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Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression最新文献

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Hyper-activated IRF-1 and STAT1 contribute to enhanced Interferon stimulated gene (ISG) expression by Interferon α and γ co-treatment in human hepatoma cells 过度激活的IRF-1和STAT1通过干扰素α和γ共同治疗促进人肝癌细胞中干扰素刺激基因(ISG)的表达

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-08-01 DOI: 10.1016/j.bbaexp.2006.08.003

Xiao-Nan Zhang , Jiang-Xia Liu , Yun-Wen Hu , Hui Chen , Zheng-Hong Yuan

{"title":"Hyper-activated IRF-1 and STAT1 contribute to enhanced Interferon stimulated gene (ISG) expression by Interferon α and γ co-treatment in human hepatoma cells","authors":"Xiao-Nan Zhang , Jiang-Xia Liu , Yun-Wen Hu , Hui Chen , Zheng-Hong Yuan","doi":"10.1016/j.bbaexp.2006.08.003","DOIUrl":"https://doi.org/10.1016/j.bbaexp.2006.08.003","url":null,"abstract":"<div><p>Previous reports suggest that type I and type II Interferon can co-operatively inhibit some virus replication, e.g. HCV, SARS-CoV, HSV-1. To find out the molecular mechanism underlying this phenomenon, we analyzed the transcription profile stimulated by IFN-α and IFN-γ in Huh-7 cells and found that the transcription of a subset of IFN stimulated genes (ISGs) including BclG, XAF1, TRAIL and TAP1 was enhanced when IFN-α and γ were both present. Promoter analysis of BclG revealed that IRF-1 and STAT1 were both required in this process. Enhanced IRF-1/DNA complex formation was observed in interferon co-treatment group by gel shift analysis. Furthermore, IRF-1 activation was found to be generally required in this cluster of ISGs. STAT1 tyrosine phosphorylation was elevated by IFN combination treatment, however, only the hyper-transactivation of GAS but not ISRE was observed. In conclusion, hyper-activation of IRF-1 and elevated STAT1 dimer formation may be two general switches which contribute to a much more robust antiviral symphony against virus replication when type I and type II IFNs are co-administered.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 8","pages":"Pages 417-425"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92115812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Targeted disruption of the genes, mlcR and ariB, which encode GAL4-type proteins in Penicillium citrinum 靶向破坏柑橘青霉中编码gal4型蛋白的基因mlcR和ariB

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-08-01 DOI: 10.1016/j.bbaexp.2006.08.001

S. Baba , Y. Abe , C. Ono , M. Hosobuchi

{"title":"Targeted disruption of the genes, mlcR and ariB, which encode GAL4-type proteins in Penicillium citrinum","authors":"S. Baba , Y. Abe , C. Ono , M. Hosobuchi","doi":"10.1016/j.bbaexp.2006.08.001","DOIUrl":"10.1016/j.bbaexp.2006.08.001","url":null,"abstract":"<div><p>The role of two genes, <em>mlcR</em> and <em>ariB</em>, was investigated by gene disruption experiments. The <em>mlcR</em> gene in the ML-236B biosynthetic gene cluster of <em>Penicillium citrinum</em> encodes a putative 50.2-kDa protein with a Zn (II) <sub>2</sub>Cys<sub>6</sub> DNA-binding domain, and has similarity to most of the GAL4-type regulatory proteins. The <em>mlcR</em> disruptant did not produce ML-236B or its intermediates, suggesting that <em>mlcR</em> is involved in ML-236B biosynthesis. Transcriptional analysis of the <em>mlcR</em> disruptant by Northern hybridization and RT-PCR indicated that MlcR activates the transcription of <em>mlcA</em>, <em>B</em>, <em>C</em>,<em>D</em>, <em>F</em>, <em>G</em> and <em>H</em> in a pathway-specific manner. On the other hand, MlcR did not affect the transcription of <em>mlcE</em> and the genes outside the ML-236B cluster. The <em>ariB</em> gene, next to <em>mlcR</em>, encodes another GAL4-type protein. Transcriptional analysis of the <em>ariB</em> disruptant indicated that it is a transcriptional activator of the genes outside the ML-236B cluster, and is not related to ML-236B biosynthesis.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 8","pages":"Pages 410-416"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26316592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

HNF4α and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression HNF4α和NF-E2是小鼠Abcc6基因表达的关键转录调控因子

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-08-01 DOI: 10.1016/j.bbaexp.2006.08.002

