Journal of Medical Hypotheses and Ideas最新文献

Can nanoparticles be beneficial for the early detection and treatment of Alzheimer disease 纳米颗粒是否有助于阿尔茨海默病的早期发现和治疗

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.08.001

Somayeh Mirsadeghi, Rassoul Dinarvand

引用次数: 2

An appraisal of the Journal of Medical Hypotheses and Ideas: A medium for evidence-based scholarly communications 对《医学假设与观念杂志:循证学术交流的媒介》的评价

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.09.002

Armen Yuri Gasparyan

引用次数: 0

“Post Modern Medicine” would be “calculable and energy-based medicine”: A hypothesis paper “后现代医学”将是“可计算的、以能量为基础的医学”:一篇假设论文

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.09.005

Hila Yousefi , Nima Rezaei

{"title":"“Post Modern Medicine” would be “calculable and energy-based medicine”: A hypothesis paper","authors":"Hila Yousefi , Nima Rezaei","doi":"10.1016/j.jmhi.2015.09.005","DOIUrl":"10.1016/j.jmhi.2015.09.005","url":null,"abstract":"<div><p>The approach of current modern medicine towards human body system is solely molecular and cellular. Despite the great efforts, current medicine has not been successful enough, and spectrum of disorders has remained untreated. It emphasizes on the essential need for more careful approach to the body system. Prior to the molecules and cells human body system has been composed of countless of atomic and subatomic particles, considering laws of quantum physics and the principles of chemistry the energy levels of energy photons of these particles play the most crucial role in designing human body characteristics and conformations.In this hypothesis paper, we outline the novel approach towards human body system and concluded that exposing a form of energy to the energy photons of the subatomic particles in one of the molecules of oxygen bound to phosphor in phosphate group would be beneficial therapeutic method regarding all types of cancers, refuting concerns of variety of gene mutations and signaling cascades engaged with engendering and progression of various types of cancers.</p></div>","PeriodicalId":100803,"journal":{"name":"Journal of Medical Hypotheses and Ideas","volume":"9 2","pages":"Pages 104-106"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jmhi.2015.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87506624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Enhancing visual performance in individuals with cortical visual impairment (homonymous hemianopsia): Tapping into blindsight 增强皮质性视觉障碍(同名性偏盲)患者的视觉表现:进入盲视

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.12.001

Faith A. Birnbaum , Steven A. Hackley , Lenworth N. Johnson

{"title":"Enhancing visual performance in individuals with cortical visual impairment (homonymous hemianopsia): Tapping into blindsight","authors":"Faith A. Birnbaum , Steven A. Hackley , Lenworth N. Johnson","doi":"10.1016/j.jmhi.2015.12.001","DOIUrl":"10.1016/j.jmhi.2015.12.001","url":null,"abstract":"<div><p>Homonymous hemianopsia is a type of cortical blindness in which vision is lost completely or partially in the left half or the right half of the field of vision. It is prevalent in approximately 12% of traumatic brain injury and 35% of strokes. Patients often experience difficulty with activities such as ambulating, eating, reading, and driving. Due to the high prevalence of homonymous hemianopsia and its associated difficulties, it is imperative to find methods for visual rehabilitation in this condition. Traditional methods such as prism glasses can cause visual confusion and result in patient noncompliance. There is a large unmet medical need for improving this condition. In this article, we propose that modifying visual stimuli to activate non-cortical areas of visual processing, such as lateral geniculate nucleus and superior colliculus, may result in increased visual awareness. Presenting high contrast and low spatial frequency visual stimuli can increase visual detection in patients with cortical blindness, a phenomenon known as blindsight. Augmented virtual reality goggles have the potential to alter real-time visual input to high contrast and low spatial frequency images, possibly improving visual detection in the blind hemifield and providing an alternative therapy for homonymous hemianopsia.</p></div>","PeriodicalId":100803,"journal":{"name":"Journal of Medical Hypotheses and Ideas","volume":"9 2","pages":"Pages S8-S13"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jmhi.2015.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73056987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Mesenchymal stem cells injection with core decompression in the treatment of Kienbock disease 间充质干细胞注射联合核心减压治疗Kienbock病

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.11.001

Saeed Reza Mehrpour , Alireza Mobasseri , Behzad Amoozgar

引用次数: 1

The developmental perspective of the chronic alcoholism: Who’s holding the burden of proof? 慢性酒精中毒的发展视角:谁来承担举证责任?

