Mutation Research/Reviews in Genetic Toxicology最新文献_第7页

DNA damage and mutagenesis induced by nitrogen mustards 氮芥诱导的DNA损伤及诱变

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-12-01 DOI: 10.1016/0165-1110(94)90015-9

Lawrence F. Povirk , David E. Shuker

{"title":"DNA damage and mutagenesis induced by nitrogen mustards","authors":"Lawrence F. Povirk , David E. Shuker","doi":"10.1016/0165-1110(94)90015-9","DOIUrl":"10.1016/0165-1110(94)90015-9","url":null,"abstract":"<div><p>The nitrogen mustards are bifunctional alkylating agents which, although used extensively in cancer chemotherapy, are themselves highly carcinogenic. All nitrogen mustards induce monofunctional guanine-N7 adducts, as well as interstrand N7-N7 crosslinks involving the two guanines in GNC · GNC (5′ → 3′ / 5′ ← 3′) sequences. In addition, the aromatic mustards melphalan and chlorambucil also induce substantial alkylation at adenine N3, while cyclophosphamide forms phosphotriesters with relatively high frequency. Nitrogen mustards are genotoxic in virtually every assay, and produce a wide array of mutations, including base substitutions at both G · C and A · T base pairs, intragenic as well as multilocus deletions, and chromosomal rearrangements. Mutational spectra generated by these agents in various model systems vary widely, and no single lesion has been implicated as being primarily responsible for mustard-induced mutagenesis. On the contrary, adducts of both adenine and guanine, and monofunctional as well as bifunctional adducts, appear to be involved. Further, it is still not known which types of mutation are responsible for mustard-induced cancers, since no genes have yet been identified which are consistently altered in these malignancies.</p></div>","PeriodicalId":100940,"journal":{"name":"Mutation Research/Reviews in Genetic Toxicology","volume":"318 3","pages":"Pages 205-226"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-1110(94)90015-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18534101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 258

Chlorophyll and chlorophyllin as modifiers of genotoxic effects 叶绿素和叶绿素作为基因毒性作用的修饰因子

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-12-01 DOI: 10.1016/0165-1110(94)90017-5

Debisri Sarkar , Archana Sharma , Geeta Talukder

引用次数: 100

Nucleoside and nucleobase analog mutagens 核苷和核碱基类似物诱变剂

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-12-01 DOI: 10.1016/0165-1110(94)90016-7

Kazuo Negishi , Tadayashi Bessho , Hikoya Hayatsu

引用次数: 20

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites 2-乙酰氨基芴、2-氨基芴及其代谢物和模式代谢物的遗传毒性

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-10-01 DOI: 10.1016/0165-1110(94)90025-6

Robert H. Heflich, Robin E. Neft

{"title":"Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites","authors":"Robert H. Heflich, Robin E. Neft","doi":"10.1016/0165-1110(94)90025-6","DOIUrl":"10.1016/0165-1110(94)90025-6","url":null,"abstract":"<div><p>2-Acetylaminofluorene and 2-aminofluorene are among the most intensively studied of all chemical mutagens and carcinogens. Fundamental research findings concerning the metabolism of 2-acetylaminofluorene to electrophilic derivatives, the interaction of these derivatives with DNA, and the carcinogenic and mutagenic responses that are associated with the resulting DNA damage have formed the foundation upon which much of genetic toxicity testing is based. The parent compounds and their proximate and ultimate mutagenic and carcinogenic derivatives have been evaluated in a variety of prokaryotic and eukaryotic assays for mutagenesis and DNA damage. The reactive derivatives are active in virtually all systems, while 2-acetylaminofluorene and 2-aminofluorene are active in most systems that provide adequate metabolic activation. Knowledge of the structures of the DNA adducts formed by 2-acetylaminofluorene and 2-aminofluorene, the effects of the adducts on DNA conformation and synthesis, adduct distribution in tissues, cells and DNA, and adduct repair have been used to develop hypotheses to understand the genotoxic and carcinogenic effects of these compounds. Molecular analysis of mutations produced in cell-free, bacterial, in vitro mammalian, and intact animal systems have recently been used to extend these hypotheses.</p></div>","PeriodicalId":100940,"journal":{"name":"Mutation Research/Reviews in Genetic Toxicology","volume":"318 2","pages":"Pages 73-174"},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-1110(94)90025-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18529188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 194

Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability 脱氧核糖核苷三磷酸水平：维持遗传稳定性的关键因素

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-08-01 DOI: 10.1016/0165-1110(94)90006-X

Bernard A. Kunz , Susanne E. Kohalmi , Thomas A. Kunkel , Christopher K. Mathews , Evan M. McIntosh , John A. Reidy

引用次数: 0

Modulating influence of inorganic arsenic on the recombinogenic and mutagenic action of ionizing radiation and alkylating agents in Drosophila melanogaster 无机砷对电离辐射和烷基化剂对黑腹果蝇重组致突变作用的调节作用

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-08-01 DOI: 10.1016/0165-1110(94)90007-8

M.E. de la Rosa , J. Magnusson , C. Ramel , R. Nilsson

{"title":"Modulating influence of inorganic arsenic on the recombinogenic and mutagenic action of ionizing radiation and alkylating agents in Drosophila melanogaster","authors":"M.E. de la Rosa , J. Magnusson , C. Ramel , R. Nilsson","doi":"10.1016/0165-1110(94)90007-8","DOIUrl":"10.1016/0165-1110(94)90007-8","url":null,"abstract":"<div><p>In bacterial systems and in mammalian in vitro cell cultures, inorganic arsenic has been found to potentiate the mutagenic action of UV as well as of a number of mutagenic agents, probably by interfering with the later steps of DNA-repair. The <em>Drosophila</em> wing spot test (SMART) was used to study the modulating action of inorganic arsenic on the recombinogenic and mutagenic effects of the alkylating agents ethylnitrosourea (ENU), methylmethane sulphonate (MMS), and ethylene oxide (EO) as well as of gamma-rays. It was found, that arsenic in this in vivo test system exerted an inhibitory effect on mitotic recombination induced by alkylating agents and gamma-irradiation. These results are in contrast to the synergistic effect of inorganic arsenic on point mutations and deletions as reported for human lymphocytes and primary fibroblasts. The reason for the discrepancy between the mammalian systems and <em>Drosophila</em> with respect to the modulating action of arsenic is discussed.</p></div>","PeriodicalId":100940,"journal":{"name":"Mutation Research/Reviews in Genetic Toxicology","volume":"318 1","pages":"Pages 65-71"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-1110(94)90007-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18527262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Editoral Board 编辑委员会

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-08-01 DOI: 10.1016/0165-1110(94)90005-1

引用次数: 0

The genetic toxicology of toluene 甲苯的遗传毒理学

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-06-01 DOI: 10.1016/0165-1110(94)90003-5

Douglas McGregor

引用次数: 25

Genotoxicity and carcinogenicity of metronidazole 甲硝唑的遗传毒性和致癌性

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-06-01 DOI: 10.1016/0165-1110(94)90001-9

Lubomír Dobiáš , Milena Černá , Pavel Rössner , Radim Šrám

引用次数: 101

Contents volume 317 (1994) 目录第317卷（1994年）

Mutation Research/Reviews in Genetic Toxicology Pub Date : 1994-06-01 DOI: 10.1016/0165-1110(94)90004-3

引用次数: 0