Neuroimmunology Reports最新文献_第8页

Interferon-beta-1a induced retinopathy in a 14-year-old female patient with multiple sclerosis 一名 14 岁女性多发性硬化症患者因干扰素-β-1a 引起的视网膜病变

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-02-29 DOI: 10.1016/j.nerep.2024.100202

C. Tsimakidi, M. Gontika, D. Gkougka, K Rizonaki, S. Fanouraki, C. Kotsalis

引用次数: 0

Rapidly progressive cerebral dysfunction in a 5-year-old child: A reminder of subacute sclerosing panencephalitis (SSPE) and the importance of measles vaccination coverage 一名 5 岁儿童出现快速进展性脑功能障碍：提醒人们注意亚急性硬化性泛脑炎（SSPE）和麻疹疫苗接种的重要性

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2023-12-12 DOI: 10.1016/j.nerep.2023.100195

Mustafa Bakir , Nadir Khan , Jonathan Gehlbach

{"title":"Rapidly progressive cerebral dysfunction in a 5-year-old child: A reminder of subacute sclerosing panencephalitis (SSPE) and the importance of measles vaccination coverage","authors":"Mustafa Bakir , Nadir Khan , Jonathan Gehlbach","doi":"10.1016/j.nerep.2023.100195","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100195","url":null,"abstract":"<div><p>We present a case of a preschool boy admitted to the pediatric intensive care unit with generalized weakness and encephalopathy that progressed to coma and spastic paralysis over the next few weeks. Extensive evaluation of a wide range of possible diagnoses, including infectious, post-infectious, autoimmune, and paraneoplastic disorders, proved unrevealing. Owing to concerns regarding autoimmune encephalitis, the patient received plasmapheresis, intravenous immunoglobulin, high-dose glucocorticoids, anakinra, rituximab, and empirical botulinum antitoxin. Despite these treatments, the patient's neurological condition continued to deteriorate, requiring endotracheal intubation. The patient developed repeated tremors and dystonic events, which progressed to hypertonia with gaze deviation. His-EEG in the third week of admission showed Radermecker complexes most consistent with SSPE. Because of his history of travel to Afghanistan at 8 months of age, before he was vaccinated for measles, and after a measles-like illness upon return, we checked the measles IgG titer in the CSF from the initial lumbar puncture and found it to be elevated. Global coverage with the first dose of the measles vaccine has dropped to 81 % by 2021, the lowest rate since 2008. This decline raises the concern of a possible increase in the incidence of measles and its fatal complications such as SSPE.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X23000335/pdfft?md5=ef8643cee9acbe6325a3886533c4de17&pid=1-s2.0-S2667257X23000335-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138769624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transitory recurrent diplopia and dysarthria with MRI mimicking central pontine myelinolysis: a peculiar NMOSD onset 短暂性复发性复视和构音障碍，核磁共振成像模拟中枢神经髓鞘溶解：一种特殊的 NMOSD 发病情况

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-03-20 DOI: 10.1016/j.nerep.2024.100207

C. Chiavazza , E. Genovese , M. Narracci , S. Gasverde , C. Baima , D.M. Papurello

引用次数: 0

Multiple sclerosis and optic neuritis triggered by COVID-19 mRNA 由 COVID-19 mRNA 引发的多发性硬化症和视神经炎

Neuroimmunology Reports Pub Date : 2024-01-01 DOI: 10.1016/j.nerep.2023.100198

Giovanna Thais Torques Moretti , Giorgio Fabiani , Georgette Mouchaileh Evangelista Ferreira , Jessica Pizatto de Araujo , Eduardo Hummelgen

