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Seminars in Neuroscience最新文献

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Can there be growth without growth cones? 没有生长球果能有生长吗?
Seminars in Neuroscience Pub Date : 1996-04-01 DOI: 10.1006/smns.1996.0012
Hollis Cline
{"title":"Can there be growth without growth cones?","authors":"Hollis Cline","doi":"10.1006/smns.1996.0012","DOIUrl":"10.1006/smns.1996.0012","url":null,"abstract":"<div><p>In-vivo imaging of the development of complex retinotectal axon arbors indicates that arbors branches can form and extend in the absence of growth cones. A variety of imaging protocols were used to observe arbor elaboration over a range of time intervals and total observation periods. Growth cones are observed relatively rarely in the growing axon arbors. Branch addition, or backbranching, and branch extension occur without apparent specializations at growing branchtips. Branch addition within the elaborating axon arbor is discussed with respect to the process of interstitial branching of axon collaterals.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 2","pages":"Pages 89-95"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74493212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of the cytoskeleton in growth cone motility and axonal elongation 细胞骨架在生长锥运动和轴突伸长中的作用
Seminars in Neuroscience Pub Date : 1996-04-01 DOI: 10.1006/smns.1996.0010
Jean F. Challacombe, Diane M. Snow, Paul C. Letourneau
{"title":"Role of the cytoskeleton in growth cone motility and axonal elongation","authors":"Jean F. Challacombe,&nbsp;Diane M. Snow,&nbsp;Paul C. Letourneau","doi":"10.1006/smns.1996.0010","DOIUrl":"10.1006/smns.1996.0010","url":null,"abstract":"<div><p>During axonal pathfinding, the direction of nerve fiber extension is established by the growth cone, the motile structure at the distal tip of an elongating axon. It is the growth cone that navigates and directs axonal outgrowth by detecting and responding to complex molecular cues in the nervous system environment. Changes in growth cone behavior and morphology that result from contact with these cues depend on the regulated assembly and dynamic reorganization of actin filaments and microtubules. Therefore, an understanding of growth cone guidance requires resolution of the cytoskeletal rearrangements that occur as navigating growth cones respond to stimulatory and inhibitory molecular signals in their milieu. In this review, we discuss the role of the cytoskeleton in growth cone navigation.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 2","pages":"Pages 67-80"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72719149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Axonal regeneration in the mammalian CNS 哺乳动物中枢神经系统的轴突再生
Seminars in Neuroscience Pub Date : 1996-04-01 DOI: 10.1006/smns.1996.0014
Christian Brösamle, Martin E. Schwab
{"title":"Axonal regeneration in the mammalian CNS","authors":"Christian Brösamle,&nbsp;Martin E. Schwab","doi":"10.1006/smns.1996.0014","DOIUrl":"10.1006/smns.1996.0014","url":null,"abstract":"<div><p>Axons in the adult central nervous system (CNS) of higher vertebrates are in general not capable of regeneration after injury. This is in contrast to the situation in lower vertebrates (fish and in part amphibia) and the mammalian peripheral nervous system (PNS), where severed axons can regenerate, correct synaptic connections can be formed again, and function can be restored. This enigma has been the subject of extensive studies in the last decades and a large amount of data has been accumulated. This article reviews recent developments in experimental approaches to axonal regrowth in the mammalian CNS focusing mostly on in-vivo systems.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 2","pages":"Pages 107-113"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86754065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Introduction: Memory systems in the primate brain 前言:灵长类动物大脑中的记忆系统
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0001
Elisabeth Murray
{"title":"Introduction: Memory systems in the primate brain","authors":"Elisabeth Murray","doi":"10.1006/smns.1996.0001","DOIUrl":"10.1006/smns.1996.0001","url":null,"abstract":"","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85197090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Memory, action and the corpus striatum: current developments in the memory-habit distinction 记忆、行动和纹状体:记忆-习惯区分的最新进展
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0005
David Gaffan
{"title":"Memory, action and the corpus striatum: current developments in the memory-habit distinction","authors":"David Gaffan","doi":"10.1006/smns.1996.0005","DOIUrl":"10.1006/smns.1996.0005","url":null,"abstract":"<div><p>The distinction between memory and habit has been of great historical importance in theories of animal learning. The reality of animal memory is now firmly established, but it is only recently becoming clear how memory systems can influence action. In explaining the interactions between memory systems and action systems it is no longer necessary to invoke the concept of habit, since the same mechanisms appear to apply to habitual action and to non-habitual action. A review of recent ablation studies shows that, both in visual reward-association memory and visual recognition memory, the visual association cortex controls action through a direct output to the corpus striatum.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 1","pages":"Pages 33-38"},"PeriodicalIF":0.0,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73313659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
What does neuroimaging tell us about the role of prefrontal cortex in memory retrieval? 关于前额叶皮层在记忆提取中的作用，神经成像告诉了我们什么?
