Thyroid Science最新文献

{"title":"De novo thyroid-associated ophthalmopathy diagnosed after total thyroidectomy for papillary thyroid carcinoma: A case report","authors":"Hanna Deguchi-Horiuchi ,&nbsp;Mitsuru Ito ,&nbsp;Takayuki Nagai ,&nbsp;Fumio Takano ,&nbsp;Hiroyuki Yamaoka ,&nbsp;Kazuyoshi Kousaka ,&nbsp;Mako Hisakado ,&nbsp;Eijun Nishihara ,&nbsp;Shuji Fukata ,&nbsp;Mitsushige Nishikawa ,&nbsp;Yasuhiro Ito ,&nbsp;Akira Miyauchi ,&nbsp;Takashi Akamizu","doi":"10.1016/j.thscie.2023.100007","DOIUrl":"https://doi.org/10.1016/j.thscie.2023.100007","url":null,"abstract":"<div><p>We report an extremely rare case of thyroid-associated ophthalmopathy (TAO) that developed 9 years after total thyroidectomy for papillary thyroid carcinoma (PTC). A non-smoking 65-year-old woman received radioactive iodine (RAI) ablation (131I 50 mCi) after total thyroidectomy and a post-RAI whole-body scan revealed accumulation of radioiodine in the left thyroid bed. Computed tomography (CT) showed radioiodine-negative lung metastases. Subsequently, she underwent additional RAI treatment (131I 100 mCi). Approximately 9 years after the total thyroidectomy, diplopia, proptosis of the right eye, and oculomotor abnormalities appeared. T2-weighted fat-suppression images of orbital magnetic resonance imaging (MRI) showed a high signal intensity area and swelling in the inferior rectus muscle of the right eye, and laboratory tests showed high thyroid-stimulating hormone receptor antibody (TRAb) and thyroid-stimulating antibody (TSAb) levels, leading to the diagnosis of TAO. Triamcinolone acetonide (40 mg) was injected twice in the vicinity of the right inferior rectus muscle. Posttreatment orbital MRI showed improvement in inflammation and swelling of the inferior rectus muscle of the right eye; however, limited elevation of the right eye persisted. Having encountered this valuable case, it is crucial for clinicians to be aware that TAO can develop even after surgery for thyroid cancers.</p></div>","PeriodicalId":101253,"journal":{"name":"Thyroid Science","volume":"1 1","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950300023000071/pdfft?md5=dc8745fc67a1907a609c0ccc0fc3accc&pid=1-s2.0-S2950300023000071-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139107176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent massive hemoptysis from tracheal varices caused by a large goiter of Graves’ disease","authors":"Hiroshi Katoh ,&nbsp;Kana Aoki ,&nbsp;Mariko Kikuchi ,&nbsp;Takafumi Sangai","doi":"10.1016/j.thscie.2023.100006","DOIUrl":"10.1016/j.thscie.2023.100006","url":null,"abstract":"<div><h3>Background</h3><p>Tracheal varices are rare but cause massive or repeated hemoptysis that can be life-threatening. Patients with Graves’ disease or adenomatous goiter sometimes show compressive symptoms by a diffuse large goiter. However, it is extremely rare to form tracheal varicose veins that cause hemoptysis. We herein report a case of massive hemoptysis from tracheal varices caused by a large Graves’ goiter.</p></div><div><h3>Case presentation</h3><p>An 82-year-old woman was diagnosed with Graves’ disease and had been treated with thiamazole for 15 years. She was taken to an emergency room because of massive hemoptysis. Bronchofiberscope revealed hemorrhage from remarkable varicose veins in the tracheal mucosa. Apixaban for concurrent paroxysmal atrial fibrillation was immediately withdrawn. After endotracheal epinephrine administration for recurrent bleeding, she was transferred to us. She presented with a large goiter that occupied her neck, suggesting that compression by the enlarged goiter may have caused tracheal varices. Preoperative echocardiography revealed tricuspid regurgitation and elevated pulmonary artery pressure that may have supported forming tracheal varices. Upon anesthesia induction, intubation was carefully conducted under bronchoscopy with endotracheal epinephrine administration, and total thyroidectomy was performed. The postoperative course was uneventful and she was discharged in 1 week. Bronchoscopy at 1 month after the operation showed complete disappearance of the tracheal varices.