EJC Skin Cancer最新文献

{"title":"Why a 4 mm punch is not twice a 2 mm punch: The quadratic geometry of cutaneous surgical defects in skin cancer surgery","authors":"Jacques P. du Toit, Johann de Wet, Milan van Veenhuyzen, Willem Izak Visser","doi":"10.1016/j.ejcskn.2026.101147","DOIUrl":"10.1016/j.ejcskn.2026.101147","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 101147"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148230592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exceptional case of tumor lysis syndrome following Encorafénib-Binimétinib therapy for metastatic melanoma","authors":"Adielle Abecassis ,&nbsp;Laura Perray ,&nbsp;Rafaele Molinier ,&nbsp;Safa Idoudi ,&nbsp;Helene Kemp ,&nbsp;Céleste Lebbé ,&nbsp;Laetitia Vercellino ,&nbsp;Emilien Ezine ,&nbsp;Marie Fournier","doi":"10.1016/j.ejcskn.2026.100775","DOIUrl":"10.1016/j.ejcskn.2026.100775","url":null,"abstract":"<div><div>We report a case of tumor lysis syndrome (TLS) occurring 48 h after initiation of targeted therapy with Encorafénib and Binimétinib in a patient with an extensive metastatic melanoma harboring a BRAF V600E mutation. The patient required intensive care management, including systemic treatment with an antihyperuricemic agent and hemodialysis. Targeted therapy with Dabrafénib and Tramétinib was successfully reintroduced fifteen days later without TLS recurrence. TLS is a rare complication in melanoma, more commonly associated with targeted therapy or combined immunotherapy. Close monitoring is recommended in patients with high tumor burden when initiating these treatments.</div></div>","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100775"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRAF/MEK inhibitor rechallenge in patients with non-resectable or metastatic BRAF V600-mutated melanoma: A stratified, controlled, retrospective EUMelaReg multicenter study","authors":"Michael Weichenthal ,&nbsp;Iva Gavrilova ,&nbsp;Peter Mohr ,&nbsp;Berna C. Özdemir ,&nbsp;Nethanel Asher ,&nbsp;Eva Ellebaek ,&nbsp;Jens Ulrich ,&nbsp;Alexander Kreuter ,&nbsp;Aleksander Popovic ,&nbsp;Christina Ruhlmann ,&nbsp;Igor Stojkovski ,&nbsp;Shaked Lev-Ari ,&nbsp;Edgar Dippel ,&nbsp;Almudena García Castaño ,&nbsp;Lorena Bellido Hernández ,&nbsp;Henrik Schmidt ,&nbsp;Egle Ramelyte ,&nbsp;Dimitrios Ziogas ,&nbsp;Luisa Piccin ,&nbsp;Katarzyna Kozak ,&nbsp;Dirk Schadendorf","doi":"10.1016/j.ejcskn.2026.100776","DOIUrl":"10.1016/j.ejcskn.2026.100776","url":null,"abstract":"<div><h3>Background</h3><div>Therapeutic options for BRAF^V600-mutant melanoma in patients who progress on BRAF/MEK-inhibitors (BRAF/MEKi) and immune-checkpoint-inhibitor (ICI) therapy, are limited. We conducted a retrospective registry study to investigate post-ICI rechallenge with BRAF/MEKi, stratified by type of initial BRAF/MEKi therapy.</div></div><div><h3>Methods</h3><div>This retrospective study analysed patients from the EUMelaReg registry, who received adjuvant or first-line (1 L) BRAF/MEKi in the advanced setting, followed by ICI therapy and were later retreated with BRAF/MEKi. Overall response rate (ORR) for rechallenge served as primary endpoint, disease-control rate (DCR), progression-free survival (PFS), and overall survival (OS) were further endpoints. A covariate-matched control group of patients who received BRAF/MEKi only after 1 L ICI failure was selected for comparison.</div></div><div><h3>Results</h3><div>Among patients previously treated with adjuvant (n = 42) or non-adjuvant (n = 142) BRAF/MEKi, rechallenge after one interim ICI line resulted in ORRs of 26.2 % and 30.3 % and DCRs of 42.9 % and 61.8 %, respectively. Median PFS was 8.4 and 5.1 months, median OS 13.8 and 8.6 months, respectively. Overall, the rechallenge group had a 1-year OS of 43.2 %, lower than the matched control (58.9 %). The adjuvant subgroup was similar to control (55.4 %), while the advanced subgroup showed notably poorer survival (39.9 %). Subgroup analyses showed that both the pre-ICI response to BRAF/MEKi treatment and progressive disease prior to ICI were associated with outcome of the BRAF/MEKi rechallenge.