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Bipedalism and pelvic floor disorders, an evolutionary medical approach 两足行走与盆底障碍,一种进化医学方法
Continence Reports Pub Date : 2024-07-08 DOI: 10.1016/j.contre.2024.100058
Marcos García-Diez , Philip Van Kerrebroeck , Javier C. Angulo
{"title":"Bipedalism and pelvic floor disorders, an evolutionary medical approach","authors":"Marcos García-Diez ,&nbsp;Philip Van Kerrebroeck ,&nbsp;Javier C. Angulo","doi":"10.1016/j.contre.2024.100058","DOIUrl":"https://doi.org/10.1016/j.contre.2024.100058","url":null,"abstract":"<div><p>Evolutionary medicine can help to better understand the basis of pelvic floor disorders. Some evidences of the anthropological literature are reviewed, with emphasis on the paleontological clues and phylogenetic comparison of cephalo-pelvic relations in <em>Homo</em> and non-human primates, is undertaken to elucidate the origin of pelvic floor disturbances in humans. Labor difficulties inherent to bipedal gait and the encephalization process could have started several million years ago with <em>Australopithecus</em> and appear undeniable since Homo heidelbergensis, the precursor of Neanderthals. The mechanisms involved in modern human delivery with fetal rotation into the birth canal could be exclusive of <em>Homo sapiens</em>. Among pre-bipedal non-human primates only squirrel monkey can suffer severe dystocia and spontaneous pelvic organ prolapse. Better understanding of the evolutionary changes regarding the human pelvis and the pelvic floor could help us to better understand pelvic floor disorders and the interventions to avoid this highly prevalent ailment.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"11 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000127/pdfft?md5=c687d42d336f9af7db9fb05601742f96&pid=1-s2.0-S2772974524000127-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evaluation of urinary signs and symptoms in medieval medicine 中世纪医学对泌尿系统症状和体征的评估
Continence Reports Pub Date : 2024-06-22 DOI: 10.1016/j.contre.2024.100057
Javier C. Angulo , Miguel Virseda-Chamoro
{"title":"The evaluation of urinary signs and symptoms in medieval medicine","authors":"Javier C. Angulo ,&nbsp;Miguel Virseda-Chamoro","doi":"10.1016/j.contre.2024.100057","DOIUrl":"https://doi.org/10.1016/j.contre.2024.100057","url":null,"abstract":"<div><p>Medieval medicine established the basis of western sanitary knowledge. In an early period, the medical model was monastic and based mainly on botany. In High Middle Age (1000–1300 AD) classical Greek, Roman and Arabic sources were rescued by manuscript copiers, compilers and translators, especially in the Medical School of Salerno and in Toledo. The Arab and Hebrew knowledge was fundamental for this information recovery, that promoted the creation of the first medical universities in Europe (Montpelier, Bologna, Paris, Oxford, Salamanca) that spread the medical knowledge in Late Middle Ages. A non-systematic review is undertaken to analyze how urinary signs and symptoms were evaluated in medieval medicine, with emphasis in uroscopy and in the description in medical treatises of urinary symptoms; including incontinence, dysuria and retention, and their remedies in the form of oils, syrups and electuaries to restore the humoral balance</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"11 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000115/pdfft?md5=8abc144dc38643b4059fa962b0e4b450&pid=1-s2.0-S2772974524000115-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141484171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and practical considerations in delivering botulinum neurotoxin to adults with congenital neurogenic lower urinary tract dysfunction with history of genitourinary reconstruction 为有生殖泌尿系统重建史的先天性神经源性下尿路功能障碍成人注射肉毒杆菌神经毒素的挑战和实际考虑因素
Continence Reports Pub Date : 2024-06-20 DOI: 10.1016/j.contre.2024.100054
Johnny S. Su, Rose Khavari
