Ameliorating effect of Phoenix dactylifera on lambda cyhalothrin induced biochemical, hematological and hepatopathological alterations in male wistar rats

Mani Ramadhas, Krishnan Palanisamy, Munisamy Sudhagar, Vinayagam Magendira Mani
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引用次数: 3

Abstract

Lambda cyhalothrin (LTC) is a synthetic pyrethroid insecticide, widely used to control insect pests in agriculture, public health, and homes and gardens. In the present study, an attempt has been made to study the effect of lambda cyhalothrin on biochemical, hematological parameters and ameliorating effects of palm dates (Phoenix dactylifera) in male wistar rat. Adult male Wistar rats were divided into four different groups. Group I served as control; group II received lambda cyhalothrin at a dose of 8 mg/kg (1/10 LD50) dissolved in water for 21 days orally; group III received P. dactylifera (200 mg/kg BW for 21 days) orally; group IV P. dactylifera alone treated. LTC-induced liver toxicity was measured by the increased activities of serum hepatic marker enzymes like aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, along with increased elevation of lipid peroxidation and reduction in the levels of enzymic and non-enzymic antioxidants levels. Lambda cyhalothrin exposure leads to adverse effects on hematological parameters including erythrocyte (RBCs) and leukocyte (WBCs) counts, hemoglobin concentration (Hb), hematocrit (Hct) and blood indices (MCV and MCH). However, treatment with P. dactylifera normalized the levels of hepatic markers, antioxidant and non-enzymic antioxidant, lipid peroxidation products and all the hematological parameters. These findings highlight the efficacy of P. dactylifera as protective effects against lambda cyhalothrin induced toxicity.

凤仙花对氯氟氰菊酯诱导的雄性wistar大鼠生化、血液学和肝脏病理改变的改善作用
Lambda cyhalothrin (LTC)是一种合成的拟除虫菊酯类杀虫剂,广泛用于农业、公共卫生、家庭和花园的害虫控制。本研究旨在研究高效氯氰菊酯对雄性wistar大鼠生化、血液学指标及棕榈枣改良作用的影响。将成年雄性Wistar大鼠分为四组。第一组为对照组;II组给予氯氟氰菊酯8 mg/kg (1/10 LD50)溶于水口服21天;III组口服紫草草(200 mg/kg BW) 21 d;IV组单药处理。通过血清肝标记酶如天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、乳酸脱氢酶活性升高,脂质过氧化升高,酶和非酶抗氧化剂水平降低来测量ltc诱导的肝毒性。氯氟氰菊酯暴露会对血液学参数产生不良影响,包括红细胞(rbc)和白细胞(wbc)计数、血红蛋白浓度(Hb)、红细胞压积(Hct)和血液指标(MCV和MCH)。然而,用dactylifera治疗后,肝脏标志物、抗氧化剂和非酶抗氧化剂、脂质过氧化产物和所有血液学参数的水平均恢复正常。这些研究结果表明,dactylifera对氯氟氰菊酯诱导的毒性具有保护作用。
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