Anesthesiology and Perioperative Science最新文献

{"title":"Association of nociception index with postoperative immune status: a prospective observational study","authors":"Yanling Zhang,&nbsp;Anhui Zha,&nbsp;Weiyun Shen,&nbsp;Ruping Dai","doi":"10.1007/s44254-025-00104-7","DOIUrl":"10.1007/s44254-025-00104-7","url":null,"abstract":"<div><h3>Purpose</h3><p>Electroencephalography (EEG) is commonly used to assess sedation levels in general anesthesia, but its ability to indicate perioperative trauma and inflammation activation levels remains unclear. This study examines the relationship between the nociception index (NOX), an EEG-derived metric, and related immune changes in surgical patients.</p><h3>Methods</h3><p>Patients aged 18 to 75 years scheduled for elective surgery under general anesthesia, without chronic pain, hepatic or renal dysfunction, pregnancy, intensive care unit stay, and a postoperative stay of less than 1 day. We investigated the relationship between the NOX and immune-inflammatory parameters in surgical patients. NOX and bispectral index (BIS) values were recorded upon post-anesthesia care unit admission and after awakening from anesthesia. We collected immune-related indicators, including immune cell counts in routine blood tests, C-reactive protein (CRP) levels, hemoglobin, and the length of postoperative hospital stay. The association of NOX with inflammatory response from surgical stimulation and postoperative prognosis was assessed.</p><h3>Results</h3><p>A total of 100 patients were included in the analysis. NOX value is positively associated with immune-inflammatory parameters, such as the postoperative CRP level (R = 0.3313, <i>P</i> = 0.0002), changes in monocyte counts (R = 0.3078, <i>P</i> = 0.0009), and changes in hemoglobin (R = 0.4036, <i>P</i> &lt; 0.0001) before and one day after surgery, whereas the BISpro index is not associated with these parameters (All<i> P</i> &gt; 0.05). In comparison to patients with NOX values lower than the BISpro values, patients with NOX values exceeding BISpro levels showed elevated levels of immune-related indicators, such as CRP level (<i>P</i> = 0.0182), monocyte count (<i>P</i> = 0.0357), and changes in hemoglobin before and one day after surgery (<i>P</i> = 0.0234). The variation of NOX (△NOX) negatively correlates with the CRP level (R = –0.2708, <i>P</i> = 0.0073), changes in monocyte numbers (R = –0.3606, <i>P</i> = 0.0002), changes in hemoglobin (R = –0.3083, <i>P</i> &lt; 0.0001), and postoperative hospital stay (R = –0.1882, <i>P</i> = 0.0327).</p><h3>Conclusions</h3><p>Our study demonstrates that, as an EEG index, NOX and its dynamic variation may be associated with the inflammatory response induced by surgical trauma, potentially offering insights into postoperative immune status.</p><h3>Trial registration</h3><p>Registered at the Chinese Clinical Trial Registry (ChiCTR, https://www.chictr.org.cn/showproj.html?proj=199672) with No. ChiCTR2300074319.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00104-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of microbial-gut-brain axis modulation by electroconvulsive therapy in the treatment of depression","authors":"Jiaming Ji,&nbsp;Jinyan Guo,&nbsp;Jirong Yang,&nbsp;Siyang Zeng,&nbsp;Xue Han,&nbsp;Ziqing Hei,&nbsp;Weifeng Yao,&nbsp;Chaojin Chen","doi":"10.1007/s44254-025-00103-8","DOIUrl":"10.1007/s44254-025-00103-8","url":null,"abstract":"<div><h3>Purpose</h3><p>The present study aims to evaluate the effects of electroconvulsive therapy (ECT) on depressive behaviors. In addition, we explore mechanisms by which ECT alters the composition and functioning of gut microbiota through the microbiota-gut-brain axis.</p><h3>Methods</h3><p>A depression model in mice was established using chronic unpredictable mild stress. The mice were divided into three groups: control, depression, and ECT-treated. Depressive behaviors were assessed through a series of behavioral tests, including monitoring body weight, open field tests, sucrose preference and forced swim tests. Histological and microcirculatory assessments of brain and gut tissues were conducted using hematoxylin and eosin (H&amp;E) staining, Nissl staining and immunofluorescence methodology along with laser speckle contrast imaging. In addition, the inflammatory cytokines Tumor Necrosis Factor-<i>α</i> (TNF-<i>α</i>), Interleukin-6 (IL-6) and Interleukin-1<i>β</i> (IL-1<i>β</i>) were quantified in gut tissues using enzyme-linked immunosorbent assay. Metagenomic sequencing was employed to evaluate the diversity and abundance of the gut microbiota.