Biomarkers and Genomic Medicine最新文献_第9页

Role of nuclear proteins in doxorubicin-resistance of human uterine cancer cells 核蛋白在人子宫癌细胞阿霉素耐药中的作用

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.08.026

Yi-Ling Lu, Eric Hung, Hsiu-Chuan Chou

引用次数: 0

Clinical significance of increased transcriptional factor SOX4 expression in human gastric carcinoma 人胃癌中转录因子SOX4表达升高的临床意义

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.08.003

Kai-Yuan Lin , Yih-Huei Uen

引用次数: 0

Investigation of non-HDL cholesterol and C-reactive protein in diabetes patients 糖尿病患者非高密度脂蛋白胆固醇及c反应蛋白的研究

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.08.002

Wen-Tung Hsu , Hsiu-Chuan Pien , Hai-I Huang , Yi-Yu Tu , Wu-Hsien Kuo , Kwang-Yang Tsai , Li-Mien Chen

引用次数: 2

Lamellar ichthyosis with severe bilateral ectropion and self-healing collodion membrane 板层状鱼鳞病伴严重双侧外翻和自愈胶膜

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.07.011

Joh-Jong Huang , Ming-Yii Huang , Teh-Yang Huang

引用次数: 4

Migratory activity and invadosome formation in invasive oral cancer cells 侵袭性口腔癌细胞的迁移活性和侵入体形成

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.07.007

Ssu-Han Wang, Hsiu-Chuan Chou

{"title":"Migratory activity and invadosome formation in invasive oral cancer cells","authors":"Ssu-Han Wang, Hsiu-Chuan Chou","doi":"10.1016/j.bgm.2013.07.007","DOIUrl":"10.1016/j.bgm.2013.07.007","url":null,"abstract":"<div><p>The objective of this study is to explore the relationship between migration ability and invadosome organization in human oral squamous cancer cells. Wound healing assay, immunofluorescence, Western blotting, and matrix metalloproteinase zymogen gel assay were utilized to investigate the phenotype changes of three oral squamous cancer cells (OC3, OC3-I5, and OC3-IV2). Among these three cell lines, selective subpopulations of OC3, OC3-I5, and OC3-IV2 have high migratory ability compared to OC3 in a wound healing assay. Moreover, immunofluorescence showed that formation of actin dots and paxillin rings in OC3 was less than in OC3-I5 and OC3-IV2. Minor differences of other adhesion molecules and matrix metalloproteinase activity have also been observed. Enhanced cell migration ability and increased invadosomes have been detected in both <em>in vitro</em> selection cell line OC3-I5 and <em>in vivo</em> selection cell line OC3-IV2, suggesting that there may be a correlation between migration activity and invadosome formation in invasive oral cancer cells. Therefore, it would be interesting for us to continue discovering more invadosome components and evaluate whether they play any role in the regulation of the invasion ability of oral cancer cells.</p></div>","PeriodicalId":100178,"journal":{"name":"Biomarkers and Genomic Medicine","volume":"5 3","pages":"Pages 79-83"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bgm.2013.07.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86389539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UGT1A1 genotyping for irinotecan-based chemotherapy in the first-line treatment for metastatic colorectal cancer patients with hyperbilirubinemia: Report of cases UGT1A1基因分型在伊立替康化疗一线治疗转移性结直肠癌合并高胆红素血症患者中的应用

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.08.005

Yung-Sung Yeh , Ming-Xia Wu , Meng-Lin Huang , Se-Fen Chang , Chin-Fan Chen , Huang-Ming Hu , Jaw-Yuan Wang

引用次数: 0

Methylomic deep sequencing of ovarian cancer reveals diagnostic and prognostic signatures 卵巢癌的甲基组深度测序揭示了诊断和预后特征

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.08.022

Rui-Lan Huang , Hui-Chen Wang , Hung-Cheng Lai

引用次数: 0

MassARRAY-based genomic testing for colorectal cancer in the era of personalized medicine 个体化医疗时代基于massarray的结直肠癌基因组检测

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.08.018

James Chien-Hsing Lin , Qing-Dong Ling , Matt Chang , Frank Chang , Hsin-Chung Lee

