New Horizons in Clinical Case Reports最新文献

{"title":"Osteosarcoma during pregnancy - case report","authors":"Małgorzata Stefaniak * ,&nbsp;Barbara Kozakiewicz ,&nbsp;Ewa Dmoch-Gajzlerska","doi":"10.1016/j.nhccr.2017.06.187","DOIUrl":"https://doi.org/10.1016/j.nhccr.2017.06.187","url":null,"abstract":"<div><p>In Poland, sarcomas represent about 1% of all cancer diseases. Every year about 800 new cases are diagnosed. Osteosarcoma is the most frequently recognized primary malignant bone tumor.</p><p>Osteosarcomas are diagnosed more frequently in children and adolescent males, whereas in pregnant women they are extremely rare. We present a case of a 29-year-old pregnant woman with a highly diverse osteosarcoma. A patient which was in 23rd week of pregnancy was treated with multiple doses of chemotherapy while fetal health was being monitored.</p><p>The plan for a therapeutic process included inducing a pregnancy solution at the moment of the fetus reaching maturity, then continuing oncological treatment.</p><p>According to the established protocol of treatment in 34 week pregnancy was completed via cesarean section. The woman gave birth to a daughter in good condition. Surgical treatment was conducted after delivery until complete post-pregnancy healing. There was no reduction of dose or quantity of planned and conducted courses of chemotherapy due to pregnancy.</p><p>The paper offers an analysis of diagnosis and therapy of pregnant women with osteosarcoma based on own experience and on the basis of a relevant literature.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 ","pages":"Page 23"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.06.187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91723913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential diagnosis of anemia in 88 years old: Unexpected findings and geriatric dilemmas","authors":"Alexander Rabinovich *,&nbsp;Yaffa Lerman","doi":"10.1016/j.nhccr.2017.06.169","DOIUrl":"10.1016/j.nhccr.2017.06.169","url":null,"abstract":"<div><p>We report a case of functionally independent and cognitively intact 88-year-old male, suffering from anemia with suspicion for UGI bleeding. Diagnostic evaluation revealed a small bowel tumor as the source of bleeding. Our presentation will include a discussion about small bowel tumors as a relatively rare entity. The patient was operated on and the tumor was diagnosed as a distant metastasis of melanoma. Further evaluation revealed a relatively small primary melanoma tumor on the posterior part of right heel. The patient was not aware of the tumor until the diagnostic investigation. Radical Surgery was proposed as the choice of treatment with high probability of wheelchair-bound state as the functional outcome. Further discussion is related to the dilemma of choosing between aggressive treatments versus preserving quality of life in elderly persons. Modern options of melanoma treatment and their suitability to the elderly patient are presented together with a review of the literature.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 ","pages":"Page 15"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.06.169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78683031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory local recurrence during TC chemotherapy after breast-conserving surgery: a case report","authors":"Feng Mao,&nbsp;Xingtong Zhou,&nbsp;Yidong Zhou,&nbsp;Yan Lin,&nbsp;Changjun Wang,&nbsp;Li Peng,&nbsp;Qianqian Xu,&nbsp;Qiang Sun","doi":"10.1016/j.nhccr.2017.06.189","DOIUrl":"https://doi.org/10.1016/j.nhccr.2017.06.189","url":null,"abstract":"<div><h3>Introduction</h3><p>Inflammatory local recurrence after breast-conserving therapy is very rare and these patients always have poor prognosis.^<em>1</em> In common, the recurrence happens in a median of 65 months for lymph node negative patients. Fast recurrence is usually be considered correlated with ER status, lymph node status and tumor size.</p></div><div><h3>Case description</h3><p>A 70-year-old female patient had left breast conserving surgery in PUMCH on 2016-4-19, pathological results showed an IDC (triple negative) and the margins of the tumor were clear. Then she began chemotherapy (Taxol+CTX, 3 week regimen) on 5-22. At the end of June, she had a skin lesion on the left breast. We continued chemotherapy to 7-22, TC*4 in total. During this, the patient's skin lesion turned bigger and the therapy had no effect on this. We took the skin for biopsy and the skin and lymphatic was filled with breast cancer metastases.</p></div><div><h3>Conclusion</h3><p>Locally recurrence can happen in patients having had breast-conserving surgery. However, in our case, the patient has rare inflammatory local recurrence after breast conserving surgery very rapidly, even during chemotherapy. Just 2 months after surgery. So we think that the inflammatory skin lesion on breast cancer patients must be taken seriously and do biopsy as soon as possible.