Revista Portuguesa de Cardiologia (English Edition)最新文献

{"title":"Peripheral neutrophils and naive CD4 T cells predict the development of heart failure following acute myocardial infarction: A bioinformatic study","authors":"Congyi Yu,&nbsp;Wenjun Zhou","doi":"10.1016/j.repce.2021.11.002","DOIUrl":"10.1016/j.repce.2021.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Heart failure (HF) secondary to acute myocardial infarction (AMI) is still a worldwide problem with a high mortality rate. The current study aimed to explore early and reliable predictive biomarkers of HF following AMI.</p></div><div><h3>Methods</h3><p>The gene expression profile GSE59867 was downloaded from GEO. Array data from peripheral blood mononuclear cells (PBMCs) was used from 46 control patients and 111 patients with AMI at four time points: (i) first day of AMI; (ii) 4-6 days after AMI; (iii) one month after AMI; and (iv) six months after AMI. Among the 111 AMI patients, nine with HF and eight without HF were studied. CIBERSORT was used to analyze the relative proportions of immune cells in PBMCs. The proportions of immune cells in different groups were compared. Differentially expressed genes (DEGs) were analyzed with R language packages.</p></div><div><h3>Results</h3><p>The percentages of monocytes and neutrophils increased significantly on the first day of AMI, and then decreased gradually. The percentage of regulatory T cells increased significantly 4-6 days after AMI, while the percentage of resting memory CD4 cells, CD8 T cells, and resting natural killer cells decreased significantly on the first day of AMI, and then increased gradually. Patients who developed HF had a significantly higher proportion of neutrophils in PBMCs on the first day of AMI, but had a significantly lower proportion of naive CD4 T cells. Two shared genes, interleukin-1 receptor 2 (<em>IL1R2</em>) and leucine-rich repeat neuronal protein 3 (<em>LRRN3</em>), were found to have potentially important roles in predicting the development of HF following AMI.</p></div><div><h3>Conclusion</h3><p>A higher proportion of neutrophils and a lower proportion of naive CD4 T cells in PBMCs on the first day of AMI may be correlated with the development of HF following AMI. <em>IL1R2</em> and <em>LRRN3</em> may exert functions in the development of HF following AMI.</p></div>","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 839-847"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2174204921003548/pdfft?md5=8c960787580a4ecab64fdf6ab4840389&pid=1-s2.0-S2174204921003548-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ablation of ventricular arrhythmic substrate: When the whole is more than the sum of its parts","authors":"João Primo","doi":"10.1016/j.repce.2021.10.023","DOIUrl":"10.1016/j.repce.2021.10.023","url":null,"abstract":"","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 875-876"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2174204921003287/pdfft?md5=1a1a970b3d9450b57f19a005361fe6bf&pid=1-s2.0-S2174204921003287-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impella support for cardiogenic shock and high-risk percutaneous coronary intervention: A single-center experience","authors":"Mariana Brandão,&nbsp;Daniel Caeiro,&nbsp;Gustavo Pires-Morais,&nbsp;João Gonçalves Almeida,&nbsp;Pedro Gonçalves Teixeira,&nbsp;Marisa Passos Silva,&nbsp;Marta Ponte,&nbsp;Adelaide Dias,&nbsp;Marco Oliveira,&nbsp;Alberto Rodrigues,&nbsp;Pedro Braga","doi":"10.1016/j.repce.2021.11.003","DOIUrl":"10.1016/j.repce.2021.11.003","url":null,"abstract":"<div><h3>Introduction and Objectives</h3><p>The use of mechanical circulatory support is increasing in cases of cardiogenic shock (CS) and high-risk percutaneous coronary intervention (HR-PCI). The Impella® is a percutaneous ventricular assist device that unloads the left ventricle by ejecting blood to the ascending aorta. We report our center's experience with the use of the Impella® device in these two clinical settings.</p></div><div><h3>Methods</h3><p>We performed a single-center retrospective study including all consecutive patients implanted with the Impella® between 2007 and 2019 for CS treatment or prophylactic support of HR-PCI. Data on clinical and safety endpoints were collected and analyzed.</p></div><div><h3>Results</h3><p>Twenty-two patients were included: 12 were treated for CS and 10 underwent an HR-PCI procedure. In the CS-treated population, the main cause of CS was acute myocardial infarction (five patients); hemolysis was the most frequent device-related complication (63.7%). In-hospital, cumulative 30-day and one-year mortality were 58.3%, 66.6% and 83.3%, respectively. In the HR-PCI group, all patients had multivessel disease (mean baseline SYNTAX I score: 44.1±13.7). In-hospital, 30-day and one-year mortality were 10.0%, 10.0% and 20.0%, respectively. There were no device- or procedure-related deaths in either group.