":{"name":"Best practice & research. Clinical gastroenterology","volume":"72 ","pages":"101954"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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