Clinical Surgical Oncology最新文献

{"title":"Langer's arch?","authors":"Georgi P. Georgiev","doi":"10.1016/j.cson.2024.100049","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100049","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 2","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000175/pdfft?md5=b5988e711570db73eef883a9d0be9f30&pid=1-s2.0-S2773160X24000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141292319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparation of single or staged surgical management in acute obstructive non-metastatic colorectal cancer patients aged over 75","authors":"Jian Cui ,&nbsp;Jinxin Shi ,&nbsp;Hao Feng ,&nbsp;Danian Tang ,&nbsp;Xianglong Cao ,&nbsp;Wenrui Xu ,&nbsp;Zijian Li ,&nbsp;Tao Yu ,&nbsp;Chunlong Wang ,&nbsp;Qi An ,&nbsp;Gang Zhao","doi":"10.1016/j.cson.2024.100048","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100048","url":null,"abstract":"<div><h3>Purpose</h3><p>Management of obstructive colorectal cancer (OCRC) can be achieved through either emergent resection of the primary tumor (single operation), or the creation of temporary decompression stoma or self-expandable metallic stents (SEMS) insertion followed by tumor resection (staged procedure). The aim of the study was to compare the short-term outcomes of single and staged surgery in acute non-metastatic elderly OCRC patients.</p></div><div><h3>Methods</h3><p>Twenty-two elderly patients (aged over 75) scheduled to receive either single surgery (n ​= ​14) or staged surgery (n ​= ​8) for the management of acute OCRC were enrolled from 2012 to 2017. The stoma rate, postoperative complications were compared.</p></div><div><h3>Results</h3><p>The stoma rate was 42.9% in single surgery group and 25% in SEMS group. No difference was found in the rate of total complications (50% vs 25%, <em>P</em> ​= ​0.25). In the single surgery group, four patients (28.6%) experienced SSIs, and pneumonia occurred in three patients (21.4%), whereas none of the patient in staged surgery had infection related complication. Overall, the rate of infection related complication in single surgery group (50%) was significantly higher than that in staged surgery group (P ​= ​0.015).</p></div><div><h3>Conclusions</h3><p>Either single or stage surgery is feasible for acute elderly OCRC patients. However, single surgery is associated with significant increase in infection related complication.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 2","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000163/pdfft?md5=d4673fd94bd826626e1ea68c4af3a90e&pid=1-s2.0-S2773160X24000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of non-colorectal non-neuroendocrine liver oligometastases: Sarcoma, breast, gastric, and pancreatic cancers","authors":"Huda Muhammad,&nbsp;Brendan Visser","doi":"10.1016/j.cson.2024.100047","DOIUrl":"10.1016/j.cson.2024.100047","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 2","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000151/pdfft?md5=462d00407e9a50d1c722b1f0c746a871&pid=1-s2.0-S2773160X24000151-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of preoperative biliary drainage on the outcomes of surgical treatment in cholangiocarcinoma: A propensity score matching analysis","authors":"Poowanai Sarkhampee ,&nbsp;Sunhawit Junrungsee ,&nbsp;Apichat Tantraworasin ,&nbsp;Pongserath Sirichindakul ,&nbsp;Weeris Ouransatien ,&nbsp;Satsawat Chansitthichok ,&nbsp;Nithi Lertsawatvicha ,&nbsp;Paiwan Wattanarath","doi":"10.1016/j.cson.2024.100046","DOIUrl":"10.1016/j.cson.2024.100046","url":null,"abstract":"<div><h3>Background</h3><p>Hyperbilirubinemia is known to increase morbidity and mortality in patients undergoing liver resection for cholangiocarcinoma (CCA). Preoperative biliary drainage (PBD) in patients who have no acute cholangitis or require portal vein embolization is still debatable. The goal of this study is to investigate how PBD affects the surgical results after liver resection.</p></div><div><h3>Methods</h3><p>Between October 2013 and December 2020, CCA patients presenting with obstructive jaundice who underwent liver resection were retrospectively reviewed. The pre-operative, peri-operative and post-operative characteristics were extracted. To compare the outcomes of the PBD and direct surgery groups, propensity score matching analysis (PSM) and multivariable risk regression analysis were used to analyze.