Clinical Surgical Oncology最新文献

{"title":"Pleomorphic dermal sarcoma. UK multidisciplinary team members have wide variation in opinions on management and pathways","authors":"Carrie Newlands ,&nbsp;Elizabeth Gruber ,&nbsp;Franel Le Grange ,&nbsp;Rajiv Anand ,&nbsp;Simon Whitley ,&nbsp;Stephen Keohane","doi":"10.1016/j.cson.2024.100061","DOIUrl":"10.1016/j.cson.2024.100061","url":null,"abstract":"<div><h3>Background</h3><div>Pleomorphic Dermal Sarcoma (PDS) is increasing in incidence and evidence-based guidelines as to optimal management are lacking. It is unclear from guidance which cancer MDTs should be involved in the care of patients with PDS and there is anecdotally widespread variation in patient pathways and management.</div></div><div><h3>Objective</h3><div>To determine current pathways and opinions regarding management of PDS amongst members of relevant UK MDTs.</div></div><div><h3>Methods</h3><div>A survey was devised, piloted, and circulated to MDT members, via national organisations. Responses were analysed using online SurveyMonkey tools.</div></div><div><h3>Results</h3><div>105 consultant members of a relevant MDT responded, including 19 skin and 2 sarcoma MDT Chairs. There was widespread variation in referral pathways, with 25.7% of participants reporting no sarcoma MDT involvement in a hypothetical case of a patient with a 2.1 ​cm primary PDS of the scalp, with no clinically apparent regional or distant metastases (N0M0). Opinions on the correct peripheral and deep surgical excision margins (PM/DM) varied, with the majority choosing a 10 ​mm PM (53.3%). Taking periosteum as the deep margin was preferred by 50.5%. Histological clearance margins of at least 5 ​mm at the PM and at least 1 ​mm at the DM were preferred by 33.3% of participants and deemed to be acceptable as definitive treatment. Imaging at diagnosis and for surveillance showed wide variation, with 24.8% not offering any imaging at diagnosis, in the above case.</div></div><div><h3>Conclusions</h3><div>PDS pathways and clinical management have been shown to vary widely amongst UK MDT members. A modified Delphi study is proposed to develop consensus-based guidance.</div></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 4","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognosis and adjuvant chemotherapy in KRAS mutation patients with stage I lung adenocarcinoma","authors":"Shangshang Ma ,&nbsp;Kun Li ,&nbsp;Rangrang Wang ,&nbsp;Jiayi Qian ,&nbsp;Yongfei Fan ,&nbsp;Xichun Qin ,&nbsp;Mingjun Li ,&nbsp;Leilei Wu","doi":"10.1016/j.cson.2024.100069","DOIUrl":"10.1016/j.cson.2024.100069","url":null,"abstract":"<div><h3>Background</h3><div>Adjuvant chemotherapy (ACT) remains the current first-line systemic treatment option for patients with <em>KRAS</em>-mutated lung adenocarcinoma (LUAD), but the response is not effective. The prognosis of ACT in patients with <em>KRAS</em> mutations in stage I LUAD has not yet been effectively explored.</div></div><div><h3>Methods</h3><div>Detailed data about patients with stage I LUAD from Shanghai Pulmonary Hospital were collected in this ambispective study. Pearson's Chi-square test, Kaplan-Meier analysis, and Cox proportional hazard models were performed in this study. The primary observational endpoint was overall survival (OS). Sensitivity analysis was performed to assess the robustness of the findings.</div></div><div><h3>Results</h3><div>In this study population, 10.87% (194 out of 1783) of stage I LUAD patients possessed <em>KRAS</em> mutations. In the <em>KRAS</em>-mutated cohort, 7 patients harbored <em>EGFR L858R</em> point mutation, 2 patients exhibited <em>EGFR exon 19 Del</em> mutation, 2 patients had <em>ALK</em> rearrangement, and 1 patient for other <em>EGFR</em> mutations. Patients harboring <em>KRAS</em> mutations had a worse OS compared to <em>KRAS</em> wild-type (WT) patients (5-year OS rate: 96% <em>vs.</em> 82%, <em>P</em> ​&lt; ​0.001). In addition, the <em>KARS(G12C)</em> mutation was an independent factor for poor prognosis (<em>P</em> ​&lt; ​0.001). Importantly, ACT improved survival in patients with stage IB LUAD (<em>P</em> ​= ​0.02) while not improved survival in the group of stage IB patients with <em>KRAS</em> mutations (<em>P</em> ​= ​0.31).