Journal of Cardiothoracic-Renal Research最新文献_第2页

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Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/S1574-0668(06)00046-4

引用次数: 0

Quantitative tissue hemoglobin oxygen saturation measurement in decompensated heart failure 失代偿性心力衰竭的定量组织血红蛋白氧饱和度测定

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/J.JCCR.2006.05.001

C. Hogan, M. Hess, K. Ward, M. Kontos, R. Pittman

引用次数: 2

Is there a role for free radicals in the systemic inflammatory reaction 自由基在全身炎症反应中有作用吗

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/J.JCCR.2006.05.002

M. Elahi, B. Matata

引用次数: 2

Increased ERK activation and decreased MKP-1 expression in human myocardium with congestive heart failure 充血性心力衰竭患者心肌ERK激活增加和MKP-1表达降低

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/j.jccr.2006.05.006

Yafeng Dong , Daqing Gao , Lei Chen , Ruxian Lin , John V. Conte , Chiming Wei

{"title":"Increased ERK activation and decreased MKP-1 expression in human myocardium with congestive heart failure","authors":"Yafeng Dong , Daqing Gao , Lei Chen , Ruxian Lin , John V. Conte , Chiming Wei","doi":"10.1016/j.jccr.2006.05.006","DOIUrl":"https://doi.org/10.1016/j.jccr.2006.05.006","url":null,"abstract":"<div><p><span><span>Mitogen-activated protein kinase<span> (MAPK), also known as the extracellular signal regulated protein kinase (ERK), is a member of a family of serine/threonine kinases which are activated by various growth factors. To date, the activity of ERK and the nuclear dual-specificity tyrosine/threonine protein phosphatase MKP-1, a principal inactivating phosphatase of ERK1/ERK2 in many cell types, in human </span></span>myocardium<span> with congestive heart failure (CHF) remain undefined. Therefore, the current study was designed to investigate ERK and MKP-1 expression in CHF patients. Cardiac tissue from normal subjects (</span></span><em>n</em>  =<!--> <span>5) were obtained during cardiac transplantation<span><span>. ERK and MKP-1 expression were determined by immunohistochemical staining (IHCS). The staining score (0–4) and positive staining area (0–100%) were determined. Both ERK and MKP-1 were expressed in nuclear and perinuclear regions of cardiomyocytes<span>. In CHF patients, ERK phosphorylation IHCS score and positive staining area were significantly increased in right atrium<span> (RA), left atrium (LA), </span></span></span>right ventricle<span> (RV), and left ventricle<span> (LV) compared with normal subject RA, LA, and RV (normal LV tissue was not available). In contrast, MKP-1 IHCS score and positive staining area were significantly decreased in CHF patients RA, LA, RV, and LV myocardium compared with normal subjects. The cardiomyocyte diameter determined by BioQuant system was significantly increased in CHF myocardium compared with normal subjects. These studies suggest that activation of ERK and inhibition of MKP-1 may play a significant pathophysiological role in progression of cardiac hypertrophy and congestive heart failure.</span></span></span></span></p></div>","PeriodicalId":100759,"journal":{"name":"Journal of Cardiothoracic-Renal Research","volume":"1 2","pages":"Pages 123-130"},"PeriodicalIF":0.0,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jccr.2006.05.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72286367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rapid progression and recovery of hypertrophic obstructive cardiomyopathy during tacrolimus therapy 他克莫司治疗肥厚型梗阻性心肌病的快速进展和恢复

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/j.jccr.2006.05.003

Duncan W. Motherwell, Adrian J.B. Brady

引用次数: 0

Rapid progression and recovery of hypertrophic obstructive cardiomyopathy during tacrolimus therapy 他克莫司治疗期间肥厚性梗阻性心肌病的快速进展和恢复

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/J.JCCR.2006.05.003

D. Motherwell, A. Brady

引用次数: 0

Increased ERK activation and decreased MKP-1 expression in human myocardium with congestive heart failure 人充血性心力衰竭心肌中ERK活化增加，MKP-1表达降低

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/J.JCCR.2006.05.006

Yafeng Dong, Daqing Gao, Lei Chen, R. Lin, J. Conte, Chiming Wei

引用次数: 1

DNA damage and mismatch repair pathway in lung ischemia and reperfusion injury 肺缺血再灌注损伤中的DNA损伤及错配修复途径

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/J.JCCR.2006.05.007

P. Bonde, Daqing Gao, Lei Chen, L. Moreno‐Vinasco, J. Jacobson, Joe G. N. Garcia, Chiming Wei

引用次数: 0

In vitro stem cell differentiation into cardiomyocytes: Part 2: Chemicals, extracellular matrix, physical stimuli and coculture assays 体外干细胞分化为心肌细胞:第2部分:化学物质，细胞外基质，物理刺激和共培养试验

Journal of Cardiothoracic-Renal Research Pub Date : 2006-09-01 DOI: 10.1016/J.JCCR.2006.07.001

I. Dimarakis, N. Levičar, P. Nihoyannopoulos, M. Gordon, N. Habib

引用次数: 15

Outcomes of surgical ventricular restoration following recent myocardial infarction 近期心肌梗死后心室手术恢复的结果

Journal of Cardiothoracic-Renal Research Pub Date : 2006-03-01 DOI: 10.1016/j.jccr.2005.12.001

Jason A. Williams, Nishant D. Patel, Lois U. Nwakanma, John V. Conte

{"title":"Outcomes of surgical ventricular restoration following recent myocardial infarction","authors":"Jason A. Williams, Nishant D. Patel, Lois U. Nwakanma, John V. Conte","doi":"10.1016/j.jccr.2005.12.001","DOIUrl":"https://doi.org/10.1016/j.jccr.2005.12.001","url":null,"abstract":"<div><h3>Background</h3><p>Recent myocardial infarction (≤90 days) is generally considered a contraindication to performing surgical ventricular restoration (SVR). Most surgeons prefer myocardial healing and scar formation to occur before undertaking SVR, although no data exist to support this practice. We analyzed outcomes of patients undergoing SVR following recent myocardial infarction (MI) to determine the utility of SVR in these patients.</p></div><div><h3>Methods</h3><p>Retrospective review analyzed 69 consecutive SVR patients between January 2002 and June 2005 to determine clinical characteristics, operative data, and postoperative outcomes. Magnetic resonance imaging (MRI) and echocardiography were used to assess cardiac function.</p></div><div><h3>Results</h3><p><span><span>Twenty-two patients (32%) sustained a recent MI in our series. Mean age at operation was 63.5 years, with a M:F of 20:2. Preoperatively all patients carried a diagnosis of congestive heart failure<span> and were classified as New York Heart Association (NYHA) class III or IV. Six patients (27%) required perioperative intra-aortic balloon pump (IABP) support. There was only one operative mortality. Following SVR, mean </span></span>ejection fraction improved from 26% to 35% (</span><em>p</em>    =0.04). Seventy-three percent (16/22) of patients in preoperative NYHA class III/IV improved to class I/II at follow-up (<em>p</em>  <span>0.0001). Actuarial survival was 74% at 30 months. Recent MI was not an independent predictor of adverse outcomes following SVR in our series.</span></p></div><div><h3>Conclusion</h3><p>Recent MI patients demonstrate significant improvement in ventricular function and NYHA class with acceptable morbidity and mortality following SVR. These findings prompt consideration of expanding the inclusion criteria for SVR to include patients who have sustained a recent MI.</p></div>","PeriodicalId":100759,"journal":{"name":"Journal of Cardiothoracic-Renal Research","volume":"1 1","pages":"Pages 51-58"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jccr.2005.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72285116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2