Advances in Free Radical Biology & Medicine最新文献

Glucose starvation induced upregulation of Prohibitin 1 via ROS generation causes mitochondrial dysfunction and apoptosis in breast cancer cells. 葡萄糖饥饿通过ROS生成诱导prohibition - 1上调，导致乳腺癌细胞线粒体功能障碍和凋亡。

Advances in Free Radical Biology & Medicine Pub Date : 2019-12-01 DOI: 10.1016/j.freeradbiomed.2019.09.020

Ganesh Kumar Raut, Moumita Chakrabarti, D. Pamarthy, M. Bhadra

引用次数: 31

Gender differences in albumin and ascorbic acid in the vitreous antioxidant system. 玻璃体抗氧化系统中白蛋白和抗坏血酸的性别差异。

Advances in Free Radical Biology & Medicine Pub Date : 2019-11-06 DOI: 10.1016/j.freeradbiomed.2019.11.008

Schwab Christoph, Paar Margret, Fengler Vera Heike, Ivastinovic Domagoj, Haas Anton, Seidel Gerald, Glatz Wilfried, Malle Eva-Maria, Weger Martin, Velikay-Parel Michaela, Faustmann Gernot, Wedrich Andreas, Reibnegger Gilbert, Winklhofer-Roob Brigitte, Oettl Karl

引用次数: 7

A short guide to nomenclature of radicals, radical ions, iron-oxygen complexes and polycyclic aromatic hydrocarbons 自由基、自由基离子、铁氧配合物和多环芳烃的命名指南

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80029-1

James G. Traynham

引用次数: 4

The radical view 激进的观点

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80016-3

William A. Pryor (Editor-in-Chief)

引用次数: 12

Contents of volume 2 第二卷内容

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80031-X

引用次数: 0

Quinones in Biology: Functions in electron transfer and oxygen activation 醌类在生物学中的作用:电子传递和氧活化

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80030-8

Hans Nohl, Werner Jordan, Richard J. Youngman

引用次数: 154

SINGLET O2 (VOLUMES I, II, III, AND IV) 单重态o2(第一、二、三、四卷)

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80010-2

K. Davies

引用次数: 0

A Comment on Free Radical Nomenclature 对自由基命名法的评述

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80028-X

Dr. William A. Pryor (Editor-in-Chief)

引用次数: 0

Superoxide radical: A likely link between reperfusion injury and inflammation 超氧自由基:可能与再灌注损伤和炎症有关

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80018-7

Joe M. McCord

{"title":"Superoxide radical: A likely link between reperfusion injury and inflammation","authors":"Joe M. McCord","doi":"10.1016/S8755-9668(86)80018-7","DOIUrl":"10.1016/S8755-9668(86)80018-7","url":null,"abstract":"<div><p>The roles of the superoxide free radical (0<sub>2</sub><sup>.-</sup>) in the inflammatory process are known to include bactericidal action as well as participation in cell-to- cell communication via the activation of a superoxide-dependent chemo-attractant. A role for the radical is now also understood in post-ischemic injury brought about by the reintroduction of molecular oxygen. In this case the superoxide is produced within the reperfused tissue by the en~me xanthine oxidase. While the mechanisms of free radical production are biochemically distinct in these two pathological conditions, there are logical links apparent whereby an ischemia/reperfusion-induced injury would lead to inflammation, and conversely whereby an inflamed tissue could become vulnerable to ischemic injury. The occasional study notwithstanding, much evidence now supports roles for superoxide and hydrogen peroxide in reperfusion injury to the heart. In the rat and dog, xanthine oxidase appears to be the primary source of these forms of active oxygen. Manifestations of injury include inactivation of specific enzymes, functional impairment of the mitochondria, and conductance abnormalities.</p></div>","PeriodicalId":100046,"journal":{"name":"Advances in Free Radical Biology & Medicine","volume":"2 2","pages":"Pages 325-345"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S8755-9668(86)80018-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73312060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75

The role of antioxidants in the retina and retinal pigment epithelium and the nature of prooxidant-induced damage 抗氧化剂在视网膜和视网膜色素上皮中的作用以及抗氧化剂诱导损伤的性质

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80024-2

Garry J. Handelman, Edward A. Dratz

{"title":"The role of antioxidants in the retina and retinal pigment epithelium and the nature of prooxidant-induced damage","authors":"Garry J. Handelman, Edward A. Dratz","doi":"10.1016/S8755-9668(86)80024-2","DOIUrl":"10.1016/S8755-9668(86)80024-2","url":null,"abstract":"<div><p>The vertebrate retina has several features that make it vulnerable to damage from autoxidation. The photoreceptor membranes contain high levels of polyunsaturated fatty acids; abundant mitochondria are present which may leak activated oxygen species; and light exposure of the retina may cause photoxidation. These features are analyzed in detail, and the various antioxidant mechanisms of the vertebrate retina are surveyed. The interplay among oxidant stress and antioxidant defenses is illustrated by review of situations where these variables are either artificially manipulated or changed naturally. Vitamin E deficiency damages the retina in a number of well-defined vertebrate model systems, and a lipid autoxidation mechanism for this damage is widely assumed. The retina is quite sensitive to damage by elevated or prolonged light exposure; however, a free-radical role in light damage to the retina has not been established. An alternative mechanism for damage due to vitamin E deficiency and light is considered, which involves elevated vitamin A levels and vitamin A toxicity. Evidence is reviewed that the primate retina requires both vitamin E and selenium. The puzzling role of ocular melanin in light damage and protection is reviewed. Possible contributions of autoxidative damage to aging of the human retina are discussed.</p></div>","PeriodicalId":100046,"journal":{"name":"Advances in Free Radical Biology & Medicine","volume":"2 1","pages":"Pages 1-89"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S8755-9668(86)80024-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75450707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 171