J. Finsterer , B. Mamoli , A. Fuglsang-Frederiksen
{"title":"Peak-ratio interference pattern analysis in the detection of neuromuscular disorders","authors":"J. Finsterer , B. Mamoli , A. Fuglsang-Frederiksen","doi":"10.1016/S0924-980X(97)00039-8","DOIUrl":"10.1016/S0924-980X(97)00039-8","url":null,"abstract":"<div><p>Peak-ratio interference pattern analysis (peak-ratio method) is said to have a high sensitivity and to be independent of sex and age. This study was carried out to prove or disprove these findings. The peak-ratio method and qualitative motor unit action potential (MUAP) analysis were applied to the right brachial biceps and anterior tibial muscles of 44 healthy subjects, aged 23–87 years, 25 neuropathy patients, aged 21–83 years, and 29 myopathy patients, aged 19–70 years. Peak-ratio parameters were independent of sex and age. They tended to be lower in the anterior tibial muscle than in the brachial biceps muscle. Neuropathy patients typically showed decreased peak-ratio, short time intervals and increased amplitude/turn. Myopathy patients typically showed increased peak-ratio, turns/s and short time intervals. The sensitivity of the peak-ratio method was 72% for neuropathy patients and 59% for myopathy patients. The sensitivity of the peak-ratio method was similar to that of the MUAP analysis in neuropathy patients and higher than that of the MUAP analysis in myopathy patients. The specificity of the peak-ratio method was 80%. The peak-ratio method proved to be a valuable, supplementary electromyographic tool for the detection of neuromuscular disorders.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 379-384"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00039-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stimulus/response curves as a method of measuring motor cortical excitability in man","authors":"M.C. Ridding , J.C. Rothwell","doi":"10.1016/S0924-980X(97)00041-6","DOIUrl":"10.1016/S0924-980X(97)00041-6","url":null,"abstract":"<div><p>We investigated whether input/output curves of human motor cortex could provide similar information to cortical mapping under two conditions where the motor maps are known to change dramatically: ischaemic anaesthesia and amputation. Stimulus/response curves were constructed by recording the size of EMG responses evoked in arm muscles with transcranial magnetic stimulation at a single site using a range of intensities. Changes in the slope of this relationship during ischaemic anaesthesia (6 normal subjects) or amputation (two patients) were compared to changes in cortical motor maps produced by stimulating different sites at the same intensity. At rest both interventions increased map areas, as well as the slope of the stimulus/response curves. During voluntary activity they had no effect. We conclude that stimulus/response curves can detect changes in cortical motor maps, and discuss potential mechanisms for this effect.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 340-344"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00041-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20294060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Facilitation of motor evoked potentials after repetitive voluntary hand movements depends on the type of motor activity","authors":"B. Hauptmann, A. Skrotzki, H. Hummelsheim","doi":"10.1016/S0924-980X(97)00031-3","DOIUrl":"10.1016/S0924-980X(97)00031-3","url":null,"abstract":"<div><p>Recent neurophysiological studies suggest that repetitive execution of identical movements is crucial for motor learning. During and after repetitive motor action, changes in motor cortical excitability have been demonstrated by means of transcranial magnetic stimulation. Nevertheless, the frequency and intensity of movement repetition that are necessary to achieve an optimal improvement in motor function are unknown. Fourteen healthy volunteers participated in the present study, which deals with the post-exercise facilitatory and/or inhibitory effects of 5 different motor conditions, including repetitive isotonic contractions at the wrist at two different velocities and two different forearm positions, a sustained isometric hand extension and repetitive hand extensions at the wrist induced by means of transcutaneous electrical muscle stimulation. The modification of muscular response potentials in the extensor carpi radialis muscle was measured following the various motor tasks and the electrical muscle stimulation. The only statistically significant facilitatory effect was observed following an extension-relaxation task at low frequency. Furthermore, the duration of transcranially induced silent periods showed a significant reduction after this motor task.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 357-364"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00031-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Topographic mapping of trans-cranial magnetic stimulation data on surface rendered MR images of the brain","authors":"K.D. Singh , S. Hamdy , Q. Aziz , D.G. Thompson","doi":"10.1016/S0924-980X(97)96699-6","DOIUrl":"10.1016/S0924-980X(97)96699-6","url":null,"abstract":"<div><p>We present a method for the coregistration and topographic mapping of trans-cranial magnetic stimulation (TCMS) data on surface rendered images of the cortex, derived from Magnetic Resonance Images (MRI). We describe the TCMS procedure and the methods used to locate the TCM stimulation sites in the MRI coordinate system, and the algorithms needed to depict the TCMS distribution as a pseudocolour contour map on the cortical surface. The methods are validated using TCMS data from the hand (thenar) and leg (tibialis muscle). The methods used correctly depict the expected motor representations of each of these areas and we therefore propose that this technique may be used as a functional imaging tool in the investigation of cortical function in both normals and patients.