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Seminars in Neuroscience最新文献

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Brain Imaging Studies of Drug Abuse: Therapeutic Implications 药物滥用的脑成像研究:治疗意义
Seminars in Neuroscience Pub Date : 1997-01-01 DOI: 10.1006/smns.1997.0112
Monique Ernst, Edythe D. London
{"title":"Brain Imaging Studies of Drug Abuse: Therapeutic Implications","authors":"Monique Ernst,&nbsp;Edythe D. London","doi":"10.1006/smns.1997.0112","DOIUrl":"10.1006/smns.1997.0112","url":null,"abstract":"<div><p>An understanding of the neurobiological substrates of brain dysfunction associated with substance abuse is essential for the development of effective treatments for this disorder. Noninvasive brain imaging provides a powerful approach to obtain the relevant information for it permits the<em>in vivo</em>assessment of brain function under different conditions that characterize various stages of an addictive cycle.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"9 3","pages":"Pages 120-130"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1997.0112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78773740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Strategies for Treatment of Opiate Abuse 阿片类药物滥用治疗策略
Seminars in Neuroscience Pub Date : 1997-01-01 DOI: 10.1006/smns.1997.0107
Barbara Herman , Leslie Iversen
{"title":"Strategies for Treatment of Opiate Abuse","authors":"Barbara Herman ,&nbsp;Leslie Iversen","doi":"10.1006/smns.1997.0107","DOIUrl":"10.1006/smns.1997.0107","url":null,"abstract":"","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"9 3","pages":"Page 69"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1997.0107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88691793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Introduction: Functional Plasticity in Adult Cortex 成人大脑皮层的功能可塑性
Seminars in Neuroscience Pub Date : 1997-01-01 DOI: 10.1006/smns.1997.0100
Jon H. Kaas
{"title":"Introduction: Functional Plasticity in Adult Cortex","authors":"Jon H. Kaas","doi":"10.1006/smns.1997.0100","DOIUrl":"10.1006/smns.1997.0100","url":null,"abstract":"","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"9 1","pages":"Page 1"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1997.0100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84701387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Clinical Medications Development for Opiate Addiction: Focus on Nonopioids and Opioid Antagonists for the Amelioration of Opiate Withdrawal Symptoms and Relapse Prevention 阿片类药物成瘾的临床药物发展:非阿片类药物和阿片类拮抗剂改善阿片类药物戒断症状和预防复发
Seminars in Neuroscience Pub Date : 1997-01-01 DOI: 10.1006/smns.1997.0115
Barbara H. Herman , Charles P. O'Brien
{"title":"Clinical Medications Development for Opiate Addiction: Focus on Nonopioids and Opioid Antagonists for the Amelioration of Opiate Withdrawal Symptoms and Relapse Prevention","authors":"Barbara H. Herman ,&nbsp;Charles P. O'Brien","doi":"10.1006/smns.1997.0115","DOIUrl":"10.1006/smns.1997.0115","url":null,"abstract":"","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"9 3","pages":"Pages 158-172"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1997.0115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77206519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Spinal nerve segmentation in higher vertebrates: axon guidance by repulsion and attraction 高等脊椎动物的脊神经分割:排斥和吸引的轴突引导
Seminars in Neuroscience Pub Date : 1996-12-01 DOI: 10.1006/smns.1996.0042
Roger J. Keynes , Alan R. Johnson , Adrian Pini , David Tannahill , Geoffrey M.W. Cook
{"title":"Spinal nerve segmentation in higher vertebrates: axon guidance by repulsion and attraction","authors":"Roger J. Keynes ,&nbsp;Alan R. Johnson ,&nbsp;Adrian Pini ,&nbsp;David Tannahill ,&nbsp;Geoffrey M.W. Cook","doi":"10.1006/smns.1996.0042","DOIUrl":"10.1006/smns.1996.0042","url":null,"abstract":"<div><p>The development of spinal nerve segmentation in higher vertebrate embryos provides a convenient experimental system for the analysis of axon guidance mechanisms. We review evidence from chick embryo experiments that segmentation of motor and sensory axons results from a combination of contact repulsion of axon growth cones by posterior somite cells and chemoattraction of growth cones by anterior cells. We also review progress in identifying the underlying molecular mechanisms in this system, and suggest a prominent role for carbohydrate groups in mediating growth cone repulsion.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 6","pages":"Pages 339-345"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90545886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Volume contents and index 卷的内容和索引
Seminars in Neuroscience Pub Date : 1996-12-01 DOI: 10.1006/smns.1996.0050
{"title":"Volume contents and index","authors":"","doi":"10.1006/smns.1996.0050","DOIUrl":"https://doi.org/10.1006/smns.1996.0050","url":null,"abstract":"<div><p>No abstract</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 6","pages":"Pages i-xv"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136414000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tenascin-C glycoproteins in neural pattern formation and plasticity Tenascin-C糖蛋白在神经模式形成和可塑性中的作用
Seminars in Neuroscience Pub Date : 1996-12-01 DOI: 10.1006/smns.1996.0043
Andreas Faissner, Bernhard Götz, Angret Joester, Frank Wigger, Angela Scholze, Katrin Schütte
