EJC Skin Cancer最新文献

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Five-year survival after introduction of adjuvant treatment in stage III melanoma: A nationwide registry-based study III期黑色素瘤引入辅助治疗后的5年生存率:一项基于全国登记的研究
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/j.ejcskn.2026.100834
H. Helgadottir , L. Ny , G. Ullenhag , R. Mikiver , K. Isaksson , R. Olofsson Bagge
{"title":"Five-year survival after introduction of adjuvant treatment in stage III melanoma: A nationwide registry-based study","authors":"H. Helgadottir , L. Ny , G. Ullenhag , R. Mikiver , K. Isaksson , R. Olofsson Bagge","doi":"10.1016/j.ejcskn.2026.100834","DOIUrl":"10.1016/j.ejcskn.2026.100834","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100834"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormonal Milestones and Melanoma: Evaluating the Role of Menopausal Status in Female Patients 激素里程碑和黑色素瘤:评估女性患者绝经状态的作用
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/j.ejcskn.2026.100837
V. Burmeister , S. Preis , O.-D. Persa , T. Biedermann
{"title":"Hormonal Milestones and Melanoma: Evaluating the Role of Menopausal Status in Female Patients","authors":"V. Burmeister , S. Preis , O.-D. Persa , T. Biedermann","doi":"10.1016/j.ejcskn.2026.100837","DOIUrl":"10.1016/j.ejcskn.2026.100837","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100837"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does the delay from diagnosis to sentinel lymph node biopsy increase the chance of metastatic spread to the sentinel lymph node, overall survival and melanoma-specific survival in cutaneous melanoma patients? 从诊断到前哨淋巴结活检的延迟是否会增加转移扩散到前哨淋巴结的机会、皮肤黑色素瘤患者的总生存率和黑色素瘤特异性生存率?
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/j.ejcskn.2026.100826
K. Krishnan , R. Wade , H. Peach
{"title":"Does the delay from diagnosis to sentinel lymph node biopsy increase the chance of metastatic spread to the sentinel lymph node, overall survival and melanoma-specific survival in cutaneous melanoma patients?","authors":"K. Krishnan , R. Wade , H. Peach","doi":"10.1016/j.ejcskn.2026.100826","DOIUrl":"10.1016/j.ejcskn.2026.100826","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100826"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of psychiatric comorbidity on survival and healthcare costs in melanoma patients: A real world, population-based study 精神合并症对黑色素瘤患者生存和医疗费用的影响:一项真实世界、基于人群的研究
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/j.ejcskn.2026.100843
A. Buja , C. Trevisiol , F. Cassalia , M. Rugge , M. Zorzi , P. del Fiore , I. Pantaleo , C.R. Rossi , P. Conte , D. Franceschini , A. Belloni Fortina , S. Mocellin
{"title":"Impact of psychiatric comorbidity on survival and healthcare costs in melanoma patients: A real world, population-based study","authors":"A. Buja , C. Trevisiol , F. Cassalia , M. Rugge , M. Zorzi , P. del Fiore , I. Pantaleo , C.R. Rossi , P. Conte , D. Franceschini , A. Belloni Fortina , S. Mocellin","doi":"10.1016/j.ejcskn.2026.100843","DOIUrl":"10.1016/j.ejcskn.2026.100843","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100843"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Disease Control in Advanced Melanoma Using Electrochemotherapy and Systemic Therapy: A Case Report 电化疗和全身治疗对晚期黑色素瘤的长期疾病控制:1例报告
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/j.ejcskn.2026.100855
N. Kempa-Kamińska , P. Szymańska , M. Migdał , M. Ziętek
{"title":"Long-term Disease Control in Advanced Melanoma Using Electrochemotherapy and Systemic Therapy: A Case Report","authors":"N. Kempa-Kamińska , P. Szymańska , M. Migdał , M. Ziętek","doi":"10.1016/j.ejcskn.2026.100855","DOIUrl":"10.1016/j.ejcskn.2026.100855","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100855"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
99Tc-Tilmanocept sentinel node biopsy and long-term outcomes in melanoma 99Tc-Tilmanocept前哨淋巴结活检和黑色素瘤的长期预后
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/j.ejcskn.2026.100786
A. Roshan , T. Pasha , G. Kounidas , F. O'Leary , S. Murphy , T. Tajsic , A. Patel , L. Aloj , J. Buscombe , A. Durrani
{"title":"99Tc-Tilmanocept sentinel node biopsy and long-term outcomes in melanoma","authors":"A. Roshan , T. Pasha , G. Kounidas , F. O'Leary , S. Murphy , T. Tajsic , A. Patel , L. Aloj , J. Buscombe , A. Durrani","doi":"10.1016/j.ejcskn.2026.100786","DOIUrl":"10.1016/j.ejcskn.2026.100786","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100786"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjuvant therapy with locoregional interferon-beta versus surgery alone for resected stage II/III cutaneous melanoma: A multicenter randomized phase III trial (JCOG1309, J-FERON) 局部干扰素辅助治疗与单纯手术治疗切除的II/III期皮肤黑色素瘤:一项多中心随机III期试验
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-20 DOI: 10.1016/j.ejcskn.2026.100796
K. Namikawa , D. Ogata , M. Yokoyama , Y. Sano , H. Fukuda , A. Takahashi , T. Takenouchi , Y. Nakamura , S. Yoshikawa , A. Hiura , H. Uchi , A. Tsutsumida , J. Uehara , K. Yoshino , Y. Shibayama , S. Fukushima , E. Nakano , Y. Nakamura , Y. Kiniwa , M. Aoki , N. Yamazaki