</p></div><div><h3>Results</h3><p>A total of 355 patients were enrolled, with 99 of them undergoing PBD. At diagnosis, those with PBD showed significantly greater bilirubin levels than those without (20.7 vs 9.6 ​mg/dL, p ​&lt; ​0.001). However, after drainage, the bilirubin level in the PBD group was lower than the direct surgery group (5.5 vs 9.6 ​mg/dL, p ​&lt; ​0.001). Overall postoperative morbidity and mortality were unaffected by PBD in full patient cohort. However, after PSM, PBD was associated with decreased major post-hepatectomy liver failure (PHLF) and 90-day mortality rate, (20.3% vs 39.24%, p ​= ​0.014 and 3.8% vs 22.8%, p ​= ​0.001, respectively). At multivariable analysis of PSM patient cohort, PBD was associated with decreased major post-operative complication (RR 0.64, 95%CI 0.419–0.986), PHLF (RR 0.40, 95%CI 0.227–0.705) and 90-day mortality (RR 0.21, 95%CI 0.086–0.629).</p></div><div><h3>Conclusion</h3><p>PBD was associated with decreased post-hepatectomy liver failure and postoperative mortality after liver resection in jaundiced CCA patients.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 2","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X2400014X/pdfft?md5=a80a5d767d9fdb0cb84a2b2fa0857b4e&pid=1-s2.0-S2773160X2400014X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of free flap reconstruction after resection of extremity and trunk soft tissue sarcomas. Results of two referral centers in Argentina","authors":"Sergio D. Quildrian ,&nbsp;Walter S. Nardi ,&nbsp;María G. Vega ,&nbsp;Jorge A. Chapela","doi":"10.1016/j.cson.2024.100042","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100042","url":null,"abstract":"<div><h3>Introduction</h3><p>For patients affected by extremity or trunk soft-tissue sarcomas (STS) large resections might be needed to achieve negative margins. This is a common scenario especially in locally advanced or recurrent tumors often within a pre-irradiated field. The objective of this study was to evaluate the results of free-flap reconstructions (FFR) after sarcoma surgery.</p></div><div><h3>Objective</h3><p>The endpoints were surgical results, quality of surgical margins and oncological outcome.</p></div><div><h3>Methods</h3><p>Retrospective analysis of patients with extremity and trunk STS with free-flap reconstruction between 2008 and 2022. Demographic and tumor data, perioperative treatment, margin status, morbidity and evolution were evaluated.</p></div><div><h3>Results</h3><p>Of 467 patients, 25 (5.35%) required 26 free-flap reconstructions. Surgery was performed on an irradiated field in 8 (32%) patients. Reconstructions were mostly needed for distal lower extremity resections and the most common type of flap used was antero-lateral tight (ALT) flap. No R2 resections were performed. R0 and R1 resections were achieved in 22 (84.6%) and 4 (15.4%), respectively. All R1 resections were preplanned positive along a preserved critical structure. Surgical morbidity rate was 26% (7/26) and the re-operation rate was 15% (4/26) with 7.7% flap losses (2/26). At a median follow-up of 38 months, 7 (28%) patients presented local recurrences.</p></div><div><h3>Conclusion</h3><p>In a referral sarcoma center, having a multidisciplinary surgical team capable of complex resections and reconstructions is of utmost importance for a correct and integral surgical planning. This allows optimal oncologic resections with acceptable morbidity.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 2","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000102/pdfft?md5=6d17535901518222a974c5e50a578554&pid=1-s2.0-S2773160X24000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140647220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of patients with liposarcoma: A retrospective review over 12 ​Years in a single center","authors":"Teck Liang Tie,&nbsp;Suryasmi Duski","doi":"10.1016/j.cson.2024.100043","DOIUrl":"10.1016/j.cson.2024.100043","url":null,"abstract":"<div><h3>Background</h3><p>Liposarcoma is the most common soft tissue sarcoma, which comprises around 20% of soft tissue sarcoma. While diverse therapeutic approaches exist for liposarcoma, the primary goal remains the achievement of effective local disease control. Wide resection of liposarcoma is the cornerstone of treatment. Radiotherapy is often employed as an adjuvant measure to enhance the local disease control. At Hospital Kuala Lumpur, the treatment protocol includes R0 resection and followed by adjuvant radiotherapy. This study aims to review the demographic characteristic of liposarcoma patients and evaluate the efficacy of their treatment based on the treatment protocol.