Reprodu??o & Climatério最新文献

{"title":"Caracterização da produção científica sobre polimorfismo genético e endometriose","authors":"Gabriela Pimentel Porfirio ,&nbsp;Alessandra Bernadete Trovó de Marqui","doi":"10.1016/j.recli.2016.10.003","DOIUrl":"10.1016/j.recli.2016.10.003","url":null,"abstract":"<div><p>Endometriosis is considered a chronic disease, mainly characterized by chronic pelvic pain and infertility. Your etiology remains unclear, though genetic factors such as single nucleotide polymorphisms may contribute to the development of endometriosis. Thus, this study aimed to characterize the scientific production about genetic polymorphism and endometriosis. A literature survey was conducted in PubMed using the terms “genetic polymorphism and endometriosis”. Inclusion criteria were: English, free full text and published in the last three years (2014‐2016). Items not directly related to the subject were excluded by reading the title or abstract, and review articles. 35 articles were identified and 14 were included in this review. There was a predominance of articles published in 2015 (50%), conducted in Brazil (43%) and most of them were published in journals with impact factor up to 2.5. There was heterogeneity in the investigated genes with a small emphasis on those classified as metabolic enzymes. Half of the researches associated the polymorphisms that were being investigated with endometriosis, indicating that they may be implicated in the pathogenesis of this disease. In conclusion, the scientific production is growing and it is significant on the role of genetic polymorphisms in the etiology of endometriosis.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"32 1","pages":"Pages 48-52"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127723329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criação de um banco de dados personalizado de baixo custo em um serviço público de reprodução humana","authors":"Andressa do Rosário Rocha,&nbsp;Rafael Portela,&nbsp;Vanessa Rodrigues Alves,&nbsp;Nilka Donadio,&nbsp;Artur Dzik,&nbsp;Mario Cavagna","doi":"10.1016/j.recli.2016.03.004","DOIUrl":"10.1016/j.recli.2016.03.004","url":null,"abstract":"<div><p>Efficient <em>software</em> it's absolutely necessary for any human assisted reproduction (ART) lab. Perola Byington Public Hospital's ART center has used a spreadsheet in Excel with more than 200 columns for data storage of all <em>in vitro</em> fertilization cycles for years, making it very difficult to create complex statistics to analyze data and lead to quick statistic evaluation. Since we are working with a very tight budget, we selected an open source <em>software</em> created by the Centers for Disease Control and Prevention, and after months of programming we created CRSMinfo, which contains a form with subdivision of procedures, including all the information for research and automatic sorting of the data. The use of CRSMinfo <em>software</em> at Perola Byington Hospital has been extremely efficient, improving the protocols for the realization of studies and researches.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"32 1","pages":"Pages 66-69"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124325789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto da cirurgia bariátrica na fertilidade feminina – Revisão","authors":"Flavia Lino Erse de Melo ,&nbsp;Marco Melo","doi":"10.1016/j.recli.2017.04.001","DOIUrl":"10.1016/j.recli.2017.04.001","url":null,"abstract":"<div><p>The prevalence of people who are overweight or obese has increased dramatically in high‐income countries over the past 20 years. There is a strong association between obesity and infertility, and weight loss can increase fecundity in obese women. Reproductive age women comprise the majority of bariatric patients, and many may be interested in conceiving after surgery. Bariatric surgery has been shown to improve menstrual cyclicity in anovulatory women. Moreover, the increased risk of miscarriage in obese women may decline after bariatric surgery. However, little is published on the impact of surgical weight loss on spontaneous or in vitro fertilization (IVF)‐treatment‐related pregnancy rates. The purpose of this review is to synthesize the recent literature on bariatric surgery and fertility to help on patient counseling.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"32 1","pages":"Pages 57-62"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2017.