Acute Pain最新文献_第6页

Dyloject®, a novel injectable diclofenac solubilised with cyclodextrin: Reduced incidence of thrombophlebitis compared to injectable diclofenac solubilised with polyethylene glycol and benzyl alcohol Dyloject®，一种新型可注射双氯芬酸与环糊精溶解:与可注射双氯芬酸与聚乙二醇和苯甲醇溶解相比，可降低血栓性静脉炎的发生率

Acute Pain Pub Date : 2009-03-01 DOI: 10.1016/j.acpain.2008.11.001

Robert D. Colucci, Curtis Wright IV, Fred H. Mermelstein, Daniel G. Gawarecki, Daniel B. Carr

{"title":"Dyloject®, a novel injectable diclofenac solubilised with cyclodextrin: Reduced incidence of thrombophlebitis compared to injectable diclofenac solubilised with polyethylene glycol and benzyl alcohol","authors":"Robert D. Colucci, Curtis Wright IV, Fred H. Mermelstein, Daniel G. Gawarecki, Daniel B. Carr","doi":"10.1016/j.acpain.2008.11.001","DOIUrl":"10.1016/j.acpain.2008.11.001","url":null,"abstract":"<div><h3>Background</h3><p><span><span>Thrombophlebitis<span> is a common complication of a widely used formulation of injectable diclofenac that employs propylene glycol and </span></span>benzyl alcohol (PG–BA) as solvents. Initial studies of Dyloject</span><sup>®</sup>, a novel injectable diclofenac solubilised with hydroxypropyl-β-cyclodextrin (HPβCD), suggested that this complication occurred less frequently and with lower severity with the newer formulation.</p></div><div><h3>Methods</h3><p><span>We conducted a safety analysis of seven single-dose clinical trials that enrolled 531 patients receiving either a rapid intravenous (IV) bolus of Dyloject</span><sup>®</sup> or a 30<0.01). In a subset of clinical studies that included an observer-rated thrombophlebitis assessment, the incidence of mild irritation was similar for both products (5.4% for Dyloject<sup>®</sup> and 4.9% for PG–BA diclofenac). Differences between the formulations were most evident in the higher incidence of moderate to severe thrombophlebitis after PG–BA diclofenac (2.4% incidence) compared to Dyloject<sup>®</sup> (0% incidence).</p></div><div><h3>Conclusion</h3><p><span>HPβCD, the solubilising agent in Dyloject</span><sup>®</sup>, may be less irritating and result in less clinical thrombophlebitis than the cosolvents propylene glycol and benzyl alcohol used in PG–BA diclofenac.</p></div>","PeriodicalId":100023,"journal":{"name":"Acute Pain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.acpain.2008.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77408706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Acute and chronic pain following breast surgery 乳房手术后的急性和慢性疼痛

Acute Pain Pub Date : 2009-03-01 DOI: 10.1016/j.acpain.2009.01.001

Serene H. Chang, Vivek Mehta, Richard M. Langford

{"title":"Acute and chronic pain following breast surgery","authors":"Serene H. Chang, Vivek Mehta, Richard M. Langford","doi":"10.1016/j.acpain.2009.01.001","DOIUrl":"10.1016/j.acpain.2009.01.001","url":null,"abstract":"<div><h3>Background</h3><p><span>Successful acute pain management after </span>breast surgery remains challenging, and if not achieved, may increase the likelihood of subsequent chronic pain.</p></div><div><h3>Aims</h3><p>This article aimed to evaluate the evidence for varied techniques described for peri-operative pain management in breast surgery, and to review the literature on chronic pain after breast surgery and particularly ‘post-mastectomy pain syndrome’.</p></div><div><h3>Method</h3><p>A Pubmed search was performed, with the key words “mastectomy” and “pain” for articles in the English language in the adult human population (age>=<!--> <span>2104). Twenty three were randomised controlled trials<span> and the rest were prospective or retrospective audits<span> and case series. Inconsistent trial methodology precluded a meta-analysis. Paravertebral local anaesthetic<span> nerve blockade resulted in lower pain scores and fewer side effects than opioid-based regimens. Three risk factors emerged predicting chronic pain post-mastectomy: higher post-operative pain scores, age <65 years and inclusion of major reconstructive surgery.</span></span></span></span></p></div><div><h3>Conclusion</h3><p>Paravertebral block should be considered for use in major breast surgery. Pain control should be optimised/a priority for both acute care and to potentially reduce chronic pain.</p></div>","PeriodicalId":100023,"journal":{"name":"Acute Pain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.acpain.2009.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81321712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Timing of intraoperative parecoxib analgesia in colorectal surgery 结直肠手术术中帕瑞昔布镇痛的时机选择

Acute Pain Pub Date : 2008-12-01 DOI: 10.1016/j.acpain.2008.07.002

L.H. Lee , M.G. Irwin , T.J. Yao , M.K. Yuen , C.W. Cheung

{"title":"Timing of intraoperative parecoxib analgesia in colorectal surgery","authors":"L.H. Lee , M.G. Irwin , T.J. Yao , M.K. Yuen , C.W. Cheung","doi":"10.1016/j.acpain.2008.07.002","DOIUrl":"10.1016/j.acpain.2008.07.002","url":null,"abstract":"<div><h3>Objective</h3><p><span>The aim of this study was to determine the analgesic effect<span><span> of parecoxib when administered either before or at the end of surgery </span>in patients undergoing colorectal </span></span>laparotomy.</p></div><div><h3>Methods</h3><p>Sixty patients were randomised to three groups of 20. The PS group received intravenous parecoxib 40mg at skin closure. A control group (SS) received saline at both time points.</p></div><div><h3>Results</h3><p>In both SP and PS groups, morphine consumption was smaller. There was a 40–55% reduction in cumulative morphine consumption in both treatment groups at all time points up to 48h after anaesthesia finished. The greatest reduction was from 12h to 24h which showed a 66% reduction for the SP group and a 55% reduction for the PS group compared to control (<em>p</em>    <span><span>0.0167). For SP and PS groups, the time to first post-operative analgesic request tended to be longer and the number of patients requesting morphine in the </span>recovery room was less.</span></p></div><div><h3>Conclusion</h3><p>Parecoxib administration at the end of surgery is as effective as at the beginning with regard to analgesic and opioid-sparing effects.</p></div>","PeriodicalId":100023,"journal":{"name":"Acute Pain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.acpain.2008.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80435037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

When to think about chronic pain, to avoid progression of acute pain to chronic pain 当考虑慢性疼痛时，要避免急性疼痛发展为慢性疼痛

Acute Pain Pub Date : 2008-12-01 DOI: 10.1016/j.acpain.2008.08.012

引用次数: 0

Managing acute pain in patients with a substance abuse or dependence disorder 药物滥用或依赖障碍患者的急性疼痛管理

Acute Pain Pub Date : 2008-12-01 DOI: 10.1016/j.acpain.2008.08.007

引用次数: 0

Progression of acute to chronic pain: How to prevent it 急性到慢性疼痛的进展:如何预防

Acute Pain Pub Date : 2008-12-01 DOI: 10.1016/j.acpain.2008.08.011

引用次数: 0

Burns pain 烧伤疼痛

Acute Pain Pub Date : 2008-12-01 DOI: 10.1016/j.acpain.2008.08.005