</p></div><div><h3>Conclusion</h3><p>Although tracheal varices due to compression by a large goiter are extremely rare, pulmonary hypertension may further accelerate establishing tracheal varices that leads to massive and recurrent hemoptysis. Tracheal varices associated with a large goiter can be treated by total thyroidectomy with careful intubation.</p></div>","PeriodicalId":101253,"journal":{"name":"Thyroid Science","volume":"1 1","pages":"Article 100006"},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295030002300006X/pdfft?md5=41b7e487a38a8b5fcac9d8f6e051bebb&pid=1-s2.0-S295030002300006X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139015875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related reduction of the prevalence of ectopic intrathyroidal thymus in children and its size reduction with age","authors":"Kenji Iwaku ,&nbsp;Jaeduk Yoshimura Noh ,&nbsp;Natsuko Watanabe ,&nbsp;Kiminori Sugino ,&nbsp;Koichi Ito","doi":"10.1016/j.thscie.2023.100004","DOIUrl":"10.1016/j.thscie.2023.100004","url":null,"abstract":"<div><p>Ectopic intrathyroidal thymus in children refers to the failure of the thymus to descend from the thyroid during intrauterine development, and although rare, it presents with characteristic features on thyroid ultrasonography. The prevalence of ectopic intrathyroidal thymus and the changes in the size of intrathyroidal thymus over time were analyzed among 4130 children who underwent thyroid ultrasonography at the Ito Hospital from January 2003 to September 2015 (896 boys and 3234 girls; median age: 6 years [range: 0–15]). Male children (25 cases, 2.79%) more prominently demonstrated ectopic intrathyroidal thymus than female children (26 cases, 0.80%). The median age of the children with this condition was 6 years (range: 1–14 years), and the median maximum diameter of the ectopic thymus was 7.2 mm (range: 4.2–17.0 mm). The ectopic thymus was located in the right thyroid lobe in 24 (47.1%) cases, in the left thyroid lobe in 23 (45.1%) cases, and was bilateral in 4 (7.8%) cases. The prevalence decreased with age. The thymus size decreased by ≥ 20% in 11 (40.7%) cases, increased by ≥ 20% in 1 (3.7%) case, and changed in size (decreased or increased) by &lt; 20% in 15 (55.6%) cases among the 27 (52.9%) cases assessed for the changes in the sizes of ectopic intrathyroidal thymus glands over time. The ectopic intrathyroidal thymus decreases its prevalence with age. Additionally, the size of an ectopic intrathyroidal thymus frequently appears to decrease over time during follow-up of cases.</p></div>","PeriodicalId":101253,"journal":{"name":"Thyroid Science","volume":"1 1","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950300023000046/pdfft?md5=c3d3ffc3708c66452cf797f676204f0e&pid=1-s2.0-S2950300023000046-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor coordination is partially impaired in neonatal mice with moderate hypothyroidism but not with mild hypothyroidism","authors":"Michifumi Kokubo ,&nbsp;Izuki Amano ,&nbsp;Hiroyuki Yajima ,&nbsp;Wataru Miyazaki ,&nbsp;Yusuke Takatsuru ,&nbsp;Asahi Haijima ,&nbsp;Shogo Haraguchi ,&nbsp;Noriyuki Koibuchi","doi":"10.1016/j.thscie.2023.100005","DOIUrl":"10.1016/j.thscie.2023.100005","url":null,"abstract":"<div><p>Thyroid hormones regulate metabolism in various organs and brain development. Severe form of congenital hypothyroidism causes growth retardation and intellectual disability. However, neuronal phenotypes caused by mild or moderate perinatal hypothyroidism have not yet been fully studied. To evaluate the effect of mild or moderate perinatal hypothyroidism on early development of postnatal mice, we induced hypothyroidism by administering propylthiouracil (PTU) during the perinatal period, from embryonic day 14 to postnatal day (PND) 21. We examined the motor coordination of newborns and vestibular function from PND 3 to PND 21. Animals in the moderate hypothyroid (50 ppm PTU-administered) group showed impaired motor coordination by a righting reflex test and a rotarod test, whereas animals in the mild hypothyroid (5 ppm PTU-administered) group showed normal motor coordination. Hypothyroidism did not affect vestibular function. Then, we measured mRNA and protein levels of glutamate receptor subunits in the cerebellum in developmental period. The levels of AMPA receptor subunit ｍRNA were altered initially, followed by alteration of NMDA receptor subunit mRNA in the later period. On the other hand, protein level has changed only in AMPA receptor subunit 1 (GluA1) on PND 8. These results indicate that moderate perinatal hypothyroidism impairs motor coordination during early postnatal development. The altered protein level of GluA1 in the cerebellum may be involved in such impairments.