Wing Ho Chau , Chung Yan Cheung , Hung Wing Li , Man Shing Wong
{"title":"Non-invasive detection kit for early diagnosis of Alzheimer's disease","authors":"Wing Ho Chau , Chung Yan Cheung , Hung Wing Li , Man Shing Wong","doi":"10.1016/j.inv.2022.100004","DOIUrl":"10.1016/j.inv.2022.100004","url":null,"abstract":"<div><p>The present invention discloses a new Alzheimer's disease (AD) diagnostic kit that tests blood, saliva and urine, providing a faster, more sensitive, affordable and non-invasive way than conventional method of detection. This detection assay only requires a few microliters of the body fluids to quantify the target AD-related protein biomarkers.</p><p>The assay is based on the immunoreaction between the target protein biomarkers and their corresponding pair of antibodies followed by fluorescence labelling with a newly developed cyanine turn-on fluorophore. The intensity of the fluorescence signal can act as an index to evaluate the severity of AD.</p><p>Therefore, the present invention can serve as an analytical tool for early diagnosis, progression monitoring and staging.</p></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"2 ","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772444122000027/pdfft?md5=82b6043b5d2b8be28ed524385c2f30d5&pid=1-s2.0-S2772444122000027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88277627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A versatile modular plant for converting biogas into advanced biofuels","authors":"Francesco Negri , Matteo Fedeli , Massimo Barbieri , Flavio Manenti","doi":"10.1016/j.inv.2022.100008","DOIUrl":"10.1016/j.inv.2022.100008","url":null,"abstract":"<div><p>The patented technology is a novel, portable, non-invasive, and flexible technical solution for converting biogas into valuable chemical compounds, such as bio-methanol and bio-dimethyl ether (bio-DME). It consists of compact modules, connected to each other through a flange-valve-flange system, to be installed downstream an existing traditional biogas plant.</p><p>The two main sections of the module are those of reforming and synthesis: in the first the biogas is converted into bio-syngas (H<sub>2</sub>/CO/CO<sub>2</sub>), while in the second the bio-syngas is transformed into advanced biofuels such as bio-methanol and bio-DME. Parts of the synthesis module can always be changed with small investments to switch the final products, according to local market needs and price volatilities. Downstream at the synthesis section, it is possible to add a module for the separation and the purification of the chemical products.</p><p>The technology has been validated at the 0.15 MWe industrial scale.</p></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"2 ","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772444122000064/pdfft?md5=11531d5b5ba35aad401e4b3c78c5d1ec&pid=1-s2.0-S2772444122000064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74964304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Periodic magnetic finishing machine","authors":"Mohsen Bahrami , Alireza Moradi , Majid Dashti Maljaei","doi":"10.1016/j.inv.2022.100007","DOIUrl":"10.1016/j.inv.2022.100007","url":null,"abstract":"<div><p>The present invention is related to finishing mechanical, electronic, and jewelry workpieces. The system comprises a container -including an abrasive medium-, a control unit, a measurement unit, and a display. Adjusting the rotational and vibration motion is conducted using magnetic coils and eccentric weights in the control unit. Moreover, the control system can tune the container's tilt angle. The magnetic coils enclose the container producing a magnetic field, thereby pulling the abrasive particles against the target surfaces. The container is held by two motors located at its top and bottom, which provide the rotational movement of the container around its axis. Besides, the rotary motors that hold the container are bound by the structure related to the vibration motors, which are paid by the vibration motors of the container assembly and the materials inside it due to the resulting vibration. Finally, these motors are placed on the device's frame with the help of a vibration damping system (springs), which allows the device to be adjusted at different tilt angles and create a rocking motion with the help of an angular movement mechanism. The printing circuit companies, ornamental jewelry companies, and factories producing mechanical parts are potential customers of this equipment that can use this machine for surface finishing aiming to increase the surface smoothness on a micro scale for a large number of parts.</p></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"2 ","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772444122000052/pdfft?md5=3bbac011d39bf5d1fa394ca35a226fc6&pid=1-s2.0-S2772444122000052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79037755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biarticular energy-recovering transfemoral prosthesis for trip prevention and sit-to-stand assistance","authors":"John Landers, Heike Vallery, Gerwin Smit","doi":"10.1016/j.inv.2022.100003","DOIUrl":"10.1016/j.inv.2022.100003","url":null,"abstract":"<div><p>The invention is a prosthetic leg for above-knee amputees that helps prevent tripping and provides support for strenuous movments. The design harvests energy from walking to further lift the foot and decrease the risk of tripping. The invention also harvests energy during the sitting motion and uses it to power the leg when the user stands up.