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133861887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CA125, progesterone & β-hCG in prediction of first trimester abortion","authors":"Amr Adel Mansy ,&nbsp;Engy Taher ,&nbsp;Mohamed Abdelrahman ,&nbsp;Sarah M. Shehata","doi":"10.1016/j.recli.2017.03.003","DOIUrl":"10.1016/j.recli.2017.03.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Pregnancy loss is a common medical problem in reproductive-age as more than fifty percent of human pregnancies are aborted before term. The majority are unrecognized occurring before or with the expected next menses. About 10–12 percent of all clinically diagnosed pregnancies are lost as first-trimester or early second trimester. The rate of fetal death after 14 weeks’ gestation is much lower than the rate of pre-embryonic and embryonic loss. CA125 is a member of the mucin family glycoproteins. CA125 has found application as a tumor marker or biomarker that its level may be increased in the serum of some patients with specific types of cancers. Some studies detected that the abortion risk is increased in pregnant women with higher CA125 levels. Progesterone belongs to the C21 group of progestogen. Its main source in humans is the corpus luteum.</p><p>Human chorionic gonadotropin (HCG) is a glycoprotein produced by syncytiotrophoblast.</p></div><div><h3>Aim of the work</h3><p>The aim of this study was to determine the effectiveness of measuring maternal serum β-HCG, progesterone, CA125 in prediction of first trimester abortion.</p></div><div><h3>Patients</h3><p>The study included 90 pregnant women attending the ANC clinic in El-Shatby Maternity University Hospital. Patients were divided equally into two groups: Group I: 45 women with threatened abortion, subdivided into 2 subgroups: Subgroup A – Cases ended in abortion; Subgroup B – Cases continued as normal pregnancies. Group II: 45 pregnant women with normal pregnancy and were further subdivided into two subgroups: Subgroup C – Cases ended in abortion; Subgroup D – Cases continued as normal pregnancies.</p></div><div><h3>Exclusion criteria</h3><p>(1) Multiple pregnancies; (2) Anembryonic pregnancy; (3) Pregnant women with prior treatment with progesterone; (4) History of endometriosis; (5) Fibromyoma with pregnancy.</p></div><div><h3>Methods</h3><p>After clinical and sonographic examination, 3<!--> <!-->mL venous blood have been taken once for estimation of serum level of β-hCG, progesterone and CA125 by quantitative ELISA.</p></div><div><h3>Results</h3><p>This is a case–control study. Out of the 90 pregnancies, 15 cases (16.6%) had aborted during follow-up, 9 cases (60%) of them had history of threatened abortion while 6 cases (40%) had no history of threatened abortion. Regarding Serum Progesterone level between studied groups, the calculated <em>p</em> value was &lt;0.001. For Serum β HCG, the calculated <em>p</em> value was &lt;0.001. In Serum CA125 the calculated <em>p</em> value was &lt;0.001.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"32 1","pages":"Pages 24-30"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2017.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131821912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Células‐tronco oriundas do fluxo menstrual: possíveis aplicações","authors":"Gisela Rodrigues da Silva Sasso ,&nbsp;Michele Longoni Calió ,&nbsp;Luiz Fernando Portugal Fuchs ,&nbsp;Cristiane de Paula Teixeira ,&nbsp;Ricardo Santos Simões ,&nbsp;Rinaldo Florencio‐Silva","doi":"10.1016/j.recli.2016.05.003","DOIUrl":"10.1016/j.recli.2016.05.003","url":null,"abstract":"<div><p>Adult stem cells are present in several human tissues, including the endometrium. Menstrual blood derived stem cells (MenSCs) are mesenchymal stem cells that can be obtained in a non‐invasive manner. Due to its rapid proliferation rate, low immunogenicity and low tumorigenicity, MenSCs are used extensively in tissue engineering. They can be induced into multiple cell lineages under certain conditions. MenSCs contribute to tissue repair via several different mechanisms, highlighting their great promise in clinical applications. Endometrial stem cells may also be used to shed light on the pathogenesis of endometriosis and endometrial carcinoma. This review will cover recent progress in this field.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"32 1","pages":"Pages 39-42"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.05.