New Horizons in Clinical Case Reports最新文献

{"title":"Bouveret’s Syndrome: The rarest obstructing gallstone","authors":"Joshua Bramson ,&nbsp;Arthur Topilow ,&nbsp;Ronald Matteotti","doi":"10.1016/j.nhccr.2017.08.004","DOIUrl":"10.1016/j.nhccr.2017.08.004","url":null,"abstract":"<div><p>Bouveret’s Syndrome is the rarest form of gallstone ileus. It is characterized by the passage of a large gallstone through a cholecystoduodenal fistula resulting in obstruction of the proximal bowel. The rarity, and non-specific presentation of Bouveret’s Syndrome, make it a frequently overlooked diagnosis, with a significant associated mortality. We report the case of an 86 year old male presenting to the Emergency Department with nausea, vomiting, and constipation. Diagnosis of Bouveret’s Syndrome was made by CT scan of the abdomen demonstrating a large stone in the proximal duodenum. After failed attempts at endoscopic removal of the gallstone, the patient was taken for surgical enterotomy and foreign body retrieval. Bouveret’s syndrome is a rare entity with limited evidence to favor one approach to management over another. In this case, we review the diagnostic and therapeutic options for this rare form of small bowel obstruction.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"2 ","pages":"Pages 17-19"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80125563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiropractic pain control in myelofibrosis: A case report","authors":"Eric Chun-Pu Chu ,&nbsp;Raymond S.M. Wong","doi":"10.1016/j.nhccr.2017.08.001","DOIUrl":"10.1016/j.nhccr.2017.08.001","url":null,"abstract":"<div><h3>Background</h3><p>Myelofibrosis (MF) is a rare hematological disease. Currently available therapies mainly offer symptom control with limited curative benefits.</p></div><div><h3>Case presentation</h3><p>A 58-year-old man old man presented with MF for several years and had undergone splenectomy and targeted therapy with ruxolitinib. During the last 3 years of his life, he suffered from intractable bone pain that was resistant to medical, analgesic and physical therapies. However, significant pain alleviation was achieved shortly after starting chiropractic treatment. Patient’s condition continued to deteriorate and he died of septic complications.</p></div><div><h3>Conclusions</h3><p>Bone and joint pain is the common symptom of cancer. This report highlights the potential benefits of integrating chiropractic into a multidisciplinary approach to cancer care. In rare diseases like myelofibrosis, the main limitation of this report was the lack of the related references for comparative analysis. Further studies regarding the efficacy of chiropractic therapy in controlling various cancer pains are needed to guide decision making.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"2 ","pages":"Pages 7-9"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79053772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational strategy in NASH diversity: learning from mouse models","authors":"Cristina Alonso ,&nbsp;Marta Iruarrizaga-Lejarreta ,&nbsp;Laura dela Cruz-Villar ,&nbsp;Itziar Mincholé ,&nbsp;Ibon Martínez-Arranz ,&nbsp;José M Mato","doi":"10.1016/j.nhccr.2017.06.150","DOIUrl":"10.1016/j.nhccr.2017.06.150","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;p&gt;Nonalcoholic steatohepatitis (NASH) is a histological definition that groups together defects in diverse biochemical processes causing hepatic fat accumulation, inflammation, necrosis and fibrosis. Increasing evidence points to different subtypes of nonalcoholic fatty liver disease (NAFLD) which progress to NASH and fibrosis at different rates and may respond differently to treatment. The identification of the types of mechanisms leading to NASH and the discovery of non-invasive biomarkers of NASH subtypes are central for the development of effective treatments and precise diagnosis. This study aims to capture the metabolic signature of different NASH subtypes through a translational research.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;p&gt;We undertook metabolomic serum analysis in a mouse model that spontaneously develops NASH, methionine adenosyltransferase 1a knockout (&lt;em&gt;Mat/a&lt;/em&gt;-KO), and compared with WT mice. Top fifty metabolites that more significantly differentiated between genotypes were selected and translated to a human cohort: 535 biopsied patients (353 steatosis, 182 NASH). For that, we performed a Silhouette cluster analysis and validate the process in 1000-fold repetition of a random partition (50/50) of samples into two cohorts with equal proportional representation of steatosis/NASH. The frequency distribution of NAFLD patients into subtypes and of metabolites that significantly differentiated between NASH and steatosis per subtype was calculated.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Silhouette cluster analysis revealed that &lt;em&gt;Mat/a&lt;/em&gt;-KO signature sub-classified the patients into two clusters, one showing a serum metabolic profile similar to that observed in &lt;em&gt;Mat/a&lt;/em&gt;-KO mice (M-subtype) and other showing a different profile (non-M-subtype). Following the criteria based on 2:70% reproducibility of the frequency distribution, 262 patients were classified as M-subtype and 171 as non-M-subtype. The remaining 102 patients showed a reproducibility of less than 70%. A NASH biomarkers list per subtype was generated based on the frequency distribution (2:70% reproducibility) of the metabolites that significantly differentiated between NASH and steatosis: 54 and 6 metabolites for M- and non-M-subtypes, respectively.