Advances in Free Radical Biology & Medicine最新文献

Glucose starvation induced upregulation of Prohibitin 1 via ROS generation causes mitochondrial dysfunction and apoptosis in breast cancer cells. 葡萄糖饥饿通过ROS生成诱导prohibition - 1上调，导致乳腺癌细胞线粒体功能障碍和凋亡。

Advances in Free Radical Biology & Medicine Pub Date : 2019-12-01 DOI: 10.1016/j.freeradbiomed.2019.09.020

Ganesh Kumar Raut, Moumita Chakrabarti, D. Pamarthy, M. Bhadra

引用次数: 31

Gender differences in albumin and ascorbic acid in the vitreous antioxidant system. 玻璃体抗氧化系统中白蛋白和抗坏血酸的性别差异。

Advances in Free Radical Biology & Medicine Pub Date : 2019-11-06 DOI: 10.1016/j.freeradbiomed.2019.11.008

Schwab Christoph, Paar Margret, Fengler Vera Heike, Ivastinovic Domagoj, Haas Anton, Seidel Gerald, Glatz Wilfried, Malle Eva-Maria, Weger Martin, Velikay-Parel Michaela, Faustmann Gernot, Wedrich Andreas, Reibnegger Gilbert, Winklhofer-Roob Brigitte, Oettl Karl

引用次数: 7

A short guide to nomenclature of radicals, radical ions, iron-oxygen complexes and polycyclic aromatic hydrocarbons 自由基、自由基离子、铁氧配合物和多环芳烃的命名指南

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 Epub Date: 2007-12-27 DOI: 10.1016/S8755-9668(86)80029-1

James G. Traynham

引用次数: 4

The radical view 激进的观点

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 Epub Date: 2007-12-27 DOI: 10.1016/S8755-9668(86)80016-3

William A. Pryor (Editor-in-Chief)

引用次数: 12

Quinones in Biology: Functions in electron transfer and oxygen activation 醌类在生物学中的作用:电子传递和氧活化

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 Epub Date: 2007-12-27 DOI: 10.1016/S8755-9668(86)80030-8

Hans Nohl, Werner Jordan, Richard J. Youngman

引用次数: 154

Contents of volume 2 第二卷内容

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 Epub Date: 2007-12-27 DOI: 10.1016/S8755-9668(86)80031-X

引用次数: 0

SINGLET O2 (VOLUMES I, II, III, AND IV) 单重态o2(第一、二、三、四卷)

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 DOI: 10.1016/S8755-9668(86)80010-2

K. Davies

引用次数: 0

A Comment on Free Radical Nomenclature 对自由基命名法的评述

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 Epub Date: 2007-12-27 DOI: 10.1016/S8755-9668(86)80028-X

Dr. William A. Pryor (Editor-in-Chief)

引用次数: 0

Superoxide radical: A likely link between reperfusion injury and inflammation 超氧自由基:可能与再灌注损伤和炎症有关

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 Epub Date: 2007-12-27 DOI: 10.1016/S8755-9668(86)80018-7

Joe M. McCord

{"title":"Superoxide radical: A likely link between reperfusion injury and inflammation","authors":"Joe M. McCord","doi":"10.1016/S8755-9668(86)80018-7","DOIUrl":"10.1016/S8755-9668(86)80018-7","url":null,"abstract":"<div><p>The roles of the superoxide free radical (0<sub>2</sub><sup>.-</sup>) in the inflammatory process are known to include bactericidal action as well as participation in cell-to- cell communication via the activation of a superoxide-dependent chemo-attractant. A role for the radical is now also understood in post-ischemic injury brought about by the reintroduction of molecular oxygen. In this case the superoxide is produced within the reperfused tissue by the en~me xanthine oxidase. While the mechanisms of free radical production are biochemically distinct in these two pathological conditions, there are logical links apparent whereby an ischemia/reperfusion-induced injury would lead to inflammation, and conversely whereby an inflamed tissue could become vulnerable to ischemic injury. The occasional study notwithstanding, much evidence now supports roles for superoxide and hydrogen peroxide in reperfusion injury to the heart. In the rat and dog, xanthine oxidase appears to be the primary source of these forms of active oxygen. Manifestations of injury include inactivation of specific enzymes, functional impairment of the mitochondria, and conductance abnormalities.</p></div>","PeriodicalId":100046,"journal":{"name":"Advances in Free Radical Biology & Medicine","volume":"2 2","pages":"Pages 325-345"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S8755-9668(86)80018-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73312060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75

The generation of utilization of chlorinated oxidants by human neutrophils 人体中性粒细胞对氯化氧化剂的产生和利用

Advances in Free Radical Biology & Medicine Pub Date : 1986-01-01 Epub Date: 2007-12-27 DOI: 10.1016/S8755-9668(86)80025-4

Samuel T. Test, Stephen J. Weiss

{"title":"The generation of utilization of chlorinated oxidants by human neutrophils","authors":"Samuel T. Test, Stephen J. Weiss","doi":"10.1016/S8755-9668(86)80025-4","DOIUrl":"10.1016/S8755-9668(86)80025-4","url":null,"abstract":"<div><p>The human neutrophil uses the hydrogen peroxide-myeloperoxidase-chloride system to generate a complex mixture of chlorinated oxidants which includes both hypochlorous acid (HOCI) and a wide spectrum of nitrogen-chlorine (N-C1) derivatives. Although these species differ in their reactivity with susceptible target molecules, they are capable of mediating diverse biologic effects. These effects range from the modulation of cellular function and induction of cell lysis to the regulation of neutrophil proteoIytic enzyme activity and enzyme-inhibitor interactions. When chlorinated oxidants are used by neutrophils to mediate ceil injury, HOCI appears to be the toxic species involved. The endogenous, long-lived, N-CI derivatives generated by triggered neutrophils cause little injury to microbial or mammalian targets by virtue of their hydrophilic characteristics. However, the presence of appropriate endogenous or exogenous nitrogenous compounds in the extracellular medium can result in the generation of lipophilic N-C1 oxidants having a heightened cytotoxic potential. Chlorinated oxidants are also able to participate in the regulation of neutrophil elastase and collagenase activity during release of these enzymes from intracellular lysosomal granules. Elastase activity is indirectly up-regulated by the oxidative destruction of its primary inhibitor, α1-proteinase inhibitor, while collagenase is oxidatively converted from a latent, inactive enzyme to a fully proteolytic product. Thus, neutrophils are able to convert the short-lived, nonspecific reactivity of HOCI into highly specific and long-acting effects by modifying cellular or plasma constituents that are critical to the development of the inflammatory response.</p></div>","PeriodicalId":100046,"journal":{"name":"Advances in Free Radical Biology & Medicine","volume":"2 1","pages":"Pages 91-116"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S8755-9668(86)80025-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83224267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 114