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0007
Randy L. Buckner, Steven E. Petersen
{"title":"What does neuroimaging tell us about the role of prefrontal cortex in memory retrieval?","authors":"Randy L. Buckner,&nbsp;Steven E. Petersen","doi":"10.1006/smns.1996.0007","DOIUrl":"10.1006/smns.1996.0007","url":null,"abstract":"Abstract The past five years have seen an outpouring of neuroimaging studies of memory — using both positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). These studies have convincingly demonstrated that neuroimaging can be used to study the functional anatomy of normal human memory and that neuroimaging can precisely localize memory related brain activations within small areas of cortex. As one illustration of the application of neuroimaging in the study of memory, this review shows how several laboratories have produced data that converge on the notion that specific areas in the prefrontal cortex are active during long-term memory retrieval. Moreover, the data further suggest that distinct prefrontal brain areas might make differential contributions to different kinds of long-term memory retrieval.","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 1","pages":"Pages 47-55"},"PeriodicalIF":0.0,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78894148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 135
Neuroanatomy of the monkey entorhinal, perirhinal and parahippocampal cortices: Organization of cortical inputs and interconnections with amygdala and striatum 猴嗅内、嗅周和海马旁皮层的神经解剖学:皮层输入的组织及其与杏仁核和纹状体的相互联系
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0002
Wendy A. Suzuki
{"title":"Neuroanatomy of the monkey entorhinal, perirhinal and parahippocampal cortices: Organization of cortical inputs and interconnections with amygdala and striatum","authors":"Wendy A. Suzuki","doi":"10.1006/smns.1996.0002","DOIUrl":"10.1006/smns.1996.0002","url":null,"abstract":"<div><p>Experimental lesion studies in monkeys have demonstrated that the cortical areas surrounding the hippocampus, including the entorhinal, perirhinal and parahippocampal cortices play an important role in declarative memory (i.e. memory for facts and events). A series of neuroanatomical studies, motivated in part by the lesion studies, have shown that the macaque monkey entorhinal, perirhinal and parahippocampal cortices are polymodal association areas that each receive distinctive complements of cortical inputs. These areas also have extensive interconnections with other brain areas implicated in non-declarative forms of memory including the amygdala and striatum. This pattern of connections is consistent with the idea that the entorhinal, perirhinal and parahippocampal cortices may participate in a larger network of structures that integrates information across memory systems.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 1","pages":"Pages 3-12"},"PeriodicalIF":0.0,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78832388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 148
What have ablation studies told us about the neural substrates of stimulus memory? 消融术研究告诉我们刺激记忆的神经基质是什么?
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0003
Elisabeth A. Murray
{"title":"What have ablation studies told us about the neural substrates of stimulus memory?","authors":"Elisabeth A. Murray","doi":"10.1006/smns.1996.0003","DOIUrl":"10.1006/smns.1996.0003","url":null,"abstract":"<div><p>Recent studies examining the neural substrates of stimulus memory in monkeys have found that the ‘rhinal’ cortex (i.e. the entorhinal and perirhinal cortex), makes a pivotal contribution to memory. Indeed, the rhinal cortex appears to be the only critical medial temporal lobe structure for stimulus recognition and certain kinds of associative memory as well. Thus, the mnemonic contributions of certain medial temporal structures, especially the amygdala and hippocampus, appear to have been overemphasized, and should be reconsidered.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 1","pages":"Pages 13-22"},"PeriodicalIF":0.0,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75693396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 164
Neuronal responses and recognition memory 神经元反应和识别记忆
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0004
Brown M.W.
{"title":"Neuronal responses and recognition memory","authors":"Brown M.W.","doi":"10.1006/smns.1996.0004","DOIUrl":"10.1006/smns.1996.0004","url":null,"abstract":"<div><p>Recognition memory requires identification of a stimulus plus judgement concerning its prior occurrence. Information concerning the prior occurrence of stimuli is signalled by neurons in the anterior inferior temporal and perirhinal cortex. Typically these neurons respond less when a visual stimulus is seen for the second time than when it is first seen, even if the two occurrences of the stimulus are widely separated in time. The properties of such responses, together with those of similar responses in related brain regions, are discussed in relation to recognition memory.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 1","pages":"Pages 23-32"},"PeriodicalIF":0.0,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79539418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Lateral frontal cortical contribution to memory 侧额叶皮质对记忆的贡献
Seminars in Neuroscience Pub Date : 1996-02-01 DOI: 10.1006/smns.1996.0008
Michael Petrides
{"title":"Lateral frontal cortical contribution to memory","authors":"Michael Petrides","doi":"10.1006/smns.1996.0008","DOIUrl":"10.1006/smns.1996.0008","url":null,"abstract":"<div><p>Recent studies of the mnemonic effects of selective lesions within the lateral frontal cortex in the monkey have suggested that the mid-dorsolateral region may be a specialized system for the monitoring and manipulation of information within working memory. This impairment appears against a background of normal performance on several basic mnemonic tasks. By contrast, a more severe impairment follows damage to the mid-ventrolateral frontal region. Functional activation studies with normal human subjects have confirmed the suggestion from the animal work that the mid-dorsolateral region is involved in the monitoring and manipulation of information within working memory.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 1","pages":"Pages 57-63"},"PeriodicalIF":0.0,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80097936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 65
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