{"title":"Multiple sclerosis and optic neuritis triggered by COVID-19 mRNA","authors":"Giovanna Thais Torques Moretti , Giorgio Fabiani , Georgette Mouchaileh Evangelista Ferreira , Jessica Pizatto de Araujo , Eduardo Hummelgen","doi":"10.1016/j.nerep.2023.100198","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100198","url":null,"abstract":"<div><h3>Background</h3><p>In December 2019, the World Health Organization declared COVID-19 a pandemic; an unprecedented health crisis has rocked the world. Enormous efforts by governments, the pharmaceutical industry, and health professionals, including a new mRNA vaccine technology against SARS-CoV-2, have been massively employed to control the COVID-19 pandemic. The vaccine's primary mechanism is based on S glycoprotein, the leading viral surface antigen, which induces protective neutralizing antibodies.</p></div><div><h3>Case presentation</h3><p>This project aims to present two cases of demyelinating syndromes in previously asymptomatic patients. The triggering factor in both cases was vaccination against COVID-19 with mRNA vaccines.</p></div><div><h3>Case Report</h3><p>The first case is a young female, 25 years old, previously asymptomatic, one week after the ChAdOx1 Vaccine developed right hemiparesis. Brain MRI and MRI of the spinal cord demonstrated multiple hyperintense lesions, acute and chronic. The second case is an 8-year-old Caucasian male; 12 days after the double dose of the Pfizer-BioNTech vaccine, the patient complained of bilateral visual blurring. The patient was pulsed with methylprednisolone one g/day/5 days with complete recovery.</p></div><div><h3>Conclusion</h3><p>Rarely can vaccines trigger multiple sclerosis or optic neuritis. This report demonstrated two demyelinating syndromes triggered by the m-RNA COVID-19 vaccine.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100198"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X23000360/pdfft?md5=1e126c4ed0de1246d9be568a068d877f&pid=1-s2.0-S2667257X23000360-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139111690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allopurinol treatment in pediatric multiple sclerosis 别嘌醇治疗小儿多发性硬化症

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-04-01 DOI: 10.1016/j.nerep.2024.100209

Yousef A Assaleh , Farah Thabet , Kalthoum Graies-Tlili , Brahim Tabarki

引用次数: 0

Chronic inflammatory demyelinating polyneuropathy or subacute Guillain-Barré syndrome? Not always an easy differential diagnosis 慢性炎症性脱髓鞘多发性神经病还是亚急性格林-巴利综合征？鉴别诊断并非易事

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2023-12-16 DOI: 10.1016/j.nerep.2023.100196

Elisabetta Cecconi , Sara Torricelli , Gabriele Rosario Rodolico , Martina Sperti , Maddalena Spalletti , Roberto Fratangelo , Valentina Bessi , Leonello Guidi , Sabrina Matà

{"title":"Chronic inflammatory demyelinating polyneuropathy or subacute Guillain-Barré syndrome? Not always an easy differential diagnosis","authors":"Elisabetta Cecconi , Sara Torricelli , Gabriele Rosario Rodolico , Martina Sperti , Maddalena Spalletti , Roberto Fratangelo , Valentina Bessi , Leonello Guidi , Sabrina Matà","doi":"10.1016/j.nerep.2023.100196","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100196","url":null,"abstract":"<div><p>Guillain-Barré syndrome (GBS) is an immuno-mediated disorder of the peripheral nervous system with an acute onset of 2–4 weeks, and a monophasic course. In the subacute variant the symtpoms nadir is reached in 4–8 weeks. However, in sporadic cases the onset and the evolution of the disease may be different than expected, leading to significant diagnostic difficulties.</p><p>Case report: A 78-yrs old man presented at our Hospital with a 4-month history of progressive, diffuse motor and sensory deficit. He had previously undergone two electrophysiological examinations with uncertain findings. At hospitalization the nerve conduction study (NCS) and the cerebrospinal fluid examination were consistent with inflammatory demyelinating polyradiculoneuropathy. While a 5-day high-dose of intravenous methylprednisolone proved to be ineffective, a single intravenous immunoglobulin cycle risulted in a significant clinical improvement without relapse after an 18-month follow-up. Based on clinical and neurophysiological findings, a diagnosis of atypical subacute GBS was finally made.</p><p>Conclusion: Although generally accepted that GBS has an acute onset within a few weeks, with a maximum of 8 weeks in the subacute variant, this case report shows that it may initially present with a very slow clinical progression and inconsistent NCS findings. However, its recognition and differentiation from the chronic inflammatory nerve disorders, which have a chronic, long-term evolution, is mandatory to provide the correct therapy protocol.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"5 ","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667257X23000347/pdfft?md5=bc393de806866f1835e31510e0e11ef3&pid=1-s2.0-S2667257X23000347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Atypical Myelin Oligodendrocyte Glycoprotein Antibody Disease Presenting with Isolated Elevated Intracranial Pressure” [Neuroimmunology Reports Volume 1, December 2021, 100028] 非典型髓鞘少突胶质细胞糖蛋白抗体病伴有孤立性颅内压升高》勘误 [《神经免疫学报告》第 1 卷，2021 年 12 月，100028]

