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The advances of the Chinese Brucella suis strain 2 vaccine 中国猪布鲁氏菌2株疫苗的研究进展

Animal Research and One Health Pub Date : 2023-07-03 DOI: 10.1002/aro2.6

Peng Li, Hui Jiang, Yu Feng, Guangzhi Zhang, Menachem Banai, Jiabo Ding

{"title":"The advances of the Chinese Brucella suis strain 2 vaccine","authors":"Peng Li, Hui Jiang, Yu Feng, Guangzhi Zhang, Menachem Banai, Jiabo Ding","doi":"10.1002/aro2.6","DOIUrl":"https://doi.org/10.1002/aro2.6","url":null,"abstract":"Brucellosis, a worldwide crucial zoonotic disease, poses global socioeconomic risks to the system by threatening human health and animal reproduction. In recent years, with the increase of animal husbandry, animal brucellosis has become a remarkable health issue in China. To prevent and control the spread of brucellosis, Brucella suis live strain S2 vaccine has been licensed as a multivalent vaccine against the three major zoonotic Brucella species, for example, Brucella melitensis (small ruminants), Brucella abortus (bovids), and B. suis (swine). Following this process, the country enforced control measures based upon B. suis S2 vaccination, which reduced the disease burden in 2022 to 0.66% in the livestock population. The aim of this paper is to review and discuss the biological properties of the S2 vaccine and its wide use in vaccination programs of China, highlighting oral vaccination advantages, validation, and standardization of this vaccine as well as the progress of the S2 vaccination program achieved in the national control of the three zoonotic Brucella species.","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"1 1","pages":"115-126"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50119132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress in the therapy of brucellosis 布鲁氏菌病治疗研究进展

Animal Research and One Health Pub Date : 2023-07-03 DOI: 10.1002/aro2.5

Chen Li, Yingdi Wang, Qisheng Peng

{"title":"Research progress in the therapy of brucellosis","authors":"Chen Li, Yingdi Wang, Qisheng Peng","doi":"10.1002/aro2.5","DOIUrl":"https://doi.org/10.1002/aro2.5","url":null,"abstract":"Brucellosis is a zoonotic bacterial disease posing serious threats to the health of humans and animals. Currently, effective therapeutics available for brucellosis are in urgent demand. Brucellosis is transmitted to humans through diet or contact with infected animals. Several live-attenuated vaccine strains are commercially available for animals, such as Brucella melitensis Rev.1, Brucella abortus S19, and RB51. However, no secure and effective vaccine for human beings has been developed yet against brucellosis, for which antibiotic therapy is the most frequently used and valid. Nevertheless, excessive antibiotics could prohibit the sensitivity of Brucella and develop resistance in humans. In addition, other clinical treatments, such as surgical treatment, have little effect on brucellosis. Therefore, novel treatment protocols should be explored. Based on numerous experimental studies, it is speculated that brucellosis can be fundamentally treated by inhibiting the activation of the type IV secretion system and changing the acidic environment of eBCV. In addition, previous literature showed that traditional Chinese medicine therapy also had certain efficacy, providing a new perspective angle for the exploration of treatment options.","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"1 1","pages":"127-136"},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50119131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From probiotics to postbiotics: Concepts and applications 从益生菌到后生物素：概念和应用

Animal Research and One Health Pub Date : 2023-07-03 DOI: 10.1002/aro2.7

Chunchen Liu, Ning Ma, Yue Feng, Min Zhou, Huahui Li, Xiujun Zhang, Xi Ma

引用次数: 0

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