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 345-351"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)96699-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20294061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The volitional unit: a functional concept in cortico-motoneuronal connections in humans","authors":"J.F. Jabre, B.T. Salzsieder","doi":"10.1016/S0924-980X(97)00043-X","DOIUrl":"10.1016/S0924-980X(97)00043-X","url":null,"abstract":"<div><p>We used the EMG precision decomposition technique to resolve complex EMG signals and derive information about the firing times of a family of motor units (MUs) and the force they produce. The active units shared a common behavior among their firing rates, a concept described by DeLuca et al. and termed the ‘common drive’. This ‘common’ behavior was extracted as the average of the firing rates of MUs and found to track the subject's force trajectory. In this paper, we propose the existence of functional cortico-motoneuronal connections which provide for a large number of combinations between affector cortical motoneurons (CMNs) and effector spinal motoneurons (SMNs) for the generation of a purposeful movement. We argue that these connections provide the essential link between volition and movement and function as a ‘volitional unit’ which consists of the CMNs, the SMNs and the anatomical and interneuronal connections between them.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 365-369"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00043-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cortical mechanism underlying externally cued gait initiation studied by contingent negative variation","authors":"Shogo Yazawa , Hiroshi Shibasaki , Akio Ikeda , Kiyohito Terada , Takashi Nagamine , Manabu Honda","doi":"10.1016/S0924-980X(97)00034-9","DOIUrl":"10.1016/S0924-980X(97)00034-9","url":null,"abstract":"<div><p>In order to clarify the cortical mechanism underlying gait initiation, we examined the scalp distribution of the contingent negative variation (CNV) preceding externally cued gait initiation in a simple reaction-time paradigm in 10 healthy right-handed men, and compared the results with the CNV preceding simple foot dorsiflexion. A pair of auditory stimuli was given with an interstimulus (S1–S2) interval of 2 s and gait consisting of at least 3 steps was initiated with the right footstep as fast as possible in response to S2. Brisk dorsiflexion of the right foot was employed as a control task. It was found that the late CNV in the gait initiation task started about 1 s before S2, and was largest at Cz (−9.3 ± 3.1 μV) without clear asymmetry over the scalp. However, it was ill defined in the parietal area. In the foot dorsiflexion task, the late CNV was maximal at Cz (−7.1 ± 2.9 μV), and clearly seen also over the parietal area. The late CNV at Cz was significantly (<em>P</em> < 0.01) larger in the gait initiation than in the simple foot dorsiflexion. The amplitude of the late CNV preceding the foot dorsiflexion task was not significantly different between the sitting and the standing posture. In view of the results of previous invasive studies in both humans and animals which showed some frontal areas, including the supplementary motor area (SMA) and the primary motor cortex, as the generators of the late CNV, it is suggested that the cerebral cortex is active in initiation of externally triggered gait in a different way from the simple foot movement, and that bilateral SMAs may play a more important role in gait initiation than in simple foot movement.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 390-399"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00034-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Importance of soft tissue inhomogeneity in magnetic peripheral nerve stimulation","authors":"Makoto Kobayashia , Shoogo Ueno , Takahide Kurokawa","doi":"10.1016/S0924-980X(97)00035-0","DOIUrl":"10.1016/S0924-980X(97)00035-0","url":null,"abstract":"<div><p>In magnetic peripheral nerve stimulation with a figure-of-eight coil, a ‘tangential-edge’ coil orientation (the nerve is beneath the coil intersection and perpendicular to the coil wings) is ideal theoretically. However, some experimental results show that strong muscle responses are elicited with a ‘symmetrical-tangential’ coil orientation (the nerve is beneath the coil intersection and parallel to the coil wings), which is inconsistent with the cable theory. We hypothesized that the 10:1 conductivity difference between muscle and fat would cause inconsistent results during magnetic median nerve stimulation in the elbow, which was verified using an inhomogeneous volume conductor model. The induced electric fields were measured in a model composed of saline solutions of different concentrations divided by a cellophane sheet. A nerve was imagined along the boundary between the two solutions, and the coil was held in a ‘symmetrical-tangential’ position. Virtual cathodes, which were off the nerve in the homogeneous model, were on the nerve in the inhomogeneous model. The previous inconsistent results were explained by considering soft tissue inhomogeneity without any modification of the assumption in the cable theory that only the induced electric field component parallel to the nerve is responsible for nerve excitation.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 406-413"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00035-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Dumitru , John C. King , Sanjeev D. Nandedkar