</div></div><div><h3>Conclusions</h3><div><em>KRAS</em> mutation could co-occur with <em>EGFR</em> mutation and <em>ALK</em> rearrangement. <em>KRAS</em> mutation was associated with poor prognosis in stage I LUAD patients. In addition, ACT did not improve prognosis in stage IB LUAD patients with <em>KRAS</em> mutations. Our findings require more research to be confirmed.</div></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 4","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between expression of p53 protein in breast cancer and axillary lymph node metastasis","authors":"Zhang Fang","doi":"10.1016/j.cson.2024.100067","DOIUrl":"10.1016/j.cson.2024.100067","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the expression of p53 protein in cancer tissue of breast cancer, analyze the relationship between positive rate of expression of p53 protein and axillary lymph node status.</div></div><div><h3>Method</h3><div>137 breast cancer patients in general hospital of PLA from June 2023 to October 2023 were selected and divided into axillary lymph node metastasis group and non-axillary lymph node metastasis group according to routine pathological outcome after surgery. Detect the situation of expression of p53 protein in cancer tissue using immunohistochemical method. The rate of expression of p53 protein between axillary lymph node metastasis group and non-axillary lymph node metastasis group were compared by χ2 test. At the same time, the relationship between the expression of p53 protein in breast cancer tissue and the age, the longest tumor diameter and tumor TNM stage was analyzed.</div></div><div><h3>Result</h3><div>The rate of expression of p53 protein was 60.78%, 43.02% in the axillary lymph node metastasis group and non-axillary lymph node metastasis group respectively. The difference was statistically significant (χ2 ​= ​4.040, P ​= ​0.044＜0.05). The expression of p53 protein in breast cancer tissue was of no relationship with age (P ​= ​0.945＞0.05),the longest tumor diameter (P ​= ​0.200＞0.05) and tumor TNM stage (P ​= ​0.300 ​&gt; ​0.05).</div></div><div><h3>Conclusion</h3><div>There was a close relationship between expression of p53 protein in breast cancer tissue and axillary lymph node metastasis, and it can be regard as a predictive factor in the axillary lymph node status.</div></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 4","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the challenges of primary angiosarcoma of the breast: Comprehensive review and a case report","authors":"Mengjia Han ,&nbsp;Xiaoyun Xiao ,&nbsp;Zhuo Wu ,&nbsp;Wei Wu ,&nbsp;Junwei Cui ,&nbsp;Zijia Lai ,&nbsp;Zilin Zhuang ,&nbsp;Bingbing Ma ,&nbsp;Rong Lei ,&nbsp;Cui tan ,&nbsp;Yan Nie","doi":"10.1016/j.cson.2024.100062","DOIUrl":"10.1016/j.cson.2024.100062","url":null,"abstract":"<div><div>Primary angiosarcoma of the breast (PBA), comprising less than 1% of all malignant breast tumors, presents challenges in both diagnosis and management. Given the unclear pathogenesis, consensus on the optimal treatment for primary angiosarcoma is lacking. Surgery remains the mainstay of management, while the role of adjuvant therapies remains controversial. Here, we present a case of primary angiosarcoma in a teenager with thalassemia. Following complete surgical excision, the patient could not to complete the full course of chemotherapy due to an intolerable side effect. Nonetheless, the patient remained free of recurrence or metastasis during the 1-year follow-up period. This case underscores the importance of thorough tumor removal in the management of primary angiosarcoma, emphasizing the need for interdisciplinary collaboration to refine treatment strategies and customize optimal approaches for individual patients. We also comprehensively reviewed a large body of literature and relevant data on the epidemiology, molecular mechanisms, and clinical treatment of PBA, in order to provide a better understanding of this disease.