Chinese journal of digestive diseases最新文献

{"title":"Experimental study on pancreatic cancer gene therapy using the HSV-TK gene mediated by a retroviral vector","authors":"Xie Suqing, Xu Guoming, Li Zhao-shen, Cao Guang-wen","doi":"10.1046/J.1443-9573.2000.00006.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00006.X","url":null,"abstract":"OBJECTIVE: To study the value of the herpes simplex virus type I thymidine kinase (HSV-TK) gene mediated by a retroviral vector in the treatment of human pancreatic cancer cell line 8988. \u0000 \u0000 \u0000 \u0000METHODS: The HSV-TK gene was directionally cloned into a site following the SV40 promoter that was adjacent to the 5′ LTR (long terminal repeats) and the neomycin phosphotransferase gene in the retroviral vector pMNSM. This enabled the TK gene to integrate into the chromatin of the host cell. The recombinant plasmid pMNS-TK-M was then transfected into the retrovirus-packaging cell Pa317. Finally, the HSV-TK gene was transfected into pancreatic cancer cell line 8988 by the recombinant retrovirus after selection with G418. \u0000 \u0000 \u0000 \u0000RESULTS: The HSV-TK gene was stably integrated into the host cell and its expression confirmed by Southern blotting and drug-sensitivity tests. In vitro studies showed that the acyclovir (ACV) sensitivity level in the 8988/TK+ cells was higher than that of the parent cells. The cells that were transfected with the TK gene were significantly susceptible to ACV. In vivo studies in nude mice showed that intraperitoneal injection of ACV might postpone the formation of implanted tumors and produce a treatment effect on the tumors. \u0000 \u0000 \u0000 \u0000CONCLUSIONS: This study demonstrated that the HSV-TK/ACV retroviral system could be used in vivo to treat pancreatic cancer.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83831730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniprobe sonography in the evaluation of 169 patients with gastrointestinal disease","authors":"Z. Qi, Y. Yao-zong, Xu Jiayu, Wang Fengzhao, Jiang Shihu, Wu Yunlin, Zhao Pei-qing","doi":"10.1046/J.1443-9573.2000.00010.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00010.X","url":null,"abstract":"OBJECTIVE: It is still difficult to precisely differentiate elevated lesions of the gastrointestinal mucosa or estimate the depth of malignant lesions by using conventional endoscopy and biopsy. The aim of the present study was to assess the clinical value of miniprobe sonography (MPS). \u0000 \u0000 \u0000 \u0000METHODS: A total of 169 patients (including 83 patients who underwent endoscopic treatment or surgery) with gastrointestinal disease were examined by using MPS in conjunction with endoscopic examination. The diagnosis according to MPS was compared with macroscopic findings, endoscopic biopsy and surgical results. \u0000 \u0000 \u0000 \u0000RESULTS: In the case of elevated lesions of the gastrointestinal mucosa with negative biopsies, compared with surgical findings, the diagnostic accuracy of MPS was 98.3% (115/117). In the case of malignant lesions, MPS findings with regard to the lesion depth were 100% in agreement with those from surgical biopsy (31/31). \u0000 \u0000 \u0000 \u0000CONCLUSION: The MPS technique is significantly superior to conventional endoscopy with pathological biopsy in the differentiation of elevated lesions of the gastrointestinal mucosa and thus has important clinical value. But in the case of malignant lesions, only the depth of infiltration into the gastrointestinal wall can be correctly assessed by MPS, so its value is limited in the identification of lymph nodes and distal metastases.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86971229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of telomerase activity in the differential diagnosis of benign and malignant ascites","authors":"D. Zhihua, Cai Hong-pei, Li Shi, Shen Jianwei","doi":"10.1046/J.1443-9573.2000.00003.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00003.X","url":null,"abstract":"OBJECTIVE: To evaluate telomerase activity as a marker for the differentiation of benign and malignant ascites. \u0000 \u0000 \u0000 \u0000METHODS: Exfoliated cells were harvested from various kinds of ascitic fluid and telomerase activity was determined by TRAP-PCR-ELISA (tartrate-resistant acid phosphatase–polymerase chain reaction–enzyme-linked immunosorbent assay). \u0000 \u0000 \u0000 \u0000RESULTS: Telomerase activity could not be detected in the ascites of hepatic cirrhosis or peritoneal tuberculosis but was detected in 29 of 34 (85.2%) cancerous ascites. \u0000 \u0000 \u0000 \u0000CONCLUSIONS: Telomerase activity may be present in cancerous ascites and could be used as a marker for the differential diagnosis of benign and malignant ascites.