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Seminars in Neuroscience最新文献

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The role of the basal ganglia in procedural memory 基底神经节在程序性记忆中的作用
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0006
Steven P. Wise
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引用次数: 40
Author index 1995 作者索引1995
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90007-1
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引用次数: 0
Subject index 1995 1995年主题索引
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90008-X
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引用次数: 0
5-HT receptor knockouts: Constitutive, inducible or tissue-specific 5-HT受体敲除:构成性、诱导性或组织特异性
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90003-9
Regis Grailhe, Rene Hen
{"title":"5-HT receptor knockouts: Constitutive, inducible or tissue-specific","authors":"Regis Grailhe,&nbsp;Rene Hen","doi":"10.1016/1044-5765(95)90003-9","DOIUrl":"10.1016/1044-5765(95)90003-9","url":null,"abstract":"<div><p>Recently, molecular cloning has confirmed and extended our knowledge of the heterogeneity of 5-HT receptors. Besides creating some confusion, molecular techniques have provided new tools to study the function of 5-HT receptors. Recent results gained from targeted disruption of the genes encoding the 5-HT<sub>1B</sub> and 5-HT<sub>2C</sub> receptors have provided confirmation of pharmacological studies as well as unexpected effects. Such ‘constitutive knockouts’ might undergo compensatory changes during their development that could confound the interpretation of the mutant phenotype. New strategies are currently being developed that may enable receptor expression to be turned on and off at will in specific tissues.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"7 6","pages":"Pages 395-400"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/1044-5765(95)90003-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89583236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
5-HT4, 5-HT6, 5-HT7; molecular pharmacology of adenylate cyclase stimulating receptors 5-ht4、5-ht6、5-ht7;腺苷酸环化酶刺激受体的分子药理学
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90001-2
T. Branchek
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引用次数: 9
Introduction: 5-HT's role in the central nervous system 5-HT在中枢神经系统中的作用
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90000-4
John S. Kelly
{"title":"Introduction: 5-HT's role in the central nervous system","authors":"John S. Kelly","doi":"10.1016/1044-5765(95)90000-4","DOIUrl":"10.1016/1044-5765(95)90000-4","url":null,"abstract":"","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"7 6","pages":"Pages 371-373"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/1044-5765(95)90000-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72740824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
5-HT4, 5-HT6, 5-HT7; molecular pharmacology of adenylate cyclase stimulating receptors 5-ht4、5-ht6、5-ht7;腺苷酸环化酶刺激受体的分子药理学
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90001-2
Theresa A. Branchek
{"title":"5-HT4, 5-HT6, 5-HT7; molecular pharmacology of adenylate cyclase stimulating receptors","authors":"Theresa A. Branchek","doi":"10.1016/1044-5765(95)90001-2","DOIUrl":"10.1016/1044-5765(95)90001-2","url":null,"abstract":"<div><p>Throughout the nervous system the receptors for the neurotransmitter serotonin form an unusually diverse set. Receptor-mediated responses to serotonin utilize a large collection of biochemical second messenger pathways, such as the stimulation or inhibition of adenylate cyclase activity, the hydrolysis of phosphoinositides, the mobilization of calcium and direct gating of ion channels. This diversity of structure and activity has been substantiated by the application of molecular cloning techniques which have now yielded at least 15 distinct molecular entities. The most recent subset of receptors for serotonin to be cloned are those that couple to the stimulation of adenylate cyclase activity. These subtypes: 5-HT<sub>4</sub>, 5-HT<sub>6</sub> and 5-HT<sub>7</sub>, although sharing a common signal transduction pathway, are remarkably divergent in their amino acid sequences, distribution in the brain and pharmacological properties. This digression from the expected relationships of receptor subtypes based on other serotonin receptors, as well as other biogenic amino receptor families, is unexpected and raises many questions about the extreme diversity of this signaling system.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"7 6","pages":"Pages 375-382"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/1044-5765(95)90001-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120556307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Visualization and characterization of 5-HT receptors and transporters in vivo and in man 体内和人体内5-羟色胺受体和转运体的可视化和表征
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90006-3
Allan Fletcher , Victor W. Pike , Ian A. Cliffe
{"title":"Visualization and characterization of 5-HT receptors and transporters in vivo and in man","authors":"Allan Fletcher ,&nbsp;Victor W. Pike ,&nbsp;Ian A. Cliffe","doi":"10.1016/1044-5765(95)90006-3","DOIUrl":"10.1016/1044-5765(95)90006-3","url":null,"abstract":"<div><p>Ascending and descending efferent pathways from the nuclei of serotonergic neurones located in brainstem raphe nuclei project to all regions of the central nervous system. Therefore, in considering the major physiological roles played by this neurotransmitter system, it is not surprising that serotonin is implicated in the aetiologies of many CNS dysfunctions which underlie psychiatric and neurological disorders. The presynaptic serotonin uptake mechanism and the many receptor subtypes that mediate the neurotransmitter roles of serotonin have been, and continue to be, targeted by drug discovery programmes aimed at identifying improved therapies for CNS disorders. Here we review the radioligands available for the important task of visualizing and characterizing these targets in the living human brain using either positron emission tomography (PET) or single photon emission tomography (SPECT). Such studies are crucial for extending our knowledge of the involvement of serotonin neurotransmission in the aetiologies of these disorders and for the development of new and more effective therapies. Particularly important recent advances in the methodologies for imaging the 5-HT transporter, the 5-HT<sub>2A</sub> receptor and the 5-HT<sub>1A</sub> receptor will almost certainly lead to important clinical research into the changes occurring in serotonergic neurotransmission during the onset, progression and treatment of affective and neurodegenerative disorders.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"7 6","pages":"Pages 421-431"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/1044-5765(95)90006-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"119849219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Visualization and characterization of 5-HT receptors and transporters in vivo and in man 体内和人体内5-羟色胺受体和转运体的可视化和表征
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90006-3
A. Fletcher, V. Pike, I. A. Cliffe
{"title":"Visualization and characterization of 5-HT receptors and transporters in vivo and in man","authors":"A. Fletcher, V. Pike, I. A. Cliffe","doi":"10.1016/1044-5765(95)90006-3","DOIUrl":"https://doi.org/10.1016/1044-5765(95)90006-3","url":null,"abstract":"","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"2015 1","pages":"421-431"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87206391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Activation of 5-HT neuronal activity during motor behavior 运动行为中5-HT神经元活动的激活
Seminars in Neuroscience Pub Date : 1995-12-01 DOI: 10.1016/1044-5765(95)90004-7
Barry L. Jacobs, Casimir A. Fornal
{"title":"Activation of 5-HT neuronal activity during motor behavior","authors":"Barry L. Jacobs,&nbsp;Casimir A. Fornal","doi":"10.1016/1044-5765(95)90004-7","DOIUrl":"10.1016/1044-5765(95)90004-7","url":null,"abstract":"<div><p>Brain serotonin (5-HT) neuronal activity is activated preferentially in association with motor activity. This is especially clear during changes in tonic motor output and during repetitive responses mediated by central pattern generators, such as locomotion, respiration and chewing. These and other data support the hypothesis that the primary function of the brain serotonin system is to facilitate motor output. Concurrently, the system coordinates autonomic and neuroendocrine function with the present motor demand, and inhibits information processing in various sensory pathways. Reciprocally, when the serotonin system is briefly inactivated (e.g. during focussed attention), this disfacilitates motor function and disinhibits sensory information processing.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"7 6","pages":"Pages 401-408"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/1044-5765(95)90004-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83835882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 43
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