The role of cell adhesion molecules during the development and regeneration of the neuromuscular system

The neuromuscular system provides an ideal model for the elucidation of the molecular mechanisms involved in neuron–target cell interactions, and the development and maintenance of synaptic connections. Many processes important in neuronal development occur during the formation of neuromuscular connections and synaptogenesis. These include the process of pathfinding by motor neurons, selection of target tissues and synaptogenesis. In the present paper we discuss the molecular mechanisms that probably play a role in the development of skeletal muscle innervation, with particular emphasis on cell adhesion molecules (CAMs).