</p><p>The prosthesis is unpowered and lightweight, with polycentric joints and a single pneumatic actuator. The actuator harvests, stores, and releases energy in both tension and in compression and is biarticular, allowing it to power both the knee and the ankle. The invention's unique geometry allows it to exert forces at the joints that can mimic the muscle forces produced in a healthy leg during specific movments. The technology is currently designed to mimic leg forces during sitting and standing, but could also be tuned to mimic leg forces of other movements. While walking, the invention harvests energy from the leg's momentum and uses it to lift the foot higher off the ground during swing, increasing toe clearance. This decreases the chance of tripping and greatly increases walking safety, especially among the elderly and impaired who fall more frequently and can sustain serious injureies from a fall. The combination of these two functions makes the invention ideal for low-mobility prosthetic users.</p><p>The invention is currently at TLR 3, and the authors are seeking commercial partners who are interested in continuing the invention's development and bringing it to market, or who would wish to implement this technology under a license.</p></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"2 ","pages":"Article 100003"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772444122000015/pdfft?md5=01d1253bc5fd45b5ab128b82958cbe86&pid=1-s2.0-S2772444122000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84294114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automated high-resolution sampling and multi-mode operando spectroscopy of (bio-)chemical reactions for kinetic analysis, reaction characterization, and quality control","authors":"Robbert van Putten, E. Uslamin, E. Pidko","doi":"10.1016/j.inv.2021.100002","DOIUrl":"https://doi.org/10.1016/j.inv.2021.100002","url":null,"abstract":"","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85909781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robbert van Putten , Evgeny A. Uslamin , Evgeny A. Pidko
{"title":"Automated high-resolution sampling and multi-mode operando spectroscopy of (bio-)chemical reactions for kinetic analysis, reaction characterization, and quality control","authors":"Robbert van Putten , Evgeny A. Uslamin , Evgeny A. Pidko","doi":"10.1016/j.inv.2021.100002","DOIUrl":"https://doi.org/10.1016/j.inv.2021.100002","url":null,"abstract":"<div><p>This invention describes an apparatus that enables the automated removal of small samples from fluids such as those encountered in (bio-)chemical reactors. These samples can then be used for, <em>e.g.</em>, kinetic analysis and quality control applications. The system was explicitly designed to be compatible with harsh and aggressive reaction conditions and can be used up to 250°C and 345 bar. The system was incorporated into a high-pressure capable <em>operando</em> reaction analysis platform that enabled simultaneous sampling of the reaction mixture and <em>operando</em> monitoring of the reaction using multiple channels of spectroscopy, thereby offering accessible and convenient data-rich experimentation. We have started a company to further develop the technology and bring it to market. We are actively looking for early adopters, collaborators, joint-venturing, and investors.</p></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"1 ","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772444121000021/pdfft?md5=a5641bfe9bba367e4aa18193a8cd8c55&pid=1-s2.0-S2772444121000021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91764640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Apparatus and process for energy self-sustainable and high-yield conversion of acid gases (H2S and CO2) into syngas","authors":"Massimo Barbieri , Flavio Manenti","doi":"10.1016/j.inv.2021.100001","DOIUrl":"10.1016/j.inv.2021.100001","url":null,"abstract":"<div><p>H<sub>2</sub>S and CO<sub>2</sub> are two well-known emissions with cumbersome management and not yet established bulk utilization plans. The invention converts H<sub>2</sub>S and CO<sub>2</sub> in syngas and, as the only by-products, elemental sulphur and water by means of a dedicated (i) Regenerative Thermal Reactor (RTR) and (ii) Acid Gas to syngas (AG2S) process layout thanks to the overall reaction: 2 H<sub>2</sub>S + CO<sub>2</sub> = H<sub>2</sub> + CO + S<sub>2</sub> + H<sub>2</sub>O. The reaction is globally endothermic, but it can energetically supplied in situ thanks to a minor injection of oxygen/air. The oxygen injection generates the exothermic reaction S + O<sub>2</sub> = SO<sub>2</sub> in an appropriate amount so as to achieve and preserve the optimal conversion temperature. The SO<sub>2</sub> generated for energy sustainability is therefore converted within the process layout. The once-through conversion is 75%v for the H<sub>2</sub>S and 50%v for the CO<sub>2</sub>. The unreacted reactants are split from the syngas and by-products and recycled upstream for complete conversion. The invention is the first process utilizing no sources, neither bio nor fossil, but only emissions to generate syngas and, hence, hydrogen. Two moles of syngas are obtained every three moles of emissions, also achieving the total neutralization of H<sub>2</sub>S and a relevant cut of CO<sub>2</sub>. Technology development has reached out the industrialization level. The laboratory testing has been developed in Politecnico di Milano, at the facilities of the Center for Sustainable Process Engineering Research (SuPER); the bench-scale tests have been exerted at the Sotacarbo Sustainable Energy Center SpA facilities and the industrial application is just started at Itelyum Regeneration srl, an ecorefinery for exhausted oil recovery.</p></div>","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"1 ","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277244412100001X/pdfft?md5=b15144460cb13a99932d21893675abbe&pid=1-s2.0-S277244412100001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90463308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rhetoric, Dialectic, and Poetics in the Renaissance","authors":"","doi":"10.2307/j.ctv16kkz9p.6","DOIUrl":"https://doi.org/10.2307/j.ctv16kkz9p.6","url":null,"abstract":"","PeriodicalId":100728,"journal":{"name":"Invention Disclosure","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89288997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}