Journal of Environmental Medicine最新文献

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Interlaboratory comparisons of red blood cell cholinesterase activity 红细胞胆碱酯酶活性的实验室间比较

Journal of Environmental Medicine Pub Date : 1900-01-01 DOI: 10.1002/(SICI)1099-1301(199901/03)1:1<19::AID-JEM9>3.0.CO;2-Z

S. N. Kales, G. Polyhronopoulos, J. Aldrich, E. Dimitriadis, D. Christiani

{"title":"Interlaboratory comparisons of red blood cell cholinesterase activity","authors":"S. N. Kales, G. Polyhronopoulos, J. Aldrich, E. Dimitriadis, D. Christiani","doi":"10.1002/(SICI)1099-1301(199901/03)1:1<19::AID-JEM9>3.0.CO;2-Z","DOIUrl":"https://doi.org/10.1002/(SICI)1099-1301(199901/03)1:1<19::AID-JEM9>3.0.CO;2-Z","url":null,"abstract":"Comparisons of red blood cell cholinesterase values (AChE, EC 3.1.1.7) from different laboratories can be difficult. This study evaluated different methods of interlaboratory comparison. Eleven subjects gave triplicate samples for analysis by three commercial laboratories. Comparisons were made relative to the mid-point of each laboratory’s reference range (mid-range), and by transformation to Ellman assay activity in U/mL using published/derived conversion factors. To observe each laboratory’s reliability, four subjects submitted two additional duplicate samples to each laboratory. The mean intraspecimen variabilities were 3%, range 1%–8%; 4%, range 0–9%; and 13%, range 2%–24% for laboratories 1–3, respectively. The mean mid-range percent for laboratory 3 was substantially lower than the means for laboratories 1 and 2. Therefore, laboratory 3 values were adjusted based on the means for laboratories 1 and 2 and the mid-point suggested by laboratory 3’s assay kit. The mean AChE relative to these mid-points were 109%, 107%, and 107% for laboratories 1–3, respectively. Ellman activities were 19.0, 19.9 and 20.8 U/mL for laboratories 1–3, respectively. Intrasubject differences for both comparison methods showed agreement that approximated intraspecimen variabilities for each laboratory. Comparisons involving laboratory 3 showed the poorest agreement consistent with laboratory 3’s greater intraspecimen variation. AChE from different laboratories can be compared by both methods evaluated in this study. All comparisons are limited by the precision and reliability of the laboratories involved. Copyright © 1999 John Wiley & Sons, Ltd.","PeriodicalId":100780,"journal":{"name":"Journal of Environmental Medicine","volume":"24 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79190302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambient mineral particles in the small airways of the normal human lung 正常人体肺部小气道中的环境矿物颗粒

Journal of Environmental Medicine Pub Date : 1900-01-01 DOI: 10.1002/(SICI)1099-1301(199901/03)1:1<39::AID-JEM6>3.0.CO;2-5

A. Churg, M. Brauer, S. Vedal, B. Stevens

引用次数: 24

Biomarkers of nephrotoxicity in children environmentally exposed to lead in Poland 波兰环境暴露于铅的儿童肾毒性的生物标志物

Journal of Environmental Medicine Pub Date : 1900-01-01 DOI: 10.1002/(SICI)1099-1301(199901/03)1:1<33::AID-JEM7>3.0.CO;2-K

Katarina Osman, C. Elinder, A. Schütz, A. Grubb

{"title":"Biomarkers of nephrotoxicity in children environmentally exposed to lead in Poland","authors":"Katarina Osman, C. Elinder, A. Schütz, A. Grubb","doi":"10.1002/(SICI)1099-1301(199901/03)1:1<33::AID-JEM7>3.0.CO;2-K","DOIUrl":"https://doi.org/10.1002/(SICI)1099-1301(199901/03)1:1<33::AID-JEM7>3.0.CO;2-K","url":null,"abstract":"Nephropathy has been reported in children with overt lead intoxication. Only recently low-level lead exposure has been associated with renal effects, especially with regard to tubular function. The objective of the present study was to investigate the relation between lead exposure and renal function in children in the Katowice region, an industrial area in Poland. This cross-sectional study involved 157 children, aged 4–14 years. Blood lead concentration was used as an index of lead exposure. Glomerular filtration rate was estimated using the height adjusted serum creatinine calculation (crea-GFR) and measurement of cystatin C in serum. The renal tubular function was evaluated by measuring the urinary concentration of protein HC. The median blood lead concentration was 0.35 μmol/L (72 μg/L) with a range of 0.09–1.36 μmol/L. Crea-GFR (n = 143) decreased significantly (p = 0.002) with increasing concentrations of lead in the blood. Serum cystatin C (n = 84) increased with blood lead (p = 0.004). There was an association (p = 0.002) between blood lead and urinary concentration of protein HC (n = 49). In summary, the present findings indicate that the association between blood lead and the markers of renal function on both a glomerular and a tubular level may be caused by environmental lead exposure. Copyright © 1999 John Wiley & Sons, Ltd.","PeriodicalId":100780,"journal":{"name":"Journal of Environmental Medicine","volume":"7 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87587456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

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