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Mitochondrial Communications最新文献

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A novel mitochondrial quality control pathway: Autophagic secretion of mitochondria (ASM) 一种新的线粒体质量控制途径：线粒体自噬分泌（ASM）
Mitochondrial Communications Pub Date : 2023-01-01 Epub Date: 2022-12-10 DOI: 10.1016/j.mitoco.2022.12.001
Hayden Weng Siong Tan , Guang Lu , Han-Ming Shen
{"title":"A novel mitochondrial quality control pathway: Autophagic secretion of mitochondria (ASM)","authors":"Hayden Weng Siong Tan , Guang Lu , Han-Ming Shen","doi":"10.1016/j.mitoco.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.mitoco.2022.12.001","url":null,"abstract":"","PeriodicalId":100931,"journal":{"name":"Mitochondrial Communications","volume":"1 ","pages":"Pages 13-15"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correcting abnormal mitochondrial dynamics to facilitate tumor treatment 纠正线粒体动力学异常促进肿瘤治疗
Mitochondrial Communications Pub Date : 2023-01-01 Epub Date: 2023-07-28 DOI: 10.1016/j.mitoco.2023.07.001
Bowen Yang, Yumeng Lin, Ying-Qiang Shen
{"title":"Correcting abnormal mitochondrial dynamics to facilitate tumor treatment","authors":"Bowen Yang,&nbsp;Yumeng Lin,&nbsp;Ying-Qiang Shen","doi":"10.1016/j.mitoco.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.mitoco.2023.07.001","url":null,"abstract":"<div><p>Mitochondrial dynamics are closely related to various cellular physiological activities, including cell proliferation, homeostasis, and cell migration, and are regulated by a variety of enzymes, proteins and cytokines. Abnormal mitochondrial dynamics have been identified in multiple diseases, such as Charcot-Marie-Tooth type 2A, Parkinson's disease, Alzheimer's disease and cancer. A small fraction of these diseases can be treated by targeting drugs that correct unbalanced mitochondrial dynamics. Further in-depth research into mitochondrial dynamics is significant to helping us better understand the pathogenesis of these diseases, leading to the development of targeted drugs to halt the progression of the disease and even cure it completely. In this review, we discuss primary aspects of mitochondrial dynamics, alterations in mitochondrial dynamics under stress, and abnormities in mitochondrial dynamics that promote diseases. We look forward to exploring the regulation of mitochondrial dynamics, which will provide new ideas for treating those diseases in the future.</p></div>","PeriodicalId":100931,"journal":{"name":"Mitochondrial Communications","volume":"1 ","pages":"Pages 35-47"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fusion activators enhance mitochondrial function 融合激活剂增强线粒体功能
Mitochondrial Communications Pub Date : 2023-01-01 Epub Date: 2023-03-12 DOI: 10.1016/j.mitoco.2023.03.001
William M. Rosencrans, David C. Chan
{"title":"Fusion activators enhance mitochondrial function","authors":"William M. Rosencrans,&nbsp;David C. Chan","doi":"10.1016/j.mitoco.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.mitoco.2023.03.001","url":null,"abstract":"","PeriodicalId":100931,"journal":{"name":"Mitochondrial Communications","volume":"1 ","pages":"Pages 33-34"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation OPA1-Exon4b通过ATP调节肝癌细胞的迁移和侵袭
Mitochondrial Communications Pub Date : 2023-01-01 Epub Date: 2022-11-07 DOI: 10.1016/j.mitoco.2022.08.001
Haite Tang , Zhijuan Hu , Liang Yang , Zifeng Ruan , Hao Wang , Yunhao Zhou , Feixiang Bao , Xingguo Liu
{"title":"OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation","authors":"Haite Tang ,&nbsp;Zhijuan Hu ,&nbsp;Liang Yang ,&nbsp;Zifeng Ruan ,&nbsp;Hao Wang ,&nbsp;Yunhao Zhou ,&nbsp;Feixiang Bao ,&nbsp;Xingguo Liu","doi":"10.1016/j.mitoco.2022.08.001","DOIUrl":"https://doi.org/10.1016/j.mitoco.2022.08.001","url":null,"abstract":"<div><p>Optic Atrophy 1 (OPA1), a mitochondrial inner protein, is involved in both mitochondrial fusion dynamic and cell apoptosis. OPA1 Exon4b (OPA1-Exon4b) was reported to be downregulated in hepatocellular carcinoma (HCC). However, the relationship between OPA1-Exon4b and HCC remains unclear. Here we demonstrated that OPA1-Exon4b is related with migration using genome-wide transcriptome profiling. OPA1-Exon4b overexpression suppresses the migration and invasion, and cellular ATP production in HCC cells. The inhibition of migration and invasion by OPA1-Exon4b overexpression could be rescued by ATP addition, showing that OPA1-Exon4b suppresses the migration and invasion by decreasing ATP. We further demonstrated OPA1 overexpression induces the enlargement of mtDNA nucleoids in HCC cells. Thus, our study demonstrated a key role of OPA1-Exon4b to regulate the migration and invasion in HCC, which could provide a new prospect for the clinical diagnosis and therapy of HCC.</p></div>","PeriodicalId":100931,"journal":{"name":"Mitochondrial Communications","volume":"1 ","pages":"Pages 16-22"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The metabolism and function of phospholipids in Mitochondria 磷脂在线粒体中的代谢和功能
Mitochondrial Communications Pub Date : 2023-01-01 Epub Date: 2022-11-07 DOI: 10.1016/j.mitoco.2022.10.002
Jun Dong , Fei Ye , Jiacheng Lin , He He, Zhiyin Song
{"title":"The metabolism and function of phospholipids in Mitochondria","authors":"Jun Dong ,&nbsp;Fei Ye ,&nbsp;Jiacheng Lin ,&nbsp;He He,&nbsp;Zhiyin Song","doi":"10.1016/j.mitoco.2022.10.002","DOIUrl":"https://doi.org/10.1016/j.mitoco.2022.10.002","url":null,"abstract":"<div><p>Mitochondria are important organelles of eukaryotic cells and involved in a variety of cellular processes including oxidative phosphorylation for generating ATP, apoptosis, steroid synthesis, and signal transduction. Mitochondrion contains double membranes, which are mainly composed of phospholipids. Although mitochondria can synthesize some of phospholipids, most of phospholipids are biosynthesized in the endoplasmic reticulum (ER). ER-mitochondria contacts are required for the transfer of some phospholipids, which are critical for mitochondrial phospholipids metabolism, membrane organization and functions. In this review, we will focus on the synthesis, metabolism and function of mitochondrial phospholipids and the role of mitochondria in lipid metabolism. Additionally, we will discuss the connection between mitochondrial phospholipids disorder and human diseases.</p></div>","PeriodicalId":100931,"journal":{"name":"Mitochondrial Communications","volume":"1 ","pages":"Pages 2-12"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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