Vanessa Douet, Christopher M. VanWart, Matthew B. Heller, Sabrina Reinhard, Olivier Le Saux

{"title":"HNF4α and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression","authors":"Vanessa Douet, Christopher M. VanWart, Matthew B. Heller, Sabrina Reinhard, Olivier Le Saux","doi":"10.1016/j.bbaexp.2006.08.002","DOIUrl":"10.1016/j.bbaexp.2006.08.002","url":null,"abstract":"<div><p>Mutations in an ABC transporter gene called <em>ABCC6</em> are responsible for pseudoxanthoma elasticum (PXE), a rare heritable disease characterized by elastic fiber calcification in skin, ocular and vascular tissues. The presumed function of this ABC transporter is to export metabolites from polarized cells. However, the endogenous substrate(s) are unknown and the exact relationship with elastic fibers is unclear. As <em>ABCC6</em> is only expressed at high level in liver and kidneys, tissues seemingly unrelated to the PXE phenotype, we explored the transcriptional regulation of the murine <em>Abcc6</em> gene to define the transcriptional signal conferring tissue specificity and to gather clues on its possible biological function. We cloned 2.9kb of the <em>mAbcc6</em> 5′-flanking region and several deletion constructs linked to a luciferase reporter gene. We delineated a proximal promoter and a liver-specific enhancer region. We also demonstrated that the proximal region is a TATA-less promoter requiring an intact CCAAT-box and Sp1 binding for its basal activity. By using reporter assays and chromatin immunoprecipitations, we showed that HNF4α and surprisingly, NF-E2, enhanced the <em>mAbcc6</em> promoter activity. The involvement of both HNF4α and NF-E2 in the <em>mAbcc6</em> gene regulation suggests that Abcc6 might be involved in a detoxification processes related to hemoglobin or heme.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 8","pages":"Pages 426-436"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26271594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

New type of kdp region with a split sensor-kinase kdpD gene located within two divergent kdp operons from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius 在嗜热嗜酸的酸藻酸环杆菌的两个不同的kdp操纵子中发现了一种新的kdp区域，该区域具有一个分裂的传感器激酶kdpD基因

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-08-01 DOI: 10.1016/j.bbaexp.2006.07.006

Erik Schleußinger, Roland Schmid, Evert P. Bakker

引用次数: 8

Influences along the path to maturity: Regulation of cellular levels of RNA 成熟过程中的影响:细胞RNA水平的调节

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-08-01 DOI: 10.1016/j.bbaexp.2006.08.006

Michelle Craig Barton

引用次数: 0

Cofactor CLIM2 promotes the repressive action of LIM homeodomain transcription factor Lhx2 in the expression of porcine pituitary glycoprotein hormone α subunit gene 辅助因子CLIM2促进LIM同源结构域转录因子Lhx2对猪垂体糖蛋白激素α亚基基因表达的抑制作用

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-08-01 DOI: 10.1016/j.bbaexp.2006.08.004

Takao Susa, Takanobu Sato, Tetsuo Ono, Takako Kato, Yukio Kato

{"title":"Cofactor CLIM2 promotes the repressive action of LIM homeodomain transcription factor Lhx2 in the expression of porcine pituitary glycoprotein hormone α subunit gene","authors":"Takao Susa, Takanobu Sato, Tetsuo Ono, Takako Kato, Yukio Kato","doi":"10.1016/j.bbaexp.2006.08.004","DOIUrl":"https://doi.org/10.1016/j.bbaexp.2006.08.004","url":null,"abstract":"<div><p>We have cloned a porcine orthologue of cofactor CLIM2 (Ldb1/NLI) from the porcine pituitary cDNA library by protein–protein interaction with the Yeast Two-Hybrid System using porcine Lhx2 as a bait protein. Porcine CLIM2 shows a high identity (99%) in the dimerization domain, nuclear localization signal and LIM binding domain with those of man and mouse. The expression of CLIM2 gene in the anterior pituitary lobe was detected during the porcine fetal and postnatal period by RT-PCR analysis, suggesting that this protein is constitutively expressing and plays a basic role in the anterior pituitary. Transfection assay to the pituitary tumor derived LβT2 cells, and the Chinese hamster ovary cells demonstrated that CLIM2 acts as a corepressor of the porcine Lhx2 function. Interestingly, CLIM2 alone apparently repressed the high level of αGSU gene expression in LβT2 cells. These data suggest that CLIM2 is a basic factor in the pituitary development and function, and plays the role of repressor to modify the function of Lhx2 on the αGSU gene expression.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 8","pages":"Pages 403-409"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92151208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Porcine APP cDNAs: Molecular cloning and characterization, expression analysis, chromosomal localization and SNP analysis 猪APP cdna:分子克隆与鉴定、表达分析、染色体定位与SNP分析

