Journal of Joint Surgery and Research最新文献

{"title":"Temporal changes in synovitis and chronic pain after total knee arthroplasty: A two-year longitudinal study","authors":"Natsuki Sugimura,&nbsp;Koji Aso,&nbsp;Hiroyuki Wada,&nbsp;Masashi Izumi,&nbsp;Masahiko Ikeuchi","doi":"10.1016/j.jjoisr.2025.04.002","DOIUrl":"10.1016/j.jjoisr.2025.04.002","url":null,"abstract":"<div><h3>Purpose</h3><div>Chronic post-surgical pain (CPSP) following total knee arthroplasty (TKA) leads to significant patient dissatisfaction post-operatively. Previous cross-sectional research has identified post-TKA synovitis as a key factor influencing CPSP, but there is a lack of longitudinal data. This study aimed to analyze risk factors for post-TKA pain and synovitis, including pre-operative elements, to better understand their roles in CPSP.</div></div><div><h3>Methods</h3><div>A cohort of 49 knees from 42 patients undergoing TKA for osteoarthritis was assessed. Demographic data, pre-operative and post-operative radiographic findings, pre-operative magnetic resonance imaging, intra-operative blood loss, and post-operative C-reactive protein levels were documented. Chronic pain, measured using the WOMAC pain subscale, and synovitis, quantified by our original “total PD score” using power Doppler (PD) ultrasonography, were recorded pre-operatively and at six months, one year, and two years post-operatively. Multivariable analysis was used to identify factors contributing to chronic pain and synovitis at these time points.</div></div><div><h3>Results</h3><div>Multivariable analysis showed that the total PD score was significantly associated with chronic pain at one and two years post-TKA. Pre-operative WOMAC pain subscale scores were also significantly associated with chronic pain at one year. For synovitis, the pre-operative total PD score was associated at the two year mark, and body mass index (BMI) was found to be a contributing factor at six months, one year, and two years.</div></div><div><h3>Conclusions</h3><div>Greater overall synovitis on PD ultrasonography was significantly associated with chronic pain post-TKA. Greater pre-operative synovitis and lower BMI were identified as contributing factors to post-TKA synovitis on PD ultrasonography. Further research is warranted to explore additional unassessed factors influencing post-TKA synovitis and to enhance imaging assessments.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 2","pages":"Pages 96-102"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates in the management of lateral patellar instability","authors":"Amber M. Parker ,&nbsp;Naofumi Hashiguchi ,&nbsp;Miho J. Tanaka","doi":"10.1016/j.jjoisr.2025.04.001","DOIUrl":"10.1016/j.jjoisr.2025.04.001","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this study was to review current concepts in the evaluation and management of lateral patellar instability, focusing on anatomical risk factors, diagnostic approaches, and treatment strategies.</div></div><div><h3>Methods</h3><div>A comprehensive review of the literature examining anatomical considerations, risk factors, diagnostic methods, and treatment options for patellar instability was conducted. The review focused on the medial patellofemoral complex (MPFC) anatomy, various imaging modalities, and conservative and surgical management approaches.</div></div><div><h3>Results</h3><div>Patellar instability involves multiple anatomical risk factors, including abnormalities in dynamic/static stabilizers, osseous restraints, and lower extremity alignment. The MPFC, consisting of the medial patellofemoral ligament (MPFL) and medial quadriceps tendon–femoral ligament, provides primary restraint against lateral instability in early knee flexion. While 94–100% of first-time dislocations involve MPFL injury and can be managed conservatively, patients with multiple risk factors show 70–90% recurrence rates. Surgical treatment through MPFC reconstruction shows low redislocation rates (1.8–4.5%) and may be combined with additional procedures such as tibial tubercle osteotomy, trochleoplasty, or alignment correction based on individual pathoanatomy.