CJC Pediatric and Congenital Heart Disease最新文献

{"title":"Isolated Left Subclavian Artery, Multiple Ventricular Septal Defects, and Pulmonary Hypertension in a Child: A Case Report","authors":"Mohammad Reza Khalilian MD , Manouchehr Hekmat MD , Saeed Sadr MD , Abdolhossein Tavallai-Zavvareh MD , Tahmineh Tahouri MD","doi":"10.1016/j.cjcpc.2024.07.001","DOIUrl":"10.1016/j.cjcpc.2024.07.001","url":null,"abstract":"","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need for Preoperative Prostaglandin E1 for d-Transposition After Balloon Atrial Septostomy","authors":"Thita Pacharapakornpong MD ,&nbsp;Linda Edwards MD ,&nbsp;Steven Rathgeber MD","doi":"10.1016/j.cjcpc.2024.08.004","DOIUrl":"10.1016/j.cjcpc.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><div>The necessity of prostaglandin E1 (PGE) usage before arterial switch operation (ASO) in infants with d-transposition of the great arteries (dTGA) after balloon atrial septostomy (BAS) remains controversial.</div></div><div><h3>Methods</h3><div>This study is a single-centre, retrospective review of infants with dTGA who underwent ASO from January 2014 to December 2021. Parameters analysed included post-BAS oxygen saturation, time from BAS to PGE discontinuation, necessity of reinitiation, interval before PGE restart, and lowest saturation before PGE reintroduction.</div></div><div><h3>Results</h3><div>Among the 35 cases of dTGA who underwent ASO, 31 (88%) required BAS, with 23 (65%) requiring PGE infusion. Of those 23 infants, 14 (60%) necessitated PGE reinitiation after discontinuation. A significant difference in post-BAS oxygen saturation was observed between the groups requiring PGE reinitiation (79.2% ± 4.7%) and those not needing reinitiation (89.0% ± 2.0%) (<em>P</em> &lt; 0.001). The relative risk for the reinitiation group with BAS oxygen saturation levels ≤80% was 2.5 (95% confidence interval: 1.3-4.6). No disparity was observed in postoperative outcomes or PGE adverse effects such as fever, apnoea, bradycardia, and congestive heart failure requiring diuretic between the groups.</div></div><div><h3>Conclusions</h3><div>Given no significant differences in PGE adverse effects and a 2.5 times higher risk of reinitiation with post-BAS saturation below 80%, maintaining PGE until saturation reaches 80% for a few days before discontinuation may help reduce the risk of rebound hypoxaemia.</div></div>","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards Understanding Deterioration in Systemic Right Ventricular Function in the Setting of Tricuspid Regurgitation: Is There a Point of No Return?","authors":"William A. McEachern MD, MPH, MSCI,&nbsp;Timothy C. Slesnick MD","doi":"10.1016/j.cjcpc.2024.08.003","DOIUrl":"10.1016/j.cjcpc.2024.08.003","url":null,"abstract":"","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Venous Pressure And NT-proBNP Phenotypes as Surrogates for Invasive Fontan Haemodynamics in Adults","authors":"William R. Miranda MD ,&nbsp;C. Charles Jain MD ,&nbsp;Heidi M. Connolly MD ,&nbsp;Alexander Van De Bruaene MD ,&nbsp;Gruschen R. Veldtman MBChB ,&nbsp;Alexander C. Egbe MD","doi":"10.1016/j.cjcpc.2024.07.003","DOIUrl":"10.1016/j.cjcpc.2024.07.003","url":null,"abstract":"<div><div>We hypothesized that phenotyping patients using a combination of resting peripheral venous pressure (PVP) and N-terminal pro–brain natriuretic peptide (NT-proBNP) would predict invasive Fontan haemodynamics. Accordingly, 35 adults with a history of Fontan palliation were categorized into 3 groups according to PVP and NT-proBNP values: normal, ↑NT-proBNP (≥300 pg/dL) or ↑PVP (≥15 mm Hg), and ↑PVP+↑NT-proBNP. Those in the normal values group universally had normal resting pulmonary artery wedge and Fontan pressures, with a single patient having abnormal exercise values; conversely, all patients in the ↑PVP+↑NT-proBNP group had increased resting Fontan or pulmonary artery wedge pressures, with those in the ↑NT-proBNP or ↑PVP group constituting an intermediate group.</div></div>","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic Assessment of Cardiac Function and Reserve Under Exercise in Post–COVID-19 Children: A Prospective Cross-sectional Study","authors":"Mikiko Harada MD, PhD,&nbsp;Tobias Engl,&nbsp;Katharina Köble MSc,&nbsp;Frauke Mühlbauer MD,&nbsp;Lisa Baumgartner MPH, PhD,&nbsp;Daniel Goeder MSc,&nbsp;Maximilian Dettenhofer MD,&nbsp;Renate Oberhoffer-Fritz MD, PhD","doi":"10.1016/j.cjcpc.2024.08.001","DOIUrl":"10.1016/j.cjcpc.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular impairment has been observed in adults with coronavirus disease 2019 (COVID-19), even in those with mild symptoms. Physical activity can reveal subtle cardiovascular dysfunction that is not apparent at rest. However, there are limited data on cardiovascular function in children and adolescents after the COVID-19 infection. This study aimed to assess cardiovascular function in paediatric and adolescent populations with a history of COVID-19 infection and controls by conducting 2-dimensional transthoracic echocardiography at rest (TTE-R) and exercise stress echocardiography (ESE).