{"title":"Challenges and practical considerations in delivering botulinum neurotoxin to adults with congenital neurogenic lower urinary tract dysfunction with history of genitourinary reconstruction","authors":"Johnny S. Su,&nbsp;Rose Khavari","doi":"10.1016/j.contre.2024.100054","DOIUrl":"https://doi.org/10.1016/j.contre.2024.100054","url":null,"abstract":"<div><h3>Purpose:</h3><p>While intradetrusor botulinum neurotoxin (BoNT) injection is a well-established treatment of neurogenic detrusor overactivity, its administration in individuals with complex genitourinary (GU) reconstruction can be difficult. The objective of this report is to highlight our institution’s experience with challenges and practical solutions in delivering BoNT to this unique patient population.</p></div><div><h3>Materials and Methods:</h3><p>We performed a retrospective review of our institution’s database of adults with congenital neurogenic lower urinary tract dysfunction (NLUTD) with history of complex GU reconstruction who received intradetrusor BoNT injections performed by a single surgeon between 2016 and 2023. In patients with multiple injections, the most recent procedure was used as the index case for analysis.</p></div><div><h3>Results:</h3><p>A total of 17 patients were included, with a mean age of 27 years (range 21–46). The most common diagnosis was myelomeningocele (n=13), followed by sacral agenesis (n=2), Williams syndrome (n=1), and urethral atresia (n=1). The most common GU reconstruction was augmentation cystoplasty (n=11). 75% (12/16) of the patients had a continent catheterizable channel (CCC) and 31% (5/16) had undergone prior bladder neck reconstruction or closure.</p></div><div><h3>Conclusion:</h3><p>Additional considerations and instruments are required for safe and effective BoNT injections in individuals with congenital NLUTD and reconstruction. Adequate preparation by the staff and the provider may be needed. Our recommendation generally favors the utilization of a flexible cystoscope or a rigid scope with a smaller sheath size to minimize trauma to the CCC, bladder neck, or urethra. Additionally, it is advisable to consider reconstituting BoNT in higher concentrations to enable the administration of fewer injections. Furthermore, performing these procedures in the operating room under anesthesia allows for the development of a well-considered strategy prior to any attempts in the office setting We hope that this manuscript sparks discussion between pediatric urologists and adult urologist to expand our knowledge on strategies needed for delivering BoNT to individuals with complex and restricting GU surgeries.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"11 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000085/pdfft?md5=0af5912814bce5c56118cb095546c8db&pid=1-s2.0-S2772974524000085-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does pelvic floor morphometry change in women with pelvic organ prolapse after a short period of supine lying? 患有盆腔器官脱垂的妇女在短时间仰卧后,盆底形态是否会发生变化?
Continence Reports Pub Date : 2024-06-14 DOI: 10.1016/j.contre.2024.100055
Lori B. Forner, Marie-Pierre Cyr, Paul W. Hodges, Michelle D. Smith
{"title":"Does pelvic floor morphometry change in women with pelvic organ prolapse after a short period of supine lying?","authors":"Lori B. Forner,&nbsp;Marie-Pierre Cyr,&nbsp;Paul W. Hodges,&nbsp;Michelle D. Smith","doi":"10.1016/j.contre.2024.100055","DOIUrl":"10.1016/j.contre.2024.100055","url":null,"abstract":"<div><h3>Introduction:</h3><p>Advice for women with pelvic organ prolapse (POP) often includes lying down to decrease the effects of gravity on the pelvic floor. The aim of this study was to compare pelvic floor morphometry before and after 30 min of supine lying in women with symptomatic POP.</p></div><div><h3>Methods:</h3><p>Pelvic floor morphometry was assessed in vaginally parous, premenopausal women with symptomatic POP <span><math><mo>≥</mo></math></span> stage 1. The modified Pelvic Organ Prolapse Quantification system was used in supine to assess points Ba (anterior vaginal wall), Bp (posterior vaginal wall), and C (cervix). Transperineal ultrasound imaging was used in supine and standing to assess the following measures at rest and bearing down: bladder neck position, bladder position, rectal ampulla position, levator plate angle, anorectal angle, levator anteroposterior distance, and levator hiatal area. Measures taken before and after 30 min of supine lying were compared.