</div></div><div><h3>Conclusion</h3><div>Rechallenge with BRAF/MEKi therapy under real-world conditions for advanced melanoma provides a valid treatment option. For patients who received their initial BRAF/MEKi therapy as adjuvant therapy there seems to be only limited impairment of outcomes.</div></div>","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100776"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoimmunotherapy with topical imiquimod 5% to enhance systemic nivolumab in patients with melanoma satellitosis/in transit metastases","authors":"X.A. Vence-Nogueira ,&nbsp;J.M. de Castro-Garrido ,&nbsp;C. López-Sánchez ,&nbsp;L. Rusiñol ,&nbsp;M. Majem ,&nbsp;O. Yélamos","doi":"10.1016/j.ejcskn.2026.100816","DOIUrl":"10.1016/j.ejcskn.2026.100816","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100816"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of an AI-Based Whole-Slide Image Prognostic Assay with Gene Expression Profiling in Early-Stage Melanoma","authors":"C. Bossard ,&nbsp;Y. Salhi ,&nbsp;A. Khammari ,&nbsp;M. Brousseau ,&nbsp;Y. Le Corre ,&nbsp;S. Salhi ,&nbsp;G. Quéreux ,&nbsp;J. Chetritt","doi":"10.1016/j.ejcskn.2026.100813","DOIUrl":"10.1016/j.ejcskn.2026.100813","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100813"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of delayed sentinel lymph node biopsy on metastatic burden and prognosis in patients with sentinel node-positive melanoma. A multicenter retrospective observational study in the Mediterranean area","authors":"E. Samaniego-González ,&nbsp;A. Tejera-Vaquerizo ,&nbsp;S. Podlipnik ,&nbsp;S. Ribero ,&nbsp;E. Nagore-Insa ,&nbsp;E. Nagore ,&nbsp;A. Boada ,&nbsp;J. Cañueto ,&nbsp;S. Paradela ,&nbsp;B. De Unamuno ,&nbsp;P. Rodríguez-Jiménez ,&nbsp;S. Puig ,&nbsp;J. Malvehy ,&nbsp;C. Carrera ,&nbsp;C. Carrera ,&nbsp;G. Roccuzzo ,&nbsp;C. Requena ,&nbsp;E. Manrique-Silva ,&nbsp;N. Richarz ,&nbsp;A. Ruiz-Villanueva ,&nbsp;M.A. González-Morán","doi":"10.1016/j.ejcskn.2026.100842","DOIUrl":"10.1016/j.ejcskn.2026.100842","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100842"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-Related Toxicity and Treatment Continuation: A Sex-Based Analysis","authors":"F. Tonko ,&nbsp;S. Preis ,&nbsp;L. Wein ,&nbsp;T. Biedermann ,&nbsp;L. Heinzerling ,&nbsp;O.-D. Persa","doi":"10.1016/j.ejcskn.2026.100839","DOIUrl":"10.1016/j.ejcskn.2026.100839","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100839"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-Onset Vitiligo in patients with a history of Melanoma: A Diagnostic challenge","authors":"V.M. Rodriguez ,&nbsp;W. López","doi":"10.1016/j.ejcskn.2026.100852","DOIUrl":"10.1016/j.ejcskn.2026.100852","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100852"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micrografting reconstruction in oncology. Experience at National Cancer Institute of Naples","authors":"C. Caracò,&nbsp;A. Amore,&nbsp;A. Lenta,&nbsp;L. Benedetto","doi":"10.1016/j.ejcskn.2026.100863","DOIUrl":"10.1016/j.ejcskn.2026.100863","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100863"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple occurrences of melanoma over a 33-year period - a case report.","authors":"V. Rothová ,&nbsp;P. Kopecká ,&nbsp;P. Fialová ,&nbsp;V. Fait","doi":"10.1016/j.ejcskn.2026.100866","DOIUrl":"10.1016/j.ejcskn.2026.100866","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100866"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}