{"title":"Tenascin-C glycoproteins in neural pattern formation and plasticity","authors":"Andreas Faissner,&nbsp;Bernhard Götz,&nbsp;Angret Joester,&nbsp;Frank Wigger,&nbsp;Angela Scholze,&nbsp;Katrin Schütte","doi":"10.1006/smns.1996.0043","DOIUrl":"10.1006/smns.1996.0043","url":null,"abstract":"<div><p>It is widely accepted that astroglia plays an important role in the regulation of neural pattern formation, for example by guiding migrating neuroblasts and growth cones or by designing transient tissue boundaries. In this context, the tenascin-C glycoproteins of the extracellular matrix have attracted increased attention, because they are selectively expressed by glial lineages in the brain and exert both stimulatory and inhibitory effects on CNS neurons. Several lines of evidence suggest that these properties are encoded by distinct molecular domains. This concept has been probed by the use of recombinant proteins in various in-vitro assays. The present review summarizes these studies which show that several functions of tenascin-C can be reproduced with isolated, defined segments of the molecule.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 6","pages":"Pages 347-356"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83399512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Signal transduction by GPI-anchored receptors in the nervous system 神经系统中gpi锚定受体的信号转导
Seminars in Neuroscience Pub Date : 1996-12-01 DOI: 10.1006/smns.1996.0048
Lloyd Vaughan
{"title":"Signal transduction by GPI-anchored receptors in the nervous system","authors":"Lloyd Vaughan","doi":"10.1006/smns.1996.0048","DOIUrl":"10.1006/smns.1996.0048","url":null,"abstract":"<div><p>A particularly intriguing role in communication within the nervous system is played by glycosyl phosphatidylinositol (GPI)-anchored glycoproteins. Although our understanding of how neuronal GPI-linked molecules transduce signals is still in its infancy, it is now possible to assemble a tentative model to describe their functioning. Shared features of these otherwise diverse receptors will be outlined, with particular emphasis given to the exclusively GPI-anchored contactin/F11 subgroup of the immunoglobulin superfamily. Contactin/F11 itself, with five extracellular ligands and an intracellular pathway involving Fyn, serves to illustrate the wide range of signalling possible through this group of receptors.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 6","pages":"Pages 397-403"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84749533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
The role of cell adhesion molecules during the development and regeneration of the neuromuscular system 细胞粘附分子在神经肌肉系统发育和再生过程中的作用
Seminars in Neuroscience Pub Date : 1996-12-01 DOI: 10.1006/smns.1996.0045
Sam Fazeli, Frank S. Walsh
{"title":"The role of cell adhesion molecules during the development and regeneration of the neuromuscular system","authors":"Sam Fazeli,&nbsp;Frank S. Walsh","doi":"10.1006/smns.1996.0045","DOIUrl":"10.1006/smns.1996.0045","url":null,"abstract":"<div><p>The neuromuscular system provides an ideal model for the elucidation of the molecular mechanisms involved in neuron–target cell interactions, and the development and maintenance of synaptic connections. Many processes important in neuronal development occur during the formation of neuromuscular connections and synaptogenesis. These include the process of pathfinding by motor neurons, selection of target tissues and synaptogenesis. In the present paper we discuss the molecular mechanisms that probably play a role in the development of skeletal muscle innervation, with particular emphasis on cell adhesion molecules (CAMs).</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 6","pages":"Pages 367-377"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76578308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Plasminogen activators and their interaction with the extracellular matrix in neural development, plasticity and regeneration 纤溶酶原激活剂及其与细胞外基质在神经发育、可塑性和再生中的相互作用
Seminars in Neuroscience Pub Date : 1996-12-01 DOI: 10.1006/smns.1996.0049
Nicholas W. Seeds, Glenn Friedman, Steven Hayden, Douglas Thewke, Susan Haffke, Paul McGuire, Alphonse Krystosek
{"title":"Plasminogen activators and their interaction with the extracellular matrix in neural development, plasticity and regeneration","authors":"Nicholas W. Seeds,&nbsp;Glenn Friedman,&nbsp;Steven Hayden,&nbsp;Douglas Thewke,&nbsp;Susan Haffke,&nbsp;Paul McGuire,&nbsp;Alphonse Krystosek","doi":"10.1006/smns.1996.0049","DOIUrl":"10.1006/smns.1996.0049","url":null,"abstract":"<div><p>Plasminogen activators are extracellular serine proteases, which are actively secreted by developing and regenerating neurons. These molecules, as discussed in this review, have been implicated in cell migration, axonal growth, growth factor activation, and synaptic remodeling associated with learning. Secreted plasminogen activators not only bind to their specific cell surface receptors, where they retain full proteolytic activity, but they also associate with extracellular matrix molecules including fibronectin and laminin. Plasminogen activator association with specific matrix proteins may target these proteins for degradation, altering the matrix composition and leading to intracellular signaling and influencing cell differentiation. The secreted plasminogen activators can bring about the degradation of matrix molecules either directly, or indirectly via the formation of plasmin.</p></div>","PeriodicalId":101157,"journal":{"name":"Seminars in Neuroscience","volume":"8 6","pages":"Pages 405-412"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smns.1996.0049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77612691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
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