</p></div><div><h3>Results:</h3><p>Twenty-one women (median (range) age: 39 (29–50) years) with varied stages of POP (33% stage 1, 57% stage 2, and 10% stage 3) were included. Most measures of pelvic floor morphometry were unchanged after 30 min of supine lying compared to before lying. Participants had greater resting levator hiatal area in supine and levator anteroposterior distance at rest and bearing down in supine after lying down (p <span><math><mo>≤</mo></math></span> 0.001), suggesting reduced pelvic floor muscle activity.</p></div><div><h3>Conclusion:</h3><p>Findings suggest that a 30-min period of supine lying does not improve support of the pelvic organs.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"11 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000097/pdfft?md5=dc7256e8e1c6e91f9addd166c8b21c85&pid=1-s2.0-S2772974524000097-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary catheters and urinals throughout history 历史上的导尿管和小便池
Continence Reports Pub Date : 2024-06-04 DOI: 10.1016/j.contre.2024.100053
{"title":"Urinary catheters and urinals throughout history","authors":"","doi":"10.1016/j.contre.2024.100053","DOIUrl":"10.1016/j.contre.2024.100053","url":null,"abstract":"<div><p>Emptying an overfilled bladder has been a severe medical problem in mankind since ancient times. This review presents highlights the main historical milestones in the development and use of urine catheters. Some of the most famous designers and makers are also commented. Besides, the historic role of urinals, both as sanitary elements and sometimes as therapeutic devices for male incontinence, is presented.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"11 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000073/pdfft?md5=570704425fde375091c78d74ce3a13ee&pid=1-s2.0-S2772974524000073-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bladder dysfunction caused by tuberculosis: A historical review 结核病导致的膀胱功能障碍:历史回顾
Continence Reports Pub Date : 2024-05-29 DOI: 10.1016/j.contre.2024.100052
Etienne Cuénant , Philip Van Kerrebroeck
{"title":"Bladder dysfunction caused by tuberculosis: A historical review","authors":"Etienne Cuénant ,&nbsp;Philip Van Kerrebroeck","doi":"10.1016/j.contre.2024.100052","DOIUrl":"https://doi.org/10.1016/j.contre.2024.100052","url":null,"abstract":"<div><p>Tuberculosis has become an infrequent disease in Western society, hence has tuberculosis of the bladder. However, when tuberculosis was prevalent, urogenital tuberculosis and tuberculosis of the bladder could be the consequence if untreated, and were responsible for severe bladder dysfunction. Before antibiotic treatment became available, chronic bladder tuberculosis caused irreversible damage and often necessitated bladder reconstruction or even cystectomy. The specific antibiotic treatment of tuberculosis eradicated bladder dysfunction caused by tuberculosis. We aim to review the history of urogenital tuberculosis and the consequent dysfunction of the bladder based on existing literature.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"11 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000061/pdfft?md5=7047a93bab76027ff6cab3c9cdb00fb5&pid=1-s2.0-S2772974524000061-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sterile abscess formation following periurethral injections with synthetic polycaprolactone microspheres suspended in a carboxymethylcellulose gel (Urolon®): A case report 尿道周围注射悬浮在羧甲基纤维素凝胶(Urolon®)中的合成聚己内酯微球后形成无菌脓肿:病例报告
Continence Reports Pub Date : 2024-05-09 DOI: 10.1016/j.contre.2024.100050
J.E.M. Budo, J.P. Heesakkers