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 ","pages":"Pages 23-24"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.06.189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91723179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcome for NRTI-sparing regimen consisting of dolutegravir and rilpivirine in HIV-1 infected patients","authors":"Mari Kato * ,&nbsp;Hiroaki Togami ,&nbsp;Atsushi Hirano ,&nbsp;Naoko Fukushima ,&nbsp;Shuuichi Matsumoto ,&nbsp;Yoshiyuki Yokomaku ,&nbsp;Masaaki Takahashi","doi":"10.1016/j.nhccr.2017.06.175","DOIUrl":"https://doi.org/10.1016/j.nhccr.2017.06.175","url":null,"abstract":"<div><h3>Objectives</h3><p>The nucleoside reverse transcriptase inhibitors (NRTI) have been an important 'back-bone' of an antiretroviral therapy (ART) for HIV-1 infected patients. However, these agents have been associated with both short and long-term toxicity. Therefore, there has been growing interest in evaluating NRTI-sparing regimens. Now we have administered dolutegravir (DTG) and rilpivirine (RPV) to HIV-1 infected patients as a new NRTI-sparing regimen. However, there are few data on the outcome of ART regimen consisting of DTG and RPV. In this study, we examined treatment outcome for this NRTI-sparing regimen in HIV-1 infected patients.</p></div><div><h3>Method</h3><p>We examined 27 HIV-1 infected patients treated with NRTI-sparing regimen consisting of DTG and RPV in Nagoya Medical Center, Japan. We checked efficacy and safety for this regimen from 2014 to 2015, retrospectively.</p></div><div><h3>Results</h3><p>Median duration of this NRTI-sparing regimen for 27 Japanese HIV-1 infected patients (26 males, 1 female; mean age 57 years) was 323 days. The reasons for changing to this regimen were pill burden (n=13), lipodystrophy related to NRTI (n=7), myelopathy (n=2), renal dysfunction (n=1), dyslipidemia (n=1), respectively. Finally, 25 patients have continued this regimen. After starting this regimen, HIV viral load were soon less than the detection limit for all patients. Virologic failure and regimen discontinuations by severe adverse reactions were not confirmed for individuals. In addition, abnormal laboratory data (ALT, AST, etc) were not shown for all patients.</p></div><div><h3>Conclusions</h3><p>Current UK and US treatment guidelines do not recommend NRTI-sparing regimens for people starting ART due to concerns about toxicity, treatment discontinuation, and drug resistance. In this study, 12 patients had been already treated with NRTI-sparing regimen (Raltegravir + RPV). As these patients were elder, it was essential to reduce pill burden. Therefore, a new NRTI-sparing regimen, DTG + RPV, will be available in the future because of reducing pill burden, few drug interactions and low toxicity.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 ","pages":"Page 18"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.06.175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91723077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of repetitive transcranial magnetic stimulation for the recovery of central cord syndrome","authors":"J. Hyun, S. Kim, T. U. Kim","doi":"10.1016/J.NHCCR.2017.06.177","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.177","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"21 1","pages":"18-19"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73176427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Kikuchi Disease and Lupus Erythematosus in a Schizophrenic Patient with Extreme Anorexia","authors":"Lamia Abu Ghazaleh, Ludmila Vysman, A. Tanai, A. Tanai, H. Orbach, H. Orbach","doi":"10.1016/J.NHCCR.2017.06.180","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.180","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"22 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76558974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer detected only by positron emission tomography with extensive osteolytic bone metastases mimicked Multiple Myeloma: A case report","authors":"Yidong Zhou, F. Mao, Changjun Wang, Yan Lin, Yu Xiao, B. Pan, Xingtong Zhou, R. Yao, Q. Sun","doi":"10.1016/J.NHCCR.2017.06.193","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.193","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"51 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86752308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One center experience of pneumatosis cystoides intestinalis","authors":"V. Mokricka, Polina Zalizko, M. Pavărs, A. Āboliņš, A. Puķītis","doi":"10.1016/J.NHCCR.2017.06.195","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.195","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"24 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88372918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced GO/NOGO ACC-sensitive Activity in A Case of Parkinson's Disease with Impulse Control Disorders","authors":"S. Palermo, R. Morese, M. Zibetti, Francesca Dematteis, Maria ConsueloValentini, L. Lopiano","doi":"10.1016/J.NHCCR.2017.06.155","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.155","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 1","pages":"9-9"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80236431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse colon polyposis unexpected, total regression due to combined treatment on liver metastasis","authors":"Zsanett Bíró, A. Papp, Ö. Horváth, A. Vereczkei","doi":"10.1016/j.nhccr.2017.06.196","DOIUrl":"https://doi.org/10.1016/j.nhccr.2017.06.196","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"824 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78905649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}