Neuroimmunology Reports Pub Date : 2024-01-01 Epub Date: 2024-03-16 DOI: 10.1016/j.nerep.2024.100203

Alexandria Valdrighi , Jeffrey Russ , Emmanuelle Waubant , Nailyn Rasool , Carla Francisco

引用次数: 0

A case of stress cardiomyopathy (Takotsubo syndrome) associated with neuromyelitis optica spectrum disorder (NMOSD) 一例应激性心肌病（Takotsubo综合征）伴视神经脊髓炎谱系障碍（NMOSD）

Neuroimmunology Reports Pub Date : 2023-12-01 Epub Date: 2023-09-09 DOI: 10.1016/j.nerep.2023.100185

Rezafarhad Manteghifasaei, Mohammad Ali Arami

引用次数: 0

Approach to Anti-MuSK Myasthenia gravis: The ultimate mimicker 抗MuSK重症肌无力的方法：终极模仿者

Neuroimmunology Reports Pub Date : 2023-12-01 Epub Date: 2023-10-14 DOI: 10.1016/j.nerep.2023.100189

Abeer Sabry Safan , Nadir Kharma , Beatriz Canibaño , Mohammed Al-Hatou

{"title":"Approach to Anti-MuSK Myasthenia gravis: The ultimate mimicker","authors":"Abeer Sabry Safan , Nadir Kharma , Beatriz Canibaño , Mohammed Al-Hatou","doi":"10.1016/j.nerep.2023.100189","DOIUrl":"https://doi.org/10.1016/j.nerep.2023.100189","url":null,"abstract":"<div><h3>Background</h3><p>Anti-Muscle-specific tyrosine kinase – Myasthenia gravis (MuSK-MG) is a rare neuromuscular junction (NMJ) disease subtype with variable clinical presentation and often atypical electromyography findings. While amyotrophic lateral sclerosis (ALS) can present with respiratory failure, its median respiratory insufficiency onset is estimated at six months from the onset of diagnosis, with variability predicted by baseline functional vital capacity (FVC) and bulbar onset-ALS. Anti-MuSK-MG presentation with the predominately irritable myopathic diaphragm is rarely reported.</p></div><div><h3>Clinical presentation</h3><p>We report a case of Anti-MuSK-MG presenting with persistent respiratory insufficiency and bulbar dysfunction initially misdiagnosed as bulbar-type ALS due to bulbar findings and tongue atrophy. Electromyography (EMG) and single fiber EMG (SFEMG) defied former diagnosis (ALS) with findings of asymmetrical right ulnar and spinal accessory decrements on slow rate repetitive nerve stimulation (RNS), abnormal jitter on SFEMG, and irritable myopathy pattern of the diaphragm and proximal muscles. The serology marker is positive for Anti-MuSK Antibody, and negative AhCR anti-body. With supportive care and Rituximab, the patient's bulbar and respiratory function gradually improved.</p></div><div><h3>Conclusions</h3><p>Anti<strong>-</strong>MusK-MG presenting with persistent respiratory insufficiency has been reported with atypical electromyography findings of myopathy and denervation. We report an intriguing case of MuSK-MG with irritable diaphragm myopathy pattern presenting with myasthenic crisis mimicking bulbar subtype ALS.</p></div>","PeriodicalId":100950,"journal":{"name":"Neuroimmunology Reports","volume":"4 ","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50193890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Baló Concentric Sclerosis with rituximab: A case study with long-term follow-up 利妥昔单抗治疗Baló同心性硬化症：一项长期随访的病例研究

Neuroimmunology Reports Pub Date : 2023-12-01 Epub Date: 2023-07-18 DOI: 10.1016/j.nerep.2023.100177

Lina Okar , Beatriz Canibano , Dirk Deleu

引用次数: 0