{"title":"Sterile abscess formation following periurethral injections with synthetic polycaprolactone microspheres suspended in a carboxymethylcellulose gel (Urolon®): A case report","authors":"J.E.M. Budo,&nbsp;J.P. Heesakkers","doi":"10.1016/j.contre.2024.100050","DOIUrl":"10.1016/j.contre.2024.100050","url":null,"abstract":"<div><p>Periurethral injection of bulking agents is a technique used to treat urinary incontinence due to stress incontinence, preferably caused by intrinsic sphincter deficiency. The variety of the nature of existing bulking agents leads to different success rates and complications. This case report describes the formation of pseudo-abscesses after periurethral injections with a bioresorbable implant consisting of synthetic polycaprolactone microspheres suspended in a carboxymethylcellulose gel carrier.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"10 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000048/pdfft?md5=ec75410be569c8257dcd2f18c799488b&pid=1-s2.0-S2772974524000048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel clinical classification for male urinary incontinence: MI-CRONS 男性尿失禁的新型临床分类:MI-CRONS
Continence Reports Pub Date : 2024-05-09 DOI: 10.1016/j.contre.2024.100051
George Kasyan , Bagrat Grigoryan , Dmitry Pushkar
{"title":"A novel clinical classification for male urinary incontinence: MI-CRONS","authors":"George Kasyan ,&nbsp;Bagrat Grigoryan ,&nbsp;Dmitry Pushkar","doi":"10.1016/j.contre.2024.100051","DOIUrl":"https://doi.org/10.1016/j.contre.2024.100051","url":null,"abstract":"<div><h3>Introduction:</h3><p>The aim of this study is to develop a new simple and practical classification of male urinary incontinence (UI) based on the clinical features and type of urinary incontinence.</p></div><div><h3>Materials &amp; methods:</h3><p>MI-CRONS classification is a system based on severity of incontinence and patients’ characteristics. Clinical evaluation of incontinence severity is based on preservation of voiding, proportion of void/lost urine, absorbable device usage, level of physical efforts that causes urine loss and nocturnal incontinence. Following patients’ characteristics of patients were included in classification system: history of radical prostatectomy, history of pelvic radiation, surgery for prostatic obstruction, neurogenic or non-neurogenic bladder disorders, and urethral strictures and disorders. This MI-CRONS classification system uses five uppercase Latin letters as follows: Male Incontinence — Cancer, Radiation, Obstruction, Neurogenic, Stricture. The classification could be used for stress, urgency, and mixed UI forms.</p></div><div><h3>Results:</h3><p>The new MI-CRONS classification system was applied to 85 of 86 patients evaluated in this retrospective study. Patients were classified by MI-CRONS to estimate an inclusiveness and complicity of proposed classification only. One patient was not classified using the new MI-CRONS classification due to history of bladder exstrophy and augmentation cystoplasty. Most of the men studied had a stress form of urinary incontinence and the most common types were 2 (n = 18) and 3 (n = 17) after radical prostatectomy.</p></div><div><h3>Conclusion:</h3><p>The MI-CRONS has demonstrated prompt potential for classifying male incontinence of any type. The classification is a simple tool to describe these patients and could be useful for daily practice and clinical trials. Although further multicenter studies are needed to evaluate the predictive value of this tool. A Delphi consensus would be proposed with international experts for the further development of MI-CRONS.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"10 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277297452400005X/pdfft?md5=f613bd39056ae9a946f9fec66a8028b7&pid=1-s2.0-S277297452400005X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140951939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The durability of filter cap for OT-Balloon catheter, a novel urethral catheter for intermittent balloon catheterization 用于间歇性球囊导尿的新型尿道导管 OT-Balloon 导管过滤帽的耐用性
Continence Reports Pub Date : 2024-05-04 DOI: 10.1016/j.contre.2024.100049
Tomofumi Watanabe , Motoo Araki , Takuya Sadahira
