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The Journal of Liquid Biopsy最新文献

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Cancer in a drop: Liquid biopsy highlights from the World Conference on Lung Cancer (WCLC) 2025 一滴癌症：2025年世界肺癌大会（WCLC）的液体活检亮点
The Journal of Liquid Biopsy Pub Date : 2025-12-01 Epub Date: 2025-11-29 DOI: 10.1016/j.jlb.2025.100449
Nadia Ghazali , Ana Ortega-Franco , Diego de Miguel-Perez , Erick F. Saldanha , Konstantinos Venetis , Pasquale Pisapia , Surbhi Singhal , Benjamin A. Bleiberg , Carolina Reduzzi , Roberto Borea
{"title":"Cancer in a drop: Liquid biopsy highlights from the World Conference on Lung Cancer (WCLC) 2025","authors":"Nadia Ghazali ,&nbsp;Ana Ortega-Franco ,&nbsp;Diego de Miguel-Perez ,&nbsp;Erick F. Saldanha ,&nbsp;Konstantinos Venetis ,&nbsp;Pasquale Pisapia ,&nbsp;Surbhi Singhal ,&nbsp;Benjamin A. Bleiberg ,&nbsp;Carolina Reduzzi ,&nbsp;Roberto Borea","doi":"10.1016/j.jlb.2025.100449","DOIUrl":"10.1016/j.jlb.2025.100449","url":null,"abstract":"<div><div>The role of liquid biopsy in oncological care continues to expand, with multiple studies presented at the International Association for the Study of Lung Cancer (IASLC) 2025 World Conference on Lung Cancer (WCLC 2025). This review summarizes recent advances in liquid biopsy for thoracic oncology, encompassing both non–small cell lung cancer (NSCLC) and small cell lung cancer (SCLC).</div><div>In early detection and screening, proteomic profiling has identified potential biomarkers predictive of future lung cancer risk. The integration of proteomics with clinical and imaging data can improve pulmonary nodule malignancy prediction. In resectable NSCLC, tumour-informed whole-genome sequencing (WGS) assay demonstrated high sensitivity for minimal residual disease (MRD) detection, with MRD clearance following neoadjuvant osimertinib or chemo-immunotherapy associated with favorable outcomes.</div><div>In advanced NSCLC, longitudinal liquid biopsy analyses reveal dynamic subclonal evolution driving early treatment resistance. Circulating tumor DNA (ctDNA) clearance following targeted therapy in MET exon 14 skipping and BRAF-mutated tumors was associated with improved clinical outcomes. Emerging biomarkers such as ctDNA tumour fraction and circulating microRNA signatures are promising for radiotherapy stratification and prediction of immunotherapy-related toxicities.</div><div>In SCLC, MRD monitoring enables earlier detection of disease progression and supports ctDNA-guided selection of patients for consolidation immunotherapy following chemotherapy. Overall, these advances demonstrate the expanding role of liquid biopsy in improving early detection, guiding treatment, and improving disease monitoring in lung cancer.</div></div>","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"10 ","pages":"Article 100449"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALMA platform: a Pan-cancer agnostic multi-modal liquid biopsy approach for enhanced MRD detection and therapy monitoring ALMA平台：一种泛癌症诊断的多模式液体活检方法，用于增强MRD检测和治疗监测
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100337
Dr. Lara Paracchini , Dr. Lorena Ancona , Dr. Luca Beltrame , Dr. Sonia Ismari , Dr. Micaela Piemontese , Dr. Laura Mannarino , Dr. Francesca Chemi , Paolo Zucali (Prof.) , Paolo Bossi (Prof.) , Domenica Lorusso (Prof.) , Dr. Alberto Puccini , Maurizio D'Incalci (Prof.) , Dr. Sergio Marchini
