Zeitschrift für Immunit?tsforschung: Immunobiology最新文献_第4页

Precipitating and Non-precipitating Complement Consuming IgG Subclass Antibodies in Pigeon Breeders' Disease 鸽子饲养者病中沉淀性和非沉淀性补体消耗IgG亚类抗体

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-08-01 DOI: 10.1016/S0340-904X(79)80072-X

G. de Ridder , L. Berrens

引用次数: 4

Light Chain Heterogeneity of Type λ Anti-Streptococcal Group A-variant Polysaccharide Antibodies in Rabbits 兔λ型抗链球菌a群变多糖抗体的轻链异质性

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-08-01 DOI: 10.1016/S0340-904X(79)80059-7

S. Weiss , Kerstin Hild, D.G. Braun

引用次数: 3

Generation of Virus Specific Cytotoxic T Cells In Vitro. III. Spleen Cells Stimulated by Viral Antigens Generate Alloreactive Cytotoxic T Cells 病毒特异性细胞毒性T细胞的体外生成3。脾细胞受病毒抗原刺激产生同种异体细胞毒性T细胞

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-08-01 DOI: 10.1016/S0340-904X(79)80065-2

U. Koszinowsk , D. Greber, I. Neuschaefer-Rube

{"title":"Generation of Virus Specific Cytotoxic T Cells In Vitro. III. Spleen Cells Stimulated by Viral Antigens Generate Alloreactive Cytotoxic T Cells","authors":"U. Koszinowsk , D. Greber, I. Neuschaefer-Rube","doi":"10.1016/S0340-904X(79)80065-2","DOIUrl":"10.1016/S0340-904X(79)80065-2","url":null,"abstract":"<div><p>Cytotoxic T lymphocytes (CTL) from DBA/2 strain mice primed with Sendai virus (SV) in vivo were activated by secondary stimulation of spleen cells with viral antigens in vitro and analyzed for their target antigen specificity. These effector cells lysed syngeneic Sendai virus infected target cells, marginally a variety of non-infected targets and had a strong cytotoxic effect on H-2b targets. Studies on the antigenic requirements revealed that all SV preparations which generated specific CTL also induced the alloreactive populations. Similar results were found in the response to Newcastle disease virus (NDV) and some influenza A viruses; all these viruses were mitogenic for lymphocytes. Experiments on the cellular requirements indicated that virus specific and alloreactive cells can be separated by their requirements for help and for restimulation. By competition experiments both activities could be attributed to clearly separable T cell subpopulations. The induction mechanism of alloreactive T cells by viral antigens is discussed.</p></div>","PeriodicalId":101288,"journal":{"name":"Zeitschrift für Immunit?tsforschung: Immunobiology","volume":"156 1","pages":"Pages 83-95"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(79)80065-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56339691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Generation of Effector Cells from T Cell Subsets. I. Similar Requirements for Lyt T Cell Subpopulations in the Generation of Alloreactive and H-2 Restricted Killer Cells 从T细胞亚群产生效应细胞。1 .同种异体反应性和H-2限制性杀伤细胞的产生对Lyt细胞亚群的相似要求

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-08-01 DOI: 10.1016/S0340-904X(79)80066-4

