Biomedicine & Aging Pathology最新文献

{"title":"Ameliorating effect of Phoenix dactylifera on lambda cyhalothrin induced biochemical, hematological and hepatopathological alterations in male wistar rats","authors":"Mani Ramadhas,&nbsp;Krishnan Palanisamy,&nbsp;Munisamy Sudhagar,&nbsp;Vinayagam Magendira Mani","doi":"10.1016/j.biomag.2014.04.002","DOIUrl":"10.1016/j.biomag.2014.04.002","url":null,"abstract":"<div><p><span><span><span>Lambda cyhalothrin (LTC) is a synthetic </span>pyrethroid insecticide, widely used to control insect pests in agriculture, </span>public health, and homes and gardens. In the present study, an attempt has been made to study the effect of lambda cyhalothrin on biochemical, hematological parameters and ameliorating effects of palm dates (</span><em>Phoenix dactylifera)</em><span> in male wistar rat. Adult male Wistar rats were divided into four different groups. Group I served as control; group II received lambda cyhalothrin at a dose of 8</span> <!-->mg/kg (1/10 LD50) dissolved in water for 21 days orally; group III received <em>P. dactylifera</em> (200<!--> <!-->mg/kg BW for 21 days) orally; group IV <em>P. dactylifera</em><span> alone treated. LTC-induced liver toxicity<span><span><span><span><span> was measured by the increased activities of serum hepatic marker enzymes like aspartate transaminase, alanine transaminase, </span>alkaline phosphatase, </span>lactate dehydrogenase, along with increased elevation of </span>lipid peroxidation<span> and reduction in the levels of enzymic and non-enzymic antioxidants levels. Lambda cyhalothrin exposure leads to adverse effects on hematological parameters including erythrocyte (RBCs) and leukocyte (WBCs) counts, hemoglobin concentration (Hb), hematocrit (Hct) and blood indices (MCV and MCH). However, </span></span>treatment with </span></span><em>P. dactylifera</em> normalized the levels of hepatic markers, antioxidant and non-enzymic antioxidant, lipid peroxidation products and all the hematological parameters. These findings highlight the efficacy of <em>P. dactylifera</em> as protective effects against lambda cyhalothrin induced toxicity.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 3","pages":"Pages 273-279"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2014.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82596518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of anti-arthritic activity of ethyl acetate fraction of Cassia auriculata Linn. leaves","authors":"D.D. Bandawane,&nbsp;S. Beautikumari,&nbsp;S.S. Gate,&nbsp;A.N. Patel","doi":"10.1016/j.biomag.2013.10.009","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.10.009","url":null,"abstract":"<div><h3>Aim of the study</h3><p><span><em>Cassia auriculata</em></span><span> L. (Caesalpiniaceae) is a herb, used as a traditional Indian medicine for inflammation and rheumatism and it is reported to have anti-inflammatory and analgesic activity. In view of its potent anti-inflammatory activity, the present study was designed to evaluate its anti-arthritic activity and to identify the phytoconstituents responsible for the proposed activity.</span></p></div><div><h3>Material and methods</h3><p><span>Anti-arthritic activity of ethyl acetate fraction of </span><em>Cassia auriculata</em><span><span> leaves (EACA) was evaluated using Freund's complete adjuvants<span> (FCA) induced arthritic models in wistar rats<span>. Arthritic assessment was carried out on basis of parameters including paw oedema, motor incordination and nociceptive threshold. At the end of study period, animals were sacrificed and various biochemical, </span></span></span>oxidative stress, haematological, radiological and histological parameters were evaluated. The ethyl acetate fraction of </span><em>Cassia auriculata</em><span> leaves (EACA) was subjected to qualitative and quantitative phytochemical<span><span> investigation along with HPTLC analysis using standard biomarker </span>quercetin<span> and gallic acid.</span></span></span></p></div><div><h3>Results</h3><p>Administration of EACA<span><span> significantly attenuated the behavioural, biochemical, haematological, radiological alteration induced by the FCA in dose dependent manner. Tibiotarsal joint was extracted for </span>histopathology. The overall results indicate that EACA exerts potent protective effect against FCA induced arthritic rats which is due to its major phytoconstituents quercetin and gallic acid.