</p></div><div><h3>Method and material</h3><p>This is a retrospective cohort study. A total of 72 patients (male/female ​= ​43/29) were included in this study. Recorded parameters included the histologic subtype, tumor location, treatment modality, resection margin, radiotherapy status, and occurrences of local recurrence and metastasis.</p></div><div><h3>Result</h3><p>Histopathological examination revealed a varied spectrum of liposarcoma subtypes, with the predominant subtype being atypical lipomatous tumor (n ​= ​35), followed by myxoid liposarcoma (n ​= ​32), two cases of dedifferentiated liposarcoma, and three cases of pleomorphic liposarcoma. Of these patients, 69 underwent resection, while three necessitated amputations. Total 62 achieving negative and 10 cases had R1 margins. Adjuvant radiotherapy was administered in 58 cases. Overall, the local recurrence was observed in only six cases.</p></div><div><h3>Conclusion</h3><p>This study emphasizes that achieving R0 resection is the fundamental approach in the treatment of liposarcoma and is able to minimize the risk of local recurrence.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 2","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000114/pdfft?md5=9a7e709be8275846f088f8a25dacb874&pid=1-s2.0-S2773160X24000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140766881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide analysis of the breast cancer guidelines adherence in Bulgaria","authors":"Dobromir Dimitrov ,&nbsp;Iskra Daskalova ,&nbsp;Ivelina Petrova ,&nbsp;Meri Shoshkova ,&nbsp;Tsanko Yotsov ,&nbsp;Damyan Boychev ,&nbsp;Tihomir Andreev ,&nbsp;Nikolai Ramadanov ,&nbsp;Martin Karamanliev","doi":"10.1016/j.cson.2024.100044","DOIUrl":"10.1016/j.cson.2024.100044","url":null,"abstract":"<div><h3>Introduction</h3><p>The diagnosis and treatment of breast cancer have tremendously changed in the last decades improving the survival and quality of life of the patients. Adherence to clinical practice guidelines in oncology significantly improves patients’ recurrence-free and overall survival. Nowadays, no national registry/database for breast cancer patients is available. This study aims to perform a nationwide analysis of the breast cancer guidelines adherence in Bulgaria, in particular regarding the diagnostic methods for histological confirmation and the types of radical surgery performed using an artificial intelligence (AI) powered software.</p></div><div><h3>Materials and methods</h3><p>We analyzed data from January 2019 to August 2023 nationwide using the platform with access to anonymized medical information from Bulgaria's leading territorial oncology hospitals. A total of 13,790 patients met the inclusion criteria.</p></div><div><h3>Results</h3><p>The gold standard diagnostic tool, CNB, was done in 5427 patients (39.35%), an intraoperative frozen section was performed as a method for confirmation of breast cancer in 6257 patients (45.37%) and the standard technique for lymph node evaluation, sentinel lymph node biopsy, was done in 357 patients (2.99%).</p></div><div><h3>Conclusion</h3><p>In Bulgaria, there are still difficulties in achieving comparable rates of core-needle biopsy for the diagnosis of breast cancer and we have demonstrated unacceptably high rates of frozen section use for intraoperative diagnosis of breast cancer. Breast-conserving surgery is widely accepted and available, but still, the rates are lower than usual for developed countries. The rates of sentinel lymph node biopsy, however, are unreasonably low.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 2","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000126/pdfft?md5=515dd0a0605a48fa490612aebfb3e8a8&pid=1-s2.0-S2773160X24000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (V. 2023)” [Clin. Surg. Oncol. 