M.M. Simon , U.H. Koszinowski

{"title":"Generation of Effector Cells from T Cell Subsets. I. Similar Requirements for Lyt T Cell Subpopulations in the Generation of Alloreactive and H-2 Restricted Killer Cells","authors":"M.M. Simon , U.H. Koszinowski","doi":"10.1016/S0340-904X(79)80066-4","DOIUrl":"10.1016/S0340-904X(79)80066-4","url":null,"abstract":"<div><p>Lyt T cell subsets involved in the generation of H-2 restricted and alloreactive cytotoxic effector cells were analysed using anti Lyt antisera. Our data show that Lyt 1, 2, 3 + T cells are required for the induction of primary and secondary H-2 restricted and TNP-specific killer cells. In contrast, primary and secondary H-2 restricted and virus-specific T effector cells were obtained from selected Lyt 2, 3 + T cell populations and were not dependent on the presence of Lyt 1, 2, 3+ T cells. Allogeneic responses to selected K, I, or D region differences were obtained only in the presence of Lyt 1,2,3 + T cells; yet alloreactive killer cells were effectively generated from selected Lyt 2,3+ T cell populations deprived of Lyt 1,2,3+ T cells, when responder and stimulator cells differed at either K + D, K + I, I and D regions or in the entire H-2 region.</p><p>Taken together, the results suggest that there is no qualitative difference between alloreactive and H-2 restricted cytotoxic responses in their requirements for particular Lyt T cell subsets. The findings indicate that the number of different antigenic determinants rather than their association with MHC self determinants is critical for the requirement of Lyt 1, 2, 3+ T cells during the sensitization phase.</p></div>","PeriodicalId":101288,"journal":{"name":"Zeitschrift für Immunit?tsforschung: Immunobiology","volume":"156 1","pages":"Pages 96-109"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(79)80066-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56339775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Editorial Comment 社论评论

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-08-01 DOI: 10.1016/S0340-904X(79)80055-X

引用次数: 0

Differentiation of Herpes Simplex Virus Type 1 and Type 2 by Immunofluorescence: Discriminative Staining by Labelled IgG Preparations 单纯疱疹病毒1型和2型的免疫荧光鉴别:标记IgG制剂的鉴别染色

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-06-01 DOI: 10.1016/S0340-904X(79)80029-9

U. Schilt

引用次数: 4

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-06-01 DOI: 10.1016/S0340-904X(79)80032-9

W. Spielmann

引用次数: 0

Isolation of Late Complement Components by Affinity Chromatography: I. Purification of the Human Complement Component C9 and Production of a C9-Defective Human Serum 用亲和层析法分离晚期补体成分:1 .人补体成分C9的纯化和C9缺陷人血清的制备

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-06-01 DOI: 10.1016/S0340-904X(79)80025-1

E.W. Rauterberg , C.H. Schieck, G. Hänsch

{"title":"Isolation of Late Complement Components by Affinity Chromatography: I. Purification of the Human Complement Component C9 and Production of a C9-Defective Human Serum","authors":"E.W. Rauterberg , C.H. Schieck, G. Hänsch","doi":"10.1016/S0340-904X(79)80025-1","DOIUrl":"10.1016/S0340-904X(79)80025-1","url":null,"abstract":"<div><p>A new procedure for the isolation of the human complement component C9 is described. This procedure offers the possibility to prepare functionally pure C9 in a one-step procedure with a high recovery of 10–22% of the biological activity. The <sup>125</sup>iodinated C9 had a molecular weight of 78,000 daltons and was only contaminated in traces with other proteins. Further purification by absorption with an «anti-impurity» column lead to a C9 preparation which behaved as a homogenous single polypeptide chain in SDS polyacrylamide gel electrophoresis after reduction with mercaptoethanol. It formed a single bell-shaped precipitate in crossed immunoelectrophoresis with antibodies against human serum in the gel of the second dimension. The recovery of the biological activity after the second purification step was in the order of 6–10%. Both preparative steps could be performed within a few hours. 450 μg C9 protein were isolated from 135 ml human serum. A human serum completely defective in C9 was prepared by the extensive absorption of a smaller volume of human serum proteins with the anti-C9 column.</p></div>","PeriodicalId":101288,"journal":{"name":"Zeitschrift für Immunit?tsforschung: Immunobiology","volume":"155 5","pages":"Pages 365-377"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(79)80025-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75750126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Authors’ Index 作者的指数

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-06-01 DOI: 10.1016/S0340-904X(79)80035-4

引用次数: 0

Protein I and Protein II from the Outer Membrane of Escherichia Coli are Mouse B-Lymphocyte Mitogens 大肠杆菌外膜蛋白I和蛋白II是小鼠b淋巴细胞有丝分裂原

Zeitschrift für Immunit?tsforschung: Immunobiology Pub Date : 1979-06-01 DOI: 10.1016/S0340-904X(79)80027-5

Wolfgang G. Bessler , Ulf Henning

引用次数: 26