Journal of Cardiothoracic-Renal Research最新文献_第3页

Contribution of endothelin-1 in cardiac myocyte dysfunction in Type 1 diabetic rats 内皮素-1在1型糖尿病大鼠心肌细胞功能障碍中的作用

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/j.jccr.2005.10.001

Yanfeng Ding, Ruijiao Zou, Robert L. Judd, Dean D. Schwartz, Juming Zhong

{"title":"Contribution of endothelin-1 in cardiac myocyte dysfunction in Type 1 diabetic rats","authors":"Yanfeng Ding, Ruijiao Zou, Robert L. Judd, Dean D. Schwartz, Juming Zhong","doi":"10.1016/j.jccr.2005.10.001","DOIUrl":"https://doi.org/10.1016/j.jccr.2005.10.001","url":null,"abstract":"<div><h3>Background</h3><p>Cardiac complications have been demonstrated as a major cause of morbidity and mortality in the diabetic population. However, the mechanisms underlying diabetes-induced cardiomyopathy remain unclear. We tested the hypothesis that endothelin-1 (ET-1) plays an important role in diabetes-induced pathogenesis of ventricular myocyte dysfunction.</p></div><div><h3>Methods</h3><p><span>Diabetic rat was induced by an intravenous injection of </span>streptozotocin<span><span><span><span> (STZ). The potential contribution of endothelin to </span>diabetic cardiomyopathy was determined by chronic treatment of rats with the ET-1 </span>receptor antagonist<span>, bosentan<span>. Myocyte contractility and intracellular </span></span></span>calcium homeostasis were compared using an edge detection/micro-fluorescent system.</span></p></div><div><h3>Results</h3><p><span>Ventricular myocytes isolated from diabetic rats exhibited significant depression in cell contractility and altered intracellular Ca</span><sup>2+</sup> ([Ca<sup>2+</sup>]<sub>i</sub>) transient. On the other hand, L-type Ca<sup>2+</sup> channel activity in diabetic myocytes was not altered. Bosentan treatment successfully prevented myocyte contractile dysfunction and [Ca<sup>2+</sup>]<sub>i</sub> depression in diabetic rats without affecting myocyte function from control rats. Bosentan had no effect on Ca<sup>2+</sup> channel activity in myocytes obtained from both control and diabetic rats.</p></div><div><h3>Conclusion</h3><p>These data demonstrate that elevated ET-1 in diabetic animals plays an important role in the diabetes-induced cardiac myocyte dysfunction. Blockade of ET-1 receptor may be a potential therapeutic strategy in the treatment of diabetes-induced heart failure.</p></div>","PeriodicalId":100759,"journal":{"name":"Journal of Cardiothoracic-Renal Research","volume":"1 1","pages":"Pages 23-30"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jccr.2005.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72285119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/j.jccr.2006.01.001

Chiming Wei (Editor-in-Chief, The Journal of Cardiothoracic-Renal Research (JCRR); President, Asian-Pacific Cardiothoracic-Renal Association)

引用次数: 0

Oxidative stress and DNA damage–DNA repair system in vascular smooth muscle cells in artery and vein grafts 动、静脉移植血管平滑肌细胞氧化应激与DNA损伤- DNA修复系统

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/J.JCCR.2005.11.003

S. H. McLaren, Daqing Gao, Lei Chen, R. Lin, J. Eshleman, V. Dawson, M. Trush, V. Bohr, M. Dizdaroglu, G. Williams, Chiming Wei

引用次数: 8

Stem cells and cardiovascular tissue repair: Mechanism, methods, and clinical applications 干细胞与心血管组织修复:机制、方法及临床应用

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/J.JCCR.2005.12.003

Qi Zhang, Rosalina Madonna, Weifeng Shen, E. Perin, F. Angeli, F. Murad, E. Yeh, L. Buja, R. de Caterina, J. Willerson, Y. Geng

引用次数: 13

Outcomes of surgical ventricular restoration following recent myocardial infarction 近期心肌梗死后心室手术恢复的结果

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/j.jccr.2005.12.006

Irving L. Kron

引用次数: 0

Contribution of endothelin-1 in cardiac myocyte dysfunction in Type 1 diabetic rats 内皮素-1在1型糖尿病大鼠心肌细胞功能障碍中的作用

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/J.JCCR.2005.10.001

Yanfeng Ding, R. Zou, R. Judd, D. Schwartz, J. Zhong

引用次数: 2

Constructing gene expression-based diagnostic rules for understanding individualized etiology of heart failure 构建基于基因表达的心衰个体化病因诊断规则

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/J.JCCR.2005.12.002

Zhong Gao, G. Tomaselli, Chiming Wei, R. Winslow

引用次数: 2

Breaking the barrier of chronic allograft nephropathy (CAN)—Transplant's next major challenge 打破慢性移植物肾病（CAN）的屏障——移植的下一个主要挑战

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/j.jccr.2005.12.007

Edward S. Kraus

引用次数: 0

Angiotensin II stimulates a novel angiotensin II type 1 receptor-associated protein, GLP gene expression in rat kidney proximal tubular cells 血管紧张素II刺激大鼠肾近端小管细胞中新型血管紧张素Ⅱ1型受体相关蛋白GLP基因表达

