Anesthesiology and Perioperative Science最新文献

{"title":"Selective venoconstriction with centhaquine in perioperative and critical care medicine: A pharmacological lever for enhancing venous return and integrative hemodynamic management","authors":"Athanasios Chalkias","doi":"10.1007/s44254-025-00119-0","DOIUrl":"10.1007/s44254-025-00119-0","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00119-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of transcutaneous electrical stimulation of the Xi and Yuan acupoints on postoperative pain after endoscopic nasal surgery: a randomized controlled trial","authors":"Fan Yao,&nbsp;Kairui Liu,&nbsp;Shengnan Shi,&nbsp;Lili Wang,&nbsp;Jiale Zhao,&nbsp;Shugen Xiao,&nbsp;Ying Shen,&nbsp;Xingrui Gong,&nbsp;Mazhong Zhang","doi":"10.1007/s44254-025-00118-1","DOIUrl":"10.1007/s44254-025-00118-1","url":null,"abstract":"<div><h3>Purpose</h3><p>Opioids for postoperative pain control often cause side effects and affect postoperative recovery. Combined electrical stimulation of the Xi and Yuan acupoints has been reported to exhibit an analgesic effect. We evaluated the effect of transcutaneous electrical acupoint stimulation (TEAS) of the Xi and Yuan acupoints on postoperative pain after nasal surgery in a randomized controlled trial.</p><h3>Methods</h3><p>Sixty patients undergoing either endoscopic sinus surgery or septoplasty surgery were randomized to Sham or TEAS (Xi and Yuan acupoint stimulation) groups in a 1:1 ratio. The primary outcome was the numeric rating scale (NRS) for pain on postoperative day 1. The secondary outcomes included intraoperative propofol and remifentanil consumption, time to extubation after anesthesia, and 15-item Quality of Recovery scale (QoR15). Data were analyzed using intention-to-treat analysis.</p><h3>Results</h3><p>TEAS decreased NRS on postoperative day 1 (<i>P</i> = 0.020, with NRS before surgery and surgery site adjusted). A mixed-model repeated-measures analysis demonstrated that TEAS decreased NRS over the first 3 days after endoscopic nasal surgery (<i>P</i> = 0.035). TEAS also significantly reduced intraoperative propofol (<i>P</i> = 0.001) and remifentanil (<i>P</i> = 0.009) requirements, shortened time to extubation (<i>P</i> = 0.003), and improved postoperative QoR15 (<i>P</i> &lt; 0.05). Notably, septoplasty and preoperative pain were identified as risk factors for higher postoperative pain intensity on postoperative day 1.</p><h3>Conclusions</h3><p>These results demonstrate that electrical stimulation of both the Xi and Yuan acupoints significantly reduces pain intensity on postoperative day 1 and throughout the first 3 postoperative days following endoscopic nasal surgery.</p><h3>Trial registration</h3><p>Registered on the Chinese Clinical Trial Registry (https://www.chictr.org.cn/showproj.html?proj=230970), No. ChiCTR2400084850, on May 27, 2024. Principal investigator: Xingrui Gong.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00118-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing anesthesia: AI-driven protein structure prediction and its clinical impact","authors":"Yuqi Zhang,&nbsp;Yan Wu,&nbsp;Keqin Wang,&nbsp;Ziqian Zhang,&nbsp;Yucheng Liu,&nbsp;Yangyang Chen,&nbsp;Tianyu Yin,&nbsp;Xinghe Wang,&nbsp;Su Liu","doi":"10.1007/s44254-025-00122-5","DOIUrl":"10.1007/s44254-025-00122-5","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00122-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of anesthetic-induced immune dysregulation","authors":"Tatiane Renata Fagundes,&nbsp;Carolina Coradi,&nbsp;Marina Rayciki Sotomayor,&nbsp;Aline Graciele Henriques Campos,&nbsp;Luísa Cristina Fortuna da Silva,&nbsp;Hellena Alves Ferneda,&nbsp;Wilson da Silva Pereira Junior,&nbsp;Gabriela Bonetti Bellandi,&nbsp;Maria Eduarda Pardal Simonato,&nbsp;Valentina Vieira Steffanello,&nbsp;Larissa de Oliveira Manes,&nbsp;Rafael Gomes Paz,&nbsp;Edina Cassiane Padilha,&nbsp;Felipe da Silva Bender,&nbsp;Ricardo Nogueira Vincensi,&nbsp;Maria Paula de Andrade Berny,&nbsp;Mateus Lucas Falco,&nbsp;Odirlei João Titon,&nbsp;Carolina Panis","doi":"10.1007/s44254-025-00117-2","DOIUrl":"10.1007/s44254-025-00117-2","url":null,"abstract":"<div><p>Anesthesia is essential in modern surgical practice, ensuring patient comfort, immobility, and amnesia. However, its impact on the immune system has become a growing area of