</div></div><div><h3>Conclusions</h3><div>Successful management of patellar instability requires a comprehensive evaluation of anatomical risk factors and individualized treatment approaches. While conservative management is appropriate for first-time dislocations without significant risk factors, surgical intervention through MPFC reconstruction and associated procedures shows promising outcomes in preventing recurrence and improving function in high-risk patients.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 2","pages":"Pages 103-112"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a wearable system to estimate knee adduction moment of patients with knee osteoarthritis during gait using a single inertial measurement unit","authors":"Ayako Akiba ,&nbsp;Kengo Harato ,&nbsp;Hiroshi Yoshihara ,&nbsp;Yu Iwama ,&nbsp;Kohei Nishizawa ,&nbsp;Takeo Nagura ,&nbsp;Masaya Nakamura","doi":"10.1016/j.jjoisr.2025.02.005","DOIUrl":"10.1016/j.jjoisr.2025.02.005","url":null,"abstract":"<div><h3>Purpose</h3><div>The external knee adduction moment (KAM) during gait is an important mechanical factor for knee osteoarthritis (KOA). Three-dimensional motion capture (MoCap) has been used to measure KAM, but it has limitations including cost, measuring time, and space. The purpose of this study was to develop a simple and wearable system to estimate KAM.</div></div><div><h3>Methods</h3><div>Thirty-nine female and seven male subjects diagnosed with KOA were included. Simultaneous measurements of 5 ​m walk using MoCap and inertial measurement unit (IMU) attached to the knee were performed, and a deep learning algorithm based on a gait phase detection algorithm and one-dimensional convolutional neural network model was used to estimate KAM. In addition, the reliability of the artificial intelligence system was also evaluated.</div></div><div><h3>Results</h3><div>The mean absolute percent error (MAPE) and mean absolute error (MAE) of estimated KAM peak of the training data and test datasets were 13.0% and 0.0428 Nm.s/(BW∗Ht) and 17.3% and 0.0505 Nm.s/(BW∗Ht), respectively, and those of estimated KAM impulse were 20.4% and 0.0214 Nm.s/(BW∗Ht) and 21.4% and 0.0212 Nm.s/(BW∗Ht), respectively. The Pearson correlation coefficients between estimated KAM (peak, impulse) and MoCap KAM (peak, impulse) were 0.870 and 0.975 in the training dataset and 0.591 and 0.690 in the test dataset. The intraclass correlation coefficients (ICCs) of estimated KAM impulse were 0.83, 0.94, 0.70, and 0.82 for ICCs (1.1), (1,k), (2,1), and (2,k) respectively.</div></div><div><h3>Conclusions</h3><div>The wearable system showed reasonable accuracy and reliability in estimating KAM of KOA during gait. The simple equipment in the system enables the measurement of KAM during daily practice in the clinic or hospital if there is available space to walk 5 ​m.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 2","pages":"Pages 84-89"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-assisted total knee arthroplasty: Systematic review of surgical assist robotic systems available in Japan","authors":"Keizo Wada ,&nbsp;Daisuke Hamada ,&nbsp;Yasuaki Tamaki ,&nbsp;Shota Shigekiyo ,&nbsp;Koichi Sairyo","doi":"10.1016/j.jjoisr.2025.04.003","DOIUrl":"10.1016/j.jjoisr.2025.04.003","url":null,"abstract":"<div><h3>Purpose</h3><div>Surgical assistant robots are now available for total knee arthroplasty (TKA). This review aimed to clarify the characteristics, accuracy, learning curve, and clinical results of robotic-assisted (RA) TKA performed using systems that are currently available in Japan (MAKO, ROSA, NAVIO/CORI, and VELYS).</div></div><div><h3>Methods</h3><div>The PubMed database was searched to identify studies on RA-TKA.</div></div><div><h3>Results</h3><div>MAKO is a semi-active robot using an oscillating saw. It is a computed tomography-based platform capable of determining the size and location of an implant pre-operatively. ROSA offers both imageless and image-based options using two-dimensional radiographs that are transformed into a three-dimensional model of the knee. NAVIO and CORI are handheld robotic platforms that support image-free anatomic data collection and streamlined intra-operative surgical planning with dynamic gap balancing. VELYS is an image-free, operating room bedrail-mounted, RA system that positions an oscillating saw for the surgeon to perform bone resection with real-time cut-plane tracking to compensate for any leg movement. Although there are some characteristic differences among the surgical assistant robots, the present review reveals that robot-controlled osteotomy may be more accurate than conventional techniques using a conventional guide and bone saw, with favorable short-term outcomes after RA-TKA.