EJC Skin Cancer最新文献

{"title":"Nomograms in Skin Cancer: Current State, Future Directions","authors":"A. Ortiz Brugués , E. Chatziioannou , K. Lallas , T. Amaral , J. Malvehy","doi":"10.1016/j.ejcskn.2026.100875","DOIUrl":"10.1016/j.ejcskn.2026.100875","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100875"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Role of Baseline Eosinophil Count in Metastatic Melanoma Treated with Nivolumab and Ipilimumab","authors":"C. Trojaniello , D. Mallardo , V. Vanella , F. Sparano , M.G. Vitale , E. Simeone , L. Festino , A. Facchini , A.L. Marretta , A. Esposito , M. Ottaviano , A. Lagodin D'Amato , B. Alfano , P.A. Ascierto","doi":"10.1016/j.ejcskn.2026.100884","DOIUrl":"10.1016/j.ejcskn.2026.100884","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100884"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete response with combined sonidegib and pembrolizumab in synchronous advanced basal cell carcinoma and metastatic cutaneous squamous cell carcinoma: A case report","authors":"Paola Valeria Marchese,&nbsp;Carolina Ortiz,&nbsp;Julia Lostes Bardaji,&nbsp;Francesca Comito,&nbsp;Eva Muñoz-Couselo","doi":"10.1016/j.ejcskn.2026.101150","DOIUrl":"10.1016/j.ejcskn.2026.101150","url":null,"abstract":"<div><div>Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most common skin cancers. While most cases are managed with local therapies, advanced disease may require systemic treatment. Hedgehog pathway inhibitors are standard for advanced BCC, whereas PD-1 inhibitors are effective in cSCC. However, no established strategy exists for synchronous advanced BCC and cSCC. We report a case of a patient with synchronous locally advanced BCC and metastatic cSCC treated with combined pembrolizumab and sonidegib, achieving a complete clinical and metabolic response. This case highlights a potential therapeutic approach, warranting further investigation to confirm its safety and efficacy.</div></div>","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 101150"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes and management following progressive disease with anti-PD-(L)1 therapy in patients with advanced cutaneous squamous cell carcinoma","authors":"Jeremy Mo,&nbsp;Ann-Sophie Bohne,&nbsp;Mirjam Nägeli,&nbsp;Caroline Gaudy-Marqueste,&nbsp;Charley Chen,&nbsp;Anne Zaremba,&nbsp;John Park,&nbsp;Rahul Ladwa,&nbsp;Nicholas Della Marta,&nbsp;Margarida Matias,&nbsp;Lucia Festino,&nbsp;Sydney Ch’ng,&nbsp;Alexander C.J. van Akkooi,&nbsp;Paolo A. Ascierto,&nbsp;Lisa Zimmer,&nbsp;Jean Jacques Grob,&nbsp;Johanna Mangana,&nbsp;Axel Hauschild,&nbsp;Alexander M. Menzies,&nbsp;Serigne N. Lo,&nbsp;Ines Pires da Silva","doi":"10.1016/j.ejcskn.2026.101157","DOIUrl":"10.1016/j.ejcskn.2026.101157","url":null,"abstract":"<div><h3>Aim</h3><div>Anti-programmed death-1/ligand-1 (anti-PD-(L)1) therapies are effective for advanced cSCC. This international study examines response patterns and subsequent management strategies following anti-PD-(L)1 therapy.</div></div><div><h3>Method</h3><div>This retrospective cohort study involved 10 centres across 6 countries. Key outcomes included objective response rate (ORR), progression-free survival (PFS), duration of response (DOR), and overall survival (OS) for anti-PD-(L)1 and subsequent therapy.</div></div><div><h3>Results</h3><div>One-hundred and fifty-nine patients with advanced cSCC who received anti-PD-(L)1 were evaluated. At median follow-up of 19.3 months (95% CI; 17.5 – 22.2), ORR was 67%. The 12-month and 24-month PFS rates were 62% (95% CI: 55–70) and 55% (95% CI: 47–64), while 12-month and 24-month OS rates were 81% (95% CI: 75–88) and 71% (95% CI: 63 – 80). Disease progression occurred in 47 patients (30%); 11% who progressed within 6 weeks of receiving anti-PD-(L)1 therapy, 55% with primary resistance, 28% with secondary resistance, 6% with late progression. Among 21 patients who received subsequent systemic therapies; 8 received cetuximab monotherapy (ORR 50%, DOR 8.5 months [95% CI; 6.9 - NR]) and 5 received anti-PD-(L)1 rechallenge (ORR 20%, one responder with response duration of 3.2 months). In multivariate analysis, a head and neck primary tumour site was associated with higher ORR, and prolonged PFS.