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;We identified a serum specific metabolomic signature characteristic of Mat1a-KO mice and found that about half of NAFLD patients share it, suggesting that in these patients SAMe synthesis may be impaired. Interestingly, this phenotype was observed in patients with steatosis and NASH, which suggests that impaired SAMe synthesis may occur early in the development of NAFLD in a subgroup of patients. This translational strategy can be applied to different mouse models with diverse mechanisms leading to NASH. These results also indicate that the traditional, mainly pathology-driven classification of NAFLD/NASH, can be refined and perhaps represented by metabolomics classifi","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 ","pages":"Page 7"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.06.150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87325805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute renal failure and severe lactic acidosis due to metformin","authors":"Sirmpilantze Tamta, K. Christina, Poulas Andreas, Charalambous Natasa, Lambas Vaggelis, Rozi Fotini, Mavras Georgios, Lampropoulos E. Christos","doi":"10.1016/J.NHCCR.2017.06.167","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.167","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"399 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85489311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung cancer diagnosed by a metastatic lesion in the mandible","authors":"S. McKernon, Kathryn Taylor, C. Balmer","doi":"10.1016/J.NHCCR.2017.06.181","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.181","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"48 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82037637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendritic cell based immunotherapy in solid tumours","authors":"Thomas Felzmann *","doi":"10.1016/j.nhccr.2017.06.135","DOIUrl":"10.1016/j.nhccr.2017.06.135","url":null,"abstract":"<div><p>In the treatment of cancer great expectations rest on novel concepts of immuno-oncology. Various concepts for harnessing the immune systems power in controlling cancer cells were developed over the last two to three decades. Three categories of therapeutic modalities may be distinguished: (i) adoptive cancer immune therapy, the latest of which are chimeric antigen-receptor T-cells; (ii) immune modulatory approaches, the most prominent being immune checkpoint inhibitors; and (iii) cancer vaccine technologies, such as the use of tumour antigen-charged dendritic cells (DC).</p><p>We focused on the latter approach. A DC-based cancer immunotherapy method was developed that aimed to stick as closely as possible to the physiologic initiation of an immune response. The concept was investigated in a phase I clinical trial for the treatment of bone and soft tissue sarcoma; and in a randomised phase II clinical trial aimed at treating glioblastoma multiforme. No conclusive evidence regarding the efficacy of our DC cancer vaccination approach was generated. However, several lessons learned during our clinical trials that might enhance the chances for developing a successful cancer vaccine in future trials. A promising approach in immuno-oncology will most likely be a combination of various approaches. Currently, first clinical trials investigate the combination of cancer vaccines with immune checkpoint inhibitors.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 ","pages":"Page 1"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.06.135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74122357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epiploic Appendagitis masquerading as acute appendicitis","authors":"Gautam Menon *,&nbsp;Arathi Menon,&nbsp;Jay Menon","doi":"10.1016/j.nhccr.2017.06.163","DOIUrl":"10.1016/j.nhccr.2017.06.163","url":null,"abstract":"<div><h3>Introduction</h3><p>Epiploic appendagitis is considered as a relatively uncommon surgical condition. We report our observational study which suggest that it is more common that appreciated.</p></div><div><h3>Case description</h3><p>In a weekend on call, out of 4 patients undergoing diagnostic laparoscopy for suspected appendicitis, we encountered 2 clear cases of epiploic appendagitis. These patients had CT scan suggestive of inflammatory process in right iliac fossa; the inflammatory markers were elevated. Diagnostic laparoscopy revealed appendage epilpoicae as the culprit.</p></div><div><h3>Results and conclusions</h3><p>Patients underwent appendicectomy and excision of the appendage with resolution of the symptoms. We conclude that this entity is much more common that appreciated. In cases of serosanguinous fluid in the abdomen and normal looking appendix, search should be undertaken not to overlook a torted appendage.</p></div><div><h3>Take-home message</h3><p>The patients with epiploic appendagitis tend to look well; they are excruciately tender in the area overlying the appendage. Though self-resolving, if identified, the best option is to excise the appendage for early resolution of the symptoms.</p></div>","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 ","pages":"Page 13"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhccr.2017.06.163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86514479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive pulmonary aspergillosis in three nasopharyngeal cancer patients","authors":"Wen-Liang Yu","doi":"10.1016/j.nhccr.2017.06.168","DOIUrl":"https://doi.org/10.1016/j.nhccr.2017.06.168","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"1 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79232467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dasatinib related pericardial effusion requiring pericardial drainage","authors":"K. Mouyis, S. Metaxa, C. Missouris","doi":"10.1016/J.NHCCR.2017.06.179","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.179","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"131 1","pages":"19-20"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79616285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Local Recurrence During TC Chemotherapy after Breast-Conserving Surgery: A Case Report","authors":"F. Mao, Xingtong Zhou, Yidong Zhou, Yan Lin, Changjun Wang, Li-hua Peng, Qianqian Xu, Q. Sun","doi":"10.1016/J.NHCCR.2017.06.189","DOIUrl":"https://doi.org/10.1016/J.NHCCR.2017.06.189","url":null,"abstract":"","PeriodicalId":100954,"journal":{"name":"New Horizons in Clinical Case Reports","volume":"71 1","pages":"23-24"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86401316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}