{"title":"Motor unit action potentials recorded with concentric electrodes: physiologic implications","authors":"Daniel Dumitru , John C. King , Sanjeev D. Nandedkar","doi":"10.1016/S0924-980X(97)00025-8","DOIUrl":"10.1016/S0924-980X(97)00025-8","url":null,"abstract":"<div><p>Computer simulations of concentric needle electrode recording characteristics assume a hemisphere spatial recording territory for the electrode's core with the cannula shielding electrical activity arising from those muscle fibers located behind the cannula with respect to the electrode's core. It is also believed that the motor unit action potential's (MUAP) duration is generated by the number of muscle fibers within the electrode's hemispherical recording territory. This presumption suggests that rotating the needle will necessarily alter the number of muscle fibers within the hemispherical recording territory and hence lead to an alteration in MUAP duration. Comparisons were performed for different needle orientations with documentation of no statistically significant alteration in MUAP duration. Additionally, referential recording montages with the concentric needle electrode revealed that the electrode's core records MUAPs with durations comparable to those detected by the cannula. These findings strongly suggest that the recording territory of the concentric needle electrode, with respect to MUAP duration, is not a hemisphere but a sphere encompassing most if not all of the MUAP's muscle fibers in a manner similar to that of a monopolar needle. These findings have significant implications regarding presently used MUAP simulation techniques and require a reconceptualization of how the concentric needle electrode records electrical activity within a volume conductor.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 333-339"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00025-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20294059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-exercise depression of motor evoked potentials as a function of exercise duration","authors":"Ali Samii, Eric M. Wassermann, Mark Hallett","doi":"10.1016/S0924-980X(97)00033-7","DOIUrl":"10.1016/S0924-980X(97)00033-7","url":null,"abstract":"<div><p>Post-exercise facilitation and post-exercise depression are phenomena described in motor evoked potentials (MEPs) elicited to transcranial magnetic stimulation. Brief, non-fatiguing muscle activation produces post-exercise facilitation, and prolonged fatiguing muscle activation produces post-exercise depression. We studied 12 normal subjects to determine whether post-exercise depression occurs before fatigue is reached. We recorded MEPs from the resting extensor carpi radialis muscle after increasing the duration of isometric wrist extension, at 50% of maximum voluntary contraction, until the muscle fatigued. Fatigue was defined as the inability to maintain that force. The mean exercise duration before the muscle fatigued was 130 s, and post-exercise depression occurred only beyond 90 s of exercise. We conclude that post-exercise depression is detectable only after prolonged muscle activation.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 352-356"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00033-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20294062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Dumitrua , John C. King , Sanjeev D. Nandedkar
{"title":"Concentric/monopolar needle electrode modeling: spatial recording territory and physiologic implications","authors":"Daniel Dumitrua , John C. King , Sanjeev D. Nandedkar","doi":"10.1016/S0924-980X(97)00045-3","DOIUrl":"10.1016/S0924-980X(97)00045-3","url":null,"abstract":"<div><p>Scaled 20:1 physical models of monopolar and standard concentric needle electrodes are investigated with a constant current bipolar generator to determine the amplitude versus radial distance characteristics of these two electrodes. Each model is examined at three scaled and simulated tissue penetration depths (4, 10 and 20 mm) with measurements documented from 20 to 9000 /Am radially in front and behind the models. The monopolar compared to concentric electrode has a smaller response to a standardized stimuli but a flatter response curve at distances of less than 1500 μm The cannula of the concentric needle also has a flatter response than that of its core. When compared to a remote reference such as that at scaled depths of tissue penetration approximating 4 mm or less the cannula-to-remote reference potential exceeds the amplitude of the core-to-remote reference, recording a net negative potential at 6500 μm in front and 3500 um behind the core. This study offers an explanation for the clinically observed larger magnitude potentials detected with monopolar compared to concentric electrodes resulting from a larger recording cross-sectional area with more fibers contributing to the potential even though the magnitude of potential at any one location is comparatively smaller in magnitude than that for the concentric electrode. Additionally, the physiologic duration of a motor unit is anticipated to be considerably longer than presently measured clinically with automated methods because of the electrodes' ability to detect such small signals from a large region of the volume conductor.</p></div>","PeriodicalId":100400,"journal":{"name":"Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control","volume":"105 5","pages":"Pages 370-378"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0924-980X(97)00045-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20295264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}