</span></p></div><div><h3>Conclusion</h3><p>From our study we can come to a conclusion that the quercetin and gallic acid present in EACA possess promising ant-arthritic activity by modulating bone erosion which may be attributed to its anti-inflammatory and analgesic activity.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 2","pages":"Pages 105-115"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.10.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137345286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant mediated antiulcer effect of Eupatorium triplinerve Vahl against acetic acid induced ulcerative colitis in mice","authors":"Manigandan Krishnan,&nbsp;Richard L. Jayaraj,&nbsp;Jayasekar Megala,&nbsp;Namasivayam Elangovan","doi":"10.1016/j.biomag.2013.12.002","DOIUrl":"10.1016/j.biomag.2013.12.002","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Ulcerative colitis<span> (UC) is associated with tainted neutrophil infiltration<span>, deregulated pro-inflammatory mediators, characterized by severe oxidative stress of the intestine. In the present study, an effort was made to evaluate the effect of methanolic fractions of </span></span></span><span><em>Eupatorium</em><em> triplinerve</em></span> (<em>E.</em> <em>triplinerve</em>) (ET) on acetic acid induced ulcerative colitis in male adult mice.</p></div><div><h3>Methods</h3><p><span>Colitis in mice was induced with 3.0% acetic acid (v/v) in saline via rectal route. Pre-intervention with </span><em>E.</em> <em>triplinerve</em> extract (100<!--> <!-->mg and 200<!--> <!-->mg<!--> <!-->kg⁻¹<span> body weight, oral) and reference drug<span> ranitidine (50</span></span> <!-->mg<!--> <!-->kg⁻¹ body weight used as reference, oral) 4<!--> <!-->days before induction of colitis and was extended up to 8<!--> <!-->days.</p></div><div><h3>Results</h3><p>The phase of inflammation before <em>E.</em> <em>triplinerve</em><span><span> extract pre-treatment significantly showed attenuated macroscopic damage, argyrophilic nuclear organization regions (AgNORs) count and histological changes. Similarly, extract also effectively detracts the activity of both Myeloperoxidase (MPO) and </span>Malondialdehyde<span><span> (MDA) levels by enhancing the cellular antioxidant enzyme levels (Glutathione-s-transferase [GST], </span>Glutathione<span><span> peroxidise [GPx] and Catalase [CAT]) at the site of </span>ulceration.</span></span></span></p></div><div><h3>Conclusions</h3><p>The <em>E.</em> <em>triplinerve</em><span> based therapy resolved that some constituents in extract have an antiulcer effect against UC at colon specific area through its inviolable radical scavenging activity.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 2","pages":"Pages 153-160"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84683715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver damage associated with exposure to aspirin and diazinon in male rats and the ameliorative effect of selenium","authors":"Abdel-Tawab H. Mossa ,&nbsp;Tarek M. Heikal ,&nbsp;Enayat Abdel Aziz Omara","doi":"10.1016/j.biomag.2014.01.004","DOIUrl":"10.1016/j.biomag.2014.01.004","url":null,"abstract":"<div><h3>Purpose</h3><p><span><span>The widespread use of organophosphorus insecticides (OPIs) consequently leads to the exposure of manufacturing workers, field applicators, the ecosystem, and finally the public to the possible toxic effects of OPIs. In addition, </span>drugs or pharmaceutical products, which are used to cure diseases, are also </span>xenobiotics<span> with both therapeutic/toxic potentials. It is evident from the literature, which is very limited, that drug/insecticide interactions can result in altered response/toxicity, which is of clinical relevance. The aim of the present study was designed to assess the adverse effects of exposure to aspirin<span> and diazinon and their combination on liver of male rats and hepatoprotective potential of selenium (Se).