research, as anesthetic agents can modulate immune function in complex ways. Emerging evidence suggests that anesthetics may induce immune dysregulation, affecting both innate and adaptive immunity, with potential consequences for patient outcomes, particularly in the context of infection, inflammation and cancer. This review provides a comprehensive understanding of the immunological effects of anesthesia, exploring the molecular and cellular pathways involved. It examines how anesthetics can either suppress or modulate immune responses, depending on factors including drug type, dose and patient-specific characteristics. We discuss their influence on innate immunity, including the activity of natural killer cells, macrophages and neutrophils, as well as their impact on adaptive immunity, particularly T-cell activation, cytokine production and antigen presentation. In addition, we highlight the immunological consequences of commonly used anesthetic agents in clinical practice.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00117-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmacytoid dendritic cells in sepsis-associated acute lung injury: a potential therapeutic target","authors":"Shuangfa Zou,&nbsp;Jie Bai,&nbsp;Canxin Liang,&nbsp;Jinfeng Yang,&nbsp;Ji Xiao","doi":"10.1007/s44254-025-00121-6","DOIUrl":"10.1007/s44254-025-00121-6","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00121-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145145285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing high and total spinal anesthesia during thoracic segmental spinal anesthesia: a clinical perspective","authors":"Imran Ahmed Khan,&nbsp;Satish Kumar,&nbsp;Naresh Wamanrao Paliwal","doi":"10.1007/s44254-025-00116-3","DOIUrl":"10.1007/s44254-025-00116-3","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00116-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145144669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine protects against N-Nitrosodiethylamine induced acute hepatic damage by modulating autophagy and apoptosis through SIRT1","authors":"Ruixin Wu,&nbsp;Sailan Tang,&nbsp;Aoxue Xu,&nbsp;Qi Xue,&nbsp;Shuwen He,&nbsp;Qizhi Liao,&nbsp;Chanjuan Chen,&nbsp;Dachen Zhou,&nbsp;Xianwen Hu,&nbsp;Nianliang Zhang,&nbsp;Gang Li,&nbsp;Ye Zhang,&nbsp;Chunxia Huang","doi":"10.1007/s44254-025-00113-6","DOIUrl":"10.1007/s44254-025-00113-6","url":null,"abstract":"<div><h3>Purpose</h3><p>Dexmedetomidine (DEX) has been extensively studied for its protective effects on multiple organs, primarily attributed to its anti-inflammatory and anti-apoptotic properties. However, the molecular mechanisms underlying its effects in acute hepatic damage induced by N-Nitrosodiethylamine (DEN) remain unclear. This study aims to investigate the role of DEX in mitigating DEN-induced acute hepatic damage and elucidate the involvement of the silent information regulator 1 (SIRT1)-autophagy axis in this process.</p><h3>Methods</h3><p>Acute hepatic damage was induced by a single intraperitoneal injection of 1% DEN (10 mg/kg). DEX (20, 40, or 80 μg/kg) was administered intraperitoneally 30 min prior to DEN exposure. Additionally, the SIRT1 inhibitor Selisistat (EX527) or the autophagy inhibitor 3-MA was administered intraperitoneally 30 min after DEN injection. Histopathological changes, inflammatory and oxidative responses were assessed 24 h post-DEN exposure. The roles of autophagy and SIRT1 were further examined using hepatocyte-specific SIRT1 knockout mice (SIRT1^f/fALB^cre+/−). </p><h3>Results</h3><p>A single injection of DEN significantly induced acute hepatic damage, characterized by marked elevations in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hepatocyte necrosis, inflammatory cell infiltration, and increased oxidative stress burden. Dexmedetomidine pretreatment effectively attenuated hepatic damage, as evidenced by significant reductions in ALT, AST, and reactive oxygen species (ROS) accumulation. The expressions of LC3B and SIRT1 were upregulated following DEX pretreatment, with increased co-localization between the two proteins. However, the hepatoprotective effects of DEX were abolished when SIRT1 was inhibited by EX527 or genetically deleted in in SIRT1^f/fALB^cr^e^+/^– mice.