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Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics最新文献

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Testosterone as growth stimulant in man 睾酮作为男性的生长刺激剂
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80009-5
J.J. van der Werff ten Bosch
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引用次数: 3
Management of the eye manifestations of thyroid disease 甲状腺疾病眼部表现的处理
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80015-0
I.R. McDougall, J.P. Kriss
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引用次数: 5
The inherited errors of the thyroid system 甲状腺系统的遗传性错误
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80003-4
John B. Stanbury, Deanna Talley
{"title":"The inherited errors of the thyroid system","authors":"John B. Stanbury,&nbsp;Deanna Talley","doi":"10.1016/S0362-5486(77)80003-4","DOIUrl":"10.1016/S0362-5486(77)80003-4","url":null,"abstract":"<div><p>Some of the inborn errors of the thyroid system are reconsidered after reflection on old studies and in the light of some new information. The peroxidase defect is seen as at least four distinct entities with deficient iodination of tyrosyl residues of thyroglobulin as the final common expression. Three of these may be allelic for thyroid peroxidase, but the fourth, the Pendred syndrome, is almost surely not.</p><p>Present information does not seem to allow for three separate errors which in the past have been designated as ‘coupling defect’, ‘thyroglobulin synthesis defect’, and the syndrome of ‘abnormal plasma iodoprotein’.</p><p>Patients with the syndrome of thyroid hormone unresponsiveness differ in different kindreds. The disorders may or may not be allelic. Recent findings on the molecular mechanism of thyroid hormone action promise an early understanding of the nature of this disorder, perhaps as an error in the protein of nuclear chromatin which binds the hormone. Other inborn errors of the thyroid are briefly mentioned.</p></div>","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 167-176"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80003-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82919333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antiarrhythmic effects of local anesthetics and calcium antagonists 局部麻醉剂和钙拮抗剂的抗心律失常作用
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80001-0
B.N. Singh (Director, Inpatient Cardiology, Cedars-Sinai Medical Center and Associate Professor of Medicine)
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引用次数: 12
Side effects of antiarrhythmic drugs 抗心律失常药物的副作用
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80002-2
B.N. Singh (Director, Inpatient Cardiology, Cedars-Sinai Medical Center and Associate Professor of Medicine)
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引用次数: 6
Hypothyroidism 甲状腺功能减退
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80004-6
H.K. Ibbertson
{"title":"Hypothyroidism","authors":"H.K. Ibbertson","doi":"10.1016/S0362-5486(77)80004-6","DOIUrl":"https://doi.org/10.1016/S0362-5486(77)80004-6","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 177-196"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80004-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137403905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital and juvenile nongoitrous hypothyroidism 先天性和青少年非甲状腺功能减退症
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80005-8
M. Pierre Koenig
{"title":"Congenital and juvenile nongoitrous hypothyroidism","authors":"M. Pierre Koenig","doi":"10.1016/S0362-5486(77)80005-8","DOIUrl":"10.1016/S0362-5486(77)80005-8","url":null,"abstract":"<div><p>Nongoitrous congenital and juvenile hypothyroidism is a rather common endocrine disorder occurring in approximately 1:5000–1:8500 normal children. The most frequent cause is thyroid ectopy (‘cryptothyroidism’) followed by atrophy of unknown cause and chronic atrophic thyroiditis. The clinical symptomatology is defined by disturbances of general metabolism and, most typically, by retarded somatic and mental development, leading in its extreme form when untreated, to so-called cretinism. The i treatment with thyroid hormone replacement has to be administered as early as possible. The prognosis for mental development depends on the brain damage present when treatment was started. Screening of thyroid function in neonates is the most reasonable method to make an early diagnosis.</p></div>","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 2","pages":"Pages 197-204"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80005-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78803816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical studies of thyrotropin and thyrotropin-releasing-hormone 促甲状腺素及促甲状腺素释放激素的临床研究
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80014-9
Michael D. Okerlund, Francis S. Greenspan
{"title":"Clinical studies of thyrotropin and thyrotropin-releasing-hormone","authors":"Michael D. Okerlund,&nbsp;Francis S. Greenspan","doi":"10.1016/S0362-5486(77)80014-9","DOIUrl":"10.1016/S0362-5486(77)80014-9","url":null,"abstract":"<div><p>Most clinical studies with thyrotropin have utilized bovine TSH since human TSH has not been available, but more general use of the latter may be possible in the near future. The use of BTSH has been limited to stimulation testing of thyroid function, and the compound has shown lesser, but occasional, usefulness in the treatment of metastatic thyroid carcinoma.</p><p>The radioimmunoassay of HTSH has largely replaced the TSH stimulation test in the differential diagnosis of hypothyroidism and has become a valuable tool in the management of thyroid disease. More recently the availability of synthetic TRH has opened a new aspect to the understanding of hypothalamic-pituitary-thyroid interrelationships. The TRH test has also become important in the diagnosis and management of thyroid disease. The role of TRH in the therapy of hypothalamic or thyroid disease is yet to be determined and its usefulness in psychological investigations will no doubt be studied further.</p></div>","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 79-94"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80014-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73983359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of androgens and related substances in surgical conditions including burns 在外科手术条件下使用雄激素和相关物质，包括烧伤
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80013-7
Joseph I. Weinstein , Isaac Kaplan
{"title":"Use of androgens and related substances in surgical conditions including burns","authors":"Joseph I. Weinstein ,&nbsp;Isaac Kaplan","doi":"10.1016/S0362-5486(77)80013-7","DOIUrl":"10.1016/S0362-5486(77)80013-7","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 65-77"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80013-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82742668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pathophysiology and pharmacotherapy of tremor 震颤的病理生理及药物治疗
Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics Pub Date : 1977-01-01 DOI: 10.1016/S0362-5486(77)80016-2
Donald B. Calne, Harold L. Klawans
{"title":"Pathophysiology and pharmacotherapy of tremor","authors":"Donald B. Calne,&nbsp;Harold L. Klawans","doi":"10.1016/S0362-5486(77)80016-2","DOIUrl":"10.1016/S0362-5486(77)80016-2","url":null,"abstract":"","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 113-123"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80016-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82406630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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