Insulin最新文献

{"title":"The ever-expanding universe","authors":"","doi":"10.1016/S1557-0843(08)80047-4","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80047-4","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"3 4","pages":"Pages 204-207"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1557-0843(08)80047-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91698412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2009 Events calendar","authors":"","doi":"10.1016/S1557-0843(08)80058-9","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80058-9","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"3 4","pages":"Pages 249-251"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1557-0843(08)80058-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91738840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of U-500 insulin in the treatment of severe insulin resistance","authors":"Elaine Cochran MSN, CRNP,&nbsp;Phillip Gorden MD","doi":"10.1016/S1557-0843(08)80049-8","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80049-8","url":null,"abstract":"<div><p><strong>Background:</strong> Glycemic control is essential in the management of diabetes. However, many patients with diabetes are not achieving therapeutic targets, partly because they are receiving insufficient doses of insulin. This is particularly problematic in patients with severe insulin resistance, defined as insulin requirement &gt;200 units/kg per day (&gt;3 units/kg per day for pediatric patients). It is difficult to use U-100 forms of insulin at doses &gt;200 units/kg per day because of the volume of insulin being administered subcutaneously. U-500, a concentrated form of insulin, may be useful in the treatment of these patients.</p><p><strong>Objective:</strong> Current practice regarding the use of U-500 insulin has been published elsewhere. This article presents an updated algorithm for the administration and dosing of U-500 insulin, based on clinical experience with severe forms of insulin resistance. Guidelines are provided for dose escalation of U-500 insulin.</p><p><strong>Methods:</strong> We reviewed the results of treatment with U-500 insulin in patients with severe insulin resistance. We analyzed the results, updated a pre-existing algorithm, provided additional practical information on the administration and dosing of U-500 insulin, and compared the cost of U-500 with that of U-100 insulin.</p><p><strong>Results:</strong> To date, we have treated 56 patients (age range, 9–54 years) with severe insulin resistance using U-500 insulin. Doses ranged from 1.5 to 566 units/kg per day. Based on the pharmacodynamic properties of U-500 insulin, this concentrated form must be administered and dosed differently than regular U-100 insulin. U-500 insulin cost more than U-100 insulin on a per-milliliter basis, but cost less in the end because of the lower volumes of insulin required and fewer syringes and pump cartridges needed to administer U-500 insulin.</p><p><strong>Conclusions:</strong> In our experience, U-500 insulin is a useful tool in the management of patients with severe insulin resistance. U-500 insulin alleviates the volume-related problems associated with U-100 insulin, making treatment with higher doses of insulin (≥200 units per day) more effective with U-500 insulin than with U-100 insulin.</p></div>","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"3 4","pages":"Pages 211-218"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1557-0843(08)80049-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91698414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bajar de peso con diabetes","authors":"","doi":"10.1016/S1557-0843(08)80057-7","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80057-7","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"3 4","pages":"Page 248"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1557-0843(08)80057-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91698416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of U-500 insulin in the treatment of severe insulin resistance","authors":"E. Cochran, P. Gorden","doi":"10.1016/S1557-0843(08)80049-8","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80049-8","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"100 1","pages":"211-218"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77080164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight change in intensive insulin therapy for type 2 diabetes mellitus as a function of glycosylated hemoglobin (A1C) level achieved: The deep south diabetes program","authors":"Josann W. Duane, W. Conway","doi":"10.1016/S1557-0843(08)80050-4","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80050-4","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"15 1","pages":"219-231"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74597010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Losing weight with diabetes","authors":"","doi":"10.1016/S1557-0843(08)80056-5","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80056-5","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"3 4","pages":"Page 247"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1557-0843(08)80056-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137195761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of needlestick injuries among nurses using novofine® autocover® safety needles and nurses' satisfaction with the needles: The NOVAC Study","authors":"Odile Lautier, H. Mosnier-Pudar, D. Durain, Sophie Gonbert, Luminita Spinu, P. Faure","doi":"10.1016/S1557-0843(08)80051-6","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80051-6","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"14 1","pages":"232-237"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79029051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of needlestick injuries among nurses using novofine® autocover® safety needles and nurses' satisfaction with the needles: The NOVAC Study","authors":"Odile Lautier IDE,&nbsp;Helen Mosnier-Pudar MD,&nbsp;Danielle Durain IDE,&nbsp;Sophie Gonbert MD, PhD,&nbsp;Luminita Spinu MD, PhD,&nbsp;Pierre Faure DPharm","doi":"10.1016/S1557-0843(08)80051-6","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80051-6","url":null,"abstract":"<div><p><strong>Background:</strong> Needlestick injuries among health care professionals are a costly problem, both economically and in terms of anxiety and stress. NovoFine® Autocover® (NFA) 30G safety needles (Novo Nordisk A/S, Bagsvaerd, Denmark) were designed to minimize the risk of such injuries when used with insulin pens, which are increasingly preferred over syringes for injecting insulin.</p><p><strong>Objective:</strong> This prospective study compared the risk of needlestick injury with NFA needles and regular needles on insulin pens among nurses who administered insulin to patients.</p><p><strong>Methods:</strong> Nurses with ≥3 months' experience in diabetes care were eligible for participation. Nurses were trained in the use of NFA needles and then instructed to use them in their daily practice for 4 weeks, recording details of the injections administered and any injuries that occurred in a logbook.</p><p><strong>Results:</strong> A total of 143 nurses at 52 hospitals located throughout France received training. Demographic data were available for 139 nurses (mean age 38.4 years, 96.4% female, with a mean of 8 years' diabetes experience): 123 of the nurses used NFA needles (7854 injections administered), 122 of whom also used regular needles (4491 injections). No needlestick injuries occurred with NFA needles, whereas 1 needlestick injury occurred with a regular needle. Nurses were very satisfied with the NFA needles, giving them a score of 8.1 on a scale of 0 to 10, rating personal safety as a particularly important benefit (score 9.5). Nurses preferred NFA needles to both regular needles on insulin pens and needles on syringes, citing personal safety and the saving of time as the main reasons.</p><p><strong>Conclusions:</strong> These results suggest that NFA needles could reduce the risk of needlestick injuries and that nurses would welcome their other advantages, such as ease of use and saving of time.</p></div>","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"3 4","pages":"Pages 232-237"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1557-0843(08)80051-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91698410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Report from the 44th Annual Meeting of the European Association for the Study of Diabetes","authors":"","doi":"10.1016/S1557-0843(08)80048-6","DOIUrl":"https://doi.org/10.1016/S1557-0843(08)80048-6","url":null,"abstract":"","PeriodicalId":100678,"journal":{"name":"Insulin","volume":"3 4","pages":"Pages 208-210"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1557-0843(08)80048-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91698413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}