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.07.001

Zihni Sulaj , Altin Kuqo , Gentian Vyshka

引用次数: 1

Induction of spontaneous neo-angiogenesis and tube formation in human endometrial stem cells by bioglass 生物玻璃诱导人子宫内膜干细胞自发新生血管生成和输卵管形成

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.09.004

Atefeh Shamosi , Mehdi Farokhi , Jafar Ai , Esmaeel Sharifi

{"title":"Induction of spontaneous neo-angiogenesis and tube formation in human endometrial stem cells by bioglass","authors":"Atefeh Shamosi , Mehdi Farokhi , Jafar Ai , Esmaeel Sharifi","doi":"10.1016/j.jmhi.2015.09.004","DOIUrl":"10.1016/j.jmhi.2015.09.004","url":null,"abstract":"<div><p>Endothelial dysfunction is a broad pathological disorder of the endothelium (innermost layer of blood vessels) which is assigned by vasoconstriction, thrombosis and ischemic diseases, alone or with other disorders such as coronary artery disease, hypertension and atherosclerosis. The fundamental imperfection of endothelial layer injury due to decrease in the number of functional endothelial progenitor cells and inhibition of endothelial progenitor cell differentiation, resulting into impairment of angiogenesis, vasculogenesis, tube formation properties and endothelial regeneration. Multiple significant therapeutic achievements in impediment and treatment of vascular diseases include the use of antithrombotic agents, statin class of drugs, lifestyle changes, and revascularization therapies. Nevertheless, a certain number of patients with endothelial dysfunction disease are resistant to the usual therapies, so new therapeutic strategies for endothelial dysfunction disease are urgently needed. Recent studies show that stem cell-based therapy has important promise for repair and treatment of vascular dysfunction. In this study, we describe a novel choice for treatment of endothelial dysfunction in vascular regenerative medicine via the human endometrial stem cell culture (as a new source for the increasing the number of endothelial progenitor cells) with bioglass (angiogenic agent) to investigate the enhancing expression of CD34, CD31 and gene markers of endothelial progenitor cells and endothelial cells. In the end, application of immuno-privileged, readily available sources of adult stem cells like human endometrial stem cells with bioglass would be a promising strategy to increase the number of endothelial progenitor cells and promote spontaneous angiogenesis needed in endothelial layer repair and regeneration.</p></div>","PeriodicalId":100803,"journal":{"name":"Journal of Medical Hypotheses and Ideas","volume":"9 2","pages":"Pages 94-98"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jmhi.2015.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86462836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Reprogramming of adult stem/progenitor cells into iPSCs without reprogramming factors 无重编程因子的成体干细胞/祖细胞重编程成iPSCs

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.09.003

Behnam Ebrahimi

{"title":"Reprogramming of adult stem/progenitor cells into iPSCs without reprogramming factors","authors":"Behnam Ebrahimi","doi":"10.1016/j.jmhi.2015.09.003","DOIUrl":"10.1016/j.jmhi.2015.09.003","url":null,"abstract":"<div><p>Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has attracted considerable attention in both the scientific and public communities. This is due to the importance of iPSCs in drug screening, disease modeling, cell transplantation therapies and regenerative medicine. A lot of efforts have been devoted to the generation of iPSCs with fewer reprogramming factors and with higher efficiencies. It has been shown that removal of reprogramming barriers increases the efficiency of iPSC generation from differentiated cells up to 90%. Interestingly, having relatively fast cell cycle kinetics, plasticity and endogenous expression of particular pluripotency regulators make adult stem/progenitor cells potentially elite cells poised to become iPSCs. Moreover, it has been demonstrated that adult stem/progenitor cells are more amenable to pluripotent reprogramming than mature cells. Accordingly, it is hypothesized that certain adult stem cells could be reprogrammed into iPSCs without overexpression of exogenous pluripotency transcription factors by only combinatorial modulation of barriers and enhancers and relying on the endogenous expression of key reprogramming factors (e.g. Oct4, Sox2, etc.).</p></div>","PeriodicalId":100803,"journal":{"name":"Journal of Medical Hypotheses and Ideas","volume":"9 2","pages":"Pages 99-103"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jmhi.2015.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72620734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature 使用双膦酸盐治疗SAPHO综合征的意义:病例报告和当前文献的讨论

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.04.002

Patricia Gorecki , Philipp Stockmann , Jörg H.W. Distler , Wolfgang Wuest , Daniela Schmidt , Friedrich Wilhelm Neukam , Emeka Nkenke , Falk Wehrhan

引用次数: 7

Psyllium seed may be effective in the treatment of gastroesophageal reflux disease (GERD) in patients with functional constipation 车前子可能是有效的治疗胃食管反流病(GERD)患者的功能性便秘

Journal of Medical Hypotheses and Ideas Pub Date : 2015-12-01 DOI: 10.1016/j.jmhi.2015.11.002

Mousalreza Hosseini , Masoumeh Salari , Roshanak Salari

引用次数: 9