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/j.jccr.2005.12.005

Deng-Fu Guo , Valerie Tardif , Isabelle Chenier , John S.D. Chan , Julie R. Ingelfinger , Xiang Mei Chen , Tadashi Inagami

{"title":"Angiotensin II stimulates a novel angiotensin II type 1 receptor-associated protein, GLP gene expression in rat kidney proximal tubular cells","authors":"Deng-Fu Guo , Valerie Tardif , Isabelle Chenier , John S.D. Chan , Julie R. Ingelfinger , Xiang Mei Chen , Tadashi Inagami","doi":"10.1016/j.jccr.2005.12.005","DOIUrl":"https://doi.org/10.1016/j.jccr.2005.12.005","url":null,"abstract":"<div><p><span>We have recently demonstrated that a novel angiotensin II (Ang II) type 1 receptor-associated protein, GLP induces cellular hypertrophy and Ang II stimulated GLP mRNA expression in a time-, dose-, and AT</span><sub>1</sub><span><span><span><span> receptor-dependent manner in rat immortalized renal proximal tubular cells (IRPTCs). The present studies investigated which signaling pathways are involved in Ang II stimulated GLP mRNA expression in IRPTCs. Cellular GLP mRNA expression was determined by </span>reverse transcription polymerase chain reaction. The effect of Ang II was blocked by </span>epidermal growth factor receptor inhibitor, </span>AG1478<span>, PKC<span><span><span><span><span><span> inhibitor, GF109203X, MAPK kinase inhibitor, </span>PD98059<span>, antioxidants, taurine and tiron, and NADH/NADPH oxidase inhibitor, DPI, whereas, no effects were observed on Ang II-induced GLP mRNA expression with </span></span>p38 MAPK inhibitors, </span>SB203580<span><span> and PD169316, and Janus kinase 2 inhibitor, </span>AG490. IRPTCs stably expressing GLP gene significantly increased reactive oxygen species (ROS) generation compared to control IRPTCs analyzed by </span></span>lucigenin<span> assay. Furthermore, NADH/NADPH oxidase inhibitor, DPI, and antioxidants taurine and tiron inhibited GLP-induced total protein content and de novo protein synthesis. These studies demonstrated that the stimulatory action of Ang II on GLP mRNA expression in IRPTCs is mediated by multiple signal mechanisms, </span></span>transactivation of EGF receptor and subsequent MAPK activation, PKC activation and ROS generation. Furthermore, the cellular hypertrophic effect of GLP gene in IRPTCs is mediated at least in part via ROS generation.</span></span></span></p></div>","PeriodicalId":100759,"journal":{"name":"Journal of Cardiothoracic-Renal Research","volume":"1 1","pages":"Pages 91-100"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jccr.2005.12.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72277082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress and DNA damage–DNA repair system in vascular smooth muscle cells in artery and vein grafts 动脉和静脉移植物中血管平滑肌细胞的氧化应激和DNA损伤-DNA修复系统

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/j.jccr.2005.11.003

S.H. McLaren , D. Gao , L. Chen , R. Lin , J.R. Eshleman , V. Dawson , M.A. Trush , V.A. Bohr , M. Dizdaroglu , G.M. Williams , C. Wei

{"title":"Oxidative stress and DNA damage–DNA repair system in vascular smooth muscle cells in artery and vein grafts","authors":"S.H. McLaren , D. Gao , L. Chen , R. Lin , J.R. Eshleman , V. Dawson , M.A. Trush , V.A. Bohr , M. Dizdaroglu , G.M. Williams , C. Wei","doi":"10.1016/j.jccr.2005.11.003","DOIUrl":"https://doi.org/10.1016/j.jccr.2005.11.003","url":null,"abstract":"<div><p><span><span>Graft failure in </span>coronary artery bypass grafts (CABGs) utilizing the </span>saphenous vein<span><span> is significantly higher than in those utilizing the internal mammary artery<span> (IMA) or the radial artery (RA). While a number of studies have described this phenomenon clinically, few have attempted to extensively examine the biological differences between vein and artery, or the short- and long-term effectiveness of their use. In addition, there is limited information on the role of reactive oxygen species (ROS) in the generation of </span></span>oxidative stress<span> in the vascular smooth muscle cell<span><span>, which we speculate has a significant role in inducing apoptosis and, consequently, graft failure. The purpose of this review, thus, is to concisely describe the relationship among DNA damage, DNA repair and graft failure by examining (1) DNA lesions resulting from oxidative damage, such as 8-oxo-7,8-dihydroguanine, as well as their affiliation with human diseases, (2) biological differences in DNA damage and repair capabilities of both artery and vein, and (3) DNA repair mechanisms and the significance of several </span>repair enzymes.</span></span></span></p></div>","PeriodicalId":100759,"journal":{"name":"Journal of Cardiothoracic-Renal Research","volume":"1 1","pages":"Pages 59-72"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jccr.2005.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72285114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8