{"title":"ALMA platform: a Pan-cancer agnostic multi-modal liquid biopsy approach for enhanced MRD detection and therapy monitoring","authors":"Dr. Lara Paracchini ,&nbsp;Dr. Lorena Ancona ,&nbsp;Dr. Luca Beltrame ,&nbsp;Dr. Sonia Ismari ,&nbsp;Dr. Micaela Piemontese ,&nbsp;Dr. Laura Mannarino ,&nbsp;Dr. Francesca Chemi ,&nbsp;Paolo Zucali (Prof.) ,&nbsp;Paolo Bossi (Prof.) ,&nbsp;Domenica Lorusso (Prof.) ,&nbsp;Dr. Alberto Puccini ,&nbsp;Maurizio D'Incalci (Prof.) ,&nbsp;Dr. Sergio Marchini","doi":"10.1016/j.jlb.2025.100337","DOIUrl":"10.1016/j.jlb.2025.100337","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100337"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repositioning ctDNA as a Real-Time Clinical Compass: A Meta-Analysis of 14,000 Patients Across 42 Studies 重新定位ctDNA作为实时临床指南针：42项研究中14000名患者的荟萃分析
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100338
Dr. Mohamed Tharwat Kamouna
{"title":"Repositioning ctDNA as a Real-Time Clinical Compass: A Meta-Analysis of 14,000 Patients Across 42 Studies","authors":"Dr. Mohamed Tharwat Kamouna","doi":"10.1016/j.jlb.2025.100338","DOIUrl":"10.1016/j.jlb.2025.100338","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100338"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of Circulating Tumor Cell (CTC) enrichment strategies in lung and breast cancers 肺癌和乳腺癌循环肿瘤细胞（CTC）富集策略的比较评价
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100361
Dr. Carlos Pedraz Valdunciel , Dr. Nadia Bayou , Dr Ashish Saxena , Dr Letizia Pontolilo , Dr Urko del Castillo , Dr Mara Serena Serafini , Dr Rafael Rosell (Prof) , Dr Massimo Cristofanilli (Prof) , Dr Paraskevi Giannakakou (Prof) , Dr Carolina Reduzzi
{"title":"Comparative evaluation of Circulating Tumor Cell (CTC) enrichment strategies in lung and breast cancers","authors":"Dr. Carlos Pedraz Valdunciel ,&nbsp;Dr. Nadia Bayou ,&nbsp;Dr Ashish Saxena ,&nbsp;Dr Letizia Pontolilo ,&nbsp;Dr Urko del Castillo ,&nbsp;Dr Mara Serena Serafini ,&nbsp;Dr Rafael Rosell (Prof) ,&nbsp;Dr Massimo Cristofanilli (Prof) ,&nbsp;Dr Paraskevi Giannakakou (Prof) ,&nbsp;Dr Carolina Reduzzi","doi":"10.1016/j.jlb.2025.100361","DOIUrl":"10.1016/j.jlb.2025.100361","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet gene expression profiling as a liquid biopsy tool to monitor Immunotherapy resistance in advanced NSCLC patients 血小板基因表达谱作为液体活检工具监测晚期非小细胞肺癌患者免疫治疗耐药性
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100391
Dr. Siliva Marconi , Dr. Andrea Balossino , Dr. Adriana Amaro , Dr. Sara Santamaria , Dr. Laura Damele , Dr. Maria Dono , Dr. Luca Lucente , Dr Margherita Puppo , Dr. Linda Zinoli , Dr. Giulia Barletta , Carlo Genova (Prof) , Dr. Simona Coco
{"title":"Platelet gene expression profiling as a liquid biopsy tool to monitor Immunotherapy resistance in advanced NSCLC patients","authors":"Dr. Siliva Marconi ,&nbsp;Dr. Andrea Balossino ,&nbsp;Dr. Adriana Amaro ,&nbsp;Dr. Sara Santamaria ,&nbsp;Dr. Laura Damele ,&nbsp;Dr. Maria Dono ,&nbsp;Dr. Luca Lucente ,&nbsp;Dr Margherita Puppo ,&nbsp;Dr. Linda Zinoli ,&nbsp;Dr. Giulia Barletta ,&nbsp;Carlo Genova (Prof) ,&nbsp;Dr. Simona Coco","doi":"10.1016/j.jlb.2025.100391","DOIUrl":"10.1016/j.jlb.2025.100391","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100391"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast cancer development risk: a novel signature based on EV-miRNAs from the EsomirR Study 乳腺癌发展风险：来自EsomirR研究的基于ev - mirna的新特征
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100395
Dr. Barbara Cardinali , Dr Alice Stella , Dr Simona Coco , Dr Silvia Marconi , Dr Andrea Sciutto , Dr Linda Zinoli , Francesco Boccardo (Prof.) , Alessandra Rubagotti (Prof.) , Dr Giovanna Chiorino , Dr Paola Ostano , Lucia Del Mastro (Prof.)