</p></div>","PeriodicalId":101253,"journal":{"name":"Thyroid Science","volume":"1 1","pages":"Article 100005"},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950300023000058/pdfft?md5=f6c97fc1e52174740bb210609d131c06&pid=1-s2.0-S2950300023000058-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Painless thyroiditis as a precursor to the relapse of Graves’ disease during remission","authors":"Kenji Iwaku ,&nbsp;Jaeduk Noh Yoshimura ,&nbsp;Natsuko Watanabe ,&nbsp;Kiminori Sugino ,&nbsp;Koichi Ito","doi":"10.1016/j.thscie.2023.100003","DOIUrl":"https://doi.org/10.1016/j.thscie.2023.100003","url":null,"abstract":"<div><p>The clinical profile of Graves’ disease (GD) after painless thyroiditis (PT) is nearly exclusively known from case reports, but it has never been investigated in depth. This study investigated the clinical characteristics of 18 patients (4 men, 14 women), with a median age of 32(25−48) years who developed GD out of a total of 862 patients who were diagnosed with PT based on high free thyroxine, suppressed thyroid-stimulating hormone, negative receptor antibody, and low 123I-uptake (&lt;5%). Additionally, we compared their clinical characteristics with 162 patients (39 men, 123 women), with a median age of 37 (7−71) years who had the new-onset GD. The patients who developed GD after PT included 12 (7.2%) of 167 patients who recovered from GD and 6 (1.1%) of 559 patients with chronic thyroiditis (p &lt; 0.0001). Of the 18 patients who developed GD following PT, 12 (66.7%) already recovered from a previous bout of GD and developed PT after having discontinued medical treatment and 16 (88.9%) developed GD 4–29 months after PT. The 2-year remission rates for the 16 patients who developed GD up to 29 months after PT and for the new-onset GD patients were 56.3% and 24.7% (p = 0.0070) and the 4-year remission rates were 75.0% and 38.3% (p = 0.0045), respectively. The development of PT after GD recovery may become a risk factor for GD recurrence. Patients who developed GD immediately after PT had comparatively milder disease and appeared to achieve remission in a short time.</p></div>","PeriodicalId":101253,"journal":{"name":"Thyroid Science","volume":"1 1","pages":"Article 100003"},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950300023000034/pdfft?md5=ed79d9bf27d471e8a8714ef909c3baf4&pid=1-s2.0-S2950300023000034-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138656991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Message from the Editor-in-Chief","authors":"Noriyuki Koibuchi","doi":"10.1016/j.thscie.2023.100001","DOIUrl":"https://doi.org/10.1016/j.thscie.2023.100001","url":null,"abstract":"<div><p>It is my great pleasure and honor to announce the launching of a new journal “THYROID SCIENCE” as an official journal of the Japan Thyroid Association (JTA). This is the first official statement from Editor-in-Chief of the journal.</p></div>","PeriodicalId":101253,"journal":{"name":"Thyroid Science","volume":"1 1","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950300023000010/pdfft?md5=b588a1aab3decfbebc44037d22900313&pid=1-s2.0-S2950300023000010-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92140498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remarks from the current president and president-in-elect of Japan Thyroid Association (JTA)","authors":"Akira Hishinuma,&nbsp;Tetsuya Tagami","doi":"10.1016/j.thscie.2023.100002","DOIUrl":"10.1016/j.thscie.2023.100002","url":null,"abstract":"<div><p>Congratulations on launching “Thyroid Science” as an official journal of the Japan Thyroid Association (JTA). This is an official statement from the President and President-in-Elect of the JTA</p></div>","PeriodicalId":101253,"journal":{"name":"Thyroid Science","volume":"1 1","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950300023000022/pdfft?md5=69b187f547e946f2ad1aaa40506fa978&pid=1-s2.0-S2950300023000022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135455861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}