</p><h3>Results</h3><p>ECT significantly improved depressive behaviors in mice as evidenced by increased body weight and decreased immobility time in the forced swim tests. H&amp;E staining indicated a substantial reduction in gut inflammation while Nissl staining revealed a restoration of neuronal morphology following ECT treatment. Furthermore, immunofluorescence analysis showed elevated c-Fos expression in the hippocampal region (<i>P</i> &lt; 0.05). Assessments of inflammatory cytokines demonstrated significant reductions in TNF-<i>α</i>, IL-6, and IL-1<i>β</i> levels in the ECT group. In addition, metagenomic sequencing showed that ECT enhanced gut microbiota diversity, particularly restoring the abundance of Bacteroides and Verrucomicrobia (<i>P</i> &lt; 0.05).</p><h3>Conclusion</h3><p>ECT exerts its antidepressant effects by modulating gut microbiota and enhancing the functionality of the gut-brain axis.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00103-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The innovative approach of continuous lateral parasacral ischial plane block: supine position","authors":"Peng Ye,&nbsp;Cansheng Gong,&nbsp;Jing Zhuang,&nbsp;Hanliang Fan,&nbsp;Xuan Pan,&nbsp;Xiaochun Zheng,&nbsp;Ting Zheng","doi":"10.1007/s44254-025-00101-w","DOIUrl":"10.1007/s44254-025-00101-w","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00101-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving perioperative normothermia: insights from clinical practice","authors":"Jingyuan Chen,&nbsp;Yaqing Zhan,&nbsp;Xu Zhao,&nbsp;Wenqi Huang","doi":"10.1007/s44254-025-00098-2","DOIUrl":"10.1007/s44254-025-00098-2","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00098-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the application of platelet-rich plasma in peripheral nerve injuries","authors":"Xiao-Yu Dou,&nbsp;Min An","doi":"10.1007/s44254-025-00100-x","DOIUrl":"10.1007/s44254-025-00100-x","url":null,"abstract":"<div><p>Peripheral nerve injury (PNI) can occur after various types of trauma; these are common clinical injuries. These injuries often result in chronic conditions such as neuropathic pain and permanent disabilities, severely affecting quality of life and work. Achieving optimal repair of injured peripheral nerves remains a focal point of clinical research. In recent years, platelet-rich plasma (PRP) has been increasingly applied in clinical settings due to associated high concentration of various growth factors that promote tissue repair. Here we review advances in PNI repair and the prospect of using autologous PRP as a treatment paradigm.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00100-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143845602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Impact of opioids on hospital stay and mortality in patients undergoing abdominal surgeries”","authors":"Han-bing Xu,&nbsp;Chong Fu,&nbsp;Zihan Yan,&nbsp;Hua-yue Liu,&nbsp;Fu-hai Ji","doi":"10.1007/s44254-025-00102-9","DOIUrl":"10.1007/s44254-025-00102-9","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00102-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis and machine learning in the study of intestinal ischemia/reperfusion injury","authors":"Xiao-dong Chen,&nbsp;Ke-xuan Liu","doi":"10.1007/s44254-025-00097-3","DOIUrl":"10.1007/s44254-025-00097-3","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00097-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association of erythrocytic NO-ferroheme, a surrogate marker of endothelial function with perioperative cardiovascular events in low/intermediate risk patients undergoing elective non-cardiac surgery","authors":"Hasnae Boughaleb,&nbsp;Jerome Linden,&nbsp;Arvind Soni,&nbsp;Nathalie Fabian,&nbsp;Irina Lobysheva,&nbsp;Virginie Montiel,&nbsp;Mona Momeni,&nbsp;Marie-Agnès Docquier,&nbsp;Annie Robert,&nbsp;Nancy Van Overstraeten,&nbsp;Jean-Luc Balligand","doi":"10.1007/s44254-025-00096-4","DOIUrl":"10.1007/s44254-025-00096-4","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;p&gt;Pre-operative assessment of cardiovascular risk currently relies on scores, such as the American Society of Anesthesiologists (ASA) score, biased towards high-risk, but neglecting middle/lower risk patients. Endothelial dysfunction is a precursor to cardiovascular events (CVEs), due to impaired nitric oxide (NO) bioavailability. We previously showed that the erythrocytic NO-ferroheme including the 5-coordinated NO-heme-α-hemoglobin (HbNO), a complex between NO and deoxyhemoglobin correlates with endothelial function assessed by digital tonometry. The aim of this study was to evaluate if HbNO is associated with the different cardiovascular risk factors and to explore its association with CVE in patients undergoing elective non-cardiac surgery.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;We conducted a prospective, monocentric study in adult patients scheduled for elective non-cardiac surgery. At preoperative visit, blood samples were collected, and erythrocytes isolated to measure baseline HbNO levels, along with other biomarkers routinely used to evaluate pre-operative risk factors. NO-ferroheme signals were quantified using electron paramagnetic resonance spectroscopy. Follow-up visits and data analysis using electronic health records were conducted at 1-, 3-, 6- and 12- months postoperatively. The primary endpoint was the occurrence of a composite of CVE, including arrhythmias, chest pain/unstable angina, myocardial infarction/ischemia, pulmonary edema, pulmonary embolism, stroke, deep venous thrombosis, cardiac failure and death of any cause.