Biomedicine & Preventive Nutrition最新文献_第3页

Effects of Tephrosia purpurea and Momordica dioica on streptozotocin-induced diabetic nephropathy in rats 紫荆、苦瓜对链脲佐菌素所致大鼠糖尿病肾病的影响

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.06.003

Avijeet Jain , Alok Nahata , Santram Lodhi , Abhay K. Singhai

{"title":"Effects of Tephrosia purpurea and Momordica dioica on streptozotocin-induced diabetic nephropathy in rats","authors":"Avijeet Jain , Alok Nahata , Santram Lodhi , Abhay K. Singhai","doi":"10.1016/j.bionut.2014.06.003","DOIUrl":"10.1016/j.bionut.2014.06.003","url":null,"abstract":"<div>Present study investigated the effects of Tephrosia purpurea (TP) and Momordica dioica (MD) in streptozotocin-induced diabetic nephropathy in wistar rats. Rats were divided into 12 groups (n  6). Diabetes was induced with a single dose of streptozotocin (55     days. Diabetic control group was considered as standard for comparison. Serum glucose, urea, creatinine and urine albumin levels were significantly lower in treated groups as compared to the diabetic control. Malondialdehyde was significantly (P  <<!--> 0.001) in reduced glutathione level which was reduced in diabetic control group. Change in body weight was found to be non-significant in treated groups. It was concluded that TP leaf and MD fruit extracts can provide a radical cure for drug-induced diabetic nephropathy by a reduction in renal damage.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 383-389"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87484938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Tasiamide-B a new cyanobacterial compound for treating skin cancer Tasiamide-B一种新的治疗皮肤癌的蓝藻化合物

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2013.10.001

Subramaniyan Vijayakumar, Muniaraj Menakha

{"title":"Tasiamide-B a new cyanobacterial compound for treating skin cancer","authors":"Subramaniyan Vijayakumar, Muniaraj Menakha","doi":"10.1016/j.bionut.2013.10.001","DOIUrl":"10.1016/j.bionut.2013.10.001","url":null,"abstract":"<div>Skin cancer is caused by HSP90 receptor protein molecule. It is treated with commercial drugs, like cabazitaxel and dyclonine. The aim of the present study was to predict screen and identify the potential high efficient anti-skin cancer compounds from the marine flora of cyanobacteria. To screen the bioactive compounds against skin cancer causing protein, HSP90, Glide module (Schrodinger suite) was applied. Among the 31 bioactive compounds screened, best Glide docking score of –9.144 was found in tasiamide-B. When this tasiamide-B was compared with the commercially available drugs, like cabazitaxel and dyclonine through molecular docking, tasiamide-B was found to be more effective by interacted strongly with skin cancer causing target protein, HSP90. The results of the study support the fact that in silico molecular docking studies using Glide and Hex programs are very useful in predicting skin cancer treating drug. In this study, tasiamide-B was predicted as the best active cyanobacterial compound derived from Symploca sp.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 355-358"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73185352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Studies on chemical composition of three species of Enteromorpha 三种浒苔属植物的化学成分研究

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.04.001

K. Ganesan , K. Suresh Kumar , P.V. Subba Rao , Y. Tsukui , N. Bhaskar , M. Hosokawa , K. Miyashita

{"title":"Studies on chemical composition of three species of Enteromorpha","authors":"K. Ganesan , K. Suresh Kumar , P.V. Subba Rao , Y. Tsukui , N. Bhaskar , M. Hosokawa , K. Miyashita","doi":"10.1016/j.bionut.2014.04.001","DOIUrl":"10.1016/j.bionut.2014.04.001","url":null,"abstract":"<div>Studies on proximate, mineral, fatty and amino acid composition of edible Enteromorpha species, viz. Enteromorpha compressa, Enteromorpha linza and Enteromorpha tubulosa, collected from the Northwest coast of India, revealed for species-dependent nutrient composition variation. The present study showed a higher amount of sugar (51.05±1.22%), protein (19.09±0.91%) and lipid content (5.56±0.16%) E. tubulosa. Amongst the seventeen elements analyzed (Ca, K, Mg, Na, P, As, Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, Zn, Cr, Pb), all three species showed a higher amount of calcium content. E. compressa was obtained with rich amount of macro-elements (11.42±0.017g/100g dry wt), while maximum micro- and trace-elements (81.51±6.65mg/100g dry wt) were recorded in E. linza. Amino acid analysis revealed seven out of the 10 essential amino acids were present either in excess or at-par with the reference proteins. Moreover, all the three species studied possessed relatively high n-3 fatty acids; additionally they had more unsaturated fatty acids than saturate ones, except in E. compressa. Therefore, based on the present investigation, it could be stated that the three species studied could be used as food supplements to improve the nutritive value in the omnivorous diet.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 365-369"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77423217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

