{"title":"核苷和核碱基类似物诱变剂","authors":"Kazuo Negishi , Tadayashi Bessho , Hikoya Hayatsu","doi":"10.1016/0165-1110(94)90016-7","DOIUrl":null,"url":null,"abstract":"<div><p>Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.</p></div>","PeriodicalId":100940,"journal":{"name":"Mutation Research/Reviews in Genetic Toxicology","volume":"318 3","pages":"Pages 227-238"},"PeriodicalIF":0.0000,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0165-1110(94)90016-7","citationCount":"20","resultStr":"{\"title\":\"Nucleoside and nucleobase analog mutagens\",\"authors\":\"Kazuo Negishi , Tadayashi Bessho , Hikoya Hayatsu\",\"doi\":\"10.1016/0165-1110(94)90016-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.</p></div>\",\"PeriodicalId\":100940,\"journal\":{\"name\":\"Mutation Research/Reviews in Genetic Toxicology\",\"volume\":\"318 3\",\"pages\":\"Pages 227-238\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0165-1110(94)90016-7\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/Reviews in Genetic Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0165111094900167\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/Reviews in Genetic Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0165111094900167","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Compounds with structures close to those of normal nucleosides or nucleobases may be incorporated into cells and then become constituent of their DNA. Proliferation of such cells could yield mutants. In this article, the current status of studies on such nucleoside and nucleobase analogs is described. Base mispairing mechanisms for these analogs are discussed in light of recent biochemical and biophysical findings.
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