引用次数: 0

Analysis of cancer cell death in hepatoma cell line after the treatment of lethal culture extract from Taiwan Barnettozyma spp. 台湾巴氏菌毒力培养物处理肝癌细胞株后癌细胞死亡的分析。

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.07.008

Ren-Yu Hu, Ching-Fu Lee, Yu-Ci You, Hsiu-Chuan Chou

{"title":"Analysis of cancer cell death in hepatoma cell line after the treatment of lethal culture extract from Taiwan Barnettozyma spp.","authors":"Ren-Yu Hu, Ching-Fu Lee, Yu-Ci You, Hsiu-Chuan Chou","doi":"10.1016/j.bgm.2013.07.008","DOIUrl":"10.1016/j.bgm.2013.07.008","url":null,"abstract":"<div><p>Cancer is the leading cause of death in the world, and therefore, identifying advanced anticancer drugs is the most important objective of cancer research. However, at present, most synthetic anticancer drugs developed cause serious side effects thereby reducing their therapeutic efficiency. In a previous study, we have reported that culture filtrates from <em>Barnettozyma</em> spp. can not only maintain their lethal effect under physical environment, but can also exert stronger cytotoxicity to the hepatoma cell line HepG2 than to the normal Chang's liver cell. Herein, we further classify the types of liver cancer cell death, and identify those proteins responsible for the cell death by matrix-assisted laser desorption/ionization–time-of-flight spectra to study the possible mechanism of lethal culture filtrate from a special Taiwan killer yeast <em>Barnettozyma</em> spp. (EN14S14). Results of our preliminary study indicated that autophagic induction is most likely the major form of HepG2 cell death, which is induced by the “killing” culture filtrate. Proteins differentially expressed after treatment fell into three major categories, namely, metabolism, cytoskeleton, and signal transduction.</p></div>","PeriodicalId":100178,"journal":{"name":"Biomarkers and Genomic Medicine","volume":"5 3","pages":"Pages 92-95"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bgm.2013.07.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82898532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilized mass spectrometry-based protein profiling system to identify potential biomarkers of hepatocellular carcinoma 利用基于质谱的蛋白质谱分析系统识别潜在的肝细胞癌生物标志物

Biomarkers and Genomic Medicine Pub Date : 2013-09-01 DOI: 10.1016/j.bgm.2013.07.009

Ming-Hui Yang , Hung Su , Yi-Ling Chen , Chi-Yu Lu , Wan-Chi Tsai , Yu-Chang Tyan , Yu-Chun Liu , Ching-Wen Kuo , Yu-Ching Hsu

{"title":"Utilized mass spectrometry-based protein profiling system to identify potential biomarkers of hepatocellular carcinoma","authors":"Ming-Hui Yang , Hung Su , Yi-Ling Chen , Chi-Yu Lu , Wan-Chi Tsai , Yu-Chang Tyan , Yu-Chun Liu , Ching-Wen Kuo , Yu-Ching Hsu","doi":"10.1016/j.bgm.2013.07.009","DOIUrl":"10.1016/j.bgm.2013.07.009","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is the most common malignant liver tumor. The purpose of this study is to characterize proteins secreted from the HepG2 cells, which may relate to cell differentiation and tumor metastasis. In the proteomic analysis, the secretome was identified by nano-high–performance liquid chromatography/electrospray ionization tandem mass spectrometry (nano-HPLC/ESIMS/MS) followed by peptide fragmentation pattern analysis. In this study, three proteins, p130Cas-associated protein (p130Cas/BCAR1), TAR DNA-binding protein 43 (TDP43/TARDBP) and translationally controlled tumor protein (TCTP/TPT1), were identified and confirmed by Western blotting, which showed significantly differential expression compared with the normal liver cells. Analyzing differential protein expressions in HepG2 cell by proteomic approaches suggests that p130Cas/BCAR1, TDP43/TARDBP and TCTP/TPT1 as key proteins and may serve as biomarkers for HCC.</p></div>","PeriodicalId":100178,"journal":{"name":"Biomarkers and Genomic Medicine","volume":"5 3","pages":"Pages 96-99"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bgm.2013.07.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79431095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0