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134265886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doença celíaca materna e baixo peso ao nascer","authors":"Ana Paula de Souza Lobo Machado ,&nbsp;Luciana Rodrigues Silva ,&nbsp;Fernanda de Oliveira Andrade Lopes ,&nbsp;Fernando Augusto Montanha Teixeira ,&nbsp;Vinicius Veloso Teixeira","doi":"10.1016/j.recli.2016.11.003","DOIUrl":"10.1016/j.recli.2016.11.003","url":null,"abstract":"<div><p>Celiac disease is a chronic, immune‐mediated, inflammatory disorder of the small intestine, that occurs in response to a permanent intolerance to gluten in genetically predisposed individuals. Its clinical manifestations may vary significantly, including an asymptomatic presentation. In undiagnosed celiac pregnant women, it has been associated with increased risk of low birth weight newborns. This review aims to provide a better understanding of the pathophysiological mechanisms involved in the association between maternal celiac disease and low birth weight through a literature review of the most relevant publications on the subject in the last 20 years.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"32 1","pages":"Pages 53-56"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124391201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avaliação de danos genéticos e apoptose em mulheres menopausadas que fazem uso da terapia de reposição hormonal","authors":"Polyanna Carôzo de Oliveira,&nbsp;Eneida de Moraes Marcílio Cerqueira,&nbsp;José Roberto Cardoso Meireles","doi":"10.1016/j.recli.2016.08.005","DOIUrl":"10.1016/j.recli.2016.08.005","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate through the micronucleus test in exfoliated cells of oral mucosa the genotoxicity of hormones used in hormone replacement therapy (HRT).</p></div><div><h3>Material and methods</h3><p>Forty postmenopausal women were selected and divided into four groups of ten: G0 (not submitted to HRT), G1 (HRT with estrogen), G2 (HRT with estrogen and progestogen) and G3 (HRT with tibolone). Exfoliated cells of oral mucosa were collected and processed for analysis of chromosomal damage (micronuclei) and apoptosis, inferred by the sum of nuclear degenerative alterations (picnosis, cariorréxis and condensed chromatin). Two thousand cells were analyzed by participant. Statistical analysis was performed using the conditional test to compare proportions in a situation of rare events.</p></div><div><h3>Results</h3><p>The frequency of micronuclei did not differ between groups (p<!--> <!-->&gt;<!--> <!-->0.05). Apoptotic cells were significantly higher among women from G0 when compared to the other groups (p<!--> <!-->&lt;<!--> <!-->0.01). The groups submitted to HRT did not differ in apoptosis occurrence (p<!--> <!-->&gt;<!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>These results indicate that, as assessed in this study, TRH does not induce chromosomal damage, however, due to the anti‐apoptotic effect, cells genetically damaged can proliferate, favoring the malignant transformation process</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"31 3","pages":"Pages 163-168"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.08.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122446222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualization of controlled ovarian stimulation in vitro fertilization using markers of ovarian reserve: a systematic review","authors":"Andriele dos Reis Silva ,&nbsp;Gabriela Balduino Guimarães ,&nbsp;Eduardo Camelo de Castro","doi":"10.1016/j.recli.2016.06.004","DOIUrl":"10.1016/j.recli.2016.06.004","url":null,"abstract":"<div><h3>Introduction</h3><p>The main objective of individualization of treatment in IVF is to offer every single woman the best treatment tailored to her own unique characteristics, thus maximizing the chances of pregnancy and eliminating the iatrogenic and avoidable risks resulting from ovarian stimulation. Personalization of treatment in IVF should be based on the prediction of ovarian response.</p></div><div><h3>Objective</h3><p>To summarize the predictive ability of ovarian reserve markers, and the therapeutic strategies that have been proposed in IVF after this prediction.</p></div><div><h3>Methods</h3><p>A systematic review of the existing literature was performed by searching Medline, LILACS, SciELO and Pubmed, for publications related to ovarian reserve markers and their incorporation into controlled ovarian stimulation (COS) protocols in IVF.</p></div><div><h3>Results</h3><p>251 articles were found. Ten articles published between 2010 and 2015 were selected.