The total antioxidant content and radical scavenging investigation on 17 phytochemical from dietary plant sources used globally as functional food 全球功能性食品植物源中17种植物化学物质的总抗氧化剂含量及自由基清除研究

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.03.007

Neeraj Kumar Sethiya, Ashish Trivedi, Shrihari Mishra

引用次数: 41

Isolation and molecular recognization of 6-prenyl apigenin towards MAO-A as the active principle of seeds of Achyranthes aspera

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.03.003

Shoban Janet Beula , V. Bhaskar Anada Raj , Bijo Mathew

{"title":"Isolation and molecular recognization of 6-prenyl apigenin towards MAO-A as the active principle of seeds of Achyranthes aspera","authors":"Shoban Janet Beula , V. Bhaskar Anada Raj , Bijo Mathew","doi":"10.1016/j.bionut.2014.03.003","DOIUrl":"10.1016/j.bionut.2014.03.003","url":null,"abstract":"<div><h3>Purpose</h3>The present study was undertaken to isolate the bioactive flavonoid compound from the seeds of Achyranthes aspera and establish its molecular interaction towards monoamine oxidase-A enzyme.</div><div><h3>Materials and methods</h3>The structure of the isolated flavonoid was ascertained by UV, 1H NMR, 13C NMR, DEPT 90, DEPT 135 and ESI-MS. Molecular level interaction was studied through molecular docking simulation carried out with AutoDock 4.2 in the catalytic portion of MAO-A.</div><div><h3>Results</h3>5, 7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one was isolated by chromatographic techniques. The docking study revealed that the structure of the isolated flavonoid showed to be a potent monoamine oxidase-A inhibitor with a docking score of −8.06 and calculated inhibition constant of about 1.23μM.</div><div><h3>Conclusion</h3>On the basis of molecular docking study, we propose that isolated flavonoid can successfully dock into the inhibitor-binding pocket of human monoamine oxidase-A isoform with appreciable predicted affinity. The results therefore suggest that 6-prenyl apigenin can be a promising lead for developing novel monoamine oxidase-A inhibitors.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 379-382"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87129724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Antidiabetic, hypolipidemic and histopathological analysis of Gymnema sylvestre (R. Br) leaves extract on streptozotocin induced diabetic rats 匙羹藤叶提取物对链脲佐菌素诱导的糖尿病大鼠的降糖、降血脂和组织病理学分析

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.03.008

Srinivasan Prabhu, Subramaniyan Vijayakumar

{"title":"Antidiabetic, hypolipidemic and histopathological analysis of Gymnema sylvestre (R. Br) leaves extract on streptozotocin induced diabetic rats","authors":"Srinivasan Prabhu, Subramaniyan Vijayakumar","doi":"10.1016/j.bionut.2014.03.008","DOIUrl":"10.1016/j.bionut.2014.03.008","url":null,"abstract":"<div><h3>Objective</h3>To investigate antidiabetic, hypolipidemic histopathological analysis of Gymnema sylvestre methanolic extract (GSME) in streptozotocin induced diabetic rat by administering oral doses (100, 200 and 400  mg/kg body weight) and glibenclamide (5 <<!--> 0.01) and hyperlipidaemia due to diabetes. The extract treatment also showed to enhance serum insulin level and body weight of diabetic rats as compared to diabetic control group. Furthermore, the extract has a favorable effect on the histopathological studies, in streptozotocin induced diabetes.</div><div><h3>Conclusions</h3>G. sylvestre possesses antidiabetic property as well improve body weight, and total lipid levels. GSME has also favorable effect to inhibit the histopathological changes in streptozotocin-induced diabetes.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 425-430"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.03.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91252745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Protective effect of betaine on protein, glycoproteins and amino acids in isoprenaline-induced myocardial infarction in albino rats 甜菜碱对异丙肾上腺碱诱导的白化大鼠心肌梗死中蛋白质、糖蛋白和氨基酸的保护作用