{"title":"The durability of filter cap for OT-Balloon catheter, a novel urethral catheter for intermittent balloon catheterization","authors":"Tomofumi Watanabe ,&nbsp;Motoo Araki ,&nbsp;Takuya Sadahira","doi":"10.1016/j.contre.2024.100049","DOIUrl":"https://doi.org/10.1016/j.contre.2024.100049","url":null,"abstract":"<div><h3>Objective:</h3><p>The OT-Balloon Catheter is a novel urethral catheter designed for intermittent balloon catheterization. It has a filter permeable to gases but not liquids, enabling patients to confirm adequate catheterization without the flow of urine. This study examined the characteristics of the filter cap for OT-Balloon Catheter by repeatedly exposing filters to urine samples in 2 different conditions.</p></div><div><h3>Methods:</h3><p>Urine samples were collected from 10 patients who required clean intermittent catheterization and visited Okayama University Hospital in 2023. Filters of the cap for OT-Balloon Catheter were exposed to urine samples for 30 times under 2 conditions, as follows: condition A, filters were rinsed with running water after exposure to urine; condition B, filters were never rinsed throughout the experiment. The permeability of the filters during and after the exposure was examined. The filter surface was also analyzed by stereomicroscopy.</p></div><div><h3>Results:</h3><p>None of the filters were blocked after treatment in condition A. More than 50% of the filters remained permeable after 20 and 30 exposures even in condition B. Long-term storage did not lead to increased rates of blockage. Microscopic examination found minimal urine stains on the surface of filters under condition B.</p></div><div><h3>Conclusion:</h3><p>The filter cap for OT-Balloon Catheter was resistant to blockage and maintained permeability after exposure to urine when adequately rinsed, and also when never rinsed after exposure to most samples. The durable permeability of the filter enables patients to achieve rapid, safe, and easy intermittent balloon catheterization.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"10 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000036/pdfft?md5=e662ac292e2f002269604f07161018df&pid=1-s2.0-S2772974524000036-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140902380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Carbamazepine in the treatment of refractory secondary enuresis: A case report 卡马西平治疗难治性继发性遗尿症的疗效:病例报告
Continence Reports Pub Date : 2024-04-23 DOI: 10.1016/j.contre.2024.100048
Andretta Elena , Rosato Eleonora , Zuliani Cristina , Finazzi Agrò Enrico
{"title":"Effectiveness of Carbamazepine in the treatment of refractory secondary enuresis: A case report","authors":"Andretta Elena ,&nbsp;Rosato Eleonora ,&nbsp;Zuliani Cristina ,&nbsp;Finazzi Agrò Enrico","doi":"10.1016/j.contre.2024.100048","DOIUrl":"10.1016/j.contre.2024.100048","url":null,"abstract":"<div><p>A 42-year-old woman was referred by neurology colleagues to our outpatient urology clinics. She presented with a non-monosymptomatic secondary enuresis, which started at 20 years of age When she was twenty-two she presented a single episode of a generalised tonic-clonic seizure, and she was treated with Carbamazepine (CBZ) with resolution of enuresis that reappeared when CBZ was stopped. Therefore, a video-EEG was performed, which documented an episode of enuresis during stage 1 of non-REM sleep without epileptic discharges and made it difficult for the patient to reach the deeper stages of sleep. According to these findings, the epileptic genesis of the enuresis was ruled out. A urodynamic invasive study was performed, and a normal active bladder associated with sleep disturbances was diagnosed as the combined cause of the non-monosymptomatic secondary nocturnal enuresis.</p><p>Behavioural therapy and/or antimuscarinic treatments, alone or in combination, were used without success. Then the patient restarted CBZ at a low dose (200 mg/day), and a significant reduction of enuresis episodes (1 wet night every 9–10) was obtained with no changes in the bladder diary.</p><p>CBZ effectiveness in such a case on an overactive bladder (OAB) could depend on its modulating effect in the central nervous system.</p></div>","PeriodicalId":100330,"journal":{"name":"Continence Reports","volume":"10 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772974524000024/pdfft?md5=f651adaa32d43bc20791989f8dbe9f03&pid=1-s2.0-S2772974524000024-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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