{"title":"Adjuvant therapy with locoregional interferon-beta versus surgery alone for resected stage II/III cutaneous melanoma: A multicenter randomized phase III trial (JCOG1309, J-FERON)","authors":"K. Namikawa , D. Ogata , M. Yokoyama , Y. Sano , H. Fukuda , A. Takahashi , T. Takenouchi , Y. Nakamura , S. Yoshikawa , A. Hiura , H. Uchi , A. Tsutsumida , J. Uehara , K. Yoshino , Y. Shibayama , S. Fukushima , E. Nakano , Y. Nakamura , Y. Kiniwa , M. Aoki , N. Yamazaki","doi":"10.1016/j.ejcskn.2026.100796","DOIUrl":"10.1016/j.ejcskn.2026.100796","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100796"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
10-years of first-line ipilimumab and nivolumab in the management of melanoma brain metastases: a single centre experience 伊匹单抗和纳武单抗治疗黑色素瘤脑转移的10年一线研究:单一中心经验
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-04-02 DOI: 10.1016/j.ejcskn.2026.101137
Tobias Peres , Anadil Javaid , Andreas Michael Schmitt , James Larkin
{"title":"10-years of first-line ipilimumab and nivolumab in the management of melanoma brain metastases: a single centre experience","authors":"Tobias Peres ,&nbsp;Anadil Javaid ,&nbsp;Andreas Michael Schmitt ,&nbsp;James Larkin","doi":"10.1016/j.ejcskn.2026.101137","DOIUrl":"10.1016/j.ejcskn.2026.101137","url":null,"abstract":"<div><h3>Background</h3><div>To evaluate the efficacy of first-line ipilimumab and nivolumab, alongside local therapies, in patients with melanoma brain metastases (MBM).</div></div><div><h3>Methods</h3><div>This retrospective study included MBM patients treated with first-line ipilimumab and nivolumab in the metastatic setting at the Royal Marsden Hospital, London, between 2013 and 2024. Patient outcomes and associations of local therapies with survival were assessed.</div></div><div><h3>Results</h3><div>A total of 93 MBM patients were identified, including 47 symptomatic patients and 43 patients receiving corticosteroids at treatment initiation. Median follow-up was 55.6 months (95% confidence interval (CI) 36.6–82.1). Median overall survival (OS) for the entire cohort was 9.8 months (95% CI 5.8–29.5), and median progression-free survival (PFS) was 3.4 months (95% CI 2.6–5.9). The intracranial objective response rate (ORR) was 18%. Among symptomatic patients, median OS was 5.9 months (95% CI 5.03–46), median PFS 3.2 months (95% CI 2.1–5.99), and intracranial ORR 13% versus median OS 16.3 months (95% CI 7.85–81.1), median PFS 4.4 months (95% CI 2.63–8.18), and intracranial ORR 24% in asymptomatic patients. Eastern Cooperative Oncology Group performance status ≥ 2 and elevated lactate dehydrogenase were independently associated with worse outcomes in multivariable analysis. Local therapy alongside systemic treatment was associated with a non-significant trend toward improved survival (median OS 18.3 months [95% CI 11.6–NR] vs. 5.4 months [95% CI 4.3–29.5], HR 0.68 [0.4–1.13]).</div></div><div><h3>Conclusions</h3><div>This retrospective study supports the real-world efficacy of first-line ipilimumab and nivolumab in asymptomatic MBM. Outcomes in symptomatic or corticosteroid-dependent patients remained poor.</div></div>","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 101137"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An incomplete snapshot of the European melanoma clinical practice guidelines 欧洲黑色素瘤临床实践指南的不完整快照
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-03-29 DOI: 10.1016/j.ejcskn.2026.101135
Paolo A. Ascierto, Ignazio Stanganelli, Margaret Ottaviano, Giuseppe Palmieri, Corrado Caracò
{"title":"An incomplete snapshot of the European melanoma clinical practice guidelines","authors":"Paolo A. Ascierto,&nbsp;Ignazio Stanganelli,&nbsp;Margaret Ottaviano,&nbsp;Giuseppe Palmieri,&nbsp;Corrado Caracò","doi":"10.1016/j.ejcskn.2026.101135","DOIUrl":"10.1016/j.ejcskn.2026.101135","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 101135"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147600211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-related GFAP-Astrocytopathy under PD-1 inhibition: A case report PD-1抑制下免疫相关gmap -星形细胞病变1例
EJC Skin Cancer Pub Date : 2026-01-01 Epub Date: 2026-03-28 DOI: 10.1016/j.ejcskn.2026.101136
Lea Daniello, Georgios Tassopoulos, Berenice Mareen Lang, Bastian Schilling
{"title":"Immune-related GFAP-Astrocytopathy under PD-1 inhibition: A case report","authors":"Lea Daniello,&nbsp;Georgios Tassopoulos,&nbsp;Berenice Mareen Lang,&nbsp;Bastian Schilling","doi":"10.1016/j.ejcskn.2026.101136","DOIUrl":"10.1016/j.ejcskn.2026.101136","url":null,"abstract":"<div><div>Immune checkpoint inhibitors have substantially improved survival in advanced melanoma but are also associated with immune-related adverse events. Such events can affect any organ, including the central and peripheral nervous systems. Neurological adverse events are rare and often underrecognized. We report the case of a 53-year-old woman with melanoma who developed a severe neurological adverse event after treatment with the PD-1 inhibitor nivolumab. We describe a rare case of nivolumab-associated glial fibrillary acidic protein astrocytopathy and highlight the diagnostic challenges, therapeutic considerations, and importance of early recognition of these potentially severe neurological adverse events.</div></div>","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 101136"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147600210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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