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-07-01 DOI: 10.1016/j.bbaexp.2006.06.002

Marianne Abildgaard Oerum, Christian Bendixen, Lone Bruhn Madsen, Knud Larsen

{"title":"Porcine APP cDNAs: Molecular cloning and characterization, expression analysis, chromosomal localization and SNP analysis","authors":"Marianne Abildgaard Oerum, Christian Bendixen, Lone Bruhn Madsen, Knud Larsen","doi":"10.1016/j.bbaexp.2006.06.002","DOIUrl":"10.1016/j.bbaexp.2006.06.002","url":null,"abstract":"<div><p>The human amyloid precursor protein (APP) is the precursor of Aβ, a peptide with the potential to create amyloid plaques in neurons. Mutations in the human <em>APP</em> gene are associated with the familial form of Alzheimer's disease. In addition, differential expression of three alternative pre-mRNA APP splicing variants of 695, 751, and 770 amino acids is linked to the pathogenesis. In this study, two novel transcript variants of porcine <em>APP</em> have been identified, producing isoforms of 695 and 751 amino acids, respectively. These are highly homologous to APP orthologues from other vertebrate species. Expression analyses revealed that the gene is expressed in all 30 examined porcine tissues and in a selected subset of these, differential representation of the three major APP transcript variants was observed. The APP isoform of 770 amino acids clearly predominates in non-neuronal tissues while in porcine cerebellum, the APP isoforms of 695 and 770 amino acids are expressed at equivalent levels. Employing a somatic cell hybrid panel, the <em>APP</em> gene was mapped to porcine chromosome 13 in either the 13q41 or 13q46–q49 region. A large pig population was screened for single nucleotide polymorphisms (SNPs) in <em>APP</em> exon 17 and flanking intron sequences. No missense mutations were detected; however, the allele frequencies of two silent mutations and two intron polymorphisms varied significantly among breeds.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 7","pages":"Pages 378-384"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26221868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Molecular cloning and functional expression of the Penaeus monodon 5-HT receptor 单对虾5-HT受体的分子克隆及功能表达

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-07-01 DOI: 10.1016/j.bbaexp.2006.07.004

Chalermporn Ongvarrasopone , Yaowaluck Roshorm , Suthasinee Somyong , Chetsada Pothiratana , Soontaree Petchdee , Jarasporn Tangkhabuanbutra , Samaisukh Sophasan , Sakol Panyim

{"title":"Molecular cloning and functional expression of the Penaeus monodon 5-HT receptor","authors":"Chalermporn Ongvarrasopone , Yaowaluck Roshorm , Suthasinee Somyong , Chetsada Pothiratana , Soontaree Petchdee , Jarasporn Tangkhabuanbutra , Samaisukh Sophasan , Sakol Panyim","doi":"10.1016/j.bbaexp.2006.07.004","DOIUrl":"10.1016/j.bbaexp.2006.07.004","url":null,"abstract":"<div><p>Serotonin (5-HT) mediates a number of diverse physiological functions in crustaceans by interacting with various 5-HT receptor subtypes. A putative 5-HT receptor cloned from the ovary of the black tiger prawn (<em>Penaeus monodon</em>) consisted of 2291 nucleotides, encoding a putative 5-HT<sub>1Pem</sub> receptor protein of 591 amino acids. Transient expression of 5-HT<sub>1Pem</sub> in HEK293 cells demonstrated a saturable [<sup>3</sup>H]-5-HT binding with a Kd of 10.43±1.13 nM and <em>B</em><sub>max</sub> of 1.53±0.06 pmol/mg. The putative 5-HT<sub>1Pem</sub> receptor is expressed in all tissues examined and is constitutively expressed in the ovary during ovarian maturation and spent phase. Polyclonal antibodies against the third intracellular loop (i3 loop) of the 5-HT receptor showed that the 5-HT<sub>1Pem</sub> receptor protein was expressed in the trabeculae of ovarian stages 1 and 2 but on the cortical rod and surrounding the oocyte membrane of stages 3 and 4, suggesting that receptor localization plays a critical role in regulating ovarian maturation and spawning in penaeus shrimp.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 7","pages":"Pages 328-339"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26291676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Upregulation of human angiotensinogen (AGT) gene transcription by interferon–gamma: Involvement of the STAT1-binding motif in the AGT promoter 干扰素γ对人血管紧张素原(AGT)基因转录的上调:AGT启动子中stat1结合基序的参与