</div></div><div><h3>Conclusions</h3><div>This review found that the robotic systems recently made available in Japan demonstrate a high level of accuracy and show favorable short-term outcomes.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 2","pages":"Pages 90-95"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is anterosuperior cup overhang a risk factor for iliopsoas impingement after total hip arthroplasty? A radar chart analysis","authors":"Sakura Kuniyoshi ,&nbsp;Satoshi Nakasone ,&nbsp;Mika Takaesu ,&nbsp;Takahiro Igei ,&nbsp;Fumiyuki Washizaki ,&nbsp;Masamichi Onaga ,&nbsp;Masato Ishihara ,&nbsp;Kotaro Nishida","doi":"10.1016/j.jjoisr.2025.04.004","DOIUrl":"10.1016/j.jjoisr.2025.04.004","url":null,"abstract":"<div><h3>Purpose</h3><div>Groin pain is an occasional complication of total hip arthroplasty (THA), with iliopsoas impingement (IPI) often associated with irritation between the iliopsoas tendon and an overhanging acetabular cup. Although cup overhang is typically assessed using radiography or computed tomography (CT), a more precise evaluation of cup positioning within the acetabulum may improve IPI diagnosis. This study aimed to investigate the association between IPI and circumferential cup overhang using the radar chart method to determine the precise amount of cup overhang without being affected by the metal artifacts.</div></div><div><h3>Methods</h3><div>A total of 128 patients who underwent primary THA via the direct anterior approach between 2014 and 2023 were analyzed. Patients were divided into IPI and non-IPI groups. To eliminate the influence of metal artifacts, pre-operative CT with a computer-aided design model of the acetabulum cup was generated using image matching. Radial CT planes were created at 15° intervals, and the angles of edge of the acetabular cup (ACA) and acetabular rim (ARA) were measured in each plane. The acetabular rim was represented as a clock, and radar charts were generated for each group. Cup overhang was defined as locations where the ACA exceeded the ARA.</div></div><div><h3>Results</h3><div>The radar chart of the IPI group demonstrated significant cup overhang in the 1:30 location.</div></div><div><h3>Conclusions</h3><div>These result suggests that cup overhang in the anterosuperior region, particularly in the 1:30 location, is a risk factor for IPI following THA. The radar chart method provides a comprehensive evaluation of cup positioning and may serve as a valid evaluation tool for assisting IPI diagnosis.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 2","pages":"Pages 113-120"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of early implant failure in Japanese patients undergoing unrestricted kinematic alignment total knee arthroplasty","authors":"Shuji Toyono ,&nbsp;Shigenobu Fukushima ,&nbsp;Takao Yamamoto ,&nbsp;Takashi Ito ,&nbsp;Takahiro Miyaji ,&nbsp;Akemi Suzuki ,&nbsp;Michiaki Takagi","doi":"10.1016/j.jjoisr.2025.02.004","DOIUrl":"10.1016/j.jjoisr.2025.02.004","url":null,"abstract":"<div><h3>Purpose</h3><div>Total knee arthroplasty (TKA) traditionally involves mechanical alignment with a target range of ±3°. However, unrestricted kinematic alignment (urKA) has emerged as a viable alternative, potentially maintaining a favorable implant survival rate without the constraints of neutral alignment. Japanese people have more pronounced tibial varus than other populations. This study evaluated early implant failures in Japanese patients with osteoarthritis who underwent urKA-TKA.</div></div><div><h3>Methods</h3><div>In this study, 557 knees of 460 patients who underwent urKA-TKA between June 2019 and September 2021 were retrospectively analyzed. Surgeries were conducted by four surgeons using standardized urKA techniques, ensuring consistent ligament balancing and component positioning. The primary outcome was the rate of revision for aseptic loosening over at least 2 years, with secondary outcomes focusing on post-operative alignment.</div></div><div><h3>Results</h3><div>The follow-up rate was 95%, with a mean of 3.0 years. The implant survival rate was 100% considering implant revision as the endpoint, and 99% when re-operation was included. Post-operative alignment revealed that 60.3% of tibial components and 39.3% of limbs had varus alignment exceeding 3°; however, this did not compromise implant survival during the follow-up period.