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86322270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effect of arsenic trioxide on peritoneal metastasis in nude mice with colon cancer","authors":"Cai Hong-pei, D. Zhihua, Li Shi, Zhang Xingrong, Shen Jianwei","doi":"10.1046/J.1443-9573.2000.00007.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00007.X","url":null,"abstract":"OBJECTIVE: To investigate the effects of As2O3 on the peritoneal metastasis of colon cancer in nude mice. \u0000 \u0000 \u0000 \u0000METHODS: BALB/c-nu/nu mice were injected intraperitoneally with Lovo cells and were allocated to five groups at random: control, epirubicin and varying concentrations of As2O3. The length of their survival period and rates of tumorigenesis and ascitic fluid formation were evaluated. \u0000 \u0000 \u0000 \u0000RESULTS: Epirubicin and low doses of As2O3 clearly inhibited ascitic fluid formation and extended the survival period of tumor-bearing nude mice. Moderate and large doses of As2O3 were able to eradicate cancer cells through apoptosis. \u0000 \u0000 \u0000 \u0000CONCLUSIONS: As2O3 can induce apoptosis in intraperitoneal colon cancer cells, inhibit ascitic fluid formation and extend the survival periods of nude mice to varying degrees.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85672932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of malignant esophageal/cardiac stricture with self‐expanding antireflux metallic stents: A preliminary report from 17 patients","authors":"Xu Guoming, Li Zhao-shen, W. Na, Xie Suqin, Yin Ning, W. Zhen, M. Kai, Zhou Zinguan, Zhang Bosheng, Liu Youmin, Sha Zhengbu","doi":"10.1046/J.1443-9573.2000.00005.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00005.X","url":null,"abstract":"BACKGROUND: Different types of self-expanding metallic stents are available for the palliative treatment of malignant strictures at the gastroesophageal junction. To overcome some of the disadvantages in the design of these metallic stents, we designed a silicone-covered self-expanding antireflux metallic stent that can prevent free gastroesophageal reflux after stent placement. \u0000 \u0000 \u0000 \u0000METHODS: Seventeen silicone-covered antireflux prototypes were used in 17 patients with dysphagia caused by inoperable malignant tumors involving the gastroesophageal junction. \u0000 \u0000 \u0000 \u0000RESULTS: Stent implantation was technically successful in all 17 patients. There were no procedure-related perforations or deaths. As a group, the mean dysphagia grade improved significantly (2.56 ± 0.49 vs 1.00 ± 0.51, P < 0.001) and the mean lumenal diameter was greatly increased (4.11 ± 1.02 vs 14.72 ± 4.01, P < 0.001) after stent placement. Ten patients received ambulatory 24-h esophageal pH monitoring and compared with the healthy volunteers, there were no postprocedural abnormal gastroesophageal refluxes in any patient. Three patients had substantial chest pain requiring long-term analgesics. No other complications were observed. \u0000 \u0000 \u0000 \u0000CONCLUSIONS: The newly developed self-expanding antireflux metallic stent is safe and effective for use in the palliation of dysphagia caused by malignant strictures at the gastroesophageal junction. A larger patient population would be required to give valid conclusions.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83442488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological factors in functional dyspepsia and its treatment","authors":"Pang Xiaoping, Li Yuyuan, Shang Weihong, Yan Fuying","doi":"10.1046/J.1443-9573.2000.00008.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00008.X","url":null,"abstract":"OBJECTIVE: To investigate the role of psychological factors in functional dyspepsia (FD) and the effects of antidepressant drugs on FD. \u0000 \u0000 \u0000 \u0000METHODS: The psychological status of 24 FD patients and 24 healthy people was analyzed using the Hamilton Rating Scale for Depression (HRSD), the Hamilton Anxiety Scale (HAS) and the Symptom Checklist 90 (SCL-90) scale. Antidepressants were used to treat FD patients for 8 weeks; 13 patients received Prozac, 11 patients received Seroxat. Psychometric analysis was carried out before and after treatment. \u0000 \u0000 \u0000 \u0000RESULTS: There were significant differences in somatic and psychometric scores on the HAS and SCL-90 scales in the two groups (P < 0.001). The scores of the FD patients improved significantly after 8 weeks of treatment (P < 0.001). \u0000 \u0000 \u0000 \u0000CONCLUSIONS: Psychological factors played a role in the etiology of FD. The patients commonly had depression or anxiety. Antidepressants were effective in the treatment of FD for improving both somatic and psychological symptoms.