Correcting abnormal mitochondrial dynamics to facilitate tumor treatment

Abstract

Mitochondrial dynamics are closely related to various cellular physiological activities, including cell proliferation, homeostasis, and cell migration, and are regulated by a variety of enzymes, proteins and cytokines. Abnormal mitochondrial dynamics have been identified in multiple diseases, such as Charcot-Marie-Tooth type 2A, Parkinson's disease, Alzheimer's disease and cancer. A small fraction of these diseases can be treated by targeting drugs that correct unbalanced mitochondrial dynamics. Further in-depth research into mitochondrial dynamics is significant to helping us better understand the pathogenesis of these diseases, leading to the development of targeted drugs to halt the progression of the disease and even cure it completely. In this review, we discuss primary aspects of mitochondrial dynamics, alterations in mitochondrial dynamics under stress, and abnormities in mitochondrial dynamics that promote diseases. We look forward to exploring the regulation of mitochondrial dynamics, which will provide new ideas for treating those diseases in the future.