</p><h3>Conclusions</h3><p>Dexmedetomidine significantly alleviates DEN-induced acute hepatic damage through a mechanism involving the upregulation of autophagy and SIRT1 activity. These findings suggest that DEX may be a promising therapeutic strategy for treating severe hepatic damage and other forms of acute organ injury.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00113-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145143598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The capsaicin receptor TRPV1 reduces sepsis-associated brain injury in mice by inhibiting pyroptosis","authors":"Menghong Long,&nbsp;Zhenyu Hu,&nbsp;Feiyu Long,&nbsp;Yingxu Chen,&nbsp;Li Liu,&nbsp;Maohua Wang","doi":"10.1007/s44254-025-00115-4","DOIUrl":"10.1007/s44254-025-00115-4","url":null,"abstract":"<div><h3>Purpose</h3><p>Sepsis is a life-threatening disorder marked by organ dysfunction due to infection. Transient receptor potential vanilloid 1 (TRPV1) is a non-selective, ligand-gated cation channel activated by multiple stimuli. This study investigates the role of TRPV1 in sepsis-associated encephalopathy (SAE).</p><h3>Methods</h3><p>The SAE models of wild-type and TRPV1 knockout (TRPV1^-/-) mice were established through intraperitoneal injection of 10 mg/kg lipopolysaccharide. Brain tissues and serum were collected 24 h post-injection for analysis. Rectal temperature was monitored at 12 and 24 h, and the 7-day survival rate was recorded. Mice were pretreated with capsaicin (CAP), and brain tissue and serum were collected for detection.</p><h3>Results</h3><p>TRPV1 expression was significantly elevated in the brain tissues of mice with sepsis. TRPV1^-/- aggravated SAE symptoms, as evidenced by a significant decrease in rectal temperature, a reduced 7-day survival rate, an elevated Murine Sepsis Score, and greater impairment in learning and memory. Mechanistically, TRPV1 deficiency increased NF-κB, pyroptosis-related proteins, and levels of IL-6 and TNF-α in SAE mice. CAP pretreatment significantly reduced abnormal neurons in the CA1 region, decreased NF-κB, Pro-caspase1, and Cleaved-caspase1 in brain tissues, and lowered IL-1β and IL-18 serum levels, with this effect being TRPV1-dependent.</p><h3>Conclusion</h3><p>In summary, TRPV1 deficiency worsens SAE-induced damage in mice, associated with activation of NF-κB and pyroptosis pathways. CAP pretreatment improved the damage caused by SAE by activating TRPV1.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00115-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145143592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioids worsen postoperative sleep: a narrative review","authors":"Siying Huang,&nbsp;Linlin Zhang,&nbsp;Yue Tian","doi":"10.1007/s44254-025-00114-5","DOIUrl":"10.1007/s44254-025-00114-5","url":null,"abstract":"<div><p>Sleep architecture is frequently disrupted after major surgery, leading to acute and chronic postoperative sleep disorders that may contribute to episodic hypoxia, hemodynamic instability, postoperative fatigue, cognitive dysfunction, depression. These all have potentially detrimental impacts on disease regression. Pain is a key driver of postoperative sleep disruption and opioids are widely used for pain management due to their potent analgesic and sedative effects. Opioids are conventionally believed to induce natural sleep and reduce sleep disorders. However, available evidence suggests that opioids can disrupt sleep architecture, leading to sleep deprivation, fragmentation and restriction. This systematic review investigates the detrimental effects of opioids on postoperative sleep and explores the underlying mechanisms responsible for sleep disorders. By synthesizing current evidence wehighlight the risks associated with opioid-centric pain management strategies and advocate for a more balanced approach that optimizes pain relief while mitigating opioid-induced sleep disruption.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00114-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of microRNAs in Anesthesia and Pain: Insights from the 2024 Nobel Prize in Physiology or Medicine","authors":"Murong Li,&nbsp;Feng Zhou,&nbsp;Yue Tian","doi":"10.1007/s44254-025-00112-7","DOIUrl":"10.1007/s44254-025-00112-7","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00112-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145142020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}