</div></div><div><h3>Methods</h3><div>We conducted TTE-R, including speckle tracking strain analysis of both ventricles, on 100 individuals (median age 12.3 years, 82% male), divided into 2 groups: 73 adolescents with COVID-19 infection and 27 controls. A subset of male participants (40 cases, 15 controls) underwent ESE combined with a cardiopulmonary exercise test (CPET-ESE) to examine the relationship between cardiovascular parameters and contractile reserve. Myocardial contractile reserve was evaluated by measuring the maximum increase in strain values during exercise.</div></div><div><h3>Results</h3><div>At rest, no signs of myocardial injury or inflammation were observed. Right and left ventricular contractility in the infected group were clinically equivalent to those in the controls. During CPET-ESE, peak oxygen consumption was similar between the infected and control groups. Furthermore, contractile reserve under exercise was similar in both groups.</div></div><div><h3>Conclusions</h3><div>We found no significant differences in left ventricular systolic and diastolic function and right ventricle systolic function evaluated by TTE-R between participants with a history of mild COVID-19 infection and controls. ESE provided insights for post–COVID-19 young people resuming activities and sports.</div></div>","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricuspid Regurgitation Stratification Predicts the Time Course of Systemic Right Ventricle Dysfunction Among Patients on ACE-I/ARB","authors":"Kohsaku Goto MD, PhD ,&nbsp;Katsura Soma MD, PhD ,&nbsp;Hiroyuki Tokiwa MD, PhD ,&nbsp;Masahiko Umei MD, PhD ,&nbsp;Akihito Saito MD, PhD ,&nbsp;Katsuhito Fujiu MD, PhD ,&nbsp;Ryo Inuzuka MD, PhD ,&nbsp;Yasutaka Hirata MD, PhD ,&nbsp;Norihiko Takeda MD, PhD ,&nbsp;Atsushi Yao MD, PhD","doi":"10.1016/j.cjcpc.2024.07.002","DOIUrl":"10.1016/j.cjcpc.2024.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Progressive systemic right ventricle (sRV) dysfunction is a significant challenge in adult congenital heart disease. Current guidelines do not specify effective heart failure medications for patients with sRV; however, previous studies have relied on semiquantitative assessments. The advancement of cardiac magnetic resonance (CMR) imaging as the gold-standard modality offers quantitatively accurate assessments even for complex cardiac anomalies. Therefore, we aimed to investigate prognostic factors associated with sRV dysfunction in patients on angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACE-I/ARB), using CMR-derived quantitative values.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of 17 adult patients with sRV treated with ACE-I/ARB and performed logistic regression analysis, with the primary outcome defined as sRV ejection fraction (sRVEF) deterioration.</div></div><div><h3>Results</h3><div>Over an average follow-up period of 68.7 months, sRVEF deterioration occurred in 3 patients (17%). Logistic regression analysis identified tricuspid regurgitation (TR) as a potential independent prognostic factor for the primary outcome (odds ratio = 1.11; 95% confidence interval, 1.00-1.31). Furthermore, patients with mild TR (TR fraction ≤15%; N = 12) experienced improvements in sRVEF between the initial and last CMR assessments (from 49.1% ± 8.4% to 56.7% ± 8.0%, <em>P</em> = 0.0029), with increased stroke volume from 68.2 ± 18.6 to 79.5 ± 17.2 mL (<em>P</em> = 0.0029). In contrast, these changes were not observed in patients with moderate or severe TR (TR fraction &gt;16%) (N = 5).</div></div><div><h3>Conclusions</h3><div>Our CMR-based evaluation highlights the potential utility of TR stratification in predicting the changes in sRVEF among patients with sRV on ACE-I/ARB. Future randomized controlled trials that consider TR severity are required to elucidate the significance of ACE-I/ARB therapy.</div></div>","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Cardiovascular Health in Paediatric Hypertrophic Cardiomyopathy Using the CANHEART Health Index","authors":"Victoria Srbely MSc ,&nbsp;Aamir Jeewa MD ,&nbsp;Tara Pidborochynski MSc ,&nbsp;Samuel Lemaire-Paquette MSc ,&nbsp;Michael Khoury MD ,&nbsp;Chentel Cunningham RN ,&nbsp;Santokh Dhillon MD ,&nbsp;Nassiba Alami Laroussi MD ,&nbsp;Laurence Vaujois MD ,&nbsp;Frederic Dallaire MD, PhD ,&nbsp;Daryl Schantz MD ,&nbsp;Kathryn Armstrong MD ,&nbsp;Wadi Mawad MD ,&nbsp;Timothy Bradley MD ,&nbsp;Jennifer Conway MD, MSc","doi":"10.1016/j.cjcpc.2024.06.002","DOIUrl":"10.1016/j.cjcpc.2024.06.002","url":null,"abstract":"<div><h3>Background</h3><div>Paediatric hypertrophic cardiomyopathy (HCM) is associated with sudden cardiac death, often resulting in restriction of strenuous physical activity. High levels of inactivity and a rise in youth obesity may increase risk of poor cardiovascular (CV) health in these patients. We aim to compare the CV disease risk profile of paediatric patients with HCM to Canadian youth.