IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-11-11 DOI: 10.1177/01455613221137224

Mehmet Kelleş, Yavuz Guler, Rukiye Guler

引用次数: 0

Congenital external auditory canal atresia with coexistent congenital cholesteatoma. 先天性外耳道闭锁，同时伴有先天性胆脂瘤。

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-11-24 DOI: 10.1177/01455613221142121

Surasura Haritha, Mounika Reddy Yalaka, Sarvani Pratyusha Polepeddi, Sai Swarna Birudaraju, Shobhan Babu, Sourabh Padmanabhan

引用次数: 0

Imidazole-triggered in situ fluorescence reaction system for quantitatively determination of dopamine from multiple sources. 咪唑触发的原位荧光反应系统定量测定多源多巴胺。

IF 5.6 1区化学

Talanta Pub Date : 2025-09-01 Epub Date: 2025-03-20 DOI: 10.1016/j.talanta.2025.127975

Yifei Ma, Lijie Zhang, Hong Yang, Shanshan Zhu, Jinhua Liu

{"title":"Imidazole-triggered in situ fluorescence reaction system for quantitatively determination of dopamine from multiple sources.","authors":"Yifei Ma, Lijie Zhang, Hong Yang, Shanshan Zhu, Jinhua Liu","doi":"10.1016/j.talanta.2025.127975","DOIUrl":"10.1016/j.talanta.2025.127975","url":null,"abstract":"Highly selective and sensitive determination of dopamine (DA) from multiple sources remains a persistent and significant challenge. Here, we develop an imidazole-triggered in situ fluorescence reaction system for highly selective and sensitive determination of DA from various sources (human, horse, dog, rabbit, and mouse). The system operates by catalyzing the oxidation of DA with 1,5-Dihydroxynaphthalene (1,5-DHA) through a Lewis base formed by imidazole, leading to the rapid generation of yellow azamonardine fluorescent compounds (AFC). Notably, the system demonstrates minimal background noise and a high signal-to-noise ratio of up to 300-fold with a determination limit of 33.33 pM, making it 10-100 times more sensitive than conventional enzyme-linked immunosorbent assay (ELISA) methods. Moreover, selectivity tests reveal that our system can effectively distinguish between several common interfering substances, even at concentrations as low as 10 nM. The developed system shows promising results in detecting DA from diverse sources (humans, horses, dogs, rabbits, and mice), including urine samples from clinical patients, exhibiting good agreement with traditional ELISA kits. Therefore, the established in situ fluorescence reaction system holds great potential for the determination of DA-related disorders due to its impressive analytical capabilities.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"292 ","pages":"127975"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Endonasal Surgery for Dermoid Cysts Arising From the Middle Cranial Fossa Floor: A Rare Case Series. 中颅窝底皮样囊肿的内窥镜手术：罕见病例系列。

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-11-15 DOI: 10.1177/01455613221138209

Haoyuan Xu, Wanpeng Li, Huankang Zhang, Huan Wang, Li Hu, Dehui Wang

{"title":"Endoscopic Endonasal Surgery for Dermoid Cysts Arising From the Middle Cranial Fossa Floor: A Rare Case Series.","authors":"Haoyuan Xu, Wanpeng Li, Huankang Zhang, Huan Wang, Li Hu, Dehui Wang","doi":"10.1177/01455613221138209","DOIUrl":"10.1177/01455613221138209","url":null,"abstract":"ObjectiveDermoid cysts (DCs) are congenital, slowly growing, and may cause nervous system symptoms. Related literature is limited and mainly includes case reports. We report a case series of DCs originating from the middle cranial fossa floor (MCFF) and investigate their demographic information, clinical characteristics, imaging findings, surgical procedures, and prognostic outcomes.MethodsWe reviewed the patients with DCs arising from the MCFF undergoing endoscopic endonasal surgery (EES) in our center between 2012 and 2022.ResultsA total of 5 patients with DCs were enrolled (2 males and 3 females), with a mean age of 46.2 years at the onset. All DCs originated from the MCFF with 1 case involving the middle cranial fossa bone and another 1 case affecting the dura mater. One (20.0%) patient had neurological involvement. After admission, all patients received EES with a total resection rate of 100.0% (5 of 5). After a median follow-up of 73.2 months, all patients achieved complete clinical and radiological improvements. No surgical-related complications or relapses were observed during the long-term follow-up.ConclusionEndoscopic endonasal surgery is considered a safe and effective approach for the treatment of DCs in the MCFF. A larger sample size and longer follow-up time are needed.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP577-NP586"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40468018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring variations in mitochondrial hydrogen sulfide using two-photon cyclometalated iridium(III) complex probe: A new strategy for ischemia-reperfusion drug discovery and efficacy evaluation. 利用双光子环金属化铱（III）复合物探针监测线粒体硫化氢的变化：缺血再灌注药物发现和疗效评估的新策略。

