{"title":"Persistent need to urinate: A common sensory symptom leading to urinary discomfort. A study of 79 cases","authors":"Claire Hentzen , Jalesh N. Panicker , Martina Pericolini , Enrico Finazzi Agrò , Camille Chesnel , Emilie Blouet , Frederique Le Breton , Samer Sheikh Ismaël , Rebecca Haddad , Gerard Amarenco","doi":"10.1016/j.contre.2022.100007","DOIUrl":"10.1016/j.contre.2022.100007","url":null,"abstract":"<div><h3>Aims:</h3><p>An unpleasant, inappropriate, and persistent need to urinate (PNU) is a sensory symptom reported by some patients with lower urinary tract symptoms (LUTS). However, no detailed definition of this symptom exists. This study aimed to describe the characteristics of patients reporting PNU and to discuss the pathophysiology and therapeutic approach.</p></div><div><h3>Methods:</h3><p>The clinical and urodynamic findings of patients presenting with PNU without chronic bladder pain syndrome or neurological or urological conditions between October 2019 and December 2020 were retrospectively reviewed. The treatment efficacy was self-reported at follow-up as “total cure”, “significant improvement” or “no modification”.</p></div><div><h3>Results:</h3><p>Seventy-nine patients were included (51 women (65%), mean age 49 years (Standard Deviation (SD) 18)). The mean duration of symptoms was 7 years (SD 11). Frequency was commonly associated with PNU (mean interval between voids 103 min (SD 69)) and 50 patients (63%) reported nocturia. Voiding difficulties were described in 33 cases (40%). The mean first desire to void was 112mL (SD 93) with normal maximum cystometric capacity of 397mL (SD 135), and 5 patients had detrusor overactivity. Proposed treatments were tibial nerve stimulation (n=25) with a total cure or significant improvement in 17 cases, alpha-blockers (n=8) with an improvement in 4 patients, antimuscarinics (n=29) with an improvement in only 3 patients, and antidepressant or antiepileptic (n=8) with an improvement in 5 patients.</p></div><div><h3>Conclusion:</h3><p>PNU is poorly described but could be responsible for LUTS. Further studies to understand the underlying mechanisms and to assess the therapeutic efficacy of the different options are required.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"2 ","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974522000047/pdfft?md5=718c703a6e14cf0cab595cdebccc74b8&pid=1-s2.0-S2772974522000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85941046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Continence ReportsPub Date : 2022-03-01DOI: 10.1016/j.contre.2022.100004
T. Van den Broeck , B. Crul , J.P. Heesakkers
{"title":"Neurogenic voiding dysfunction induced by vitamin B6 overdose","authors":"T. Van den Broeck , B. Crul , J.P. Heesakkers","doi":"10.1016/j.contre.2022.100004","DOIUrl":"10.1016/j.contre.2022.100004","url":null,"abstract":"<div><p>We present a case of a man who developed a neurogenic detrusor acontractility because of too much Vitamin B6 or pyridoxine intake. He developed voiding dysfunction and sensory neuropathy in both legs (numbness). The analysis gave no other explanation for the development of his complaints than the intake of excessive multivitamins, resulting in a supraphysiologic vitamin B6 level associated with neurotoxicity. Multivitamins are not only regarded as healthy but may also cause severe physical complaints, including voiding LUTS. Caretakers should bear that in mind when they encounter patients with voiding difficulties.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"1 ","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974522000023/pdfft?md5=1b22c76ba2f9c710c94d9af7dd486c3b&pid=1-s2.0-S2772974522000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82477608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Underactive and low compliance bladder: A possible Presentation of COVID-19 vaccination","authors":"Hanieh Salehi-Pourmehr , Nooriyeh Dalir Akbari , Sakineh Hajebrahimi , Siamak Salehi","doi":"10.1016/j.contre.2022.100002","DOIUrl":"10.1016/j.contre.2022.100002","url":null,"abstract":"<div><p>Vaccine-related adverse events have been increasingly reported as the COVID-19 vaccination campaign progresses worldwide. Urological symptoms after COVID-19 vaccination are reported rarely. Herein, we report a case of urinary retention following the second dose of Oxford/AstraZeneca COVID-19 vaccine injection.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"1 ","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974522000011/pdfft?md5=6949e3f725e443b832ad6b4ae5e32774&pid=1-s2.0-S2772974522000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77219665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Gopalakrishnan, Nick F. Nielsen, Andrea L. Ramirez, J. Sørensen, M. Walter, A. Krassioukov
{"title":"Time needed to perform intermittent catheterization in adults with spinal cord injury: A pilot randomized controlled cross-over study","authors":"K. Gopalakrishnan, Nick F. Nielsen, Andrea L. Ramirez, J. Sørensen, M. Walter, A. Krassioukov","doi":"10.1101/2021.08.16.21253936","DOIUrl":"https://doi.org/10.1101/2021.08.16.21253936","url":null,"abstract":"Background: Intermittent catheterization (IC), considered the gold standard for bladder management for individuals with spinal cord injury (SCI) with sufficient dexterity, is usually performed using hydrophilic (HPC) or non-hydrophilic (non-HPC) catheters. Currently, there is no evidence on the temporal burden associated with IC with either catheter. Objective: To compare both catheters regarding their time requirement for IC and participant satisfaction. Design, setting and participants: Twenty individuals with chronic (>1-year) SCI at any spinal segment were randomized to undergo two cross-over assessments within 10 days (i.e., either starting with HPC or non-HPC). We measured time taken to perform IC using a 13 step pre-determined IC protocol (e.g., enter bathroom, wash hands, transfer to toilet, etc.). Furthermore, we assessed user satisfaction of both catheters using a Likert scale (i.e., strongly agree=5, strongly disagree=1). Outcome measures and statistical analysis: Time (i.e., for each step and in total) to perform IC and participant satisfaction were compared between catheters using non-parametric statistics, i.e., Wilcoxon rank sign tests. Results are presented as median with interquartile range. Results and limitations: Participants using HPCs spent less time to prepare a catheter [15 s (10-20) vs. 41 (20-69), p=0.002] and overall to perform IC [283 s (242-352) vs. 373 (249-441), p=0.01] compared to non-HPCs. Moreover, participants rated the preparation of HPCs to be easier [5 (4-5) vs. 4 (2-4), p=0.047] compared to non-HPCs. The key limitation of this pilot study was the sample size. Conclusions: Preparation and usage of HPCs for IC is easier and faster compared to non-HPCs. IC can be a significant temporal burden for SCI individuals. Patient summary: We compared coated and uncoated catheters on time needed for intermittent catheterization and user satisfaction in individuals with spinal cord injury. Participants can manually empty their bladder quicker and easier with coated compared to uncoated catheters.","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84863183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}