</div></div><div><h3>Methods</h3><div>Patients with HCM (10-19 years) were recruited from 10 paediatric cardiac centres in Canada. The CV disease risk profile was determined using the Healthy Hearts School Program questionnaire and Cardiovascular Health in Ambulatory Care Research Team (CANHEART) health index. Poisson regressions were used to assess associations between the CV disease risk profile of paediatric patients with HCM and the overall CANHEART health score.</div></div><div><h3>Results</h3><div>A total of 56 subjects were enrolled (71% male, median age: 15.5 years [interquartile range: 13.8-16.8], median body mass index: 23.3 [interquartile range: 19.5-27.7]). Results of the CANHEART health index revealed that 89% of participants with HCM never tried smoking, 52% had a healthy body mass index, 39% consumed ≥5 fruits/vegetables per day, and 50% engaged in ≥60 minutes of walking or 20 minutes of running/jogging per day. When CANHEART intermediate and poor health index scores were combined, similar proportions were obtained for each group (HCM 82.1% vs Canadian youth 83.4%; <em>P</em> = 0.724).</div></div><div><h3>Conclusions</h3><div>Many paediatric patients with HCM in Canada have intermediate or poor CV health as determined by the CANHEART health score, with high rates of obesity and low physical activity levels driving these trends. Interventions should be developed to promote positive CV health behaviours among patients with HCM.</div></div>","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2772-8129(24)00086-1","DOIUrl":"10.1016/S2772-8129(24)00086-1","url":null,"abstract":"","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Caregiver Learning and Experiences Caring for a Child With Heart Failure: A Qualitative Study","authors":"Chentel Cunningham MN, NP, PhD Candidate ,&nbsp;Jennifer Conway MD, MSc ,&nbsp;Ziad Zahoui BScN Student ,&nbsp;Mark Haykowsky PhD ,&nbsp;Shannon D. Scott PhD, RN","doi":"10.1016/j.cjcpc.2024.05.003","DOIUrl":"10.1016/j.cjcpc.2024.05.003","url":null,"abstract":"<div><h3>Background</h3><p>Paediatric heart failure poses life-long, burdensome symptoms for the health care system and families. Diagnosis and discharge are stressful and anxiety-provoking for caregivers. They face uncertainty about their child’s health and become responsible for administering complex care in the home. Little is known about this topic. Our study aimed to explore caregiver learning and experiences caring for a child with heart failure to design and implement a knowledge translation tool.</p></div><div><h3>Methods</h3><p>Qualitative description guided our study. Recruitment occurred in a tertiary cardiac centre in Edmonton, Alberta, Canada. Data collection and analysis occurred concurrently until data redundancy was achieved. Inductive conventional content analysis was used to develop categories.</p></div><div><h3>Results</h3><p>Eleven interviews identified 2 main categories. One relates to how traumatic life experiences impact learning (eg, new diverse ways of learning, stress steepens the learning curve, and learning heart failure takes time). The other relates to families’ new life reality after diagnosis (eg, emotional distress and the new reality).</p></div><div><h3>Conclusions</h3><p>This study provides insight into caregivers’ learning needs and experiences caring for a child with heart failure. Caregivers describe how the trauma of having their child diagnosed with heart failure negatively impacts their learning capabilities and way of life going forward. Caregiver learning experiences and preferences for digital platforms is also highlighted. This knowledge will inform the design of an online educational tool about pediatric heart failure for caregiver audiences. This tool will empower and improve caregiver decision-making related to their child’s daily heart failure management, with the goal to positively impact clincal outcomes, lessen stress and anxiety.</p></div>","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772812924000411/pdfft?md5=c311883fbc040a703d8ed6067c12c6db&pid=1-s2.0-S2772812924000411-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S2772-8129(24)00063-0","DOIUrl":"10.1016/S2772-8129(24)00063-0","url":null,"abstract":"","PeriodicalId":100249,"journal":{"name":"CJC Pediatric and Congenital Heart Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772812924000630/pdfft?md5=95fddde1884f1af6007c9a6da2d5e5ab&pid=1-s2.0-S2772812924000630-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}