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Between November 2019 and June 2022, 2,500 patients were screened and 1,066 patients underwent an elective non-cardiac surgery. Among the 1,066 patients kept for the final analysis, 23 subjects developed a peri-operative CVE up to 30 days after surgery (&lt;i&gt;p-&lt;/i&gt;30d CVE). Linear regression analysis revealed several independent factors significantly correlated with HbNO levels, including hemoglobin, anticoagulant usage, and smoking status. Patients who developed &lt;i&gt;p-&lt;/i&gt;30d CVE exhibited lower mean HbNO levels (124.2 ± 96.6 nM) compared to those who did not (154.8 ± 104.1 nM; &lt;i&gt;p = &lt;/i&gt;0.028). Using a threshold of 124 nM for HbNO, levels below this cutoff (HbNO &lt; 124 nM) were associated with an increased risk of &lt;i&gt;p-&lt;/i&gt;30d CVE (OR [95% CI] = 4.21 [1.55–11.41]), as did classification in ASA III or higher (OR [95% CI] = 3.23 [1.38–7.59]). However, after excluding patients at high risk of CVE a priori, HbNO &lt; 124 nM remained associated to &lt;i&gt;p-&lt;/i&gt;30d CVE (OR [95% CI] = 5.52 [1.57–19.33]) while the association to ASA-score was no longer significant (OR [95% CI] = 0.89 [0.20–3.97]).&lt;/p&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;In patients scheduled for non-cardiac surgery, known cardiovascular risk factors, such as active smoking independently and negatively correlates with erythrocytic NO-ferroheme including HbNO. In patients without severe comorbidities, despite the limited number of CVEs obser","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00096-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical sevoflurane in the treatment of complex wounds: new application perspectives","authors":"Wei Xu,&nbsp;Hailong Bing,&nbsp;Wangli Tian,&nbsp;Linhan Wang,&nbsp;Zhengyuan Xia,&nbsp;Qinjun Chu","doi":"10.1007/s44254-025-00099-1","DOIUrl":"10.1007/s44254-025-00099-1","url":null,"abstract":"","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00099-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic prediction model for chronic postsurgical pain among adult patients: a systematic review and meta-analysis","authors":"Yanjie Dong,&nbsp;Huolin Zeng,&nbsp;Lei Yang,&nbsp;Huan Song,&nbsp;Qian Li","doi":"10.1007/s44254-025-00093-7","DOIUrl":"10.1007/s44254-025-00093-7","url":null,"abstract":"<div><h3>Purpose</h3><p>Chronic postsurgical pain (CPSP) presents a significant impact in the postoperative recovery, affecting patients’ outcomes and quality of life. Numerous prognostic prediction models have been developed to predict the risk of CPSP, however, the clinical utility remains variable. This systematic review and meta-analysis aimed to critically assessed and synthesize the existing CPSP prognostic prediction models in adult patients.</p><h3>Methods</h3><p>A comprehensive literature search was conducted in PubMed, Embase, and the Cochrane library up to August 2024. A total of 22 models were included in the systematic review, with 19 models subsequently integrated into the meta-analysis.</p><h3>Results</h3><p>The overall pooled C-index of the models was 0.79 (95% confidence interval [CI]: 0.75, 0.83; I² = 88.6%). For studies evaluating CPSP at 3 months postoperatively, the pooled C-index was 0.80 (95% CI: 0.73, 0.87; I² = 82.1%). At 4 months, the pooled C-index was 0.75 (95% CI: 0.62, 0.87; I² = 82.8%), while studies considered CPSP at 6 months showed a pooled C-index of 0.81 (95% CI: 0.73, 0.89; I² = 93.8%). For 12 months post-surgery, the C-index was 0.77 (95% CI: 0.74, 0.79; I² = 0%). Among models with external validation, the C-index was 0.76 (95% CI: 0.70, 0.82; I² = 68.2%). For orthopedic surgery, the C-index was 0.82 (95% CI: 0.74, 0.91; I² = 92.7%). For breast surgery, the C-index was 0.78 (95% CI: 0.75, 0.81; I² = 0%). For studies reported C-index, the C-index was 0.70 (95% CI: 0.66, 0.73; I² = 0%) while the C-index was 0.81 (95% CI: 0.77, 0.85; I² = 88%) for studies reported area under receiver operating characteristic curve.</p><h3>Conclusions</h3><p>While prognostic prediction models demonstrated promising discriminative performance, the high overall risk of bias raises concerns about their quality and generalizability. These findings underscore the urgent need for rigorously designed and externally validated models to improve CPSP risk prediction in clinical practice.</p></div>","PeriodicalId":100082,"journal":{"name":"Anesthesiology and Perioperative Science","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s44254-025-00093-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}