</span></span></p></div><div><h3>Methods</h3><p>Rats were oral administered with vehicle, acetyl salicylic acid (ASA) at the maximum administration dose (1350<!--> <!-->mg/personal/day<!--> <!-->=<!--> <!-->22.5<!--> <!-->mg/kg. b.wt.), diazinon (DIA) at 20<!--> <!-->mg/kg. b.wt. and Se at a dose of 200<!--> <span><span>μg/kg b.wt./day and their combinations for 28 consecutive days. Serum liver biomarkers, e.g. ALT&amp;AST, ALP<span>, ChE, </span></span>LDH, albumin, total protein were determined as well as histological and histochemical studies.</span></p></div><div><h3>Results</h3><p>Body weight was statistically (<em>P</em> <!-->≤<!--> <!-->0.05) decreased, while relative liver weight was statistically (<em>P</em> <!-->≤<!--> <!-->0.05) increased in DIA and ASA<!--> <!-->+<!--> <!-->DIA-treated groups. The activities of serum aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were statistically (<em>P</em> <!-->≤<!--> <!-->0.05) increased, while the activity of cholinesterase (ChE) was decreased in rats exposed to DIA, ASA and DIA<!--> <!-->+<!--> <span>ASA. In addition, administration of DIA, ASA and their combination resulted in damage of liver structures and increase in the immunoreactivity of caspase-3 expression in the cytoplasm of the hepatocytes as compared to the control group. Combination therapy with Se significantly (</span><em>P</em> <!-->≤<!--> <!-->0.05) restored these alterations to within the normal limits and prevents disruptions of liver structures.</p></div><div><h3>Conclusions</h3><p><span>The present study indicates that liver enzymes, </span>histopathology<span> and immunoreactivity of caspase-3 would trigger ASA- and DIA-induced liver injury. The severities of such observations were more pronounced in their combined exposure. Combination therapy with Se restored these alterations to within the normal limits and prevents disruptions of liver structures. The data throw light on the problem of simultaneous exposure to OPIs and commonly used drugs especially that are metabolised by CYP450<span>. Accordingly, ASA should be avoided since many of the adverse effects associated with these d","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 2","pages":"Pages 137-145"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2014.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86561880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifibromyalgic activity of standardized extracts of Phyllanthus amarus and Phyllanthus fraternus in acidic saline induced chronic muscle pain","authors":"A.R. Chopade,&nbsp;F.J. Sayyad","doi":"10.1016/j.biomag.2014.01.005","DOIUrl":"10.1016/j.biomag.2014.01.005","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the effects of <span><em>Phyllanthus</em></span><span> extracts on mechanical hyperalgesia<span> induced by repeated intramuscular injections of acidic saline.</span></span></p></div><div><h3>Materials and methods</h3><p>The standardized aqueous extract of <span><em>Phyllanthus amarus</em></span> whole plant (PAAE), Standardized methanolic extract of <em>P. amarus</em> leaf (PAEE), the standardized hydro-methanolic extract of <em>P. amarus</em> leaf (PAHEE) and standardized hydroethanolic extract of <em>P. fraternus</em><span><span> whole plant (PFHEE) were tested in the fibromyalgic model of acid-induced chronic pain in the rats. Mechanical hyperalgesia was assessed by measuring the withdrawal thresholds to mechanical stimuli both to the ipsilateral as well as to the contralateral paws. On 22nd day, the animals were sacrificed and the </span>gastrocnemius muscle at the site of injection was dissected for histopathological studies.</span></p></div><div><h3>Results</h3><p>PAAE, PAEE, PAHEE and PFHEE increased the mechanical withdrawal threshold (mechanical hyperalgesia) back towards the baseline responses. The percentage of maximum possible effectiveness and percentage inhibition of hyperalgesia also revealed the efficacy of <em>Phyllanthus</em> extracts. The multidose strategy did not cause tolerance.</p></div><div><h3>Conclusion</h3><p>The results of the present study suggest that in the present model, muscle-mediated pain can be alleviated by standardized extracts of <em>Phyllanthus</em><span><span> species and suggest that these can be useful in treatment of chronic </span>musculoskeletal pain<span> syndromes such as fibromyalgia.