Inhibitory effect of arsenic trioxide on peritoneal metastasis in nude mice with colon cancer

Cai Hong-pei, D. Zhihua, Li Shi, Zhang Xingrong, Shen Jianwei
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Abstract

OBJECTIVE: To investigate the effects of As2O3 on the peritoneal metastasis of colon cancer in nude mice. METHODS: BALB/c-nu/nu mice were injected intraperitoneally with Lovo cells and were allocated to five groups at random: control, epirubicin and varying concentrations of As2O3. The length of their survival period and rates of tumorigenesis and ascitic fluid formation were evaluated. RESULTS: Epirubicin and low doses of As2O3 clearly inhibited ascitic fluid formation and extended the survival period of tumor-bearing nude mice. Moderate and large doses of As2O3 were able to eradicate cancer cells through apoptosis. CONCLUSIONS: As2O3 can induce apoptosis in intraperitoneal colon cancer cells, inhibit ascitic fluid formation and extend the survival periods of nude mice to varying degrees.
三氧化二砷对结肠癌裸鼠腹膜转移的抑制作用
目的:探讨As2O3对结肠癌裸鼠腹膜转移的影响。方法:BALB/c-nu/nu小鼠腹腔注射Lovo细胞,随机分为5组:对照组、表柔比星组和不同浓度的As2O3组。评估其生存时间、肿瘤发生率和腹水形成率。结果:表柔比星和低剂量As2O3明显抑制荷瘤裸鼠腹水形成,延长荷瘤裸鼠生存期。中、大剂量As2O3均能通过细胞凋亡的方式根除癌细胞。结论:As2O3能不同程度地诱导结肠癌腹腔内细胞凋亡,抑制腹水形成,延长裸鼠生存期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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