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79365532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic analysis of recombinant interferon α 2b in the treatment of chronic hepatitis B and C","authors":"Yao Guangbi, Wang Baoen","doi":"10.1046/J.1443-9573.2000.00004.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00004.X","url":null,"abstract":"OBJECTIVE: To evaluate the long-term economic impact and benefits of interferon α 2b (IFNα 2b) treatment in patients with chronic hepatitis B and C. \u0000 \u0000 \u0000 \u0000METHODS: Data from 6500 patients with chronic hepatitis B and C from 12 teaching hospitals in different areas of China were collected and analyzed. Cohorts of these patients with either chronic hepatitis B (2198 cases) or chronic hepatitis C (756 cases) that were treated with IFNα 2b were compared with a non-IFN- treated cohort (B, 2642 cases; C, 904 cases). Data from MEDLINE and Chinese Bio-Medical Database (CBMD) searches regarding the natural course of the disease, progression, efficacy and cost of IFN therapy were also included. Using a decision analysis software program, Markov computer simulation was used to estimate the progression of the disease and perform economic analyses. \u0000 \u0000 \u0000 \u0000RESULTS: The 30-year disease progression to compensated and uncompensated cirrhosis and hepatocellular carcinoma in both chronic hepatitis B and C in the IFN-treated cohort was significantly decreased in comparison with the non-IFN-treated cohort. The results suggest that IFN treatment could increase life expectancy by 5.32 years in chronic hepatitis B and 4.06 years in chronic hepatitis C. In the IFN-treated group, life expectancy would increase by 5.41 and 4.27 quality-adjusted life-years (QALY), respectively. The cost to increase life expectancy by 1 QALY could be reduced by 5180 or 9066 yuan RMB in chronic hepatitis B or C patients treated with IFNα 2b, respectively. Over a 30-year period, the total direct medical costs would be reduced by 42 820 and 65 440 yuan RMB in chronic hepatitis B and C patients treated with IFNα 2b, respectively. \u0000 \u0000 \u0000 \u0000CONCLUSION: Interferon α 2b therapy can prolong life expectancy, improve quality of life and lower the medical costs for patients with chronic hepatitis B and C.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86304396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of transarterial thermochemotherapy in hepatic cancer","authors":"Yang Jijin, Kong Qingde, Tiang Jianming, Li Zhao-shen, M. Yulin, Gao Xinjun, Zhou Wenliang","doi":"10.1046/J.1443-9573.2000.00011.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00011.X","url":null,"abstract":"OBJECTIVE: To investigate the effectiveness and safety of transhepatic arterial infusion with warm chemotherapeutic agents in treating hepatic cancer. \u0000 \u0000 \u0000 \u0000METHODS: Thirty-five cases of hepatic cancer were treated with transhepatic arterial thermochemotherapy. Lipiodol, 5-Fu and carbonplatinum were warmed to 60–65°C before infusion into the hepatic arteries. Nine patients had two or more treatments and the effectiveness of this treatment was compared with that observed in 14 patients who received ordinary interventional treatment within the same period. Four patients had their tumors removed 2–3 months later and the pathological results were compared with those of four other patients who received regular treatment. \u0000 \u0000 \u0000 \u0000RESULTS: The tumor growth rate of the thermochemotherapy group was –10 ± 33.3%, while that of the control group was 36.4 ± 59.0%, a statistically significant difference. The tumor necrosis rates on the axial sections of the resected samples were 93.5%± 5.97% and 73.5%± 28.3%, respectively, but the difference was not statistically significant. Microscopically, the pathological changes in the two groups were similar. Only one patient in each group had arterial injury. Comparing the thermochemotherapy group (19 cases) with the control group (22 cases), all of whom received ‘sandwich’ therapy, we found that the prevalence of mild–moderate adverse effects was 72.7 and 63.6%, respectively, while that of severe adverse effects was 26.3 and 37.4%, respectively. However, these differences were of no statistical significance. \u0000 \u0000 \u0000 \u0000CONCLUSIONS: Transhepatic arterial perfusion of warmed Lipiodol and chemotherapeutic agents (60–65°C) combined with hepatic arterial embolization with gelfoam is a simple and safe method for treating hepatic cancer. It can markedly enhance the effectiveness of simple transarterial interventional therapy.