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.06.005

Balakrishnan Meena , Lawrance Anbu Rajan , Rangasamy Anandan

{"title":"Protective effect of betaine on protein, glycoproteins and amino acids in isoprenaline-induced myocardial infarction in albino rats","authors":"Balakrishnan Meena , Lawrance Anbu Rajan , Rangasamy Anandan","doi":"10.1016/j.bionut.2014.06.005","DOIUrl":"10.1016/j.bionut.2014.06.005","url":null,"abstract":"<div>Myocardial infarction is emerging as a foremost public health concern in most parts of the world even in developing countries still afflicted by infectious diseases, under nutrition and other illnesses related to poverty. There has been increasing recognition that certain natural substances have the potential to reduce the detrimental effect of a number of cardiovascular risk factors. In the present study, we have investigated the protective effect of betaine administration on changes in the levels of protein, glycoproteins and amino acids was studied in isoprenaline-induced myocardial infarction in rats as an animal model of myocardial infarction in man. Oral pre-treatment with betaine significantly attenuated (P  0.01) the isoprenaline-induced rise in the levels of troponin-T and creatine phosphokinase [CPK]. Oral supplementation of betaine also significantly (P  0.01) counteracted the isoprenaline-induced alterations in the levels of amino acids [taurine, aspartate, glutamate, arginine, hydroxy proline and homocysteine], protein content, glycoprotein components [hexose and hexosamine] and lipid peroxidation in the heart tissue and maintained their levels comparable to that of control animals. The results indicated that the overall cardioprotective effect of betaine was probably related to its ability to strengthen the myocardial membrane by its membrane stabilizing action or to a counteraction of free radicals by its antioxidant property.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 403-409"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.06.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88270879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Polychlorinated biphenyl (PCBs)-induced oxidative stress plays a role on vertebral antioxidant system: Ameliorative role of vitamin C and E in male Wistar rats 多氯联苯(PCBs)诱导的氧化应激对雄性Wistar大鼠椎体抗氧化系统的影响:维生素C和E的改善作用

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.04.004

Subramanian Karthikeyan, Muthusamy Sridhar, Govindan Ramajayam, Ramadoss Lavanya, Jagadeesan Arunakaran, Narasimhan Srinivasan

{"title":"Polychlorinated biphenyl (PCBs)-induced oxidative stress plays a role on vertebral antioxidant system: Ameliorative role of vitamin C and E in male Wistar rats","authors":"Subramanian Karthikeyan, Muthusamy Sridhar, Govindan Ramajayam, Ramadoss Lavanya, Jagadeesan Arunakaran, Narasimhan Srinivasan","doi":"10.1016/j.bionut.2014.04.004","DOIUrl":"10.1016/j.bionut.2014.04.004","url":null,"abstract":"<div>PCB are still prevalent in the environment despite the fact that they have been banned in many countries for several decades, have wide range of adverse effects in various organ systems including bone. The present study aimed at evaluating the effects of PCB on vertebral bone and the ameliorative role of vitamin C or E in the adult male Wistar rats. Group-I rats received vehicle (corn oil) intraperitoneally (i.p), group-II received Aroclor [1254] 2 mg/kg bwt/day (i.p), group-III received Aroclor [1254] (i.p) and simultaneously vitamin C 100 mg/kg bwt/day (orally), group-IV received Aroclor [1254] (i.p) and simultaneously vitamin E 50 mg/kg bwt/day (orally). After 30 days, rats were euthanized and vertebrae were dissected. The osteoblast functional markers (ALP and Collagen), osteoclast functional marker (TRAP), antioxidant enzymes (SOD, GPx and GST) and lipid peroxidation (LPO) were assessed in the vertebral bone of control and experimental animals. A significant decrease the ALP, collagen enzyme activity and increase the TRAP activity were observed in PCBs (Aroclor 1254) treated rats. SOD and GPx were increased in the PCB treated rats. Vitamin C or E given along with PCB, prevented the effects of PCB on ALP and TRAP. GST activity was effective in simultaneous administration of vitamin C treated group. LPO was altered in PCB treatment and animals remaining were not altered. PCB induces oxidative stress and stimulates osteoclast activity but suppresses osteoblast function and it perturbs the antioxidant system. Vitamin C or vitamin E was able to prevent the effects of PCB.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 411-416"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85642753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Amino acid composition and nutritional quality of gonad from jellyfish Rhopilema esculentum 水母性腺氨基酸组成及营养品质研究