</p></div><div><h3>Conclusion</h3><p>Antral follicle count (AFC) and anti-Mullerian hormone (AMH), the most sensitive markers of ovarian reserve, are ideal in planning personalized COS protocols. These markers permit prediction of the ovarian response with reliable accuracy. Following the categorization of expected ovarian response clinicians can adopt tailored therapeutic strategies for each patient.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"31 3","pages":"Pages 128-133"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.06.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129478935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acesso e permanência das usuárias do Sistema Único de Saúde no Programa de Reprodução Assistida de um hospital universitário, com ênfase na variável raça/cor","authors":"Marilise Oliveira Mesquita,&nbsp;Graziella Chaves Trevilato,&nbsp;Michelle da Silva Schons,&nbsp;Deise Lisboa Riquinho,&nbsp;Suzana Záchia,&nbsp;Eduardo Pandolfi Passos","doi":"10.1016/j.recli.2016.07.004","DOIUrl":"10.1016/j.recli.2016.07.004","url":null,"abstract":"<div><h3>Objective</h3><p>To characterize racial, economic and socio‐demographic aspects of women who accessed Assisted Reproduction Service at a university hospital, referred by primary care, and to discuss the conditions that cause the users to postpone or quit treatment, highlighting the item of user's race/color.</p></div><div><h3>Methods</h3><p>It was performed a cross‐sectional study in which all of the users that entered the Assisted Reproduction Service program, from January 2013 to March 2014, were interviewed in person (145 women). In the second stage of the work, in October and November 2015, telephone contact was made with women who had participated in the first interview, in order to understand the difficulties, success or failure of treatment and the reasons for not persisting in the program.</p></div><div><h3>Results</h3><p>It was observed that the black women had access and remained in the service in proportions similar to white women, according to the representativity of this race/color in the state of Rio Grande do Sul The second stage showed abandonment of 35% even before the start of treatment, and 30% during the treatment, and financial issues being the main reason for quiting.</p></div><div><h3>Conclusion</h3><p>Despite the high cost of medicines, there is a waiting list for the service, although, paradoxically, there is an expressive number of abandonment.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"31 3","pages":"Pages 151-158"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121465813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O impacto da infertilidade: narrativas de mulheres com sucessivas negativas pelo tratamento de reprodução assistida","authors":"Luiz Augusto Teixeira Batista ,&nbsp;Wagner Henrique Daibert Bretones ,&nbsp;Rogério José de Almeida","doi":"10.1016/j.recli.2016.05.004","DOIUrl":"10.1016/j.recli.2016.05.004","url":null,"abstract":"<div><h3>Objectives</h3><p>Describe the psychosocial impact of infertility in women trying to conceive without success through assisted reproduction.</p></div><div><h3>Methods</h3><p>This is a descriptive observational study with qualitative and exploratory approach. The records were obtained through assisted reproduction clinic in Goiânia‐GO. Four interviews with women were conducted to meet the criteria for inclusion and exclusion, through semi‐structured interview technique.</p></div><div><h3>Results</h3><p>Four categories were analyzed considered key: diagnosis and initiation of treatment; lack of social support, feelings of failure and future prospects. Infertility generates a series of feelings such as anxiety, depression, guilt, fear, social exclusion; decrease quality of life and directly affect the women's relationship with their partners, family and work environment. However, despite the frustrations the feeling that prevailed is trying to follow.</p></div><div><h3>Conclusions</h3><p>The psychosocial suffering of women facing the successive negative results need to be better addressed in the context of specialized clinics providing early psychosocial support to cope with possible frustrations with negative results.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"31 3","pages":"Pages 121-127"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2016.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132708368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}