</p></div><div><h3>Conclusion</h3><p>The short- and long-term results of Impella®-supported HR-PCI were comparable to those in the literature. In the CS group, in-hospital and short-term outcomes were poor, with high mortality and non-negligible complication rates.</p></div>","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 853-861"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217420492100355X/pdfft?md5=3e527a62bb887478dd55fa7f9f04848d&pid=1-s2.0-S217420492100355X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac resynchronization system implantation guided by three-dimensional electroanatomic mapping","authors":"Pedro Silva Cunha,&nbsp;Hélder Santos,&nbsp;Mário Martins Oliveira","doi":"10.1016/j.repce.2021.10.025","DOIUrl":"10.1016/j.repce.2021.10.025","url":null,"abstract":"","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 891-893"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2174204921003305/pdfft?md5=0b86ae08fd56b62397510a5d62b69b7b&pid=1-s2.0-S2174204921003305-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39939164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new biomarker that predicts ventricular arrhythmia in patients with ischemic dilated cardiomyopathy: Galectin-3","authors":"Onur Erdogan ,&nbsp;Ekrem Karaayvaz ,&nbsp;Tugba Erdogan ,&nbsp;Cafer Panc ,&nbsp;Remzi Sarıkaya ,&nbsp;Aytac Oncul ,&nbsp;Ahmet Kaya Bilge","doi":"10.1016/j.repce.2021.10.019","DOIUrl":"10.1016/j.repce.2021.10.019","url":null,"abstract":"<div><h3>Introduction</h3><p>Ventricular arrhythmias are caused by scar tissue in patients with ischemic dilated cardiomyopathy. The gold standard imaging technique for detecting scar tissue is magnetic resonance imaging (MRI). However, MRI is not feasible for use as a screening test, and also cannot be used in patients who have received an implantable cardioverter-defibrillator (ICD). In this study, we aimed to assess the association between levels of galectin-3 (Gal-3), which is known to be secreted by scar tissue, and the history of ventricular arrhythmias in patients with ischemic dilated cardiomyopathy who received an ICD.</p></div><div><h3>Methods</h3><p>Nineteen healthy controls and 32 patients who had previously undergone VVI-ICD implantation due to ischemic dilated cardiomyopathy were enrolled in the study. Patients were divided into three groups: the first group including patients who had received no ICD therapies, the second including patients with arrhythmia requiring therapies with no arrhythmia storm, and the third including patients who had arrhythmia storm. We assessed the association between Gal-3 levels and the history of ventricular arrhythmias in these patients.</p></div><div><h3>Results</h3><p>Gal-3 levels were significantly higher in the patient groups than in the control group (p&lt;0.01). Gal-3 levels of patients with arrhythmias requiring ICD therapies were significantly higher than in patients with ICD not requiring therapies (p=0.02). They were also higher in patients with a history of arrhythmia storm than in patients without shocks (p=0.05). Receiver operating curve analysis showed with 84% sensitivity and 75% specificity that Gal-3 levels over 7 ng/ml indicated ventricular arrhythmia that required therapies.</p></div><div><h3>Conclusion</h3><p>Gal-3 may be used to further improve risk stratification in patients with ischemic cardiomyopathy who are more prone to developing life-threatening arrhythmias.</p></div>","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 829-835"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217420492100324X/pdfft?md5=68984025752011276b726bbab59e79fc&pid=1-s2.0-S217420492100324X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current state of cardiac rehabilitation in Portugal: Results of the 2019 national survey","authors":"José Paulo Fontes ,&nbsp;Eduardo M. Vilela ,&nbsp;Anaí Durazzo ,&nbsp;Madalena Teixeira","doi":"10.1016/j.repce.2021.10.024","DOIUrl":"10.1016/j.repce.2021.10.024","url":null,"abstract":"<div><h3>Introduction</h3><p>Cardiac rehabilitation (CR) programs have a central role in cardiovascular medicine, encompassing a comprehensive framework able to holistically address various facets of cardiovascular disease. However, several obstacles to their optimal application have been reported. Over the years, the Portuguese Society of Cardiology has periodically conducted a national survey on the state of CR in Portugal.</p></div><div><h3>Objectives</h3><p>This study reports the results of the 2019 survey on CR.</p></div><div><h3>Methods</h3><p>In December 2019 a voluntary questionnaire was sent to centers offering CR programs, consisting of several items concerning this intervention.</p></div><div><h3>Results</h3><p>In 2019, 25 centers provided structured CR programs. A total of 2182 patients underwent phase II programs, representing an increase of 13% from the previous survey. Of these, 67.2% were referred due to ischemic heart disease, and 14.5% due to heart failure. Acute coronary syndromes (ACS) comprised 49.3% of referrals, leading to an estimated 9.3% CR coverage. A total of 606 patients participated in phase III programs (a decrease of 37%). Drop-out rates ranged from 0-68%; 91% of centers presented drop-out rates &lt;25%.