IF 5.6 1区化学

Talanta Pub Date : 2025-09-01 Epub Date: 2025-03-28 DOI: 10.1016/j.talanta.2025.128021

Peng Du, Tianao Zhang, Ying Wu, Zongping Yu, Chaolong Liu

{"title":"Monitoring variations in mitochondrial hydrogen sulfide using two-photon cyclometalated iridium(III) complex probe: A new strategy for ischemia-reperfusion drug discovery and efficacy evaluation.","authors":"Peng Du, Tianao Zhang, Ying Wu, Zongping Yu, Chaolong Liu","doi":"10.1016/j.talanta.2025.128021","DOIUrl":"10.1016/j.talanta.2025.128021","url":null,"abstract":"Hepatic ischemia-reperfusion injury (HIRI) is one of the main causes of liver insufficiency and failure after liver surgery. However, the effectiveness of current methods of treating HIRI is generally limited. Previous studies have shown that hydrogen sulfide (H2S) has a beneficial effect on HIRI, and an appropriate concentration of H2S can significantly reduce HIRI by protecting the mitochondria. Therefore, establishing an accurate imaging platform for monitoring variations in mitochondrial H2S is an effective strategy for anti-HIRI drug discovery and efficacy evaluation. To this end, a cyclometalated iridium(III) complex-based probe, Cym-Ir-EDB, was developed for detecting mitochondrial H2S in HIRI. Cym-Ir-EDB possesses good sensitivity, high selectivity, negligible cytotoxicity, and excellent mitochondrial-targeting ability, rendering it a promising imaging tool for analyzing variations in mitochondrial H2S in HIRI cells. Using Cym-Ir-EDB as a probe, anti-HIRI drugs were screened from isothiocyanates by monitoring variations in mitochondrial H2S in HIRI cells, for the first time. Moreover, the dynamics of mitochondrial H2S in HIRI cells were visualized and the response of HIRI to treatment with the screened erucin was monitored. The findings indicate that Cym-Ir-EDB can serve as a useful imaging platform for the precise imaging of mitochondrial H2S in HIRI, thereby contributing to anti-HIRI drug discovery and efficacy evaluation.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"292 ","pages":"128021"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary nasal septal meningioma; a rare mimicker of nasal polyp. 原发性鼻中隔脑膜瘤；一种罕见的鼻息肉假象。

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-11-25 DOI: 10.1177/01455613221142117

Elif Gozgec, Hayri Ogul

引用次数: 0

Drug-Induced Rhinitis: Narrative Review. 药物性鼻炎：叙述性综述。

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-11-15 DOI: 10.1177/01455613221141214

Saud Alromaih, Lamya Alsagaf, Nouf Aloraini, Abdulaziz Alrasheed, Ahmad Alroqi, Mohammad Aloulah, Saad Alsaleh, Tariq Alhawassi

{"title":"Drug-Induced Rhinitis: Narrative Review.","authors":"Saud Alromaih, Lamya Alsagaf, Nouf Aloraini, Abdulaziz Alrasheed, Ahmad Alroqi, Mohammad Aloulah, Saad Alsaleh, Tariq Alhawassi","doi":"10.1177/01455613221141214","DOIUrl":"10.1177/01455613221141214","url":null,"abstract":"ObjectivesRhinitis, one of the most common inflammatory conditions of the nasal mucosa, is known to affect a large proportion of people worldwide. It is generally classified into allergic and non-allergic types and both are associated with several unpleasant symptoms. Several medications prescribed for different medical conditions can cause unpleasant rhinitis as an adverse effect, which is known as drug-induced non-allergic rhinitis. The aims of this article were to review the literature to identify drugs that could induce rhinitis, prevalence of drug-induced rhinitis, and the associated pathogenic mechanisms if known.MethodsLiterature search screening for eligible papers published up to December 31st, 2021, in Medline (via PubMed) and Embase was conducted. The search included the following combination of keywords and terms: rhinitis, sneezing, congestion, allergic, non-allergic, rhinorrhea, vasomotor, medication, drug-induced.ResultsThe review findings suggest that 12 subtypes of drugs potentially could induce rhinitis. Based on their mechanisms of action, the pathogenic causes for the induction of rhinitis have been recognized for some drugs, while others remain unknown.ConclusionAwareness of the list of drugs that reportedly induce non-allergic nasal symptoms, along with taking the patient's medication history, is important in the diagnosis of rhinitis.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"582-590"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40703182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Method for Making an Auricle Framework Like Lego Building Blocks. 像乐高积木一样制作耳廓框架的新方法

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-11-30 DOI: 10.1177/01455613221143198