</div></div><div><h3>Conclusions</h3><div>The follow-up of at least 2 years for urKA-TKA in a Japanese cohort demonstrated no early implant failures with no significant effect on outcomes from deviations in varus alignment. These results support the use of urKA-TKA and underscore the need for long-term studies to further substantiate these findings in the Japanese population.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 2","pages":"Pages 79-83"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral extra-articular procedures in anterior cruciate ligament reconstruction: Narrative review on current evidence","authors":"Takeo Tokura ,&nbsp;Alan M.J. Getgood","doi":"10.1016/j.jjoisr.2024.12.001","DOIUrl":"10.1016/j.jjoisr.2024.12.001","url":null,"abstract":"<div><h3>Purpose</h3><div>Techniques for anterior cruciate ligament reconstruction (ACLR) have evolved over time, but residual anterolateral rotatory instability (ALRI) often persists, which can result in poor patient-reported outcomes and an increased rate of graft failure. The re-emergence of lateral extra-articular procedures (LEAPs), either lateral extra-articular tenodesis (LET) or the newer anterolateral ligament reconstruction, in combination with ACLR has changed practice significantly. Here we describe a literature review of ACLR and LEAPs, focusing on LET.</div></div><div><h3>Methods</h3><div>Studies describing anatomy, history, biomechanical and clinical studies, and current practice regarding ACLR and LET were searched in PubMed. Our current practice and future directions are also discussed.</div></div><div><h3>Results</h3><div>There is accumulating evidence supporting the effectiveness of LEAP in controlling ALRI and reducing the risk of anterior cruciate ligament (ACL) graft failure. A number of cadaveric studies have shown that LEAP would help control ALRI in combination with ACLR. There are also several randomized controlled studies showing that addition of LET significantly reduces the risk of ACL graft failure. However, only a paucity of data about its long-term outcomes are currently available.</div></div><div><h3>Conclusions</h3><div>LEAP has had a great impact on our daily practice. However, indications, optimal ACL graft type, and long-term outcomes still need to be thoroughly investigated.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 1","pages":"Pages 42-47"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic strategies for periprosthetic femoral fractures based on three classification systems","authors":"Tomonori Baba ,&nbsp;Taiji Watari ,&nbsp;Yasuhiro Homma ,&nbsp;Kazuo Kaneko ,&nbsp;Muneaki Ishijima","doi":"10.1016/j.jjoisr.2025.02.002","DOIUrl":"10.1016/j.jjoisr.2025.02.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The standardization of treatment strategies for periprosthetic femoral fractures is a critical objective for orthopedic surgeons. This review outlines detailed therapeutic approaches based on three classification systems: the Baba, AO/OTA, and Vancouver classifications.</div></div><div><h3>Methods</h3><div>This review examined implant stability assessment, internal fixation techniques, and revision strategies for hip function restoration in periprosthetic femoral fractures.</div></div><div><h3>Results</h3><div>The Baba classification objectively determines implant stability, guiding treatment selection. The AO/OTA classification assists in identifying the most appropriate internal fixation technique. The Vancouver classification informs the choice of reconstruction methods for revision surgery.</div></div><div><h3>Conclusions</h3><div>Management of periprosthetic femoral fractures necessitates specialized expertise in joint reconstruction while adhering to the fundamental principles of osteosynthesis to promote bony union.