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83097290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological study of symptomatic gastroesophageal reflux disease in China: Beijing and Shanghai","authors":"G. Pan, Guoming Xu, M. Ke, Shaomei Han, Huiping Guo, Zhaoshen Li, X. Fang, Zou Duowu, Lu Sucai, L. Jing","doi":"10.1046/J.1443-9573.2000.00001.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00001.X","url":null,"abstract":"OBJECTIVE: To explore the 1-year point prevalences (July–September 1996) of symptomatic gastroesophageal reflux (GER), gastroesophageal reflux disease (GERD) and reflux esophagitis (RE) in the adult population of two Chinese city-regions (Beijing and Shanghai) and to identify the conditions that predispose patients to GERD. \u0000 \u0000 \u0000 \u0000METHODS: Phase I: 5000 residents of the two regions aged between 18 and 70 years were studied via a questionnaire. The study was carried out by cluster sampling from city, suburban and rural areas by using simple random sampling. Symptom scores (Sc) of the intensity and frequency of heartburn, acid reflux and regurgitation within 1 year of the time of study were taken as indices of acid reflux (highest score, Sc = 18) and Sc ≥ 6 indicated the presence of symptomatic GER. Phase II: a small number of patients who were identified as having symptomatic GER in the survey were enrolled in a case– control study using gastroscopy and 24-h pH monitoring to obtain correct diagnostic rates of GERD and RE. Estimates of the prevalence of GERD and RE were then adjusted according to the rates of correct diagnosis. \u0000 \u0000 \u0000 \u0000RESULTS: A total of 4992 subjects completed the survey, 2.5% had heartburn once daily, 8.97% had symptomatic GER (Sc ≥ 6) and the male to female ratio was 1:1.11. Point prevalences for the year for GERD and RE were 5.77 and 1.92%, respectively. Stratified analysis indicated that the prevalence of symptomatic GER in Beijing (10.19%) was higher than that in Shanghai (7.76%) and there was also a higher prevalence of GER in males, manual laborers, people from rural areas and people older than 40 years of age in Beijing as compared with Shanghai. Stepwise logistic analysis indicated that GER had a close relationship with dental, pharyngolaryngeal disorders and respiratory diseases. The conditions that predispose patients to GERD are (OR, odds ratio): age > 40 (OR = 1.01), eating greasy/oily food (OR = 6.56), overeating (OR = 1.99), tiredness (OR = 2.35), emotional stress (OR = 2.22), pregnancy (OR = 6.80) and constipation (OR = 1.65). \u0000 \u0000 \u0000 \u0000CONCLUSIONS: Gastroesophageal reflux disease is a common disease in the adult Chinese population and it is more common in Beijing than in Shanghai.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84984692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anorectal manometric abnormalities and effect of cisapride in patients with chronic idiopathic constipation","authors":"Zou Duowu, Xu Guoming, Li Zhao-shen, Yin Ning","doi":"10.1046/J.1443-9573.2000.00012.X","DOIUrl":"https://doi.org/10.1046/J.1443-9573.2000.00012.X","url":null,"abstract":"OBJECTIVES: To investigate abnormalities in anorectal motility, changes in rectal visceral perception of balloon distention and the effect of cisapride on patients with chronic idiopathic constipation (CIC). \u0000 \u0000 \u0000 \u0000METHODS: Anorectal manometry was carried out in 30 CIC patients using the Synectics Visceral Stimulator combined with PcPolygraf before and after treatment with cisapride (10 mg three times daily for 4 weeks). Twenty age-matched controls were also studied before cisapride therapy. \u0000 \u0000 \u0000 \u0000RESULTS: Patients with CIC had lower anorectal sphincter squeeze pressures (P < 0.05), larger minimum relaxation volumes necessary to elicit the anorectal inhibitory reflux (P < 0.05), higher rectal defecation volume thresholds and higher rectal maximum tolerable volume thresholds (P < 0.01) compared with the controls. All of the abnormalities significantly improved and defecation frequency greatly increased after 4 weeks of cisapride therapy (P < 0.01). Cisapride was effective in 46.67% of patients with CIC. \u0000 \u0000 \u0000 \u0000CONCLUSIONS: Patients with CIC have abnormalities of both anorectal motility and rectal visceral perception of balloon distention. Cisapride can improve these abnormalities and is effective in approximately one-half of CIC cases.","PeriodicalId":10082,"journal":{"name":"Chinese journal of digestive diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87129793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}