</div></div><div><h3>Conclusion</h3><div>Our real-world findings reinforce the efficacy of anti-PD-(L)1 therapy in patients with advanced cSCC, with outcomes influenced by primary tumour location. The heterogeneity of subsequent treatments highlights an unmet need in the management of patients who progress on these therapies.</div></div>","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 101157"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148843637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Oncologic Safety and Functional Preservation in Acral Melanoma:Outcomes of Slow Mohs Micrographic Surgery and Reconstruction","authors":"M. Roh ,&nbsp;E.B. Choi ,&nbsp;K.Y. Chung","doi":"10.1016/j.ejcskn.2026.100799","DOIUrl":"10.1016/j.ejcskn.2026.100799","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100799"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desmoplastic Melanoma under Dermoscopic Evaluation: A Systematic Review","authors":"L. Guimarães Lopes ,&nbsp;A.L. Abreu Lessa Ribeiro ,&nbsp;A.E. Lavandoski Carvalho Maia ,&nbsp;B. Dacach Assis ,&nbsp;M. Azi Romano ,&nbsp;J. Magalhães Guitzel ,&nbsp;L. Gonçalves De Gouvea Faiçal ,&nbsp;V.C. De Siervi ,&nbsp;M.Â. Rodrigues Brandão","doi":"10.1016/j.ejcskn.2026.100822","DOIUrl":"10.1016/j.ejcskn.2026.100822","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100822"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant intralesional daromun (L19IL2/L19TNF) improves outcomes in resectable, relapsed, locally advanced melanoma regardless of prior therapy: subgroup analyses from the randomized phase 3 trial PIVOTAL","authors":"J.C. Hassel ,&nbsp;A. Hauschild ,&nbsp;M. Ziemer ,&nbsp;P. Rutkowski ,&nbsp;F. Meier ,&nbsp;L. Flatz ,&nbsp;C. Gaudy-Marqueste ,&nbsp;M. Santinami ,&nbsp;F. Russano ,&nbsp;I. von Wasielewski ,&nbsp;T.K. Eigentler ,&nbsp;M. Maio ,&nbsp;I. Zalaudek ,&nbsp;S. Haferkamp ,&nbsp;P. Quaglino ,&nbsp;J. Welzel ,&nbsp;C. Garbe ,&nbsp;D. Schadendorf ,&nbsp;P. Ascierto ,&nbsp;C. Robert ,&nbsp;K. Kähler","doi":"10.1016/j.ejcskn.2026.100868","DOIUrl":"10.1016/j.ejcskn.2026.100868","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100868"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Add-on of anti-PD-1 therapy to BRAF/MEK inhibition in patients with poor-prognosis stage IV BRAFV600-mutant melanoma, a retrospective case series","authors":"C. Bertels,&nbsp;D. Talhaoui,&nbsp;I. Dirven,&nbsp;B. Neyns","doi":"10.1016/j.ejcskn.2026.100795","DOIUrl":"10.1016/j.ejcskn.2026.100795","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100795"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant targeted therapy in melanoma: Long-term effect of systemic therapy with encorafenib + binimetinib with histologically confirmed pCR in young female with BRAFmut melanoma with large solitary liver metastasis","authors":"D. Sulc ,&nbsp;A. Chodacki ,&nbsp;M. Kocik ,&nbsp;M. Kollar","doi":"10.1016/j.ejcskn.2026.100869","DOIUrl":"10.1016/j.ejcskn.2026.100869","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100869"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotropic Melanoma: Aggressive Behavior and Multi-Pathway Dissemination.","authors":"B. Taglione ,&nbsp;D. Cortese ,&nbsp;A. Maurichi ,&nbsp;G. Gallino ,&nbsp;I. Mattavelli ,&nbsp;R. Patuzzo ,&nbsp;B. Valeri ,&nbsp;M. Cossa ,&nbsp;B.M. Scoppio ,&nbsp;E. Tolomio ,&nbsp;C. Barbieri ,&nbsp;S. Mercurio ,&nbsp;G. Spadola ,&nbsp;M. Santinami","doi":"10.1016/j.ejcskn.2026.100872","DOIUrl":"10.1016/j.ejcskn.2026.100872","url":null,"abstract":"","PeriodicalId":100396,"journal":{"name":"EJC Skin Cancer","volume":"4 ","pages":"Article 100872"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147720403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}