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 1","pages":"Pages 65-72"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achievement of minimal clinically important difference in shoulder function after reverse shoulder arthroplasty: a retrospective cohort study","authors":"Yumi Kubo ,&nbsp;Naoyuki Kubo ,&nbsp;Kotaro Yamakado","doi":"10.1016/j.jjoisr.2024.11.005","DOIUrl":"10.1016/j.jjoisr.2024.11.005","url":null,"abstract":"<div><h3>Purpose</h3><div>Reverse shoulder arthroplasty (RSA) is a surgical procedure to relieve pain and improve shoulder function. This study aimed to investigate the percentage of patients achieving a minimal clinically important difference (MCID) in the American Shoulder and Elbow Surgeons (ASES) score following RSA and to examine factors associated with MCID achievement.</div></div><div><h3>Methods</h3><div>This study included 74 patients (26 males and 48 females; mean age 76.9 ​± ​4.7 years) who underwent RSA between January 2019 and July 2022. Patients were grouped based on the change in ASES total score from pre-operative to 1 year post-operative as follows: not achieved group (&lt;16 point change); and improvement criteria achieved group (≥16 point change).</div></div><div><h3>Results</h3><div>Overall, 81% of patients achieved an ASES score change of ≥16 points. There were no significant differences in demographic characteristics between the two groups. However, the not achieved group had a significantly lower pre-operative pain visual analog scale score and a significantly higher pre-operative ASES total score than the improvement criteria achieved group. Logistic regression analysis identified pre-operative ASES total score as significantly associated with MCID achievement (odds ratio ​= ​0.91, 95% confidence interval 0.87–0.96; <em>p</em> ​= ​0.0007).</div></div><div><h3>Conclusions</h3><div>The rate of patients achieving a ≥16 point improvement in the ASES total score after RSA was 81%. A high pre-operative ASES total score was identified as a factor limiting MCID achievement, suggesting that patients with a high pre-operative function may experience less significant post-operative improvement.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 1","pages":"Pages 31-34"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive symptoms associated with the development of radiographic knee osteoarthritis: a 10-year longitudinal study from the Iwaki cohort","authors":"Eitaro Sato ,&nbsp;Eiji Sasaki ,&nbsp;Daisuke Chiba ,&nbsp;Takahiro Tsushima ,&nbsp;Yuka Kimura ,&nbsp;Yukiko Sakamoto ,&nbsp;Yoshiko Takahashi ,&nbsp;Mizuri Ishida ,&nbsp;Eiichi Tsuda ,&nbsp;Yasuyuki Ishibashi","doi":"10.1016/j.jjoisr.2024.12.002","DOIUrl":"10.1016/j.jjoisr.2024.12.002","url":null,"abstract":"<div><h3>Purpose</h3><div>This 10-year longitudinal cohort study aimed to investigate the annual rate of development of radiographic knee osteoarthritis (drKOA) and its predictive symptoms in the general Japanese population.</div></div><div><h3>Methods</h3><div>A total of 263 volunteers (154 women) from the Iwaki Health Promotion Project were followed up over 10 years. Standing anteroposterior knee radiographs were obtained and the Kellgren–Lawrence grade was evaluated. drKOA was defined as a change from grade 0 or 1 to ≥2 over 10 years. Knee symptoms were evaluated using the Knee injury and Osteoarthritis Outcome Score at baseline. Logistic regression analyses were performed to identify symptoms related to drKOA, and a predictive formula was created based on the associated symptoms.</div></div><div><h3>Results</h3><div>The overall incidence of drKOA was 52.9% (annual rate, 4.34%). Regression analysis revealed that predictive symptoms for drKOA were stiffness [<em>p</em> ​= ​0.033; odds ratio (OR) ​= ​1.89], frequent pain (<em>p</em> ​= ​0.024; OR ​= ​1.38), difficulty in ascending stairs, jumping, twisting, and kneeling (<em>p</em> ​= ​0.009–0.046; OR ​= ​1.71–2.78), and poor knee-related quality of life (<em>p</em> ​&lt; ​0.001–0.005; OR ​= ​1.53–2.18). Furthermore, the prediction formula created using these predictive symptoms demonstrated an area under the curve of 0.663, a cutoff value of 97 out of 100 points, an OR of 2.99, <em>p</em> ​&lt; ​0.001, sensitivity of 0.676, and specificity of 0.589.</div></div><div><h3>Conclusions</h3><div>The annual incidence rate of drKOA was 4.34% in the general Japanese population. The identified symptoms would be useful to predict the drKOA and consider the etiology of the early phase of this disease.</div></div>","PeriodicalId":100795,"journal":{"name":"Journal of Joint Surgery and Research","volume":"3 1","pages":"Pages 35-41"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143099730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}