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-07-01 DOI: 10.1016/j.bbaexp.2006.07.003

Sudhir Jain , Mehul Shah , Yanna Li , Govindaiah Vinukonda , Pravin B. Sehgal , Ashok Kumar

{"title":"Upregulation of human angiotensinogen (AGT) gene transcription by interferon–gamma: Involvement of the STAT1-binding motif in the AGT promoter","authors":"Sudhir Jain , Mehul Shah , Yanna Li , Govindaiah Vinukonda , Pravin B. Sehgal , Ashok Kumar","doi":"10.1016/j.bbaexp.2006.07.003","DOIUrl":"10.1016/j.bbaexp.2006.07.003","url":null,"abstract":"<div><p>Mechanisms to maintain blood pressure in the face of infection are critical to survival. The angiotensinogen (AGT) gene locus is an important component of this response. Thus the AGT gene, expressed predominantly by liver cells, is known to be a positive acute phase reactant. We have previously demonstrated activation of the AGT promoter in hepatocytes through the IL6/STAT3 signaling mechanism. We have now investigated whether IFN-gamma, a cytokine also induced in response to diverse infections, can regulate AGT gene expression, and have elucidated the molecular mechanism involved. IFN gamma treatment up-regulated AGT mRNA level and promoter activity in Hep3B hepatocytes. Sequential deletion of the promoter from the 5′ side suggested the major IFN gamma responsive DNA element to be between −303 and −103. This region contained a candidate STAT1-binding site between −271 and −279. EMSA and chromatin immuno-precipitation (ChIP) assays confirmed that IFN-gamma treatment induced the binding of STAT1 to this element. Reporter constructs containing this AGT promoter derived element in a multimerized context but not a mutant version were responsive to IFN gamma. Moreover mutating this STAT1 element in the context of the wild-type AGT holo promoter reduced responsiveness to IFN gamma. In contrast to the clear synergism between dexamethasone and IL 6 in the upregulation of the AGT promoter (through interaction between GR and STAT3), the combination of IFN gamma with IL 6 or with dexamethasone did not further increase AGT promoter activity suggesting that the IFN gamma/STAT1 pathway represents a separate signaling mechanism. These data highlight the redundancy in cytokine-mediated host response pathways aimed at the maintenance of blood pressure during infection.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 7","pages":"Pages 340-347"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.07.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26234199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein 人GM3合成酶:一种新的mRNA变体编码该蛋白的nh2末端延伸形式

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Pub Date : 2006-07-01 DOI: 10.1016/j.bbaexp.2006.07.001

Patrizia Berselli, Stefania Zava, Elena Sottocornola, Simona Milani, Bruno Berra, Irma Colombo

{"title":"Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein","authors":"Patrizia Berselli, Stefania Zava, Elena Sottocornola, Simona Milani, Bruno Berra, Irma Colombo","doi":"10.1016/j.bbaexp.2006.07.001","DOIUrl":"10.1016/j.bbaexp.2006.07.001","url":null,"abstract":"<div><p>All human GM<sub>3</sub> synthase mRNA variants until now identified predict a protein of 362 amino acids having substrate activity highly restricted to lactosylceramide. In this report we describe the identification of a new GM<sub>3</sub> synthase transcript containing an additional translation start codon, located upstream and in-frame with that up to now considered unique translation initiation site in the human GM<sub>3</sub> synthase gene. <em>In vitro</em> expression studies showed that the new transcript produces a longer form of human GM<sub>3</sub> synthase, that is efficiently translocated into the microsomal lumen and glycosylated. Moreover, stable cDNA transfection into mammalian cells gives rise to a threefold increase of GM<sub>3</sub> synthase activity, associated to a broader substrate specificity. Although this transcript has been initially identified in the human placenta, RT-PCR analyses verified the expression of an identical mRNA also in undifferentiated HL60 cells, but not in the monocytic lineage. Altogether, these results are the first demonstration of the existence of a new isoform of human GM<sub>3</sub> synthase, which could play an important role during HL60 cell differentiation. The functional relevance of the existence of two isoforms of GM<sub>3</sub> synthase is also discussed.</p></div>","PeriodicalId":100161,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","volume":"1759 7","pages":"Pages 348-358"},"PeriodicalIF":0.0,"publicationDate":"2006-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbaexp.2006.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26221913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

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