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.04.007

Huahua Yu, Rongfeng Li, Song Liu, Rong-e Xing, Xiaolin Chen, Pengcheng Li

{"title":"Amino acid composition and nutritional quality of gonad from jellyfish Rhopilema esculentum","authors":"Huahua Yu, Rongfeng Li, Song Liu, Rong-e Xing, Xiaolin Chen, Pengcheng Li","doi":"10.1016/j.bionut.2014.04.007","DOIUrl":"10.1016/j.bionut.2014.04.007","url":null,"abstract":"<div>In the present study, amino acid compositions of two jellyfish gonad samples were determined and the nutritional value was evaluated by the amino acid score method recommend by WHO/FAO and fuzzy recognition method. The two samples were abundant in amino acids. The major amino acids were both glutamic acid, lysine, glycine, aspartic acid and leucine and the contents of these amino acids were 51.47% and 52.52% of the total amino acids, respectively. The essential amino acids were 42.89% and 40.70%, the flavor amino acids were 47.39% and 50.12% and the medicinal amino acids were 66.55% and 66.92% of the total amino acids, respectively. μ (a, μi) values of the two samples were respectively 0.91 and 0.94 and SRC values were respectively 70.89 and 69.96, indicating that the essential amino acids of jellyfish gonad were well-balanced and the nutritional value of jellyfish gonad was high.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 399-402"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.04.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80086951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Isolation of chemical constituents from Spilanthes calva DC: Toxicity, anthelmintic efficacy and in silico studies 小红花化学成分的分离:毒性、驱虫功效及硅片研究

Biomedicine & Preventive Nutrition Pub Date : 2014-07-01 DOI: 10.1016/j.bionut.2014.04.002

P. Jayaraj , B. Mathew , C. Mani , R. Govindarajan

{"title":"Isolation of chemical constituents from Spilanthes calva DC: Toxicity, anthelmintic efficacy and in silico studies","authors":"P. Jayaraj , B. Mathew , C. Mani , R. Govindarajan","doi":"10.1016/j.bionut.2014.04.002","DOIUrl":"10.1016/j.bionut.2014.04.002","url":null,"abstract":"<div>Aqueous and ethanol extracts of this Spilanthes calva DC is widely used in folk medicine in South India for treating various parasitic diseases. In vitro anthelmintic activities of crude aqueous and alcoholic extract of aerial parts of the plant was investigated to provide experimental evidence for its use in folk medicine. Investigations of in vitro anthelmintic efficacy were evaluated separately on adult Pheretima posthuma and Ascaridia galli compared with Albendazole. Ethanol extract showed more anthelmintic activity than aqueous extract. Six compounds were isolated from ethanol extract compounds 3, 4 and 6 showed significant anthelmintic activity with LC50 values of 12, 11, 9.9 and 11.47, 10.56, 8.35 respectively against both the worms. The oral LD50 of the aqueous and ethanol extracts estimated in mice is greater than 5000<!--> mg/kg. Molecular docking studies were carried out for compound 6 by using ArgusLab 4.0.1. and Molegrow 2012.2.5.0 generated the enzyme binding interaction which suggested the lactone ring attained a non-coplanar conformation with benzisoxazole can contribute two significant hydrogen bonding interaction with Tyr 50 and Gln 134. This could be attributed to the slight structural resemblance with Albendazole and hydrogen bonding, π-π and non-polar interactions towards the inhibitor-binding cavity of the β-tubulin enzyme. Our study shows ingredients in S. calva DC ethanol extract contains an effective anthelmintic composition that could potentially developed as a promising plant origin anthelmintic.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 3","pages":"Pages 417-423"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77574620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4