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Patent prosecution in proteomics 蛋白质组学的专利申请
TARGETS Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02319-5
Keala Chan, Dennis Fernandez
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引用次数: 1
It's a knockout! 太棒了!
TARGETS Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02323-7
JulieP. Howard
{"title":"It's a knockout!","authors":"JulieP. Howard","doi":"10.1016/S1477-3627(03)02323-7","DOIUrl":"10.1016/S1477-3627(03)02323-7","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 3","pages":"Pages 76-77"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02323-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79897028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomic approaches for generating comprehensive protein interaction maps 生成综合蛋白质相互作用图的蛋白质组学方法
TARGETS Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02316-X
Daniel Auerbach , Michael Fetchko , Igor Stagljar
{"title":"Proteomic approaches for generating comprehensive protein interaction maps","authors":"Daniel Auerbach ,&nbsp;Michael Fetchko ,&nbsp;Igor Stagljar","doi":"10.1016/S1477-3627(03)02316-X","DOIUrl":"10.1016/S1477-3627(03)02316-X","url":null,"abstract":"<div><p>The availability of complete genome sequences of numerous model organisms has initiated the development of new approaches in biological research to complement conventional biochemistry and genetics. In this context, high-throughput methods for detecting protein interactions, such as mass spectrometry and yeast two-hybrid assays, have produced vast amounts of data that can be exploited to infer protein function and regulation. In this review, we explore different genome-wide protein interaction studies and comment on their extrapolation towards understanding protein functions. It is likely that improvements of these approaches, together with more sophisticated databases and the invention of novel technologies, will help to decipher the complex interactions among proteins and to integrate interacting proteins into existing and novel cellular pathways.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 3","pages":"Pages 85-92"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02316-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86752315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Haemozoin (malaria pigment): a unique crystalline drug target 血色素(疟疾色素):一种独特的结晶药物靶点
TARGETS Pub Date : 2003-06-01 DOI: 10.1016/S1477-3627(03)02310-9
Timothy J. Egan
{"title":"Haemozoin (malaria pigment): a unique crystalline drug target","authors":"Timothy J. Egan","doi":"10.1016/S1477-3627(03)02310-9","DOIUrl":"10.1016/S1477-3627(03)02310-9","url":null,"abstract":"<div><p>Historically, chloroquine has been the most important antimalarial. Current evidence suggests that resistance to this drug is not the result of a change in its target, which remains important in the design of novel antimalarials, an area of active research. Many studies support the hypothesis that this target is haematin, whereas a recent report suggests that the haemozoin (malaria pigment) crystal itself might in fact be the target. A detailed understanding of the mechanism and structure of this interaction could revolutionise the search for new antimalarials in the near future.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 3","pages":"Pages 115-124"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02310-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73034692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 72
Jürgen Bajorath discusses integrating disciplines in the drug discovery industry j<s:1> rgen Bajorath讨论了药物发现行业的整合学科
TARGETS Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02299-2
Jürgen Bajorath
{"title":"Jürgen Bajorath discusses integrating disciplines in the drug discovery industry","authors":"Jürgen Bajorath","doi":"10.1016/S1477-3627(03)02299-2","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02299-2","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 45-47"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02299-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89988680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New high-throughput NMR 新型高通量核磁共振
TARGETS Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02296-7
Thomas S. May (freelance writer)
{"title":"New high-throughput NMR","authors":"Thomas S. May (freelance writer)","doi":"10.1016/S1477-3627(03)02296-7","DOIUrl":"10.1016/S1477-3627(03)02296-7","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 39-40"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02296-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76243807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of RNA interference RNA干扰的应用
TARGETS Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02303-1
Hans Winkler, Steve Powell
{"title":"Applications of RNA interference","authors":"Hans Winkler,&nbsp;Steve Powell","doi":"10.1016/S1477-3627(03)02303-1","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02303-1","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 42-44"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02303-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91590625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Nematode model for obesity 线虫肥胖模型
TARGETS Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02297-9
Vida Foubister (freelance writer)
{"title":"Nematode model for obesity","authors":"Vida Foubister (freelance writer)","doi":"10.1016/S1477-3627(03)02297-9","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02297-9","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 40-41"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02297-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91634014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Drugs targets and bioterrorism defense 毒品目标和生物恐怖主义防御
TARGETS Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02294-3
David J Ecker
{"title":"Drugs targets and bioterrorism defense","authors":"David J Ecker","doi":"10.1016/S1477-3627(03)02294-3","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02294-3","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 35-37"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02294-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89988678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target validation using human tissue: from gene expression to function 使用人体组织的靶标验证:从基因表达到功能
TARGETS Pub Date : 2003-04-01 DOI: 10.1016/S1477-3627(03)02298-0
Robert A. Coleman, Kenneth L. Clark
{"title":"Target validation using human tissue: from gene expression to function","authors":"Robert A. Coleman,&nbsp;Kenneth L. Clark","doi":"10.1016/S1477-3627(03)02298-0","DOIUrl":"https://doi.org/10.1016/S1477-3627(03)02298-0","url":null,"abstract":"<div><p>Arguably, one of the main reasons for the pharmaceutical industry's current poor performance in bringing successful new drugs to market is its over-reliance on animal data in the discovery and development processes. We propose that more use should be made of donated human tissues in order to identify and validate drug targets and to discover and develop novel drugs to act upon them. We review the ways that human tissues may be used for this purpose, from the measurement of gene expression, through determination of specific protein abundance, to functional evaluation, both at the level of tissue and specific cell type. The proposal is not simply theoretical, as we provide a specific case history to illustrate these points.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"2 2","pages":"Pages 58-64"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(03)02298-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90001919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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