</div></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 4","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143166221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global disparities in surgical oncology: Bridging the gap in cancer care a challenge to overcome","authors":"Emmanuel Zappettini","doi":"10.1016/j.cson.2024.100060","DOIUrl":"10.1016/j.cson.2024.100060","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 4","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of weight and volume of modified radical mastectomy specimen with ptosis of breast in patients of breast cancer","authors":"Bhawani Pathak ,&nbsp;Rajender Kumar Karwasra","doi":"10.1016/j.cson.2024.100064","DOIUrl":"10.1016/j.cson.2024.100064","url":null,"abstract":"<div><h3>Background</h3><div>Preoperative assessment of breast features is indispensable for both cosmetic and reconstructive breast surgical procedures. In this study we aim to investigate the effect of breast ptosis on breast volume estimation by various methods.</div></div><div><h3>Methods</h3><div>Fifty patients of breast cancer planned for modified radical mastectomy were taken up. Preoperatively breast anthropometric measurement taken, grade of ptosis was noted and breast volume was calculated by anthropometry and mammography and intraopratively mastectomy specimen weight and volume was recorded. Breast volume calculated by mammography and anthropometry compared with mastectomy specimen volume and weight and correlation with ptosis was statistically analyzed.</div></div><div><h3>Results</h3><div>Mastectomy specimen volume showed best agreement with mastectomy specimen weight (r ​= ​.993, &lt;.001), followed by mammographic method (r ​= ​.985, P ​&lt; ​.001), anthropometry by breast circumference in supine method (r ​= ​.982, P ​&lt; ​.001), anthropometry by breast circumference in upright method (r ​= ​.979, P ​&lt; ​.001) and anthropometry by breast radius and mammary projection method (r ​= ​.969, P ​&lt; ​.001).</div></div><div><h3>Conclusion</h3><div>Mammography is simple, cost effective and most accurate method for breast volume estimation followed by anthropometric breast volume calculation. As size of breast and grade of breast ptosis increases the accuracy of all methods of breast volume estimation decreases.</div></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 4","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First successful laparoscopic pancreaticoduodenectomy in Bangladesh: Surgical procedure and operation outcome","authors":"Md Ismail Gazi ,&nbsp;Mohammad Salauddin Mia ,&nbsp;Mohammad Emrul Hasan Khan","doi":"10.1016/j.cson.2024.100065","DOIUrl":"10.1016/j.cson.2024.100065","url":null,"abstract":"<div><div>In October 2023, the first laparoscopic pancreaticoduodenectomy (LPD) operation was successfully conducted in Bangladesh. This case study reported the surgical technique and outcomes of Bangladesh's first LPD procedure. The patient was a 55-year-old male patient with the diagnosis of periampullary carcinoma. He underwent a classical LPD lasting 360 ​min with a blood loss of 170 ​ml. Postoperatively, he experienced no major complications such as pancreatic fistula or bile leakage but developed atelectasis, which was managed effectively. His postoperative pain, assessed on a scale from 0 to 5, significantly reduced from day 3 (score 3) to day 7 (score 1). Histological examination confirmed adenocarcinoma at the ampullary site, with an R0 resection margin achieved. Sixteen lymph nodes were retrieved, none of which showed involvement. His hospital stay was 10 days, and he returned to work 14 days post-discharge. This operation marks a significant milestone in advancing surgical practices in Bangladesh. The successful completion of the first LPD in Bangladesh demonstrated the procedure's feasibility, safety, and potential benefits in a similar resource-limited setting.