</p></div><div><h3>Conclusion</h3><p>The present survey shows an increase in the number of centers and patients undergoing phase II CR, and an increase in the estimated CR coverage after ACS. Despite this, the level of increase means that overall patient representation remained below the optimal range, while the data also showed a decrease in the number of patients in phase III programs. These findings reinforce the importance of optimization of CR entry and maintenance, in order to improve the uptake of this pivotal intervention.</p></div>","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 877-887"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2174204921003299/pdfft?md5=94d512b2c09a09e05cdc4585a78dc6de&pid=1-s2.0-S2174204921003299-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39939163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction on YouTube – is it all fake news?","authors":"Inês Fialho ,&nbsp;Marco Beringuilho ,&nbsp;Daniela Madeira ,&nbsp;João Baltazar Ferreira ,&nbsp;Daniel Faria ,&nbsp;Hilaryano Ferreira ,&nbsp;David Roque ,&nbsp;Miguel B. Santos ,&nbsp;Carlos Morais ,&nbsp;Victor Gil ,&nbsp;João B. Augusto","doi":"10.1016/j.repce.2021.10.001","DOIUrl":"10.1016/j.repce.2021.10.001","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>The Internet is a fundamental aspect of health information. However, the absence of quality control encourages misinformation. We aim to assess the relevance and quality of acute myocardial infarction videos shared on YouTube (<span>www.youtube.com</span><svg><path></path></svg>) in Portuguese.</p></div><div><h3>Methods</h3><p>We analyzed 1,000 videos corresponding to the first 100 search results on YouTube using the following terms (in Portuguese): “cardiac + arrest”; “heart + attack”; “heart + thrombosis”; “coronary + thrombosis”; “infarction – brain”, “myocardial + infarction” and “acute + myocardial + infarction”. Irrelevant (n=316), duplicated (n=345), without audio (n=24) or non‐Portuguese (n=106) videos were excluded. Included videos were assessed according to source, topic, target audience and scientific inaccuracies. Quality of information was assessed using The Health on the Net Code (HONCode from 0 to 8) and DISCERN (from 0 to 5) scores – the higher the score, the better the quality.</p></div><div><h3>Results</h3><p>242 videos were included. The majority were from independent instructors (n=95, 39.0%) and were addressed to the general population (n=202, 83.5%). One third of the videos (n=79) contained inaccuracies while scientific society and governmental/health institution videos had no inaccuracies. The mean video quality was poor or moderate; only one video was good quality without any inaccuracies. Governmental/health institutions were the source with the best quality videos (HONCode 4±1, DISCERN 2±1).</p></div><div><h3>Conclusions</h3><p>One third of the videos had irrelevant information and one third of the relevant ones contained inaccuracies. The average video quality was poor; therefore it is important to define strategies to improve the quality of online health information.</p></div>","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 815-825"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S217420492100283X/pdfft?md5=53bfb4fb9916a70b3f79c086d8c86996&pid=1-s2.0-S217420492100283X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porcelain aorta rupture after cardiopulmonary resuscitation","authors":"Iria Silva,&nbsp;Isaac Pascual,&nbsp;Carlos Morales,&nbsp;Alberto Alperi,&nbsp;Pablo Avanzas,&nbsp;Jacobo Silva,&nbsp;Cesar Moris de la Tassa","doi":"10.1016/j.repce.2021.10.026","DOIUrl":"10.1016/j.repce.2021.10.026","url":null,"abstract":"","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 897-898"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2174204921003317/pdfft?md5=48b4edb8af336bd7978125c2ddf4913a&pid=1-s2.0-S2174204921003317-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39939167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You had a myocardial infarction. Time to find out more","authors":"Daniel Ferreira","doi":"10.1016/j.repce.2021.11.001","DOIUrl":"10.1016/j.repce.2021.11.001","url":null,"abstract":"","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 827-828"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2174204921003536/pdfft?md5=4e0c045cc0d3a56a27ba315a5d945177&pid=1-s2.0-S2174204921003536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How healthy is cardiac rehabilitation in Portugal?","authors":"Ana Abreu","doi":"10.1016/j.repce.2021.11.004","DOIUrl":"10.1016/j.repce.2021.11.004","url":null,"abstract":"","PeriodicalId":101121,"journal":{"name":"Revista Portuguesa de Cardiologia (English Edition)","volume":"40 11","pages":"Pages 889-890"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2174204921003561/pdfft?md5=82e414dd732e5f6c4ce7e7703a4614e9&pid=1-s2.0-S2174204921003561-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}