{"title":"Breast cancer development risk: a novel signature based on EV-miRNAs from the EsomirR Study","authors":"Dr. Barbara Cardinali ,&nbsp;Dr Alice Stella ,&nbsp;Dr Simona Coco ,&nbsp;Dr Silvia Marconi ,&nbsp;Dr Andrea Sciutto ,&nbsp;Dr Linda Zinoli ,&nbsp;Francesco Boccardo (Prof.) ,&nbsp;Alessandra Rubagotti (Prof.) ,&nbsp;Dr Giovanna Chiorino ,&nbsp;Dr Paola Ostano ,&nbsp;Lucia Del Mastro (Prof.)","doi":"10.1016/j.jlb.2025.100395","DOIUrl":"10.1016/j.jlb.2025.100395","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100395"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Relevance of Circulating Myeloma Cell Quantification and Multiple Myeloma Staging System 循环骨髓瘤细胞定量和多发性骨髓瘤分期系统的临床意义
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100429
Dr. Jihyun Lee , PhD. Hyeryeong Jun , Ms. Soee Kim , BS. Hyeonji Cho , MD. PhD. Kihyun Kim , PhD. Jung Won Kim
{"title":"Clinical Relevance of Circulating Myeloma Cell Quantification and Multiple Myeloma Staging System","authors":"Dr. Jihyun Lee ,&nbsp;PhD. Hyeryeong Jun ,&nbsp;Ms. Soee Kim ,&nbsp;BS. Hyeonji Cho ,&nbsp;MD. PhD. Kihyun Kim ,&nbsp;PhD. Jung Won Kim","doi":"10.1016/j.jlb.2025.100429","DOIUrl":"10.1016/j.jlb.2025.100429","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100429"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding Access to Precision Oncology in Underserved Populations: Integrating Liquid Biopsy into a Statewide Lung Cancer Initiative 在服务不足的人群中扩大获得精确肿瘤学的机会：将液体活检纳入全州肺癌倡议
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100352
Dr. Aakash Desai , Ellen McNeeley , Dr. Sanad Alhushki , Dr. Juan Xavier Masjoan Junco , Dr. Maya Khalil , Dr. Yanis Boumber
{"title":"Expanding Access to Precision Oncology in Underserved Populations: Integrating Liquid Biopsy into a Statewide Lung Cancer Initiative","authors":"Dr. Aakash Desai ,&nbsp;Ellen McNeeley ,&nbsp;Dr. Sanad Alhushki ,&nbsp;Dr. Juan Xavier Masjoan Junco ,&nbsp;Dr. Maya Khalil ,&nbsp;Dr. Yanis Boumber","doi":"10.1016/j.jlb.2025.100352","DOIUrl":"10.1016/j.jlb.2025.100352","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100352"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High performance of cancer detection with using single-strand circulating DNA fragment end motif analysis 单链循环DNA片段末端基序分析的高效癌症检测
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100342
A.R. Thierry (Prof.) , Dr Ekaterina Pisareva , Ms Marianne Richaud , Dr Severine Tabone-Eglinger , Thomas Bachelot (Prof.) , Benjamin Besse (Prof) , Dr Thibault Mazard , Marc Ychou (Prof) , Dr Benoit Roch , Jacques Colinge (Prof.)
{"title":"High performance of cancer detection with using single-strand circulating DNA fragment end motif analysis","authors":"A.R. Thierry (Prof.) ,&nbsp;Dr Ekaterina Pisareva ,&nbsp;Ms Marianne Richaud ,&nbsp;Dr Severine Tabone-Eglinger ,&nbsp;Thomas Bachelot (Prof.) ,&nbsp;Benjamin Besse (Prof) ,&nbsp;Dr Thibault Mazard ,&nbsp;Marc Ychou (Prof) ,&nbsp;Dr Benoit Roch ,&nbsp;Jacques Colinge (Prof.)","doi":"10.1016/j.jlb.2025.100342","DOIUrl":"10.1016/j.jlb.2025.100342","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100342"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CTC-EXPRESS: A prospective observational study for CTC biomarker Expression and cfDNA/cfRNA assessment in metastatic breast cancer CTC- express：转移性乳腺癌中CTC生物标志物表达和cfDNA/cfRNA评估的前瞻性观察研究
The Journal of Liquid Biopsy Pub Date : 2025-11-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jlb.2025.100348
Marija Balic (Prof.) , Dr David Riseberg , Dr Carol Tweed , Dr Julia Foldi , Mrs Femke de Snoo , Mrs Lisette Stork-Sloots , Mr Frank K. Kuhr , Mr Daryl S. Spinner , Mr Maher Albitar , Adam M. Brufsky (Prof)
{"title":"CTC-EXPRESS: A prospective observational study for CTC biomarker Expression and cfDNA/cfRNA assessment in metastatic breast cancer","authors":"Marija Balic (Prof.) ,&nbsp;Dr David Riseberg ,&nbsp;Dr Carol Tweed ,&nbsp;Dr Julia Foldi ,&nbsp;Mrs Femke de Snoo ,&nbsp;Mrs Lisette Stork-Sloots ,&nbsp;Mr Frank K. Kuhr ,&nbsp;Mr Daryl S. Spinner ,&nbsp;Mr Maher Albitar ,&nbsp;Adam M. Brufsky (Prof)","doi":"10.1016/j.jlb.2025.100348","DOIUrl":"10.1016/j.jlb.2025.100348","url":null,"abstract":"","PeriodicalId":101235,"journal":{"name":"The Journal of Liquid Biopsy","volume":"9 ","pages":"Article 100348"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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