</span></span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 2","pages":"Pages 123-130"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2014.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82710138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biological time calendar","authors":"Huynh Thien Duc","doi":"10.1016/j.biomag.2014.03.006","DOIUrl":"10.1016/j.biomag.2014.03.006","url":null,"abstract":"<div><p>Time passing drives all living organismes to cellular decline with age-associated dysfuntion, diseases and death. It appeared now that ageing like any biological process<span> is surceptible to regulation. Environmental factors such as stimuli/stresses as well as endogenous factors, i.e., expression and mutation of some particular genes might act as the main regulators. Psychological factors as a human specific dimension could contribute in delaying the senescence decline.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 2","pages":"Pages 77-89"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2014.03.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80710219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiproliferative effect of coumarin by modulating oxidant/antioxidant status and inducing apoptosis in Hep2 cells","authors":"Sankaran Mirunalini,&nbsp;Krishnamoorthy Deepalakshmi,&nbsp;Jalagopal Manimozhi","doi":"10.1016/j.biomag.2014.01.006","DOIUrl":"10.1016/j.biomag.2014.01.006","url":null,"abstract":"<div><p><span><span>Considering the importance of plant derived compounds<span> in prevention of cellular damage caused by reactive oxygen species which has been implicated to several diseases, this present study was undertaken to evaluate the anticancer effects of </span></span>coumarin<span><span> by MTT assay<span>, lipid peroxidation markers and antioxidants status against Hep2 </span></span>cancer cells. A Hep2 cells was treated with different concentrations of coumarin (2.5–1000</span></span> <!-->μg/ml) for 24<!--> <span><span>h and its cytotoxicity effect were measured by MTT assay. Apoptosis was investigated in terms of acridine orange/ethidium bromide dual staining method and </span>DNA fragmentation<span>. Our present investigation showed that coumarin decreased cell viability with an IC</span></span>₅₀ value of 62.5<!--> <!-->μg/ml. The IC₅₀ was determined by dose response curve by plotting the graph of concentration versus % cell viability. Hep2 cancer cells showed decreased levels of lipid peroxidation with increased activities of enzymatic antioxidants. Among the various doses of coumarin (125, 250 and 500<!--> <!-->μg/ml), 500<!--> <span>μg/ml dose significantly decreased lipid peroxidation and increased antioxidant activities. Moreover, coumarin inhibited Hep2 cell growth and showed typical characteristics of apoptosis including the morphological changes and DNA fragmentation. On the basis of these findings, coumarin may be considered as potential therapeutic intervention of human Hep2 cancer cells.</span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 2","pages":"Pages 131-135"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2014.01.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89548203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiosteoporotic effects of L-Arginine in ovariectomied rats","authors":"Hong Guo ,&nbsp;Yu Gao ,&nbsp;Bin Gu ,&nbsp;Jing Wang ,&nbsp;Hongchen Liu","doi":"10.1016/j.biomag.2014.02.002","DOIUrl":"10.1016/j.biomag.2014.02.002","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the antiosteoporotic effects of L-Arginine on ovariectomied rats.</p></div><div><h3>Methods</h3><p><span>Forty twelve-week-old female Sprague-Dawley rats were randomly divided into four groups of bilaterally ovariectomy<span> and one group of Sham animals, with 8 animals in each group. Twelve additional weeks elapsed before initiation of the treatment with L-Arginine in order to induce significant </span></span>bone loss<span> in the ovariectomied animals. A 4-week daily treatment (5 days a week, Monday–Friday) at doses of 5 mg/kg/d, 10 mg/kg/d, 20 mg/kg/d of L-Arginine or vehicle only was administered by s.c. injection to the ovariectomied groups respectively. At the end of the treatment period, blood samples from all animals were collected for biochemical analysis. Micro-computerized tomography analysis, histopathological study and biomechanical test were performed on the femur of each animal.