Pengfei Sun, Limei Yuan, Yang Yang, Lingdong Zhu

{"title":"A Novel Method for Making an Auricle Framework Like Lego Building Blocks.","authors":"Pengfei Sun, Limei Yuan, Yang Yang, Lingdong Zhu","doi":"10.1177/01455613221143198","DOIUrl":"10.1177/01455613221143198","url":null,"abstract":"ObjectivesThe traditional Tanzer-Brent method, which uses the integral engraving of costal cartilage, provides insufficient three-dimensional sensation and is characterized by poor firmness of the auricle framework. This tends to cause the absorption deformation of the auricle framework after surgery. In order to reduce the absorption deformation as well as make the reconstructed auricle more three-dimensional and the ear shape more realistic, our ear reconstruction team invented a novel method to make an auricle framework with autologous costal cartilage. The auricle framework made by this novel method has been applied to auricle reconstruction and has achieved excellent surgical results.Patients and MethodsClinical data and postoperative data were collected for patients with unilateral microtia who received auricle reconstruction using the novel method of auricle framework construction in Plastic Surgery Hospital from January 2020 to June 2022. The therapeutic effect of this novel method was evaluated by the satisfaction rate of patients and their families and by the prevalence of postoperative complications.ResultsA total of 60 patients were enrolled in this study. The average age was (10.95 ± 2.97) years old. The mean follow-up time was 24.02 ± 1.52 months. The satisfaction rate of patients and their families was 96.7%. In terms of postoperative complications, two patients had postoperative infection, one patient had framework exposure, no patients had framework absorption and deformation, two patients had postoperative hematoma, and three patients had scar hyperplasia.ConclusionThis novel method of making the auricle framework is more standardized, easier to master for plastic surgeons, and more conducive to the clinical application of plastic surgery. Through this study, we believe that this novel method offers significant therapeutic advantages and can be used as a unified standard for construction of an auricle framework using autologous costal cartilage.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP599-NP605"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40723094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Value of Adenoid-Nasopharyngeal Ratio in the Diagnosis of Secretory Otitis Media. 腺样体-鼻咽比例在诊断分泌性中耳炎中的预测价值

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-12-04 DOI: 10.1177/01455613221144496

Ping Li, Tao Li, Liang Yu, Aiping Chen, Yisha Wu, Yuzhu Wan, Li Shi

{"title":"Predictive Value of Adenoid-Nasopharyngeal Ratio in the Diagnosis of Secretory Otitis Media.","authors":"Ping Li, Tao Li, Liang Yu, Aiping Chen, Yisha Wu, Yuzhu Wan, Li Shi","doi":"10.1177/01455613221144496","DOIUrl":"10.1177/01455613221144496","url":null,"abstract":"ObjectivesTo explore the associated factors of otitis media with effusion (OME) and analyze the diagnostic value of the adenoid-nasopharyngeal (A/N) ratio to OME.MethodsPatients with adenoid hypertrophy (AH) recently in 2 years were collected, including sex, age, duration, with/without rhinosinusitis, and examination results, including Cone Beam Computerized Tomography (CBCT) sinus imaging, tympanometry, pure tone audiometry (PTA), blood test, and allergen detection. According to Liden/Jerger's classification, the patients were divided into two groups: Type B and type C, which were defined as the tympanometry abnormal group (TAG), and the rest were classified as the tympanometry normal group (TNG).ResultsA total of 316 children were included in this study. Age and duration were significantly younger and shorter in TAG (6.0(4.0-9.0) vs.5.0(4.0-7.0)); 12.0(4.0-24.0) vs.6.0(2.0-12.0)). Compared to TNG, the allergen test results of fx5 (protein, milk, cod, wheat, peanut, and soybean) in TAG were higher (0.09(0.04-0.25) vs.0.14(0.05-0.45)), but eosinophilia in blood was lower (count: 0.21(0.13-0.35) vs. 0.18(0.12-0.27); ratio: 3.10 (1.90-4.70) vs. 2.50 (1.65-3.80)). A/N ratio and Visual obstruction ratio had a statistical difference (Z = -3.770, P < .01) but the two ratios didn't have too much disparity (0.82(0.74-0.88) VS 0.80(0.75-0.80)), and they had a positive correlation (r = 0.345, P < .01). A/N ratio of TAG was higher than TNG (0.78(0.70-0.85) vs. 0.86(0.82-0.90)) and had a positive correlation with increasing negative middle ear pressure (r = -3.777, P < .01). A/N ratio was an associated factor of OME (OR:1355.611, P = .006), the cut-off value of A/N ratio was 0.815(sensitivity: 75.3%, specificity: 64.3%, area under the curve (AUC): 0.747)ConclusionsA/N ratio indirectly reflected the abnormality of tympanometry in this study. When A/N ratio reaches 0.815, patients are at a higher risk of having OME so it could be a predictor of OME in patients with adenoid hypertrophy.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP618-NP625"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40464774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endolymphatic Sac Tumor. 内淋巴囊肿瘤

IF 17.7 1区化学

Accounts of Chemical Research Pub Date : 2025-09-01 Epub Date: 2022-11-14 DOI: 10.1177/01455613221139408

Tanner P Lyons, Laura Barry, Robert T Sataloff

引用次数: 0

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