</div></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 4","pages":"Article 100065"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized surgical approach based on Bismuth-Corlette classification for perihilar cholangiocarcinoma","authors":"I-Chin Lee ,&nbsp;Björn-Ole Stüben ,&nbsp;Mohammad Fard-Aghaie ,&nbsp;Anastasios Giannou ,&nbsp;Tarik Ghadban ,&nbsp;Asmus Heumann ,&nbsp;Jun Li","doi":"10.1016/j.cson.2024.100057","DOIUrl":"10.1016/j.cson.2024.100057","url":null,"abstract":"<div><p>Perihilar cholangiocarcinoma, a formidable adversary in the field of hepatobiliary surgery, presents multifaceted challenges. This paper reviews its historical context, classification criteria, and regional variations in definition. It emphasizes the critical role of preoperative assessment, including hepatic hilum anatomy, biliary infiltration characteristics, and residual liver volume evaluation. The impact of the Bismuth-Corlette classification on surgical approach selection is elucidated, providing insights into tailored surgical options for each subtype based on the authors’ center experience in the last ten years. The article also touches upon laparoscopic and robotic surgery potential, underscoring the need for further research in this domain. Finally, it explores the potential role of liver transplantation as a treatment option for select patients ineligible for conventional surgery.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 3","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000254/pdfft?md5=6d80f38e00063e26d79cf9abf67d9bf0&pid=1-s2.0-S2773160X24000254-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid biopsy for monitoring minimal residual disease in colorectal cancer: A promising approach with clinical implications","authors":"Zhexue Wang ,&nbsp;Junge Bai ,&nbsp;Dedi Jiang ,&nbsp;Yuegang Li ,&nbsp;Xiyue Hu ,&nbsp;Sergey Efetov ,&nbsp;Yu Cao ,&nbsp;Cuneyt Kayaalp ,&nbsp;Audrius Dulskas ,&nbsp;Darcy Shaw ,&nbsp;Ming Yang ,&nbsp;Zheng Liu ,&nbsp;Xishan Wang","doi":"10.1016/j.cson.2024.100056","DOIUrl":"10.1016/j.cson.2024.100056","url":null,"abstract":"<div><p>Colorectal cancer (CRC) is a global health concern, ranking among the leading causes of cancer-related mortality. This review critically evaluates the role of liquid biopsy in detecting minimal residual disease (MRD) in CRC. The increasing incidence, particularly in China, highlights the urgency of innovative approaches for early prediction of recurrence and metastasis. The importance of MRD should be underscored as residual tumor cells post-treatment significantly impact patient prognosis. Liquid biopsy methods, including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), exosomes, and circulating tumor RNA, are dissected for their potential in identifying molecular markers associated with CRC. The focus on ctDNA highlights its non-invasive nature, real-time monitoring capabilities, and superiority over traditional detection methods in terms of sensitivity and timeliness. The review also delves into the limitations, such as clonal hematopoiesis and the critical consideration of optimal timing for postoperative ctDNA detection. In conclusion, the review highlights the significant potential of liquid biopsy, particularly ctDNA, as a dynamic and non-invasive tool for MRD detection in CRC. By complementing traditional methods, liquid biopsy contributes to precision in tumor research and personalized treatment. These advancements offer promising avenues for improving CRC patient prognosis and tailoring individualized treatment strategies.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 3","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000242/pdfft?md5=7deada45477b79742f5dd072adc52c92&pid=1-s2.0-S2773160X24000242-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical frontiers in metastatic disease: Shaping cancer care","authors":"Mark Alexander Taylor","doi":"10.1016/j.cson.2024.100055","DOIUrl":"10.1016/j.cson.2024.100055","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 3","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000230/pdfft?md5=c54e844c551ffe0fc5feb7e4e95c9213&pid=1-s2.0-S2773160X24000230-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}