2 (2023) 100013]","authors":"Li Ren ,&nbsp;Dexiang Zhu ,&nbsp;Jin Gu ,&nbsp;Baoqing Jia ,&nbsp;Jin Li ,&nbsp;Xinyu Qin ,&nbsp;Xishan Wang ,&nbsp;Ruihua Xu ,&nbsp;Yingjiang Ye ,&nbsp;Suzhan Zhang ,&nbsp;Zhongtao Zhang ,&nbsp;Jianmin Xu ,&nbsp;Jia Fan ,&nbsp;China CRLM Guideline Group,&nbsp;Chinese College of Surgeons, Chinese Medical Doctor Association,&nbsp;Section of Gastrointestinal Surgery, Branch of Surgery, Chinese Medical Association,&nbsp;Section of Colorectal & Anal Surgery, Branch of Surgery, Chinese Medical Association,&nbsp;Colorectal Cancer Professional Committee, Chinese Anti-Cancer Association,&nbsp;Colorectal Cancer Professional Committee, Chinese Medical Doctor Association,&nbsp;Colorectal Cancer Expert Committee, Chinese Society of Clinical Oncology,&nbsp;Chinese Society of Colon & Rectal Surgeons, Chinese College of Surgeons, Chinese Medical Doctor Association,&nbsp;Metastasis Research Committee, Anorectal Branch of Chinese Medical Doctor Association,&nbsp;Colorectal Oncology Group, Branch of Oncology, Chinese Medical Association,&nbsp;Metastatic Tumor Therapy Branch of China International Exchange and Promotive Association for Medical and Health Care,&nbsp;Colorectal Disease Branch of China International Exchange and Promotive Association for Medical and Health Care","doi":"10.1016/j.cson.2024.100039","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100039","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000072/pdfft?md5=716731643ffb962e6432a3e7938503ec&pid=1-s2.0-S2773160X24000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation therapy of renal cell carcinoma skeletal metastases – Does histologic subtype predict progression?","authors":"Kavin Sundaram ,&nbsp;Joshua M. Lawrenz ,&nbsp;Precious C. Oyem ,&nbsp;Aditya Banerjee ,&nbsp;Shannon Wu ,&nbsp;Paras Shah ,&nbsp;Shireen Parsai ,&nbsp;Chirag Shah ,&nbsp;Nathan W. Mesko ,&nbsp;John Reith ,&nbsp;Lukas M. Nystrom","doi":"10.1016/j.cson.2024.100040","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100040","url":null,"abstract":"<div><h3>Introduction</h3><p>This investigation assessed whether the following factors were associated with radiographic local progression in bone metastases from renal cell carcinoma (RCC): (1) high-risk histologic features (2) lesional surgery (3) biologically effective dose (BED) of radiation therapy.</p></div><div><h3>Methods and materials</h3><p>A single-institution database identified all patients who underwent surgery and radiation therapy for bone metastases from RCC to the appendicular skeleton and pelvis from 2006 to 2016. Thirty-six patients underwent radiotherapy for 80 metastases. While all patients had surgical stabilization, 17/36 also had lesional surgery to address the metastatic lesion. Progression of each individual lesion was determined using the application of RECIST criteria to imaging at last follow-up.</p></div><div><h3>Results</h3><p>The rate of progressive disease was 8/25 (32%) in the high-risk group versus 5/55 (9%) in the standard-risk group (p ​= ​0.019). The rate of progression among high-risk metastases undergoing lesional surgery was 0/9 versus 8/16 (50%) having non-lesional surgery (p ​= ​0.0218). The rate of progression among standard-risk metastases undergoing lesional surgery was 1/16 (6%) versus 4/39 (10%) with non-lesional surgery (p ​= ​1.00). High-risk histologic features (OR: 10.592, 95% confidence interval: 1.347–83.271, p ​= ​0.025) and as well as a reduction in risk with every additional Gray of BED (OR: 0.902, 95% confidence interval: 0.827–0.984, p ​= ​0.021) were found to predict progressive disease.</p></div><div><h3>Conclusions</h3><p>Bone metastases from renal cell carcinoma with high-risk histologic features are associated with less favorable response to radiotherapy than those with standard-risk histology. Delivery of a higher BED was associated with lower odds of progression.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000084/pdfft?md5=aea0076e2d0d2be703db1b01c4dfab5a&pid=1-s2.0-S2773160X24000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing statements in previously published articles","authors":"","doi":"10.1016/j.cson.2024.100041","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100041","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000096/pdfft?md5=d0437200b706eb597a20ca458ffa2dd4&pid=1-s2.0-S2773160X24000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}