</span></p></div><div><h3>Results</h3><p><span>Serum alkaline phosphatase and </span>osteocalcin were reduced in ovariectomied rats after the administration of different dosage of L-Arginine. L-Arginine of 10 mg/kg showed the most significant effect. Micro-computerized tomography 3-D images revealed that the increase of bone mass in 5 mg/kg and 10 mg/kg groups were significant greater than that in Sham group. The biomechanical parameters of femur were improved significantly in L-Arginine 10 mg/kg group when compared to untreated ovariectomied rats.</p></div><div><h3>Conclusions</h3><p>L-Arginine (10 mg/kg) contributes significantly to the treatment of the bone loss induced by ovariectomy on rats, demonstrated by increased bone mass, improved bone structure and recovery of bone biomechanical activity.</p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 2","pages":"Pages 117-122"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2014.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76871255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camel urine inhibits inflammatory angiogenesis in murine sponge implant angiogenesis model","authors":"Abdulqader A. Alhaider ,&nbsp;Abdel Galil M. Abdel Gader ,&nbsp;Nawaf Almeshal ,&nbsp;Sarita Saraswati","doi":"10.1016/j.biomag.2013.10.003","DOIUrl":"https://doi.org/10.1016/j.biomag.2013.10.003","url":null,"abstract":"<div><p><span><span>Camel urine has traditionally been used to treat cancer, but this practice awaits scientific scrutiny, in particular its role in tumor angiogenesis<span><span>, the key step involved in tumor growth and metastasis. We aimed to investigate the effects of camel urine on key components of inflammatory </span>angiogenesis in the murine cannulated sponge implant </span></span>angiogenesis model<span>. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were implanted in Swiss albino mice and camel urine (25, 50 and 100</span></span> <!-->mg/kg/day) was administered for 14<!--> <span>days through installed cannula<span>. The implants, collected at day 14 post-implantation, were processed for the assessment of hemoglobin (Hb), myeloperoxidase (MPO), </span></span><em>N</em><span><span>-acetylglucosaminidase (NAG) and collagen, which were used as indices for angiogenesis, neutrophil and macrophage accumulation and </span>extracellular matrix<span><span> deposition, respectively. Relevant inflammatory, angiogenic and fibrogenic cytokines were also determined. Camel urine treatment attenuated the main components of the fibrovascular tissue, wet weight, </span>vascularization<span> (Hb content), macrophage recruitment (NAG activity), collagen deposition and the levels of vascular endothelial growth factor (VEGF), interleukin (IL)-1β, IL-6, IL-17, tumor necrosis factor (TNF)-α and transforming growth factor (TGF-β). A regulatory function of camel urine on multiple parameters of the main components of inflammatory angiogenesis has been revealed giving insight into the potential therapeutic benefit underlying the anti-cancer actions of camel urine.</span></span></span></p></div>","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"4 1","pages":"Pages 9-16"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.biomag.2013.10.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91654584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contraceptive activity of 4-(4-hydroxy-3-methyl-hex-5-enyl)-chroman-2,7-diol via inhibiting ovulation in Gonadotropin-primed immature rat model","authors":"Ashoke Kumar, S. Gullaiya, V. Dubey, A. Nagar, V. Singh, S. Agrawal","doi":"10.1016/J.BIOMAG.2013.12.001","DOIUrl":"https://doi.org/10.1016/J.BIOMAG.2013.12.001","url":null,"abstract":"","PeriodicalId":100181,"journal":{"name":"Biomedicine & Aging Pathology","volume":"52 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79682089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}